Thys van der Molen

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. pmc Improving physical activity in COPD: towards a new paradigm
    Thierry Troosters
    Pulmonary Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium
    Respir Res 14:115. 2013
  2. pmc Effectiveness of the Assessment of Burden of Chronic Obstructive Pulmonary Disease (ABC) tool: study protocol of a cluster randomised trial in primary and secondary care
    Annerika H M Slok
    Department of Family Medicine, Maastricht University, CAPHRI School for Public Health and Primary Care, PO Box 616, 6200 MD Maastricht, The Netherlands
    BMC Pulm Med 14:131. 2014
  3. pmc Assessing health status in COPD. A head-to-head comparison between the COPD assessment test (CAT) and the clinical COPD questionnaire (CCQ)
    Ioanna G Tsiligianni
    Department of Thoracic Medicine, Medical School, University of Crete, Heraklion, Crete, PO 71003, Greece
    BMC Pulm Med 12:20. 2012
  4. doi Beyond lung function in COPD management: effectiveness of LABA/LAMA combination therapy on patient-centred outcomes
    Thys van der Molen
    Department of General Practice, University Medical Center Groningen, Groningen, The Netherlands
    Prim Care Respir J 21:101-8. 2012
  5. pmc Health status measurement in COPD: the minimal clinically important difference of the clinical COPD questionnaire
    J W H Kocks
    Department of General Practice University Medical Center Groningen, The Netherlands
    Respir Res 7:62. 2006
  6. pmc A self-rating scale for patient-perceived side effects of inhaled corticosteroids
    Juliet M Foster
    Department of General Practice and Primary Care, University of Aberdeen, UK
    Respir Res 7:131. 2006
  7. pmc Patient-reporting of side effects may provide an important source of information in clinical practice
    Juliet M Foster
    Eur J Clin Pharmacol 63:979-80; author reply 981. 2007
  8. pmc A telehealth integrated asthma-COPD service for primary care: a proposal for a pilot feasibility study in Crete, Greece
    Ioanna G Tsiligianni
    Agia Barbara Health Care Center, Heraklion, Crete, P, O 70003, Greece
    BMC Res Notes 3:198. 2010
  9. pmc Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE study
    Martyn R Partridge
    Department of Respiratory Medicine, Faculty of Medicine, Imperial College London, London, UK
    BMC Pulm Med 6:13. 2006
  10. pmc COPD uncovered: an international survey on the impact of chronic obstructive pulmonary disease [COPD] on a working age population
    Monica J Fletcher
    Education for Health, Warwick, UK
    BMC Public Health 11:612. 2011

Collaborators

Detail Information

Publications51

  1. pmc Improving physical activity in COPD: towards a new paradigm
    Thierry Troosters
    Pulmonary Rehabilitation and Respiratory Division, UZ Gasthuisberg, Herestraat 49, B3000 Leuven, Belgium
    Respir Res 14:115. 2013
    ....
  2. pmc Effectiveness of the Assessment of Burden of Chronic Obstructive Pulmonary Disease (ABC) tool: study protocol of a cluster randomised trial in primary and secondary care
    Annerika H M Slok
    Department of Family Medicine, Maastricht University, CAPHRI School for Public Health and Primary Care, PO Box 616, 6200 MD Maastricht, The Netherlands
    BMC Pulm Med 14:131. 2014
    ..The aim of the current study is to analyse the effectiveness of the ABC tool compared with usual care on health related quality of life among COPD patients over a period of 18 months...
  3. pmc Assessing health status in COPD. A head-to-head comparison between the COPD assessment test (CAT) and the clinical COPD questionnaire (CCQ)
    Ioanna G Tsiligianni
    Department of Thoracic Medicine, Medical School, University of Crete, Heraklion, Crete, PO 71003, Greece
    BMC Pulm Med 12:20. 2012
    ..We compared the usefulness and validity of the COPD Assessment Test (CAT) and the Clinical COPD Questionnaire (CCQ), two simple questionnaires, in comparison with the St. George Respiratory Questionnaire (SGRQ)...
  4. doi Beyond lung function in COPD management: effectiveness of LABA/LAMA combination therapy on patient-centred outcomes
    Thys van der Molen
    Department of General Practice, University Medical Center Groningen, Groningen, The Netherlands
    Prim Care Respir J 21:101-8. 2012
    ....
