Bert Brunekreef

Summary

Affiliation: Utrecht University
Country: The Netherlands

Publications

  1. ncbi Design of cohort studies for air pollution health effects
    Bert Brunekreef
    Institute for Risk Assessment Sciences, University of Utrecht, Utrecht, The Netherlands
    J Toxicol Environ Health A 66:1723-9. 2003
  2. doi Traffic-related air pollution is related to interrupter resistance in 4-year-old children
    Esther Eenhuizen
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Eur Respir J 41:1257-63. 2013
  3. doi Time in bed, sleep quality and associations with cardiometabolic markers in children: the Prevention and Incidence of Asthma and Mite Allergy birth cohort study
    Nina E Berentzen
    Center for Nutrition, Prevention, and Health Services, National Institute for Public Health and the Environment, Bilthoven, The Netherlands Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Sleep Res 23:3-12. 2014
  4. doi Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age
    Salome Scholtens
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    J Allergy Clin Immunol 123:1312-8.e2. 2009
  5. doi Traffic-related air pollution and the development of asthma and allergies during the first 8 years of life
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, The Netherlands
    Am J Respir Crit Care Med 181:596-603. 2010
  6. doi Waist circumference, BMI, and lung function in 8-year-old children: the PIAMA birth cohort study
    Marga B M Bekkers
    Institute for Risk Assessment Sciences IRAS, Utrecht University, Utrecht, The Netherlands
    Pediatr Pulmonol 48:674-82. 2013
  7. doi Respiratory effects of a reduction in outdoor air pollution concentrations
    Hanna Boogaard
    Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, Utrecht, Netherlands
    Epidemiology 24:753-61. 2013
  8. doi Traffic-related air pollution, preterm birth and term birth weight in the PIAMA birth cohort study
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80178, 3508 TD Utrecht, The Netherlands
    Environ Res 111:125-35. 2011
  9. doi Uncontrolled asthma at age 8: the importance of parental perception towards medication
    Ellen S Koster
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Pediatr Allergy Immunol 22:462-8. 2011
  10. ncbi Levels and determinants of beta(1-->3)-glucans and fungal extracellular polysaccharides in house dust of (pre-)school children in three European countries
    Mariëlla E C A Giovannangelo
    Utrecht University, Institute for Risk Assessment Sciences, Utrecht, The Netherlands
    Environ Int 33:9-16. 2007

Detail Information

Publications105 found, 100 shown here

  1. ncbi Design of cohort studies for air pollution health effects
    Bert Brunekreef
    Institute for Risk Assessment Sciences, University of Utrecht, Utrecht, The Netherlands
    J Toxicol Environ Health A 66:1723-9. 2003
    ..In addition, following the examples of Sweden, the Netherlands, and Germany, the use of geographical information systems is recommended to assess exposure to air pollutants at the address rather than the community level...
  2. doi Traffic-related air pollution is related to interrupter resistance in 4-year-old children
    Esther Eenhuizen
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Eur Respir J 41:1257-63. 2013
    ....
  3. doi Time in bed, sleep quality and associations with cardiometabolic markers in children: the Prevention and Incidence of Asthma and Mite Allergy birth cohort study
    Nina E Berentzen
    Center for Nutrition, Prevention, and Health Services, National Institute for Public Health and the Environment, Bilthoven, The Netherlands Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Sleep Res 23:3-12. 2014
    ..Therefore, we consider it premature to propose that improved sleep could reduce cardiovascular risk during childhood...
  4. doi Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age
    Salome Scholtens
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    J Allergy Clin Immunol 123:1312-8.e2. 2009
    ..Asthma may be more prevalent in overweight children. However, how early overweight and changes in weight status during childhood affect the asthma risk is unclear...
  5. doi Traffic-related air pollution and the development of asthma and allergies during the first 8 years of life
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, The Netherlands
    Am J Respir Crit Care Med 181:596-603. 2010
    ..The role of air pollution exposure in the development of asthma, allergies, and related symptoms remains unclear, due in part to the limited number of prospective cohort studies with sufficiently long follow-ups addressing this problem...
  6. doi Waist circumference, BMI, and lung function in 8-year-old children: the PIAMA birth cohort study
    Marga B M Bekkers
    Institute for Risk Assessment Sciences IRAS, Utrecht University, Utrecht, The Netherlands
    Pediatr Pulmonol 48:674-82. 2013
    ..Body mass index (BMI) and waist circumference (WC) may be associated with lung function in children, as observed in adults...
  7. doi Respiratory effects of a reduction in outdoor air pollution concentrations
    Hanna Boogaard
    Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, Utrecht, Netherlands
    Epidemiology 24:753-61. 2013
    ..We assessed whether a reduction in (traffic policy-related) air pollution concentrations was associated with changes in respiratory health...
  8. doi Traffic-related air pollution, preterm birth and term birth weight in the PIAMA birth cohort study
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80178, 3508 TD Utrecht, The Netherlands
    Environ Res 111:125-35. 2011
    ..Maternal exposure to air pollution has been associated with adverse pregnancy outcomes. Few studies took into account the spatial and temporal variation of air pollution levels...
