Nico Wulffraat

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Autologous haemopoietic stem-cell transplantation in four patients with refractory juvenile chronic arthritis
    N Wulffraat
    Department of Pediatric Immunology and Haematology, University Hospital for Children Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands
    Lancet 353:550-3. 1999
  2. ncbi request reprint Autologous hemopoietic stem-cell transplantation for children with refractory autoimmune disease
    N M Wulffraat
    Department of Pediatric Immunology, Wilhelmina Children s Hospital, University Medical Centre Utrecht, PO 85090, 3508AB Utrecht, The Netherlands
    Curr Rheumatol Rep 2:316-23. 2000
  3. pmc Myeloid related protein 8 and 14 secretion reflects phagocyte activation and correlates with disease activity in juvenile idiopathic arthritis treated with autologous stem cell transplantation
    N M Wulffraat
    Department of Paediatric Immunology, Wilhelmina Children s Hospital, University Medical Centre Utrecht, The Netherlands
    Ann Rheum Dis 62:236-41. 2003
  4. ncbi request reprint Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation
    N M Wulffraat
    Department of Paediatric Immunology, Wilhelmina Children s Hospital, University Medical Centre Utrecht, PO Box 85090, The Netherlands
    Rheumatology (Oxford) 42:375-9. 2003
  5. ncbi request reprint Stem cell transplantation for autoimmune disorders. Refractory juvenile idiopathic arthritis
    Nico M Wulffraat
    Department of Paediatric Immunology and Rheumatology, Wilhelmina Children s Hospital, University Medical Center Utrecht, P O Box 85090, Utrecht 3508 AB, The Netherlands
    Best Pract Res Clin Haematol 17:277-89. 2004
  6. ncbi request reprint Treatment of refractory autoimmune diseases with autologous stem cell transplantation: focus on juvenile idiopathic arthritis
    N M Wulffraat
    Department of Pediatrics, Section Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Bone Marrow Transplant 35:S27-9. 2005
  7. pmc Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
    Alan Tyndall
    Rheumatology, University Hospital Basel, Felix Platter Spital, Burgfelderstrasse 101, Basel, CH 4012, Switzerland
    Arthritis Res Ther 9:301. 2007
  8. doi request reprint Changing winds in refractory autoimmune disease in children: clearing the road for tolerance with cellular therapies
    Joost F Swart
    Department of Pediatric Immunology and Rheumatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Opin Rheumatol 24:267-73. 2012
  9. doi request reprint Autologous bone marrow transplantation in autoimmune arthritis restores immune homeostasis through CD4+CD25+Foxp3+ regulatory T cells
    Sarah T A Roord
    Department of Pediatric Immunology, University Medical Center Utrecht, Wilhelmina Children s Hospital, Utrecht, USA
    Blood 111:5233-41. 2008
  10. ncbi request reprint Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory network
    Isme de Kleer
    University Medical Center Utrecht, Wilhelmina Children s Hospital, Home Mailbox KC 03 063 0, Department of Pediatric Immunology, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Blood 107:1696-702. 2006

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Autologous haemopoietic stem-cell transplantation in four patients with refractory juvenile chronic arthritis
    N Wulffraat
    Department of Pediatric Immunology and Haematology, University Hospital for Children Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands
    Lancet 353:550-3. 1999
    ..We report the first four children with severe forms of juvenile chronic arthritis (JCA) treated with AHSCT...
  2. ncbi request reprint Autologous hemopoietic stem-cell transplantation for children with refractory autoimmune disease
    N M Wulffraat
    Department of Pediatric Immunology, Wilhelmina Children s Hospital, University Medical Centre Utrecht, PO 85090, 3508AB Utrecht, The Netherlands
    Curr Rheumatol Rep 2:316-23. 2000
    ..ASCT in this severely ill patient group induces a very significant and drug-free remission of the disease, but carries a significantly risk of developing fatal MAS...