  5. pmc Health status measurement in COPD: the minimal clinically important difference of the clinical COPD questionnaire
    J W H Kocks
    Department of General Practice University Medical Center Groningen, The Netherlands
    Respir Res 7:62. 2006
    ..This study aimed to identify the MCID for the clinical COPD questionnaire (CCQ) in terms of patient referencing, criterion referencing, and by the standard error of measurement (SEM)...
  6. pmc A self-rating scale for patient-perceived side effects of inhaled corticosteroids
    Juliet M Foster
    Department of General Practice and Primary Care, University of Aberdeen, UK
    Respir Res 7:131. 2006
    ..In this research we aim to assess the construct validity and reliability of the ICQ and test its responsiveness to dose changes in adult asthma patients...
  7. pmc Patient-reporting of side effects may provide an important source of information in clinical practice
    Juliet M Foster
    Eur J Clin Pharmacol 63:979-80; author reply 981. 2007
  8. pmc A telehealth integrated asthma-COPD service for primary care: a proposal for a pilot feasibility study in Crete, Greece
    Ioanna G Tsiligianni
    Agia Barbara Health Care Center, Heraklion, Crete, P, O 70003, Greece
    BMC Res Notes 3:198. 2010
    ..A telemedicine COPD-asthma service may benefit Greece as it is a country, partly due to its geography, that does not have easy access to pulmonologists...
  9. pmc Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE study
    Martyn R Partridge
    Department of Respiratory Medicine, Faculty of Medicine, Imperial College London, London, UK
    BMC Pulm Med 6:13. 2006
    ....
  10. pmc COPD uncovered: an international survey on the impact of chronic obstructive pulmonary disease [COPD] on a working age population
    Monica J Fletcher
    Education for Health, Warwick, UK
    BMC Public Health 11:612. 2011
    ..The burden of disease is known to be high, though less is known about those of a younger age. The aim of this study was to investigate the wider personal, economic and societal burden of COPD on a cross country working-age cohort...
  11. doi Co-morbidities of COPD in primary care: frequency, relation to COPD, and treatment consequences
    Thys van der Molen
    Department of General Practice, University Medical Center, Groningen, The Netherlands
    Prim Care Respir J 19:326-34. 2010
    ....
  12. ncbi International Primary Care Respiratory Group (IPCRG) Guidelines: management of asthma
    Thys van der Molen
    Department of General Practice, Antonius Deusinglaan 1, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands
    Prim Care Respir J 15:35-47. 2006
    ..It covers the classification of the disease, the stepwise approach to pharmacologic therapy, disease monitoring, the management of exacerbations, and the identification of patients at risk of asthma death...
  13. doi Primary prevention of chronic obstructive pulmonary disease in primary care
    Thys van der Molen
    Department of General Practice, University Medical Center Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Proc Am Thorac Soc 6:704-6. 2009
    ..Because cigarette smoking is not only a major cause of COPD but is also a major cause of many other diseases, a decline in tobacco smoking would result in substantial health benefits...
  14. doi Fluticasone or montelukast for preschool children with asthma-like symptoms: Randomized controlled trial
    Elisabeth M W Kooi
    Department of Pediatrics, Division of Pediatric Pulmonology and Allergology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, P O Box 196, 9700 AD Groningen, The Netherlands
    Pulm Pharmacol Ther 21:798-804. 2008
    ..However, comparative studies are lacking in this age group. Therefore, we conducted a study to evaluate and compare the effect of FP and Mk in preschool children with asthma-like symptoms...
  15. doi Prescribing of asthma medication in primary care for children aged under 10
    Siebrig Schokker
    Department of General Practice, University Medical Center Groningen, University of Groningen, Netherlands
    Prim Care Respir J 19:28-34. 2010
    ..To evaluate prescriptions of asthma medication for children in primary care...
  16. pmc Socio-economic factors, gender and smoking as determinants of COPD in a low-income country of sub-Saharan Africa: FRESH AIR Uganda
    Frederik van Gemert
    Department of General Practice, Groningen Institute for Asthma and COPD GRIAC, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    NPJ Prim Care Respir Med 26:16050. 2016
    ..This applied for gender differences as well (i.e., for men, marital status and biomass fuel for heating, and for women being a former smoker). More research is needed to clarify the complexity of the different risk factors. ..