  9. doi Uncontrolled asthma at age 8: the importance of parental perception towards medication
    Ellen S Koster
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Pediatr Allergy Immunol 22:462-8. 2011
    ..The aim of this study was to identify determinants of uncontrolled asthma at age 8 in children participating in the PIAMA birth cohort study...
  10. ncbi Levels and determinants of beta(1-->3)-glucans and fungal extracellular polysaccharides in house dust of (pre-)school children in three European countries
    Mariëlla E C A Giovannangelo
    Utrecht University, Institute for Risk Assessment Sciences, Utrecht, The Netherlands
    Environ Int 33:9-16. 2007
    ..Measurements of beta(1-->3)-glucans and fungal extracellular polysaccharides (EPS) are used as markers of mold exposure in field studies. Little is known about their levels and determinants in homes...
  11. pmc Contrasts in oxidative potential and other particulate matter characteristics collected near major streets and background locations
    Hanna Boogaard
    Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 120:185-91. 2012
    ..Measuring the oxidative potential of airborne particulate matter (PM) may provide a more health-based exposure measure by integrating various biologically relevant properties of PM into a single predictor of biological activity...
  12. doi High agreement between parental reported inhaled corticosteroid use and pharmacy prescription data
    Ellen S Koster
    Division of Pharmacoepidemiology and Pharmacotherapy, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Pharmacoepidemiol Drug Saf 19:1199-203. 2010
    ..This study was conducted to assess the validity of parental reported use of inhaled corticosteroids (ICS) in children...
  13. doi Do differences in childhood diet explain the reduced overweight risk in breastfed children?
    Salome Scholtens
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Obesity (Silver Spring) 16:2498-503. 2008
    ..71, 95% confidence interval: 0.49-1.03). Breastfed children had a healthier diet at 7 years compared to nonbreastfed children, but this difference could not explain the lower overweight risk at 8 years in breastfed children...
  14. doi Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: results from the ESCAPE and TRANSPHORM projects
    Meng Wang
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands Electronic address
    Environ Int 66:97-106. 2014
    ..However, health effects of long-term exposure to constituents of PM on total CVD mortality have been explored in a single study only...
  15. doi Gas cooking, respiratory and allergic outcomes in the PIAMA birth cohort study
    WeiWei Lin
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Occup Environ Med 70:187-94. 2013
    ..Our aim was to examine the association between gas cooking and the development of respiratory and allergic outcomes longitudinally in a prospective birth cohort study...
  16. pmc BMI development of normal weight and overweight children in the PIAMA study
    Saskia M Willers
    Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 7:e39517. 2012
    ..There is evidence that rapid weight gain during the first year of life is associated with overweight later in life. However, results from studies exploring other critical periods for the development of overweight are inconsistent...
  17. pmc Air pollution exposure and lung function in children: the ESCAPE project
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 121:1357-64. 2013
    ..There is evidence for adverse effects of outdoor air pollution on lung function of children. Quantitative summaries of the effects of air pollution on lung function, however, are lacking due to large differences among studies...
  18. doi Patterns of asthma medication use: early asthma therapy initiation and asthma outcomes at age 8
    Ellen S Koster
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Pharmacoepidemiol Drug Saf 19:991-9. 2010
    ..ICS and SABA prescription occurs especially in those who were more likely to develop signs of asthma at age 8...
  19. pmc BMI and waist circumference; cross-sectional and prospective associations with blood pressure and cholesterol in 12-year-olds
    Marga B M Bekkers
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 7:e51801. 2012
    ..We studied associations between BMI and WC and blood pressure (BP) and cholesterol in 12-year-old children and prospectively changes in BMI or WC status between age 8 and 12 years and BP and cholesterol at age 12...
  20. doi Blood pressure in 12-year-old children is associated with fatty acid composition of human milk: the prevention and incidence of asthma and mite allergy birth cohort
    Lenie van Rossem
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Hypertension 60:1055-60. 2012
    ....
  21. doi Long-term exposure to traffic-related air pollution and lung cancer risk
    Rob Beelen
    Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands
    Epidemiology 19:702-10. 2008
    ..Most studies on the association between lung cancer and air pollution have investigated mortality. There have been few studies of lung cancer incidence...
  22. doi Persistence of asthma medication use in preschool children
    Mira G Zuidgeest
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Respir Med 102:1446-51. 2008
    ..Our aim is to quantify the persistent use of asthma medication, initiated in the first year of life and identify determinants of this persistent use...
  23. doi Associations between particulate matter composition and childhood blood pressure--The PIAMA study
    Natalya Bilenko
    Institute for Risk Assessment Sciences, Utrecht University, P O Box 80178, 3508 TD Utrecht, The Netherlands
    Environ Int 84:1-6. 2015
    ..Evidence for an association between ambient particulate matter (PM) exposure and blood pressure is increasing, but little is known about the relevance of different PM constituents...
  24. pmc Natural-cause mortality and long-term exposure to particle components: an analysis of 19 European cohorts within the multi-center ESCAPE project
    Rob Beelen
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 123:525-33. 2015
    ..Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality...
