Lex Wunderink

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Guided discontinuation versus maintenance treatment in remitted first-episode psychosis: relapse rates and functional outcome
    Lex Wunderink
    University Medical Center Groningen, University of Groningen, Department of Psychiatry, Groningen, The Netherlands
    J Clin Psychiatry 68:654-61. 2007
  2. ncbi request reprint Treatment delay and response rate in first episode psychosis
    A Wunderink
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Acta Psychiatr Scand 113:332-9. 2006
  3. pmc Predictive validity of proposed remission criteria in first-episode schizophrenic patients responding to antipsychotics
    Lex Wunderink
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 R B Groningen, The Netherlands
    Schizophr Bull 33:792-6. 2007
  4. pmc Clinical recovery in first-episode psychosis
    Lex Wunderink
    University Medical Center Groningen, University Psychiatric Center 5 21, University of Groningen, 9700 RB Groningen, The Netherlands
    Schizophr Bull 35:362-9. 2009
  5. doi request reprint Recovery in remitted first-episode psychosis at 7 years of follow-up of an early dose reduction/discontinuation or maintenance treatment strategy: long-term follow-up of a 2-year randomized clinical trial
    Lex Wunderink
    Department of Research and Education, Friesland Mental Health Services, Leeuwarden, the Netherlands2Department of Psychiatry, Rob Giel Research Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    JAMA Psychiatry 70:913-20. 2013
  6. doi request reprint The Prodromal Questionnaire: a case for IRT-based adaptive testing of psychotic experiences?
    Jan Van Bebber
    Interdisciplinary Center Psychopathology and Emotion Regulation ICPE, University Medical Center Groningen, The Netherlands
    Int J Methods Psychiatr Res . 2016
  7. doi request reprint The effect of childhood adversity on 4-year outcome in individuals at ultra high risk for psychosis in the Dutch Early Detection Intervention Evaluation (EDIE-NL) Trial
    Tamar C Kraan
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, the Netherlands Department of Psychosis Research, Parnassia Psychiatric Institute, The Hague, The Netherlands
    Psychiatry Res 247:55-62. 2016
  8. pmc Cognitive alexithymia is associated with the degree of risk for psychosis
    Jorien van der Velde
    Neuroimaging Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Academy for sociale studies, Hanze University of Apllied Sciences, Groningen, The Netherlands
    PLoS ONE 10:e0124803. 2015
  9. pmc The validity of the 16-item version of the Prodromal Questionnaire (PQ-16) to screen for ultra high risk of developing psychosis in the general help-seeking population
    Helga K Ising
    Department of Psychiatry, Parnassia Psychiatric Institute, Prinsegracht 63 65, 2512 EX, The Hague, The Netherlands
    Schizophr Bull 38:1288-96. 2012
  10. pmc Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication
    Jelle Vehof
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Psychopharmacology (Berl) 216:257-65. 2011

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Guided discontinuation versus maintenance treatment in remitted first-episode psychosis: relapse rates and functional outcome
    Lex Wunderink
    University Medical Center Groningen, University of Groningen, Department of Psychiatry, Groningen, The Netherlands
    J Clin Psychiatry 68:654-61. 2007
    ..To compare the consequences of a guided discontinuation strategy and maintenance treatment in remitted first-episode psychosis in terms of relapse rates and functional outcome...
  2. ncbi request reprint Treatment delay and response rate in first episode psychosis
    A Wunderink
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Acta Psychiatr Scand 113:332-9. 2006
    ..There is no consistent evidence of long duration of untreated psychosis (DUP) predicting long time to response (TTR) in first psychosis. This study aims to investigate the predictors of DUP and TTR in a first episode patient population...
  3. pmc Predictive validity of proposed remission criteria in first-episode schizophrenic patients responding to antipsychotics
    Lex Wunderink
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 R B Groningen, The Netherlands
    Schizophr Bull 33:792-6. 2007
    ..The criteria represent a practicable benchmark with clinical relevance. Their implementation should be promoted in research settings, clinical practice, and routine outcome assessment procedures...
  4. pmc Clinical recovery in first-episode psychosis
    Lex Wunderink
    University Medical Center Groningen, University Psychiatric Center 5 21, University of Groningen, 9700 RB Groningen, The Netherlands
    Schizophr Bull 35:362-9. 2009
    ..The aim of this study is to explore clinical recovery in first-episode patients, defined by meeting criteria for both symptomatic and functional remission...
  5. doi request reprint Recovery in remitted first-episode psychosis at 7 years of follow-up of an early dose reduction/discontinuation or maintenance treatment strategy: long-term follow-up of a 2-year randomized clinical trial
    Lex Wunderink
    Department of Research and Education, Friesland Mental Health Services, Leeuwarden, the Netherlands2Department of Psychiatry, Rob Giel Research Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    JAMA Psychiatry 70:913-20. 2013
    ....
  6. doi request reprint The Prodromal Questionnaire: a case for IRT-based adaptive testing of psychotic experiences?
