Wiek H van Gilst

Summary

Affiliation: University of Groningen
Country: The Netherlands

Publications

  1. ncbi Angiotensin-converting enzyme inhibition in patients with coronary artery disease and preserved left ventricular function Ischemia Management with Accupril post-bypass graft via inhibition of angiotensin-converting enzyme (IMAGINE) compared with the other
    Wiek H van Gilst
    Department of Cardiology and Clinical Pharmacology, University Medical Center Groningen, The Netherlands
    Am Heart J 151:1240-6. 2006
  2. doi Erythropoietin stimulates normal endothelial progenitor cell-mediated endothelial turnover, but attributes to neovascularization only in the presence of local ischemia
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Groningen, The Netherlands
    Cardiovasc Drugs Ther 22:265-74. 2008
  3. pmc Renal dysfunction is associated with shorter telomere length in heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Clin Res Cardiol 98:629-34. 2009
  4. doi Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, Groningen 9700 RB, The Netherlands
    Cardiovasc Res 87:30-9. 2010
  5. doi Inflammation and anaemia in a broad spectrum of patients with heart failure
    Lennaert Kleijn
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Heart 98:1237-41. 2012
  6. ncbi Renal function dependent association of AGTR1 polymorphism (A1166C) and electrocardiographic left-ventricular hypertrophy
    Tom D J Smilde
    Thorax Center, Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Am J Hypertens 20:1097-103. 2007
  7. doi Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Eur J Heart Fail 12:348-53. 2010
  8. ncbi The effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels are dependent on environmental context
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Hum Genet 122:275-81. 2007
  9. pmc Heart failure-associated anemia: bone marrow dysfunction and response to erythropoietin
    Willem Peter T Ruifrok
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Mol Med (Berl) 89:377-87. 2011
  10. pmc Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Genomics 89:362-9. 2007

Collaborators

Detail Information

Publications72

  1. ncbi Angiotensin-converting enzyme inhibition in patients with coronary artery disease and preserved left ventricular function Ischemia Management with Accupril post-bypass graft via inhibition of angiotensin-converting enzyme (IMAGINE) compared with the other
    Wiek H van Gilst
    Department of Cardiology and Clinical Pharmacology, University Medical Center Groningen, The Netherlands
    Am Heart J 151:1240-6. 2006
    ....
  2. doi Erythropoietin stimulates normal endothelial progenitor cell-mediated endothelial turnover, but attributes to neovascularization only in the presence of local ischemia
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, P O Box 30001, 9700 RB Groningen, The Netherlands
    Cardiovasc Drugs Ther 22:265-74. 2008
    ..We aimed to evaluate whether ischemia is required for erythropoietin (EPO) induced stimulation of endothelial progenitor cells (EPCs) and their related effects on endothelial and cardiac function...
  3. pmc Renal dysfunction is associated with shorter telomere length in heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Clin Res Cardiol 98:629-34. 2009
    ..We explored the association between leukocyte telomere length, a marker for biological age, and renal function in patients with CHF...
  4. doi Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, Groningen 9700 RB, The Netherlands
    Cardiovasc Res 87:30-9. 2010
    ..We intended to delineate the mechanisms of erythropoietin (EPO)-induced cardiac vascular endothelial growth factor (VEGF) production and to establish if VEGF is crucial for EPO-induced improvement of cardiac performance...
  5. doi Inflammation and anaemia in a broad spectrum of patients with heart failure
    Lennaert Kleijn
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Heart 98:1237-41. 2012
    ..Although inflammation is assumed to be an important cause of anaemia, the association between anaemia and inflammatory markers in patients with HF has not been well established...
  6. ncbi Renal function dependent association of AGTR1 polymorphism (A1166C) and electrocardiographic left-ventricular hypertrophy
    Tom D J Smilde
    Thorax Center, Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Am J Hypertens 20:1097-103. 2007
    ..We studied whether renal function modulates the association between RAS polymorphisms and LVH in a cross-sectional study of 8592 inhabitants of Groningen...
  7. doi Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Eur J Heart Fail 12:348-53. 2010
    ..We hypothesize that short telomere length contributes to the susceptibility to develop anaemia in patients with CHF...
  8. ncbi The effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels are dependent on environmental context
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Hum Genet 122:275-81. 2007
    ..The present study emphasizes the importance of including environmental factors in genetic analyses to fully comprehend the genetic architecture of a specific trait...