  25. doi Particulate matter composition and respiratory health: the PIAMA Birth Cohort study
    Ulrike Gehring
    From the aInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands bDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland cUniversity of Basel, Basel, Switzerland dMRC PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom eDivision of Respiratory Medicine, Department of Pediatrics, Erasmus University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands fNetherlands Organization for Applied Scientific Research TNO, Utrecht, The Netherlands gDepartment of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands hGroningen Research Institute for Asthma and COPD, University of Groningen, Groningen, The Netherlands iDepartment of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands and jJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Epidemiology 26:300-9. 2015
    ..Little is known about the importance of different PM constituents. We investigated the effects of PM constituents on asthma, allergy, and lung function until the age of 11-12 years...
  26. doi The association of LUR modeled PM2.5 elemental composition with personal exposure
    Denise Montagne
    Institute for Risk Assessment Sciences IRAS, University of Utrecht, Utrecht, The Netherlands
    Sci Total Environ 493:298-306. 2014
    ..5 components with measured personal concentrations was determined. The elements of interest were copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V) and zinc (Zn)...
  27. pmc Environmental exposure assessment in European birth cohorts: results from the ENRIECO project
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health 12:8. 2013
    ....
  28. doi Effect of endotoxin and allergens on neonatal lung function and infancy respiratory symptoms and eczema
    Victoria Abbing-Karahagopian
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Pediatr Allergy Immunol 23:448-55. 2012
    ..Exposure to endotoxin and allergens in house dust has been found to be associated with childhood wheeze and asthma. Neonatal lung function is rarely examined in relation to this exposure...
  29. doi Systematic evaluation of land use regression models for NO₂
    Meng Wang
    Institute for Risk Assessment Sciences IRAS, Division of Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands
    Environ Sci Technol 46:4481-9. 2012
    ..In our specific application, models based on as few as 24 training sites, however, achieved acceptable hold out validation R(2)s of, on average, 0.60...
  30. pmc Early-life determinants of total and HDL cholesterol concentrations in 8-year-old children; the PIAMA birth cohort study
    Marga B M Bekkers
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 6:e25533. 2011
    ....
  31. doi Long-chain polyunsaturated fatty acids in breast milk and early weight gain in breast-fed infants
    Salome Scholtens
    Institute for Risk Assessment Sciences, Utrecht University, The Netherlands
    Br J Nutr 101:116-21. 2009
    ..The n-3 and n-6 LCPUFA content in breast milk did not affect weight or BMI gain in the first year of life in breast-fed term infants...
  32. doi Parental reported compared with measured waist circumference in 8-year-old children
    Marga B M Bekkers
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Int J Pediatr Obes 6:e78-86. 2011
    ..In this study the agreement between parental reported and measured WC in 8-year-old children was investigated and compared with the agreement between parental reported and measured body mass index (BMI)...
  33. doi Traffic-related outdoor air pollution and respiratory symptoms in children: the impact of adjustment for exposure measurement error
    Sofie van Roosbroeck
    Environmental Epidemiology Group, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Epidemiology 19:409-16. 2008
    ..Outdoor concentrations of soot and nitrogen dioxide (NO2) outside of schools have been associated with children's respiratory and eye symptoms. We assessed how adjustments for measurement error affect these associations...
  34. pmc Performance of multi-city land use regression models for nitrogen dioxide and fine particles
    Meng Wang
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 122:843-9. 2014
    ..Transferability of LUR models from city to city has been investigated, but little is known about the performance of models based on large numbers of monitoring sites covering a large area...
  35. doi Evaluation of land use regression models for NO2 and particulate matter in 20 European study areas: the ESCAPE project
    Meng Wang
    Institute for Risk Assessment Sciences, Utrecht University, P O Box 80178, 3508 TD Utrecht, The Netherlands
    Environ Sci Technol 47:4357-64. 2013
    ..Nevertheless, in most areas LUR models still explained a substantial fraction of the variation of concentrations measured at independent sites...
  36. doi Air pollution exposure affects circulating white blood cell counts in healthy subjects: the role of particle composition, oxidative potential and gaseous pollutants - the RAPTES project
    Maaike Steenhof
    Division of Toxicology and Division of Environmental Epidemiology, Institute for Risk Assessment Sciences IRAS, Utrecht University, Utrecht, The Netherlands
    Inhal Toxicol 26:141-65. 2014
    ..Future studies should indicate if air pollution exposure-induced changes in blood cell counts results in adverse cardiovascular effects in susceptible individuals...
  37. doi Agreement of land use regression models with personal exposure measurements of particulate matter and nitrogen oxides air pollution
    Denise Montagne
    Institute for Risk Assessment Sciences IRAS, University of Utrecht, Utrecht, The Netherlands
    Environ Sci Technol 47:8523-31. 2013
    ..This study supports the use of intraurban LUR models for especially soot in air pollution epidemiology. ..