  17. doi Impact of chronic respiratory symptoms in a rural area of sub-Saharan Africa: an in-depth qualitative study in the Masindi district of Uganda
    Frederik van Gemert
    Department of General Practice, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands
    Prim Care Respir J 22:300-5. 2013
    ..No studies have been performed to examine how the community in resource poor settings of a rural area in sub-Saharan Africa lives with chronic respiratory symptoms...
  18. doi Budesonide/formoterol maintenance and reliever therapy in primary care asthma management: effects on bronchial hyperresponsiveness and asthma control
    Roland A Riemersma
    Department of General Practice, University Medical Center Groningen, Groningen, The Netherlands
    Prim Care Respir J 21:50-6. 2012
    ..SMART and its effects on bronchial hyperresponsiveness (BHR) have not been studied in primary care...
  19. doi Difference between patient-reported side effects of ciclesonide versus fluticasone propionate
    Thys van der Molen
    Department of General Practice, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Respir Med 104:1825-33. 2010
    ..Further to asthma control and quality of life, self-reported side effects of treatment can be assessed with the validated Inhaled Corticosteroid Questionnaire (ICQ)...
  20. pmc Health status instruments for patients with COPD in pulmonary rehabilitation: defining a minimal clinically important difference
    Harma Alma
    Department of General Practice, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    NPJ Prim Care Respir Med 26:16041. 2016
    ..40 on the CCQ, 3.00 on the CAT and 7.00 on the SGRQ for moderate to very severe COPD patients. The MCIDs of the CAT and SGRQ in the literature might be too low, leading to overestimation of treatment effects for patients with COPD...
  21. pmc Effectiveness of initiating extrafine-particle versus fine-particle inhaled corticosteroids as asthma therapy in the Netherlands
    Thys van der Molen
    Department of General Practice, University of Groningen, University Medical Center, Groningen, The Netherlands
    BMC Pulm Med 16:80. 2016
    ..This matched cohort, database study, compared the effectiveness of extrafine-particle with fine-particle ICS in a real-life population initiating ICS therapy in the Netherlands...
  22. pmc Development, validity and responsiveness of the Clinical COPD Questionnaire
    Thys van der Molen
    Department of General Practice, University of Groningen, Groningen, The Netherlands
    Health Qual Life Outcomes 1:13. 2003
    ..So far no validated questionnaires are available to measure symptom and functional state in daily clinical practice. The aim of this study was to develop and validate the Clinical COPD Questionnaire (CCQ)...
  23. pmc Prediction and course of symptoms and lung function around an exacerbation in chronic obstructive pulmonary disease
    Maarten van den Berge
    Department of Respiratory Medicine, University Medical Center Groningen, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands
    Respir Res 13:44. 2012
    ..We investigated the course of exacerbations in the published COSMIC study that investigated the effects of 1-year withdrawal of fluticasone after a 3-month run-in treatment period with salmeterol/fluticasone in patients with COPD...
  24. pmc Putting health status guided COPD management to the test: protocol of the MARCH study
    Janwillem Kocks
    Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    BMC Pulm Med 13:41. 2013
    ....
  25. pmc Day-to-day measurement of patient-reported outcomes in exacerbations of chronic obstructive pulmonary disease
    Jan Willem H Kocks
    Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 8:273-86. 2013
    ..This study aims to describe the day-to-day course of patient-reported health status during exacerbations of COPD and to assess its value in predicting clinical outcomes...
  26. doi Functional status measurement in COPD: a review of available methods and their feasibility in primary care
    Janwillem W H Kocks
    Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Prim Care Respir J 20:269-75. 2011
    ..This review aims to categorize systematically the available tools based on their construct (i.e. what the tool intends to measure) and to rate the tools for use in the primary care setting...
  27. pmc Asthma-Related Outcomes in Patients Initiating Extrafine Ciclesonide or Fine-Particle Inhaled Corticosteroids
    Dirkje S Postma
    University of Groningen, Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands
    Allergy Asthma Immunol Res 9:116-125. 2017
    ..We sought to compare asthma-related outcomes after patients initiated extrafine-particle ciclesonide or fine-particle ICS (fluticasone propionate or non-extrafine beclomethasone)...
  28. pmc Health status in routine clinical practice: validity of the clinical COPD questionnaire at the individual patient level
    Janwillem W H Kocks
    Department of General Practice, University Medical Center Groningen, University of Groningen, A, Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Health Qual Life Outcomes 8:135. 2010
    ..This study examines a new method, using patient interviews, to validate a short health status questionnaire, the Clinical COPD Questionnaire (CCQ), at the individual patient level...