  9. pmc Heart failure-associated anemia: bone marrow dysfunction and response to erythropoietin
    Willem Peter T Ruifrok
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Mol Med (Berl) 89:377-87. 2011
    ..Altogether, these results suggest that BM dysfunction is an important contributor to HF-associated anemia and that EPO is not an effective agent to treat HF-associated anemia...
  10. pmc Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Genomics 89:362-9. 2007
    ..These results support the idea that the interplay between the renin-angiotensin, bradykinin, and fibrinolytic systems might play an important role in t-PA and PAI-1 biology...
  11. doi The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload
    Laura M G Meems
    Department of Cardiology, University of Groningen, University Medical Center Groningen, P O Box 30 001, Postal code AB43, 9700 RB Groningen, The Netherlands
    J Steroid Biochem Mol Biol 132:282-9. 2012
    ..We hypothesized that activation of the VDR by paricalcitol would prevent fibrosis and LV diastolic dysfunction in an established murine model of cardiac remodeling...
  12. doi Sustained postoperative anaemia is associated with an impaired outcome after coronary artery bypass graft surgery: insights from the IMAGINE trial
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, P O Box 30001, Groningen 9700 RB, The Netherlands
    Heart 97:1590-6. 2011
    ..To investigate the association between sustained postoperative anaemia and outcome after coronary artery bypass graft (CABG) surgery...
  13. doi Effect of fosinopril treatment on serum C-reactive protein levels in patients with microalbuminuria
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 102:223-5. 2008
    ..Male gender was associated with a significantly larger reduction in CRP compared to female gender. In conclusion, contrary to previous observational studies, no effect of angiotensin-converting enzyme inhibition on CRP levels was found...
  14. pmc Atrial remodeling is directly related to end-diastolic left ventricular pressure in a mouse model of ventricular pressure overload
    Anne Margreet de Jong
    Department of Cardiology, University of Groningen, University Medical Center Groningen, The Netherlands The Interuniversity Cardiology Institute Netherlands, Utrecht, The Netherlands
    PLoS ONE 8:e72651. 2013
    ..Atrial fibrillation (AF) is often preceded by underlying cardiac diseases causing ventricular pressure overload...
  15. doi Incidence and epidemiology of new onset heart failure with preserved vs. reduced ejection fraction in a community-based cohort: 11-year follow-up of PREVEND
    Frank P Brouwers
    Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Eur Heart J 34:1424-31. 2013
    ..Data on epidemiology and prediction of new onset HFpEF, compared with HFrEF, have not been described...
  16. doi Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure
    Meimei Yin
    University Medical Center Groningen, Thorax Center, Department of Cardiology, University of Groningen, The Netherlands
    Am J Physiol Heart Circ Physiol 301:H459-68. 2011
    ..Altogether our results indicate that metformin may have potential to attenuate heart failure development after myocardial infarction, in the absence of diabetes and independent of systemic glucose levels...
  17. doi Telomere length and psychological well-being in patients with chronic heart failure
    Jardi Huzen
    Department of Cardiology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Age Ageing 39:223-7. 2010
    ..Shorter telomere length indicates a more advanced biological age. It is unknown whether psychological well-being is associated with telomere length in patients with the somatic condition of chronic heart failure (CHF)...
  18. doi Rosuvastatin attenuates angiotensin II-induced neointimal formation after stent implantation in the rat
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Coron Artery Dis 19:47-53. 2008
    ..We investigated the efficacy of oral rosuvastatin treatment to reduce in-stent neointima formation, both in the absence and presence of high levels of the proproliferative substance angiotensin II (Ang II)...
  19. doi Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A
    Hisko Oeseburg
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands
    Arterioscler Thromb Vasc Biol 30:1407-14. 2010
    ..Here we investigated whether the antidiabetic hormone glucagon-like peptide 1 (GLP-1) could prevent oxidative stress-induced cellular senescence in endothelial cells...
  20. doi A single dose of erythropoietin in ST-elevation myocardial infarction
    Adriaan A Voors
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Eur Heart J 31:2593-600. 2010
    ..032). Conclusion A single high dose of EPO after a successful PCI for a STEMI did not improve LVEF after 6 weeks. However, the use of EPO was related to less major adverse cardiovascular events and a favourable clinical safety profile...