  3. pmc Myeloid related protein 8 and 14 secretion reflects phagocyte activation and correlates with disease activity in juvenile idiopathic arthritis treated with autologous stem cell transplantation
    N M Wulffraat
    Department of Paediatric Immunology, Wilhelmina Children s Hospital, University Medical Centre Utrecht, The Netherlands
    Ann Rheum Dis 62:236-41. 2003
    ....
  4. ncbi request reprint Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation
    N M Wulffraat
    Department of Paediatric Immunology, Wilhelmina Children s Hospital, University Medical Centre Utrecht, PO Box 85090, The Netherlands
    Rheumatology (Oxford) 42:375-9. 2003
    ..Because symptoms of patients with systemic juvenile idiopathic arthritis (sJIA) are sometimes clinically very similar to those with FHL, we studied whether perforin expression in sJIA patients would be reduced also...
  5. ncbi request reprint Stem cell transplantation for autoimmune disorders. Refractory juvenile idiopathic arthritis
    Nico M Wulffraat
    Department of Paediatric Immunology and Rheumatology, Wilhelmina Children s Hospital, University Medical Center Utrecht, P O Box 85090, Utrecht 3508 AB, The Netherlands
    Best Pract Res Clin Haematol 17:277-89. 2004
    ..It is still unclear why especially patients with systemic juvenile idiopathic arthritis are at risk of episodes of reactive haemophagocytosis...
  6. ncbi request reprint Treatment of refractory autoimmune diseases with autologous stem cell transplantation: focus on juvenile idiopathic arthritis
    N M Wulffraat
    Department of Pediatrics, Section Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Bone Marrow Transplant 35:S27-9. 2005
    ..Infectious complications were seen frequently. We propose adjustments in future protocols to reduce this mortality in this high-risk patient group...
  7. pmc Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
    Alan Tyndall
    Rheumatology, University Hospital Basel, Felix Platter Spital, Burgfelderstrasse 101, Basel, CH 4012, Switzerland
    Arthritis Res Ther 9:301. 2007
    ..This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts...
  8. doi request reprint Changing winds in refractory autoimmune disease in children: clearing the road for tolerance with cellular therapies
    Joost F Swart
    Department of Pediatric Immunology and Rheumatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Opin Rheumatol 24:267-73. 2012
    ..To give an overview of the recent advances in cellular therapies in pediatric autoimmune diseases...
  9. doi request reprint Autologous bone marrow transplantation in autoimmune arthritis restores immune homeostasis through CD4+CD25+Foxp3+ regulatory T cells
    Sarah T A Roord
    Department of Pediatric Immunology, University Medical Center Utrecht, Wilhelmina Children s Hospital, Utrecht, USA
    Blood 111:5233-41. 2008
    ..This work provided further insight into the role of Tregs in restoration of the immune balance by aBMT and can open the way to explore therapeutic interventions to further improve treatment of AID and disease relapses...
  10. ncbi request reprint Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory network
    Isme de Kleer
    University Medical Center Utrecht, Wilhelmina Children s Hospital, Home Mailbox KC 03 063 0, Department of Pediatric Immunology, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Blood 107:1696-702. 2006
    ....
  11. ncbi request reprint Restoration of the immune balance by autologous bone marrow transplantation in juvenile idiopathic arthritis
    Eveline Delemarre
    Departement of Pediatric Immunology, Wilhelmina Children s Hospital, University Medical Center Utrecht, The Netherlands
    Curr Stem Cell Res Ther 6:3-9. 2011
    ..In this review we reviewed the current views of the cellular mechanisms that lay beneath disease induction of JIA and the disease remission caused by aBMT therapy...
  12. doi request reprint Fatal hemophagocytic lymphohistiocytosis in X-linked chronic granulomatous disease associated with a perforin gene variant
    Joris M van Montfrans
    Department of Pediatric Immunology, Wilhelmina Children s Hospital University Medical Centre Utrecht, Utrecht, The Netherlands
    Pediatr Blood Cancer 52:527-9. 2009
    ..Although this substitution has not been reported to cause primary or secondary HLH, we speculate that it may have made the patient more susceptible for HLH under the circumstances of ongoing infection associated with X-CGD...