Ellen J Wehrens

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. doi Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells
    Ellen J Wehrens
    Center for Molecular and Cellular Intervention, Department of Immunology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 118:3538-48. 2011
  2. doi Anti-tumor necrosis factor α targets protein kinase B/c-Akt-induced resistance of effector cells to suppression in juvenile idiopathic arthritis
    Ellen J Wehrens
    Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 65:3279-84. 2013
  3. ncbi T cells out of control--impaired immune regulation in the inflamed joint
    Ellen J Wehrens
    Center for Molecular and Cellular Intervention, Department of Paediatric Immunology, University Medical Centre Utrecht, P O, AB Utrecht, The Netherlands
    Nat Rev Rheumatol 9:34-42. 2013
  4. doi Self-Sustained Resistance to Suppression of CD8+ Teff Cells at the Site of Autoimmune Inflammation Can Be Reversed by Tumor Necrosis Factor and Interferon-γ Blockade
    Alessandra Petrelli
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheumatol 68:229-36. 2016
  5. doi Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells
    Eveline M Delemarre
    Laboratory of Translational Immunology, Department of Paediatric Immunology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 127:91-101. 2016
  6. doi T cells out of control-impaired immune regulation in the inflamed joint
    Ellen J Wehrens
    Center for Molecular and Cellular Intervention, Department of Paediatric Immunology, University Medical Centre Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Nat Rev Rheumatol 9:34-42. 2012
  7. pmc Human regulatory T cell suppressive function is independent of apoptosis induction in activated effector T cells
    Yvonne Vercoulen
    Department of Pediatric Immunology, Center for Molecular and Cellular Intervention, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e7183. 2009
  8. pmc Treating arthritis by immunomodulation: is there a role for regulatory T cells?
    Ellen J Wehrens
    Department of Pediatric Immunology, Wilhelmina Children s Hospital, University Medical Center Utrecht UMCU, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    Rheumatology (Oxford) 49:1632-44. 2010

Collaborators

Detail Information

Publications8

  1. doi Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells
    Ellen J Wehrens
    Center for Molecular and Cellular Intervention, Department of Immunology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 118:3538-48. 2011
    ..Furthermore, these findings suggest that for a Treg enhancing strategy to be successful in the treatment of autoimmune inflammation, resistance because of PKB/c-akt hyperactivation should be targeted as well...
  2. doi Anti-tumor necrosis factor α targets protein kinase B/c-Akt-induced resistance of effector cells to suppression in juvenile idiopathic arthritis
    Ellen J Wehrens
    Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 65:3279-84. 2013
    ..To determine whether therapeutic strategies that block interleukin-6 (IL-6) or tumor necrosis factor α (TNFα) can improve the responsiveness of Teff cells to suppression in patients with juvenile idiopathic arthritis (JIA)...
  3. ncbi T cells out of control--impaired immune regulation in the inflamed joint
    Ellen J Wehrens
    Center for Molecular and Cellular Intervention, Department of Paediatric Immunology, University Medical Centre Utrecht, P O, AB Utrecht, The Netherlands
    Nat Rev Rheumatol 9:34-42. 2013
    ..These findings have important clinical implications and will affect the development of new therapeutic strategies for autoimmune arthritis...
  4. doi Self-Sustained Resistance to Suppression of CD8+ Teff Cells at the Site of Autoimmune Inflammation Can Be Reversed by Tumor Necrosis Factor and Interferon-γ Blockade
    Alessandra Petrelli
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheumatol 68:229-36. 2016
    ..We undertook this study to investigate intrinsic resistance of CD8+ Teff cells to suppression and to determine how this can be targeted therapeutically...
  5. doi Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells
    Eveline M Delemarre
    Laboratory of Translational Immunology, Department of Paediatric Immunology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 127:91-101. 2016
    ..Therefore, Treg therapy may hamper development of long-term tolerance and should be approached with caution in the clinical autologous setting. ..
  6. doi T cells out of control-impaired immune regulation in the inflamed joint
    Ellen J Wehrens
    Center for Molecular and Cellular Intervention, Department of Paediatric Immunology, University Medical Centre Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Nat Rev Rheumatol 9:34-42. 2012
    ..These findings have important clinical implications and will affect the development of new therapeutic strategies for autoimmune arthritis...
  7. pmc Human regulatory T cell suppressive function is independent of apoptosis induction in activated effector T cells
    Yvonne Vercoulen
    Department of Pediatric Immunology, Center for Molecular and Cellular Intervention, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e7183. 2009
    ..Experiments in mice demonstrated that Treg restrict effector T cell (Teff) responses by deprivation of the growth factor IL-2 through Treg consumption, resulting in apoptosis of Teff...
  8. pmc Treating arthritis by immunomodulation: is there a role for regulatory T cells?
    Ellen J Wehrens
    Department of Pediatric Immunology, Wilhelmina Children s Hospital, University Medical Center Utrecht UMCU, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    Rheumatology (Oxford) 49:1632-44. 2010
    ..Both direct and indirect methods to target these cells will be discussed. Arguably, a therapeutic approach that combines multiple regulatory T-cell-enhancing strategies could be most successful for clinical application...