  21. pmc Cyclical stretch induces structural changes in atrial myocytes
    Anne Margreet de Jong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Cell Mol Med 17:743-53. 2013
    ..This model can contribute to investigating the mechanisms involved in the remodelling process caused by stretch and to the testing of pharmaceutical agents...
  22. doi Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1
    Niek Verweij
    Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Hypertension 61:602-8. 2013
    ..The discovery of genetic variants in the kallikrein-kinin system and in the genes encoding pre-pro-ET-1 and pre-pro-ADM provides novel insights into the (co-)regulation of these vasoactive peptides in the vascular system...
  23. doi Suicidal erythrocyte death, eryptosis, as a novel mechanism in heart failure-associated anaemia
    Hasan Mahmud
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
    Cardiovasc Res 98:37-46. 2013
    ..Excessive eryptosis may lead to anaemia. We aimed to study the role of eryptosis in heart failure (HF)-associated anaemia...
  24. doi Endogenous erythropoietin and outcome in heart failure
    Anne M S Belonje
    Departments of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Circulation 121:245-51. 2010
    ..This study aims to analyze the clinical and prognostic value of erythropoietin levels in relation to hemoglobin in a large cohort of HF patients...
  25. doi Genetic architecture of tissue-type plasminogen activator and plasminogen activator inhibitor-1
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Semin Thromb Hemost 34:562-8. 2008
    ....
  26. doi Adverse renal effects of hydrochlorothiazide in rats with myocardial infarction treated with an ACE inhibitor
    Bart Westendorp
    Department of Experimental Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Pharmacol 602:373-9. 2009
    ....
  27. doi Bradykinin protects against oxidative stress-induced endothelial cell senescence
    Hisko Oeseburg
    Department of Experimental Cardiology, AB 43, University Medical Center Groningen, Antonius Deusinglaan 1, Building 3211, 9713 AV Groningen, The Netherlands
    Hypertension 53:417-22. 2009
    ..Therefore, we conclude that bradykinin protects endothelial cells from superoxide-induced senescence through bradykinin B2 receptor- and NO-mediated inhibition of DNA damage...
  28. doi Bone marrow dysfunction in chronic heart failure patients
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, Groningen 9700 RB, The Netherlands
    Eur J Heart Fail 12:676-84. 2010
    ..To investigate whether chronic heart failure (CHF) is associated with a general dysfunction of the haematopoietic compartment...
  29. ncbi Low-dose erythropoietin improves cardiac function in experimental heart failure without increasing haematocrit
    Erik Lipsic
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur J Heart Fail 10:22-9. 2008
    ..However, the increased haematocrit associated with EPO treatment might exert concomitant deleterious effects...
  30. doi Possible association between telomere length and renal dysfunction in patients with chronic heart failure
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 102:207-10. 2008
    ..Further studies will be needed to determine whether shorter leukocyte telomere length is the cause or consequence in this population and whether it plays a role in the prognosis of renal dysfunction in HF...
  31. ncbi Effect of withdrawal of pravastatin therapy on C-reactive protein and low-density lipoprotein cholesterol
    Pim van der Harst
    Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 100:1548-51. 2007
    ..In conclusion, withdrawal from pravastatin treatment resulted in an increase in CRP to approximately baseline levels, which is not related to the increase in LDL cholesterol...
  32. doi Non-bone marrow origin of neointimal smooth muscle cells in experimental in-stent restenosis in rats
    Hendrik C Groenewegen
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Vasc Res 45:493-502. 2008
    ..To determine the contribution of bone marrow (BM)-derived cells in in-stent restenosis (ISR) and transplant arteriosclerosis (TA)...
  33. pmc AKIP1, a cardiac hypertrophy induced protein that stimulates cardiomyocyte growth via the Akt pathway
    Hongjuan Yu
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, P O Box 30 001, Groningen 9700 RB, The Netherlands
    Int J Mol Sci 14:21378-93. 2013
    ..In conclusion, our results show that AKIP1 is induced in hypertrophic hearts and can stimulate adaptive cardiomyocyte growth, which involves Akt signaling. ..
  34. doi Activation of liver X receptors with T0901317 attenuates cardiac hypertrophy in vivo
    Irma Kuipers
    Department of Experimental Cardiology, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur J Heart Fail 12:1042-50. 2010
    ..Liver X receptor has also been shown to exert anti-proliferative and anti-inflammatory properties. In this study, we evaluated the effect of LXR activation on cardiac hypertrophy in vitro and in vivo...