  38. doi Long-term exposure to air pollution and vascular damage in young adults
    Virissa Lenters
    Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Epidemiology 21:512-20. 2010
    ..There are, however, very limited data in healthy young people. We examined the association between air pollutants and indicators of vascular damage in a cohort of young adults...
  39. doi Traffic-related air pollution and pregnancy outcomes in the Dutch ABCD birth cohort study
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, 3508 TD Utrecht, The Netherlands
    Occup Environ Med 68:36-43. 2011
    ..As European data on this topic are limited, the aim of this study was to evaluate the impact of maternal exposure to traffic-related air pollution during different periods of pregnancy on preterm birth and fetal growth...
  40. doi Respiratory health effects of ultrafine and fine particle exposure in cyclists
    Maciej Strak
    Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, PO Box 80178, 3508 TD Utrecht, The Netherlands
    Occup Environ Med 67:118-24. 2010
    ..We carried out a study to investigate the acute respiratory health effects of air pollution related to commuting by bicycle...
  41. doi Air pollution and exhaled nitric oxide in Dutch schoolchildren
    Haitske Graveland
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Occup Environ Med 68:551-6. 2011
    ..No studies have simultaneously addressed the long-term and short-term associations between traffic-related air pollution and exhaled NO...
  42. doi Land use regression model for ultrafine particles in Amsterdam
    Gerard Hoek
    Institute for Risk Assessment Sciences IRAS, Division of Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands
    Environ Sci Technol 45:622-8. 2011
    ..5, soot, and coarse particles. A LUR model for PNC has been developed, with similar validity as previous models for more commonly measured pollutants...
  43. ncbi Breastfeeding, weight gain in infancy, and overweight at seven years of age: the prevention and incidence of asthma and mite allergy birth cohort study
    Salome Scholtens
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Am J Epidemiol 165:919-26. 2007
    ..These findings suggest that the lower BMI and lower risk of overweight among breastfed children later in life are already achieved at 1 year of age...
  44. doi Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
    Lancet Respir Med 3:933-42. 2015
    ..We aimed to assess the longitudinal associations between exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence...
  45. pmc Air Pollution and Lung Function in Dutch Children: A Comparison of Exposure Estimates and Associations Based on Land Use Regression and Dispersion Exposure Modeling Approaches
    Meng Wang
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 123:847-51. 2015
    ..There is limited knowledge about the extent to which estimates of air pollution effects on health are affected by the choice for a specific exposure model...
  46. doi Overweight in infancy: which pre- and perinatal factors determine overweight persistence or reduction? A birth cohort followed for 11 years
    Lenie van Rossem
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Nutr Metab 65:211-9. 2014
    ..To recognize infants at risk of persistent overweight, we compared early-life factors of children with a longitudinal pattern of persistent overweight to children with a pattern of overweight in early but not in later childhood...
  47. doi Serum Visfatin and Leptin in Relation to Childhood Adiposity and Body Fat Distribution: The PIAMA Birth Cohort Study
    Saskia M Willers
    Institute for Risk Assessment Sciences IRAS, Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands
    Ann Nutr Metab 66:63-71. 2015
    ..We hypothesized that visfatin, but not leptin, would be specifically associated with visceral adiposity. We investigated the relation of serum visfatin and leptin with measures of adiposity and body fat distribution in children...
  48. doi Elemental composition of particulate matter and the association with lung function
    Marloes Eeftens
    From the aInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands bDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland cUniversity of Basel, Basel, Switzerland dKarolinska Institute, Institute of Environmental Medicine, Stockholm, Sweden eCentre for Occupational and Environmental Health, University of Manchester, Manchester, United Kingdom fJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands gUniversity of Manchester, Manchester Academic Health Science Centre, Institute of Inflammation and Repair, University Hospital of South Manchester NHS Foundation Trust, Wythenshawe Hospital, Manchester, United Kingdom hHelmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology II, Neuherberg, Germany iUniversity of Augsburg, Environmental Science Center, Augsburg, Germany jHelmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany kSchool of Population and Public Health, University of British Columbia, Vancouver, Canada lIUF Leibniz Research Institute for Environmental Medicine, University of Dusseldorf, Dusseldorf,
    Epidemiology 25:648-57. 2014
    ..Negative effects of long-term exposure to particulate matter (PM) on lung function have been shown repeatedly. Spatial differences in the composition and toxicity of PM may explain differences in observed effect sizes between studies...
  49. doi Traffic-related air pollution and noise and children's blood pressure: results from the PIAMA birth cohort study
    Natalya Bilenko
    Utrecht University, Utrecht, The Netherlands
    Eur J Prev Cardiol 22:4-12. 2015
    ..Little is known about these associations in children. We investigated the associations of air pollution and noise exposure with blood pressure in 12-year-olds...
  50. doi Comparison of ambient airborne PM₂.₅, PM₂.₅ absorbance and nitrogen dioxide ratios measured in 1999 and 2009 in three areas in Europe
    John L Durant
    Institute for Risk Assessment Sciences IRAS, Division of Environmental Epidemiology, University of Utrecht, Utrecht, The Netherlands Department of Civil and Environmental Engineering, Tufts University, Medford, MA, USA Electronic address
    Sci Total Environ 487:290-8. 2014
    ..The changed contrasts may affect estimates of health effects related to NO2 as a marker of proximity to roads...