    Jan Van Bebber
    Interdisciplinary Center Psychopathology and Emotion Regulation ICPE, University Medical Center Groningen, The Netherlands
    Int J Methods Psychiatr Res . 2016
    ..These promising findings need to be replicated prospectively in a non-selective sample that also includes non-at-risk individuals. Copyright © 2016 John Wiley & Sons, Ltd...
  7. doi request reprint The effect of childhood adversity on 4-year outcome in individuals at ultra high risk for psychosis in the Dutch Early Detection Intervention Evaluation (EDIE-NL) Trial
    Tamar C Kraan
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, the Netherlands Department of Psychosis Research, Parnassia Psychiatric Institute, The Hague, The Netherlands
    Psychiatry Res 247:55-62. 2016
    ..The data indicate long-term negative effects of childhood adversity on depression, social functioning and health care costs at follow-up in a sample of UHR patients...
  8. pmc Cognitive alexithymia is associated with the degree of risk for psychosis
    Jorien van der Velde
    Neuroimaging Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Academy for sociale studies, Hanze University of Apllied Sciences, Groningen, The Netherlands
    PLoS ONE 10:e0124803. 2015
    ..More specifically, a type-II alexithymia pattern, with high levels of cognitive alexithymia and normal or low levels of affective alexithymia, might be a vulnerability factor for psychosis. ..
  9. pmc The validity of the 16-item version of the Prodromal Questionnaire (PQ-16) to screen for ultra high risk of developing psychosis in the general help-seeking population
    Helga K Ising
    Department of Psychiatry, Parnassia Psychiatric Institute, Prinsegracht 63 65, 2512 EX, The Hague, The Netherlands
    Schizophr Bull 38:1288-96. 2012
    ..The low number of items makes it quite appropriate for screening large help-seeking populations, thus enhancing the feasibility of detection and treatment of ultra high-risk patients in routine mental health services...
  10. pmc Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication
    Jelle Vehof
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Psychopharmacology (Berl) 216:257-65. 2011
    ..Antipsychotic affinity for the histamine H1 receptor and the muscarinic M3 receptor have been associated with the side effects weight gain, and development of diabetes, respectively...
  11. pmc Prefrontal NAA and Glx Levels in Different Stages of Psychotic Disorders: a 3T 1H-MRS Study
    Edith Liemburg
    Department of Neuroscience, and BCN Neuroimaging Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Sci Rep 6:21873. 2016
    ..Our results may indicate an initial Glx and NAA increase and subsequent decrease during illness progression that may be related to the neurotoxic effects of glutamate. ..
  12. pmc A web-based tool to support shared decision making for people with a psychotic disorder: randomized controlled trial and process evaluation
    Lian van der Krieke
    University of Groningen, University Medical Center, University Center for Psychiatry, Groningen, Netherlands
    J Med Internet Res 15:e216. 2013
    ..Evidence is needed to determine whether these decision aids are helpful in clinical practice and whether they lead to increased patient involvement and better outcomes...
  13. doi request reprint Duration of untreated psychosis and negative symptoms--a systematic review and meta-analysis of individual patient data
    Nynke Boonstra
    Friesland Mental Health Care Service, Department of Education and Research, Leeuwarden, The Netherlands
    Schizophr Res 142:12-9. 2012
    ..Longer duration of untreated psychosis (DUP) is associated with poorer outcome in terms of positive symptoms, relapse rate, and time to remission. In contrast, the association with negative symptoms is less consistent...
  14. doi request reprint Improving detection of first-episode psychosis by mental health-care services using a self-report questionnaire
    Nynke Boonstra
    Friesland Mental Health Services, Department of Education and Research, Leeuwarden, The Netherlands
    Early Interv Psychiatry 3:289-95. 2009
    ..To examine the utility of the Community Assessment of Psychic Experiences (CAPE)-42, a self-report questionnaire, to improve detection of first-episode psychosis in new referrals to mental health services...
  15. doi request reprint Effects of bilateral repetitive transcranial magnetic stimulation on treatment resistant auditory-verbal hallucinations in schizophrenia: a randomized controlled trial
    Ans Vercammen
    Department of Neuroscience, University Medical Center Groningen and BCN NeuroImaging Center, University of Groningen, The Netherlands
    Schizophr Res 114:172-9. 2009
    ..This study aimed to investigate whether 1 Hz repetitive transcranial magnetic stimulation (rTMS) of the bilateral temporo-parietal region would lead to increased effectiveness in the management of AVH, compared to left rTMS or placebo...
  16. pmc A manual-based individual therapy to improve metacognition in schizophrenia: protocol of a multi-center RCT
    Rozanne J M van Donkersgoed
    Department of Clinical Psychology and Experimental Psychopathology, Faculty of Behavioral and Social Sciences, University of Groningen, Grote Kruisstraat 2 1, 9712 TS Groningen, The Netherlands
    BMC Psychiatry 14:27. 2014
    ....
  17. ncbi request reprint [Assertive community treatment in psychiatry: less drop-out from mental health care]
    Sjoerd Sytema
    Universitair Medisch Centrum Groningen, afd Universitair Centrum Psychiatrie, Groningen, The Netherlands
    Ned Tijdschr Geneeskd 154:A1692. 2010
    ..With assertive community treatment, drop-out is averted for most patients. We consider this to be an important positive result...