  35. doi Activation of liver X receptor-alpha reduces activation of the renal and cardiac renin-angiotensin-aldosterone system
    Irma Kuipers
    Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Lab Invest 90:630-6. 2010
    ..In conclusion, LXR-alpha activation blunts ISO-induced increases in mRNA expression of renin, AT(1)R and ACE in the heart and kidney. These findings suggest a role for LXR-alpha in RAAS regulation...
  36. doi Telomere biology in cardiovascular disease: the TERC-/- mouse as a model for heart failure and ageing
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands
    Cardiovasc Res 81:244-52. 2009
    ..The TERC(-/-) mice provide exciting opportunities to expand our knowledge of telomere biology in cardiovascular disease and the potential identification of novel targets of treatment...
  37. ncbi Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization
    B Daan Westenbrink
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands
    Eur Heart J 28:2018-27. 2007
    ..We studied the effects of EPO on homing and incorporation of endothelial progenitor cells (EPC) into the myocardial microvasculature and myocardial expression of angiogenic factors...
  38. pmc The impact of coronary artery disease risk loci on ischemic heart failure severity and prognosis: association analysis in the COntrolled ROsuvastatin multiNAtional trial in heart failure (CORONA)
    Vincent G Haver
    University of Groningen, University Medical Center Groningen, Department of Cardiology, Hanzeplein 1, 9713GZ, Groningen, The Netherlands
    BMC Med Genet 15:140. 2014
    ..The impact of these loci on the disease severity and prognosis of ischemic heart failure due to CAD is currently unknown...
  39. doi Long term effects of epoetin alfa in patients with ST- elevation myocardial infarction
    Marieke L Fokkema
    Department of Cardiology, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Cardiovasc Drugs Ther 27:433-9. 2013
    ..The long term effects of erythropoiesis- stimulating agents on cardiovascular morbidity and mortality are unknown, therefore we evaluated clinical events at 1 year after PCI...
  40. doi Erythropoietin in cardiac disease: new features of an old drug
    Willem Peter T Ruifrok
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Pharmacol 585:270-7. 2008
    ....
  41. doi Genetic and pharmacological inhibition of galectin-3 prevents cardiac remodeling by interfering with myocardial fibrogenesis
    Lili Yu
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Circ Heart Fail 6:107-17. 2013
    ..Galectin-3 has been implicated in the development of organ fibrosis. It is unknown whether it is a relevant therapeutic target in cardiac remodeling and heart failure...
  42. pmc Aging, telomeres and heart failure
    Liza S M Wong
    Division of Experimental Cardiology, Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Heart Fail Rev 15:479-86. 2010
    ..In this review, we will elaborate on the current knowledge of aging of the heart, telomere biology and its potential role in the development of heart failure...
  43. doi Influence of age on the prognostic value of mid-regional pro-adrenomedullin in the general population
    Frank P Brouwers
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Heart 98:1348-53. 2012
    ..The aim of this study was to evaluate the prognostic performance of MR-proADM in the general population, controlling for these potential confounders...
  44. doi Erythropoiesis stimulation in acute ischemic syndromes
    Willem Peter T Ruifrok
    Department of Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Heart Fail Clin 6:313-21. 2010
    ..Large, randomized, placebo-controlled clinical trials are underway to give a final verdict on EPO treatment for acute coronary syndromes...
  45. doi The role of the renin-angiotensin-aldosterone system in cardiovascular progenitor cell function
    Cheng Qian
    Department of Experimental Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Clin Sci (Lond) 116:301-14. 2009
    ..In the present review we discuss what is currently known with respect to the role of the RAAS in the regulation of cardiovascular progenitor cells...
  46. doi Vitamin D status and outcomes in heart failure patients
    Licette C Y Liu
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur J Heart Fail 13:619-25. 2011
    ..The aims of this study were to determine whether a low vitamin D status is associated with prognosis in HF and whether activation of the renin-angiotensin system (RAS) and inflammatory markers could explain this potential association...
  47. ncbi Anaemia in chronic heart failure is not only related to impaired renal perfusion and blunted erythropoietin production, but to fluid retention as well
    B Daan Westenbrink
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Eur Heart J 28:166-71. 2007
    ..The present study aims to investigate the relation between anaemia, renal perfusion, erythropoietin production, and fluid retention in CHF patients...