  51. doi Long-term exposure to air pollution and cardiovascular mortality: an analysis of 22 European cohorts
    Rob Beelen
    From the aInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands bDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy cDanish Cancer Society Research Center, Copenhagen, Denmark dCenter for Epidemiology and Screening, Department of Public Health, University of Copenhagen, CSS, København K, Denmark eMRC HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, St Mary s Campus, London, United Kingdom fUniversity College London, CeLSIUS, London, United Kingdom gDepartment of Hygiene, Epidemiology, and Medical Statistics, Medical School, University of Athens, Athens, Greece hJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands iInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany jIUF Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany, and Medical Faculty, University of Dusseldorf, Dusseldorf, Germany kInstitute of Epidemiology II, Helmholtz Zentrum Munchen,
    Epidemiology 25:368-78. 2014
    ....
  52. doi Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project
    Rob Beelen
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands Electronic address
    Lancet 383:785-95. 2014
    ..Within the multicentre European Study of Cohorts for Air Pollution Effects (ESCAPE), we aimed to investigate the association between natural-cause mortality and long-term exposure to several air pollutants...
  53. doi Development of Land Use Regression models for PM(2.5), PM(2.5) absorbance, PM(10) and PM(coarse) in 20 European study areas; results of the ESCAPE project
    Marloes Eeftens
    Institute for Risk Assessment Sciences, Utrecht University, P O Box 80178, 3508 TD Utrecht, The Netherlands
    Environ Sci Technol 46:11195-205. 2012
    ..The final LUR models are used to estimate air pollution concentrations at the home addresses of participants in the health studies involved in ESCAPE...
  54. doi Early life exposure to farm animals and symptoms of asthma, rhinoconjunctivitis and eczema: an ISAAC Phase Three Study
    Bert Brunekreef
    Institute for Risk Assessment Sciences and Julius Center for Health Sciences and Primary Care, University Medical Center Universiteit Utrecht, Utrecht, The Netherlands
    Int J Epidemiol 41:753-61. 2012
    ..Associations between early life exposure to farm animals and respiratory symptoms and allergy in children have been reported in developed countries, but little is known about such associations in developing countries...
  55. ncbi Validity of residential traffic intensity as an estimate of long-term personal exposure to traffic-related air pollution among adults
    Sofie van Roosbroeck
    Division Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, P O Box 801 78, 3508 TD Utrecht, The Netherlands
    Environ Sci Technol 42:1337-44. 2008
    ..Time spent in traffic and spending time outdoors were associated with increased personal exposure of soot and PM2.5, but not NOx...
  56. doi Maternal food consumption during pregnancy and the longitudinal development of childhood asthma
    Saskia M Willers
    Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, P O Box 80178, 3508 TD Utrecht, The Netherlands
    Am J Respir Crit Care Med 178:124-31. 2008
    ..Maternal diet during pregnancy has the potential to affect airway development and to promote T-helper-2-cell responses during fetal life. This might increase the risk of developing childhood asthma or allergy...
  57. pmc Long-term effects of traffic-related air pollution on mortality in a Dutch cohort (NLCS-AIR study)
    Rob Beelen
    Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 116:196-202. 2008
    ..Several studies have found an effect on mortality of between-city contrasts in long-term exposure to air pollution. The effect of within-city contrasts is still poorly understood...
  58. pmc Self-reported truck traffic on the street of residence and symptoms of asthma and allergic disease: a global relationship in ISAAC phase 3
    Bert Brunekreef
    Institute for Risk Assessment Sciences and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Environ Health Perspect 117:1791-8. 2009
    ..Associations between traffic pollution on the street of residence and a range of respiratory and allergic outcomes in children have been reported in developed countries, but little is known about such associations in developing countries...
  59. doi Development of land use regression models for elemental, organic carbon, PAH, and hopanes/steranes in 10 ESCAPE/TRANSPHORM European study areas
    Aleksandra Jedyńska
    TNO, Netherlands Organization for Applied Scientific Research, Utrecht, The Netherlands
    Environ Sci Technol 48:14435-44. 2014
    ..The moderate to high explained variance of LUR models and the overall moderate correlation with PM2.5 model predictions support the application of especially the OC and PAH models in epidemiological studies. ..
  60. pmc What drives prescribing of asthma medication to children? A multilevel population-based study
    Mira G P Zuidgeest
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Ann Fam Med 7:32-40. 2009
    ..This challenge creates an opportunity for variability in prescribing. The aim of our study was to investigate how and to what degree patient, family, and physician characteristics influence prescribing of asthma medication in children...
  61. pmc In vitro toxicity of particulate matter (PM) collected at different sites in the Netherlands is associated with PM composition, size fraction and oxidative potential--the RAPTES project
    Maaike Steenhof
    Division of Toxicology, Institute for Risk Assessment Sciences, Utrecht University, PO Box 80177, 3508 TD Utrecht, The Netherlands
    Part Fibre Toxicol 8:26. 2011
    ..This study investigated the in vitro toxicity of ambient PM collected at different sites in the Netherlands in relation to PM composition and oxidative potential...