  29. pmc COPD management: role of symptom assessment in routine clinical practice
    Thys van der Molen
    Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands GRIAC Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 8:461-71. 2013
    ....
  30. pmc COPD exacerbations in general practice: variability in oral prednisolone courses
    Marianne de Vries
    Department of General Practice, University Medical Centre Groningen, University of Groningen, Antonius Deusinglaan 1, FA 20, 9700 AD Groningen, The Netherlands
    BMC Fam Pract 13:3. 2012
    ..It also investigates the number of general practitioners (GPs) who adjust their treatment according to the presence of diabetic co-morbidity...
  31. doi Mentoring portfolio use in undergraduate and postgraduate medical education
    Hanke Dekker
    Center for Research and Innovation in Medical Education, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    Med Teach 31:903-9. 2009
    ..Mentoring is widely acknowledged as being crucial for portfolio learning. The aim of this study is to examine how mentoring portfolio use has been implemented in undergraduate and postgraduate settings...
  32. pmc Investigating sensitivity, specificity, and area under the curve of the Clinical COPD Questionnaire, COPD Assessment Test, and Modified Medical Research Council scale according to GOLD using St George's Respiratory Questionnaire cutoff 25 (and 20) as refe
    Ioanna G Tsiligianni
    Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, Germany GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, Germany
    Int J Chron Obstruct Pulmon Dis 11:1045-52. 2016
    ..In addition, areas under the curve (AUCs) of the CCQ, CAT, and mMRC scale were compared using two SGRQ cutoff points (≥25 and ≥20)...
  33. pmc Development of a diagnostic decision tree for obstructive pulmonary diseases based on real-life data
    Esther I Metting
    Dept of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    ERJ Open Res 2:. 2016
    ..The total decision tree can be implemented in computer-assisted diagnostic systems for individual patients. A simplified version of this tree can be used in daily clinical practice as a desk tool...
  34. pmc Morning and night symptoms in primary care COPD patients: a cross-sectional and longitudinal study. An UNLOCK study from the IPCRG
    Ioanna Tsiligianni
    Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    NPJ Prim Care Respir Med 26:16040. 2016
    ..Severe morning symptoms predicted worsening of COPD health status. ..
  35. pmc Development of a tool to recognize small airways dysfunction in asthma (SADT)
    Lieke Schiphof-Godart
    Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Health Qual Life Outcomes 12:155. 2014
    ..The identification of patients who suffer from SAD is important from a clinical perspective, as targeted therapy may improve patients' well-being and treatment efficacy...
  36. pmc The minimal clinically important difference of the Control of Allergic Rhinitis and Asthma Test (CARAT): cross-cultural validation and relation with pollen counts
    Sander van der Leeuw
    1 Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2 GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    NPJ Prim Care Respir Med 25:14107. 2015
    ..The Control of Allergic Rhinitis and Asthma Test (CARAT) monitors control of asthma and allergic rhinitis...
  37. doi The Severe Respiratory Insufficiency Questionnaire scored best in the assessment of health-related quality of life in chronic obstructive pulmonary disease
    Fransien M Struik
    Department of Pulmonology Center for Home Mechanical Ventilation, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
    J Clin Epidemiol 66:1166-74. 2013
    ....
  38. ncbi Inhaled corticosteroids for recurrent respiratory symptoms in preschool children in general practice: randomized controlled trial
    Siebrig Schokker
    Department of General Practice, University Medical Center Groningen, University of Groningen, P O Box 196, 9700 AD Groningen, The Netherlands
    Pulm Pharmacol Ther 21:88-97. 2008
    ..Therefore, the role of ICS in the management of preschool children with recurrent respiratory symptoms is unclear. We assessed the effectiveness of ICS in preschool children with recurrent respiratory symptoms in general practice...
  39. doi Personality influences the reporting of side effects of inhaled corticosteroids in asthma patients
    Juliet M Foster
    Department of General Practice, University Medical Center Groningen, University of Groningen, The Netherlands
    J Asthma 45:664-9. 2008
    ..Negative affectivity is a measure of anxiety associated with increased reporting of symptoms. Few studies have explored this association with respect to drug-induced symptoms in patients taking medication for a chronic disease in real life...