  48. pmc Enhanced myogenic constriction of mesenteric artery in heart failure relates to decreased smooth muscle cell caveolae numbers and altered AT1- and epidermal growth factor-receptor function
    Ying Xu
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration GUIDE, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Heart Fail 11:246-55. 2009
    ..Recent data suggest both transactivation of EGF receptors and caveolae-like microdomains to be implicated in the activity of AT(1) receptors. Thus, we assessed their roles in increased MC in mesenteric arteries of CHF rats...
  49. doi Anemia in chronic heart failure: etiology and treatment options
    B Daan Westenbrink
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Opin Cardiol 23:141-7. 2008
    ..The review will describe current advances in the understanding of the pathophysiology of anemia and the potential therapeutic effects of recombinant human erythropoietin...
  50. doi Telomere length and outcome in heart failure
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Ann Med 42:36-44. 2010
    ..Senescence is a potential factor in the pathogenesis and progression of heart failure. In heart failure telomeres are shorter, but the prognostic value associated with telomere length has not been defined...
  51. doi Ultrasound and microbubble-targeted delivery of macromolecules is regulated by induction of endocytosis and pore formation
    Bernadet D M Meijering
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands
    Circ Res 104:679-87. 2009
    ..In conclusion, these data demonstrate that endocytosis is a key mechanism in UMTD besides transient pore formation, with the contribution of endocytosis being dependent on molecular size...
  52. doi Clinical risk stratification optimizes value of biomarkers to predict new-onset heart failure in a community-based cohort
    Frank P Brouwers
    From the Department of Cardiology F P B, W H v G, K D, M P v d B, H L H, D J v V, P v d H, R A d B and Division of Nephrology, Department of Internal Medicine R T G, S J L B, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Circ Heart Fail 7:723-31. 2014
    ....
  53. ncbi Long-term effects of pravastatin and fosinopril on peripheral endothelial function in albuminuric subjects
    Folkert W Asselbergs
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Atherosclerosis 196:349-55. 2008
    ..01). In conclusion, after 4 years of follow-up, pravastatin treatment tended to increase FMD and this effect was predominantly present in men. Fosinopril treatment did not modify FMD during long-term follow-up...
  54. ncbi Usefulness of preoperative C-reactive protein and soluble intercellular adhesion molecule-1 level for predicting future cardiovascular events after coronary artery bypass grafting
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 97:1697-701. 2006
    ....
  55. pmc Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure
    Meimei Yin
    University Medical Center Groningen, University of Groningen, Department of Cardiology, Groningen, The Netherlands
    Cardiovasc Diabetol 10:85. 2011
    ..We hypothesized that the DPP-4 inhibitor vildagliptin will increase levels of GLP-1 and may exert protective effects on cardiac function after MI...
  56. doi Prognostic value of renin and prorenin in heart failure patients with decreased kidney function
    Mariusz K Szymanski
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am Heart J 162:487-93. 2011
    ..We aimed to investigate the prognostic value of active plasma renin concentration (APRC) and prorenin in patients with HF treated with RAAS-blocking agents and its relationship with kidney function parameters...
  57. doi Proteinuria-associated endothelial dysfunction is strain dependent
    Nadir Ulu
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Am J Nephrol 30:209-17. 2009
    ..Therefore, we studied aortic endothelial function in Munich Wistar Fromter (MWF) and fawn-hooded hypertensive (FHH) inbred rat strains with genetic proteinuria to determine the specific impact of proteinuria on the development of ED...
  58. ncbi Hydrochlorothiazide increases plasma or tissue angiotensin-converting enzyme-inhibitor drug levels in rats with myocardial infarction: differential effects on lisinopril and zofenopril
    Bart Westendorp
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Eur J Pharmacol 527:141-9. 2005
    ..Whether combining different angiotensin-converting enzyme-inhibitors with hydrochlorothiazide translates into distinct clinical profiles requires further study...
  59. pmc Measurement of coronary calcium scores or exercise testing as initial screening tool in asymptomatic subjects with ST-T changes on the resting ECG: an evaluation study
    Christiane A Geluk
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, The Netherlands
    BMC Cardiovasc Disord 7:19. 2007
    ..However, it is not clear which test should be preferred as initial diagnostic test. We evaluated the prevalence of documented coronary artery disease (CAD) according to calcium scores and exercise test results...