  62. pmc Evaluation of a low-cost electrostatic dust fall collector for indoor air endotoxin exposure assessment
    Ilka Noss
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Appl Environ Microbiol 74:5621-7. 2008
    ..We therefore conclude that measuring endotoxin levels with the EDC is a valid measure of average airborne endotoxin exposure, while reproducibility over time is at least equivalent to that of reservoir dust analyses...
  63. ncbi Stakeholder needs for air pollution and health information
    Eric Gordon Sanderson
    Institute for Risk Assessment Sciences, University of Utrecht, Utrecht, The Netherlands
    J Toxicol Environ Health A 69:1819-25. 2006
    ....
  64. doi The impact of ambient NO on online measurements of exhaled and nasal NO: the PIAMA study
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Pediatr Allergy Immunol 20:665-72. 2009
    ..The currently recommended technique including inhalation through an NO scrubber effectively deals with variable levels of ambient NO on FENO. In contrast, ambient NO has an effect on measurements of nNO...
  65. doi Polymorphisms in the mannan-binding lectin gene are not associated with questionnaire-reported respiratory tract infections in children
    Jopje M Ruskamp
    Department of Pediatrics, Wilhelmina Children s Hospital, University Medical Center Utrecht, University of Utrecht, Lundlaan 6, Utrecht, The Netherlands
    J Infect Dis 198:1707-13. 2008
    ..Large-scale replication of previous associations is needed, however. We investigated the association between MBL2 polymorphisms and the frequency of RTI in a large population-based birth cohort of white children...
  66. doi Neonatal total IgE and respiratory tract infections in children with intrauterine smoke exposure
    Jopje Ruskamp
    Department of Paediatrics, Wilhelmina Children s Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands
    Arch Dis Child 95:427-31. 2010
    ..We examined whether early atopic status (defined by elevated neonatal total IgE (tIgE) or symptoms of atopic dermatitis) modified the association between ETS exposure and RTI...
  67. doi Inverse association between endotoxin exposure and canine atopic dermatitis
    Frank A Looringh van Beeck
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    Vet J 190:215-9. 2011
    ..The results indicated that endotoxin exposure is inversely associated with CAD, suggesting a protective effect of high indoor endotoxin exposure towards the development of the condition...
  68. doi Concentration response functions for ultrafine particles and all-cause mortality and hospital admissions: results of a European expert panel elicitation
    Gerard Hoek
    Institute for Risk Assessment Sciences and Copernicus Institute, University of Utrecht, Utrecht, The Netherlands
    Environ Sci Technol 44:476-82. 2010
    ..This expert elicitation provides the first quantitative evaluation of estimates of concentration response functions between urban air ultrafine particles and all-cause mortality and hospital admissions...
  69. doi Residential proximity to major roads and term low birth weight: the roles of air pollution, heat, noise, and road-adjacent trees
    Payam Dadvand
    From the aCentre for Research in Environmental Epidemiology CREAL, Barcelona, Spain bCIBER Epidemiología y Salud Pública CIBERESP, Barcelona, Spain cOffice of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA dDepartment of Maternal Foetal Medicine, ICGON, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain eUniversitat Pompeu Fabra UPF, Barcelona, Spain fInstitute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands gSchool of Public Health, University of California Berkeley, Berkeley, CA and hJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Epidemiology 25:518-25. 2014
    ..5), PM(2.5-10), PM(10), PM(2.5) absorbance, nitrogen dioxide, and nitrogen oxides), heat, and noise and buffering effect of road-adjacent trees on this association...
  70. ncbi Childhood cat allergen exposure in three European countries: The AIRALLERG study
    Mariëlla Giovannangelo
    Division of Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Sci Total Environ 369:82-90. 2006
    ..Cat allergen is a major cause of morbidity among sensitised asthma patients, but little is known about distribution of cat allergen exposure and its determinants in homes...
  71. ncbi Long-term personal exposure to traffic-related air pollution among school children, a validation study
    Sofie van Roosbroeck
    Institute for Risk Assessment Sciences, Utrecht University, P O Box 80176, 3508 TD Utrecht, The Netherlands
    Sci Total Environ 368:565-73. 2006
    ..This finding supports the use of 'living near a busy road' as a measure of exposure in epidemiological studies on the effects of traffic-related air pollution in children...
  72. doi Environmental epidemiology and risk assessment
    Bert Brunekreef
    Institute for Risk Assessment Sciences, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Universiteit Utrecht, PO Box 80178, 3508 TD Utrecht, The Netherlands
    Toxicol Lett 180:118-22. 2008
    ..Examples are provided for each of these. The strengths and weaknesses compared to experimental toxicology studies are discussed...
