J M Walboomers

Summary

Affiliation: University Hospital Vrije Universiteit
Country: The Netherlands

Publications

  1. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
  2. pmc A quantitative polymerase chain reaction-enzyme immunoassay for accurate measurements of human papillomavirus type 16 DNA levels in cervical scrapings
    M V Jacobs
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Br J Cancer 81:114-21. 1999
  3. pmc Assessment of cytotoxic T-lymphocyte phenotype using the specific markers granzyme B and TIA-1 in cervical neoplastic lesions
    H J Bontkes
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 76:1353-60. 1997
  4. ncbi Telomerase activity exclusively in cervical carcinomas and a subset of cervical intraepithelial neoplasia grade III lesions: strong association with elevated messenger RNA levels of its catalytic subunit and high-risk human papillomavirus DNA
    P J Snijders
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Cancer Res 58:3812-8. 1998
  5. pmc Analysis of MHC class I and II expression in relation to presence of HPV genotypes in premalignant and malignant cervical lesions
    F V Cromme
    Institute for Pathology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 67:1372-80. 1993
  6. pmc Processing of long-stored archival cervical smears for human papillomavirus detection by the polymerase chain reaction
    A M de Roda Husman
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 72:412-7. 1995
  7. pmc HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas
    J J Bijl
    Department of Pathology, Vrije Universiteit Hospital, Amsterdam, The Netherlands
    Am J Pathol 151:1067-74. 1997
  8. pmc Expression of CD3-zeta on T-cells in primary cervical carcinoma and in metastasis-positive and -negative pelvic lymph nodes
    T D de Gruijl
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 79:1127-32. 1999
  9. pmc Differences in MHC and TAP-1 expression in cervical cancer lymph node metastases as compared with the primary tumours
    F V Cromme
    Institute for Pathology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 69:1176-81. 1994
  10. pmc A simplified and reliable HPV testing of archival Papanicolaou-stained cervical smears: application to cervical smears from cancer patients starting with cytologically normal smears
    M V Jacobs
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Br J Cancer 82:1421-6. 2000