  60. ncbi High angiotensin II responsiveness is associated with decreased endothelium-dependent relaxation in human arteries
    Adriaan A Voors
    Department of Cardiology, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
    J Renin Angiotensin Aldosterone Syst 6:145-50. 2005
    ..However, this relation has not been well described in humans. Therefore, we investigated the relation between Ang II responsiveness and EDR in isolated human arteries...
  61. doi Effects of ivabradine and metoprolol on cardiac angiogenesis and endothelial dysfunction in rats with heart failure
    Nadir Ulu
    Departments of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Cardiovasc Pharmacol 53:9-17. 2009
    ..In MI rats, HRR either by ivabradine or metoprolol treatment increases cardiac angiogenesis. Late HRR strategy was comparable to early HRR, suggesting that the beneficial effects are independent of the time of onset of therapy after MI...
  62. doi Effects of erythropoietin after an acute myocardial infarction: rationale and study design of a prospective, randomized, clinical trial (HEBE III)
    Anne M Belonje
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Am Heart J 155:817-22. 2008
    ..Furthermore, EPO promotes endothelial progenitor cell growth, which increases angiogenesis. A recent pilot study in patients with AMI suggested that a single bolus of EPO was safe and well tolerated...
  63. doi Adequacy of endogenous erythropoietin levels and mortality in anaemic heart failure patients
    Peter van der Meer
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Eur Heart J 29:1510-5. 2008
    ..We examined the adequacy of endogenous erythropoietin (EPO) levels for the degree of anaemia in patients with chronic heart failure (CHF) and its relation to prognosis...
  64. ncbi Protective effects of erythropoietin in cardiac ischemia: from bench to bedside
    Erik Lipsic
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 48:2161-7. 2006
    ..Future clinical studies are warranted to translate the beneficial effects of EPO from basic experiments to cardiac patients...
  65. pmc Telomere length of circulating leukocyte subpopulations and buccal cells in patients with ischemic heart failure and their offspring
    Liza S M Wong
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e23118. 2011
    ..We additionally measured TL of offspring of patients and controls to examine heritability throughout different cell types...
  66. pmc Regulation of the (pro)renin-renin receptor in cardiac remodelling
    Hasan Mahmud
    University Medical Center Groningen, Thorax Center, Department of Cardiology, University of Groningen, The Netherlands
    J Cell Mol Med 16:722-9. 2012
    ..These results demonstrate that (P)RR expression is strongly up-regulated both in rodent models of heart failure and in the failing human heart, hinting to a potential role for (P)RR in cardiac pathophysiology...
  67. ncbi Unraveling the mechanisms for heart failure patients' beliefs about compliance
    Martje H L van der Wal
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Heart Lung 36:253-61. 2007
    ..Noncompliance can lead to worsening symptoms and is associated with personal beliefs about compliance. To intervene effectively, knowledge of factors related to patients' beliefs about compliance is needed...
  68. pmc Telomere biology in healthy aging and disease
    Hisko Oeseburg
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700RB Groningen, The Netherlands
    Pflugers Arch 459:259-68. 2010
    ..In the current review, we will discuss the role of telomere biology in relation to aging and aging associated diseases...
  69. doi Vascular dysfunction in adriamycin nephrosis: different effects of adriamycin exposure and nephrosis
    Nadir Ulu
    Department of Clinical Pharmacology, Groningen University Institute for Drug Exploration GUIDE, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 23:1854-60. 2008
    ..The present study, therefore, investigated in vitro vascular function in the isolated thoracic aorta and isolated perfused hearts of rats with adriamycin nephrosis, as compared to non-nephrotic adriamycin exposed rats...
  70. doi Nuclear hormone receptors as regulators of the renin-angiotensin-aldosterone system
    Irma Kuipers
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hypertension 51:1442-8. 2008
  71. ncbi A single bolus of a long-acting erythropoietin analogue darbepoetin alfa in patients with acute myocardial infarction: a randomized feasibility and safety study
    Erik Lipsic
    Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Cardiovasc Drugs Ther 20:135-41. 2006
    ..The present study evaluated the safety and tolerability of EPO treatment in non-anemic patients with acute myocardial infarction (MI)...
  72. ncbi Effect of intensive versus moderate lipid lowering on endothelial function and vascular responsiveness to angiotensin II in stable coronary artery disease
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 96:1361-4. 2005
    ..05). Endothelium improvement was accompanied by decreased vascular response to angiotensin II (p = 0.039). These findings suggest a mechanism for the clinical benefit of intensive lipid-lowering treatment in coronary heart disease...