  73. pmc Associations between PM2.5 and heart rate variability are modified by particle composition and beta-blocker use in patients with coronary heart disease
    Jeroen J de Hartog
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 117:105-11. 2009
    ..Previously we reported heterogeneous associations between particulate matter with aerodynamic diameter < 2.5 microm (PM2.5) and HRV across three study centers...
  74. doi Meta-analysis of the effects of indoor nitrogen dioxide and gas cooking on asthma and wheeze in children
    WeiWei Lin
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Epidemiol 42:1724-37. 2013
    ..We aimed to quantify the association of indoor NO2 and its main source (gas cooking) with childhood asthma and wheeze...
  75. pmc Use of passive diffusion sampling method for defining NO2 concentrations gradient in São Paulo, Brazil
    Agnes Soares da Silva
    Institute for Risk Assessment Sciences IRAS, Utrecht University, Yalelaan 2, 3508 TD, Utrecht, The Netherlands
    Environ Health 5:19. 2006
    ..This study was intended to identify a gradient of exposure to traffic-related air pollution within different areas in São Paulo to provide information for future epidemiological studies...
  76. doi Exposure science, the exposome, and public health
    Bert Brunekreef
    Institute for Risk Assessment Sciences, Universiteit Utrecht, Utrecht, The Netherlands
    Environ Mol Mutagen 54:596-8. 2013
    ..This commentary discusses recent developments in exposure science and their potential contribution to improving public health...
  77. ncbi A critique of "fine particulate air pollution and total mortality among elderly Californians, 1973-2002" by James E. Enstrom
    Bert Brunekreef
    Institute for Risk Assessment Sciences, Universiteit Utrecht, Utrecht, The Netherlands
    Inhal Toxicol 18:507-8; discussuin 509-14. 2006
  78. ncbi He who pays the piper, calls the tune
    Bert Brunekreef
    University of Utrecht Institute for Risk Assessment Sciences, University of Utrecht, Utrecht, The Netherlands
    Epidemiology 17:246-7. 2006
  79. doi Endotoxin levels in cow's milk samples from farming and non-farming families - the PASTURE study
    Ulrike Gehring
    Utrecht University, Institute for Risk Assessment Sciences, Utrecht, The Netherlands
    Environ Int 34:1132-6. 2008
    ..Children from farming families have less allergies than their peers. Consumption of farm milk or unpasteurized milk has been shown to explain (part of) the farming effect or protect against allergies independent of farming status...
  80. pmc Meeting report: national workshops for the communication of air pollution and health information: summary of four workshops in different regions of Europe
    Eric Gordon Sanderson
    Institute for Risk Assessment Sciences, Universiteit Utrecht, Utrecht, The Netherlands
    Environ Health Perspect 114:1108-12. 2006
    ..Because a broad stakeholder involvement in decision making can positively affect the development of widely supported policies, such meetings should be continued for Europe and elsewhere...
  81. ncbi Reported versus measured body weight and height of 4-year-old children and the prevalence of overweight
    Salome Scholtens
    Institute for Risk Assessment Sciences IRAS, Utrecht University, Utrecht, The Netherlands
    Eur J Public Health 17:369-74. 2007
    ..In addition, we studied the determinants and the consequences of differences between reported and measured data...
  82. ncbi The brave new world of lives sacrificed and saved, deaths attributed and avoided
    Bert Brunekreef
    Institute for Risk Assessment Sciences and Julius Center for Health Sciences and Primary Care, Utrecht University, Utrecht, The Netherlands
    Epidemiology 18:785-8. 2007
    ....
  83. ncbi Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study
    Gerard Hoek
    Institute for Risk Assessment Sciences, Environmental and Occupational Health Group, Utrecht University, Utrecht, Netherlands
    Lancet 360:1203-9. 2002
    ..We aimed to assess the relation between traffic-related air pollution and mortality in participants of the Netherlands Cohort study on Diet and Cancer (NLCS), an ongoing study...
  84. pmc Mite and pet allergen levels in homes of children born to allergic and nonallergic parents: the PIAMA study
    Rob T van Strien
    Department of Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 110:A693-8. 2002
    ..Parental mattresses in homes of allergic mothers had lower cat and mite (but not dog) allergen loadings than mattresses in homes of nonallergic parents. Paternal (as opposed to maternal) allergy seemed to have little influence...
  85. ncbi Performance of different exposure assessment approaches in a study of bitumen fume exposure and lung cancer mortality
    Igor Burstyn
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Am J Ind Med 43:40-8. 2003
    ..We compared performance of different exposure assessment approaches in a cohort study of cancer risk among European asphalt workers...
  86. ncbi The prevention and incidence of asthma and mite allergy (PIAMA) birth cohort study: design and first results
    Bert Brunekreef
    Institute for Risk Assessment Sciences, University of Utrecht, Utrecht, The Netherlands
    Pediatr Allergy Immunol 13:55-60. 2002
    ....