  40. pmc Real-life data on antibiotic prescription and sputum culture diagnostics in acute exacerbations of COPD in primary care
    Erik Bathoorn
    Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 12:285-290. 2017
    ..Here we evaluate adherence to these guidelines with regard to antibiotic prescription in AECOPD in primary care and the use of sputum cultures...
  41. pmc Feasibility and effectiveness of an asthma/COPD service for primary care: a cross-sectional baseline description and longitudinal results
    Esther I Metting
    1 Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2 GRIAC Research Institute Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    NPJ Prim Care Respir Med 25:14101. 2015
    ..In 2007, an Asthma/chronic obstructive pulmonary disease (COPD) (AC) service was implemented in the North of the Netherlands to support General Practitioners (GPs) by providing advice from pulmonologists on a systematic basis...
  42. doi The use of health status questionnaires in the management of chronic obstructive pulmonary disease patients in clinical practice
    Thys van der Molen
    University of Groningen, University Medical Center Groningen, Department of General Practice, Groningen, The Netherlands
    Expert Rev Respir Med 8:479-91. 2014
    ..New studies are needed to further determine their value on several disease outcomes. ..
  43. ncbi Cognitive performance in patients with COPD
    Jeroen J W Liesker
    Department of Pulmonary Diseases, University Hospital Groningen, Hanzeplein 1, Postbox 30001 NL 9700 RB, Groningen, The Netherlands
    Respir Med 98:351-6. 2004
    ..These neuropsychological impairments are related to the degree of hypoxemia. So far, cognitive performance has not been tested in non-hypoxemic patients with COPD...
  44. doi The impact of asthma and COPD in sub-Saharan Africa
    Frederik van Gemert
    Department of General Practice, University Medical Center Groningen, Groningen, The Netherlands
    Prim Care Respir J 20:240-8. 2011
    ..Many countries in sub-Saharan Africa have the highest risk of developing chronic diseases and are the least able to cope with them...
  45. doi Factors that influence disease-specific quality of life or health status in patients with COPD: a review and meta-analysis of Pearson correlations
    Ioanna Tsiligianni
    University Medical Center, University of Groningen, Groningen, The Netherlands
    Prim Care Respir J 20:257-68. 2011
    ..A major goal in the management of chronic obstructive pulmonary disease (COPD) is to ensure that the burden of the disease for patients with COPD is limited and that patients will have the best possible quality of life...
  46. doi The use of questionnaires for measuring patient-reported side effects of drugs: its importance and methodological challenges
    Juliet M Foster
    Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Pharmacoepidemiol Drug Saf 17:278-96. 2008
    ....
  47. pmc Guidance on the diagnosis and management of asthma among adults in resource limited settings
    Bruce J Kirenga
    Pulmonology Unit, Department of Medicine, Makerere University College of Health sciences Mulago Hospital Department of General Practice, Groningen Research Institute for Asthma and COPD GRIAC, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Afr Health Sci 15:1189-99. 2015
    ..The purpose of this review is to identify steps for asthma diagnosis and management in resource limited settings...
  48. pmc A systematic review of the role of vitamin insufficiencies and supplementation in COPD
    Ioanna G Tsiligianni
    Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Res 11:171. 2010
    ..Vitamin supplements have therefore been proposed to be a potentially useful additive to COPD therapy...
  49. doi A new perspective on optimal care for patients with COPD
    Dirkje Postma
    Department of Pulmonary Medicine and Tuberculosis, University Medical Center Groningen, University of Groningen, The Netherlands
    Prim Care Respir J 20:205-9. 2011
    ..This broader approach to disease management should result in improved care for every COPD patient now and into the future...
  50. doi Development of a questionnaire for the assessment of bronchial hyperresponsiveness
    Roland Riemersma
    Department of General Practice, University Medical Center Groningen, Groningen, Netherlands
    Prim Care Respir J 18:287-93. 2009
    ..However, challenge tests are expensive, inconvenient to patients, time consuming, and not easily accessible to general practitioners. Assessment of BHR by a questionnaire would be advantageous in the diagnosis and management of asthma...
  51. ncbi Validity of performance indicators for assessing prescribing quality: the case of asthma
    Lisa G Pont
    Department of Clinical Pharmacology, University of Groningen, The Netherlands
    Eur J Clin Pharmacol 59:833-40. 2004
    ..Indicators that are associated with sub-optimal treatment in one of the four steps of asthma management were assessed...