Collaborators

Detail Information

Publications19

  1. ncbi Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
    J M Walboomers
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 189:12-9. 1999
    ..The extreme rarity of HPV-negative cancers reinforces the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening...
  2. pmc A quantitative polymerase chain reaction-enzyme immunoassay for accurate measurements of human papillomavirus type 16 DNA levels in cervical scrapings
    M V Jacobs
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Br J Cancer 81:114-21. 1999
    ..Therefore, accurate measurements on viral DNA load in cervical scrapings require corrections for these phenomena, which can be achieved by application of this fully quantitative approach...
  3. pmc Assessment of cytotoxic T-lymphocyte phenotype using the specific markers granzyme B and TIA-1 in cervical neoplastic lesions
    H J Bontkes
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 76:1353-60. 1997
    ..These results suggest that in some carcinomas proper activation of CTLs occurs but that most likely local factors or immunoselection of resistant neoplastic cells inhibit a proper response of CTLs to these neoplastic cells...
  4. ncbi Telomerase activity exclusively in cervical carcinomas and a subset of cervical intraepithelial neoplasia grade III lesions: strong association with elevated messenger RNA levels of its catalytic subunit and high-risk human papillomavirus DNA
    P J Snijders
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Cancer Res 58:3812-8. 1998
    ....
  5. pmc Analysis of MHC class I and II expression in relation to presence of HPV genotypes in premalignant and malignant cervical lesions
    F V Cromme
    Institute for Pathology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 67:1372-80. 1993
    ..The results indicate that local differences may exist in the type of cellular immune response to HPV induced lesions...
  6. pmc Processing of long-stored archival cervical smears for human papillomavirus detection by the polymerase chain reaction
    A M de Roda Husman
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 72:412-7. 1995
    ..provided that stepwise adjustments are made until beta-globin PCR positivity is obtained and primers are chosen which amplify a maximum of about 200 bp...
  7. pmc HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas
    J J Bijl
    Department of Pathology, Vrije Universiteit Hospital, Amsterdam, The Netherlands
    Am J Pathol 151:1067-74. 1997
    ....
  8. pmc Expression of CD3-zeta on T-cells in primary cervical carcinoma and in metastasis-positive and -negative pelvic lymph nodes
    T D de Gruijl
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 79:1127-32. 1999
    ..The apparently unimpaired zeta chain expression within draining lymph nodes suggests that local tumour-derived factors at the primary site are instrumental in zeta chain down-regulation...
  9. pmc Differences in MHC and TAP-1 expression in cervical cancer lymph node metastases as compared with the primary tumours
    F V Cromme
    Institute for Pathology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 69:1176-81. 1994
    ..Furthermore, the lack of class II MHC expression in metastasised cells either reflects a different local lymphokine production or indicates that these cells may have escaped CD4+ cytotoxic T-lymphocyte (CTL)-mediated killing...
  10. pmc A simplified and reliable HPV testing of archival Papanicolaou-stained cervical smears: application to cervical smears from cancer patients starting with cytologically normal smears
    M V Jacobs
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Br J Cancer 82:1421-6. 2000
    ....
  11. ncbi Telomerase suppression by chromosome 6 in a human papillomavirus type 16-immortalized keratinocyte cell line and in a cervical cancer cell line
    R D Steenbergen
    Department of Pathology, Unit of Molecular Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Natl Cancer Inst 93:865-72. 2001
    ..CONCLUSIONS: Chromosome 6 may harbor a repressor of hTERT transcription, the loss of which may be involved in HPV-mediated immortalization...
  12. pmc Lack of MHC class I surface expression on neoplastic cells and poor activation of the secretory pathway of cytotoxic cells in oral squamous cell carcinomas
    I Cruz
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Br J Cancer 81:881-9. 1999
    ....
  13. ncbi [Human papillomavirus and screening for cervical cancer: state of art and prospects]
    C J Meijer
    Academisch Ziekenhuis Vrije Universiteit, Amsterdam
    Ned Tijdschr Geneeskd 144:1675-9. 2000
    ....
  14. ncbi Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase
    E Hooijberg
    Department of Immunology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital
    J Immunol 165:4239-45. 2000
    ..As the T cells remained dependent on cytokines and Ag stimulation for their in vitro expansion, we conclude that immortalization was achieved without malignant transformation...
  15. ncbi Analysis of major histocompatibility complex class I expression on Reed-Sternberg cells in relation to the cytotoxic T-cell response in Epstein-Barr virus-positive and -negative Hodgkin's disease
    J J Oudejans
    Department of Pathology, Free University Hospital Amsterdam, The Netherlands
    Blood 87:3844-51. 1996
    ..Probably, the function of activated CTLs is locally inhibited by the H-RS cells or by reactive cells in the vicinity of the H-RS cells...
  16. pmc General primer polymerase chain reaction in combination with sequence analysis for identification of potentially novel human papillomavirus genotypes in cervical lesions
    A J van den Brule
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    J Clin Microbiol 30:1716-21. 1992
    ....
  17. ncbi Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome
    T D de Gruijl
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    J Gen Virol 80:399-408. 1999
    ..However, neither cell-mediated nor humoral immune responses against HPV-16 L1 appear to be sufficient for the natural control of HPV infection and CIN development...
  18. ncbi Expression of the homeobox gene HOXC4 in keratinocytes of normal skin and epithelial skin tumors is correlated with differentiation
    E Rieger
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    J Invest Dermatol 103:341-6. 1994
    ..These results suggest that HOXC4 is expressed mainly in differentiated keratinocytes. Lack of differentiation (as in neoplastic cells) is accompanied by downregulation of HOXC4 expression...
  19. pmc Sensitivity of in situ detection with biotinylated probes of human papilloma virus type 16 DNA in frozen tissue sections of squamous cell carcinomas of the cervix
    J M Walboomers
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    Am J Pathol 131:587-94. 1988
    ..The detection limit was improved to at least 20 HPV-16 DNA copies per carcinoma cell...