  87. ncbi After the wall
    Bert Brunekreef
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80176, 3508 TD Utrecht, The Netherlands
    Epidemiology 13:376-8. 2002
  88. ncbi Commentary: health review committee
    Millicent Higgins
    J Toxicol Environ Health A 66:1655-87; discussion 1715-22. 2003
  89. ncbi Effects of ultrafine and fine particulate and gaseous air pollution on cardiac autonomic control in subjects with coronary artery disease: the ULTRA study
    Kirsi L Timonen
    Unit of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland
    J Expo Sci Environ Epidemiol 16:332-41. 2006
    ..5 and HRV. The results suggest that the cardiovascular effects of ambient ultrafine and PM2.5 can differ from each other and that their effect may be modified by the characteristics of the exposed subjects and the sources of PM2.5...
  90. ncbi Early respiratory infections, asthma, and allergy: 10-year follow-up of the Oslo Birth Cohort
    Per Nafstad
    Department of General Practice and Community Medicine, Medical Faculty, University of Oslo, PB 1130 Blindern, 0316 Oslo, Norway
    Pediatrics 116:e255-62. 2005
    ..We also considered birth order and attendance at a child care center as proxy measures of increased exposure to infections early in life...
  91. ncbi Allergen exposure in infancy and the development of sensitization, wheeze, and asthma at 4 years
    Jessica E Brussee
    Center for Prevention and Health Services Research, National Institute for Public Health and Environment, Bilthoven, The Netherlands
    J Allergy Clin Immunol 115:946-52. 2005
    ..The relationship between mite and pet allergen exposure in infancy and the subsequent development of sensitization and asthma is complex...
  92. ncbi The effect of prenatal exposure on total IgE at birth and sensitization at twelve months and four years of age: The PIAMA study
    Marjan Kerkhof
    Department of Epidemiology, University of Groningen, Groningen, The Netherlands
    Pediatr Allergy Immunol 16:10-8. 2005
    ..Our results suggest a short-lasting protective effect of prenatal exposure to pets on total IgE at birth and early sensitization...
  93. ncbi Fatty acids in breast milk of allergic and non-allergic mothers: The PIAMA birth cohort study
    Alet Wijga
    National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Pediatr Allergy Immunol 14:156-62. 2003
    ....
  94. pmc GIS-based estimation of exposure to particulate matter and NO2 in an urban area: stochastic versus dispersion modeling
    Josef Cyrys
    GSF, National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Environ Health Perspect 113:987-92. 2005
    ..In conclusion, despite different assumptions and procedures used for the stochastic and dispersion modeling, both models yield similar results regarding exposure estimation of the study cohort to traffic-related air pollutants...
  95. doi Prenatal exposure to a farm environment modifies atopic sensitization at birth
    Markus Johannes Ege
    University Children s Hospital, Munich, Germany
    J Allergy Clin Immunol 122:407-12, 412.e1-4. 2008
    ..Previous cross-sectional surveys have suggested that maternal exposure to animal sheds during pregnancy exerted a protective effect on atopic sensitization in children lasting until school age...
  96. pmc Traffic-related air pollution and otitis media
    Michael Brauer
    University of British Columbia, School of Occupational and Environmental Hygiene, Vancouver, British Columbia, Canada
    Environ Health Perspect 114:1414-8. 2006
    ..Although exposure to environmental tobacco smoke is a known risk factor associated with otitis media, little information is available regarding the potential association with air pollution...
  97. ncbi Respiratory symptoms in the first 7 years of life and birth weight at term: the PIAMA Birth Cohort
    Daan Caudri
    Department of Pediatrics Respiratory Medicine, Erasmus University, 3000 CB Rotterdam, The Netherlands
    Am J Respir Crit Care Med 175:1078-85. 2007
    ..The relation between birth weight and respiratory symptoms and asthma in children remains unclear. Previous studies focused on a relation at separate ages. A longitudinal analysis may lead to a better understanding...
  98. ncbi Closing the gap between science and policy on air pollution and health
    Leendert van Bree
    Netherlands Environmental Assessment Agency MNP, Bilthoven, The Netherlands
    J Toxicol Environ Health A 70:377-81. 2007
    ....
  99. pmc Do parents who smoke underutilize health care services for their children? A cross sectional study within the longitudinal PIAMA study
    Monique A M Jacobs-van der Bruggen
    National Institute of Public Health and the Environment RIVM, Bilthoven, The Netherlands
    BMC Health Serv Res 7:83. 2007
    ..This study explores the validity and generalizability of the previous assumption...
  100. ncbi Does early indoor microbial exposure reduce the risk of asthma? The Prevention and Incidence of Asthma and Mite Allergy birth cohort study
    Jeroen Douwes
    Institute for Risk Assessment Sciences IRAS, Utrecht University, Amsterdam
    J Allergy Clin Immunol 117:1067-73. 2006
    ..Exposure to microbial agents might inhibit the development of atopy and asthma...
  101. doi Health effects of air pollution observed in cohort studies in Europe
    Bert Brunekreef
    Department of Environmental Epidemiology, Institute for Risk Assessment Sciences and Julius Center for Health Sciences and Primary Care, Universiteit Utrecht, PO Box 80178, Utrecht 3508 TD, The Netherlands
    J Expo Sci Environ Epidemiol 17:S61-5. 2007
    ..The results of a number of recent European studies are discussed...