Maarten van den Berge

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. pmc Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
    Eef D Telenga
    Department of Pulmonary Diseases, University Medical Center Groningen, Groningen, Netherlands
    BMC Pulm Med 13:58. 2013
  2. doi request reprint Treatment of the bronchial tree from beginning to end: targeting small airway inflammation in asthma
    M van den Berge
    Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Allergy 68:16-26. 2013
  3. pmc Prediction and course of symptoms and lung function around an exacerbation in chronic obstructive pulmonary disease
    Maarten van den Berge
    Department of Respiratory Medicine, University Medical Center Groningen, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands
    Respir Res 13:44. 2012
  4. pmc Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity
    Maarten van den Berge
    Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Thorax 69:14-23. 2014
  5. doi request reprint Advanced glycation end products in the skin are enhanced in COPD
    Susan J M Hoonhorst
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands
    Metabolism 63:1149-56. 2014
  6. doi request reprint Small airway disease in asthma and COPD: clinical implications
    Maarten van den Berge
    Department of Pulmonary, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Chest 139:412-23. 2011
  7. doi request reprint Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells
    Loes E M Kistemaker
    Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Thorax 70:668-76. 2015
  8. doi request reprint Inhaled corticosteroids in chronic obstructive pulmonary disease: a review
    Eef D Telenga
    University Medical Center Groningen, University of Groningen, Department of Pulmonology PO Box 30 001, 9700 RB Groningen, The Netherlands
    Expert Opin Pharmacother 11:405-21. 2010
  9. pmc Advanced glycation endproducts and their receptor in different body compartments in COPD
    Susan J M Hoonhorst
    Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713, GZ, Groningen, The Netherlands
    Respir Res 17:46. 2016
  10. doi request reprint Asthma and chronic obstructive pulmonary disease: similarities and differences
    Dirkje S Postma
    University of Groningen, Department of Pulmonology, GRIAC Research Institute, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands Electronic address
    Clin Chest Med 35:143-56. 2014

Collaborators

Detail Information

Publications30

  1. pmc Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
    Eef D Telenga
    Department of Pulmonary Diseases, University Medical Center Groningen, Groningen, Netherlands
    BMC Pulm Med 13:58. 2013
    ..We investigated differences in blood and sputum inflammatory profiles between ex-, current-, and never-smokers and assessed their ICS treatment response after 2-week and 1-year treatment...
  2. doi request reprint Treatment of the bronchial tree from beginning to end: targeting small airway inflammation in asthma
    M van den Berge
    Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Allergy 68:16-26. 2013
    ..This remains a challenging area requiring further research. The aim of the current manuscript is to review the clinical relevance of small airway disease and the implications for the treatment of asthma...
  3. pmc Prediction and course of symptoms and lung function around an exacerbation in chronic obstructive pulmonary disease
    Maarten van den Berge
    Department of Respiratory Medicine, University Medical Center Groningen, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands
    Respir Res 13:44. 2012
    ..We investigated the course of exacerbations in the published COSMIC study that investigated the effects of 1-year withdrawal of fluticasone after a 3-month run-in treatment period with salmeterol/fluticasone in patients with COPD...
  4. pmc Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity
    Maarten van den Berge
    Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Thorax 69:14-23. 2014
    ....
  5. doi request reprint Advanced glycation end products in the skin are enhanced in COPD
    Susan J M Hoonhorst
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands
    Metabolism 63:1149-56. 2014
    ..In this study we assessed whether AGE accumulation in the skin is elevated in COPD and associates with disease severity...
  6. doi request reprint Small airway disease in asthma and COPD: clinical implications
    Maarten van den Berge
    Department of Pulmonary, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Chest 139:412-23. 2011
    ..The first studies in COPD are promising, and results from new studies are eagerly awaited...
  7. doi request reprint Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells
    Loes E M Kistemaker
    Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Thorax 70:668-76. 2015
    ..In vivo studies have demonstrated an indirect role for acetylcholine in epithelial cell differentiation. Here, we aimed to investigate direct effects of endogenous non-neuronal acetylcholine on epithelial cell differentiation...
  8. doi request reprint Inhaled corticosteroids in chronic obstructive pulmonary disease: a review
    Eef D Telenga
    University Medical Center Groningen, University of Groningen, Department of Pulmonology PO Box 30 001, 9700 RB Groningen, The Netherlands
    Expert Opin Pharmacother 11:405-21. 2010
    ..Although widely used, the efficacy of inhaled corticosteroids (ICS) in the treatment of COPD remains a matter of debate...
  9. pmc Advanced glycation endproducts and their receptor in different body compartments in COPD
    Susan J M Hoonhorst
    Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713, GZ, Groningen, The Netherlands
    Respir Res 17:46. 2016
    ..This study assessed the association of AGEs or RAGE in plasma, sputum, bronchial biopsies and skin with COPD and lung function, and their variance between these body compartments...
  10. doi request reprint Asthma and chronic obstructive pulmonary disease: similarities and differences
    Dirkje S Postma
    University of Groningen, Department of Pulmonology, GRIAC Research Institute, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands Electronic address
    Clin Chest Med 35:143-56. 2014
    ....
  11. doi request reprint A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis
    Anita I R Spanjer
    Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands Groningen Research Institute for Asthma and COPD GRIAC, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Thorax 71:312-22. 2016
    ..Here, we investigated if the Frizzled-8 receptor has a functional role in airway inflammation associated with chronic bronchitis...
  12. doi request reprint Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD
    Maarten van den Berge
    Dept of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Eur Respir J 40:1098-105. 2012
    ..Our findings indicate that BHR is an independent trait in COPD and provides important information on phenotype heterogeneity and disease activity...
  13. ncbi request reprint Provocation with adenosine 5'-monophosphate increases sputum eosinophils
    Maarten van den Berge
    Departments of Pulmonology, University Hospital Groningen, Groningen, The Netherlands
    Chest 123:417S. 2003
  14. doi request reprint Skin-blanching is associated with FEV(1), allergy, age and gender in asthma families
    Eef D Telenga
    Department of Pulmonology, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Med 106:1376-82. 2012
    ..Finally, we assessed which clinical and inflammatory parameters influence the variability in skin-blanching response...
  15. doi request reprint Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma: a systematic review
    Erica van der Wiel
    Department of Pulmonary Medicine and Tuberculosis and the GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 131:646-57. 2013
    ..It is important to develop simpler and more reliable tools (eg, questionnaires or bronchial provocation tests with small-particle stimuli) to assess the presence and extent of small-airways dysfunction in daily clinical practice...
  16. pmc Development of a tool to recognize small airways dysfunction in asthma (SADT)
    Lieke Schiphof-Godart
    Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Health Qual Life Outcomes 12:155. 2014
    ..The identification of patients who suffer from SAD is important from a clinical perspective, as targeted therapy may improve patients' well-being and treatment efficacy...
  17. doi request reprint Oxidant-induced corticosteroid unresponsiveness in human bronchial epithelial cells
    Irene Heijink
    Laboratory of Allergology and Pulmonary Diseases, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Thorax 69:5-13. 2014
    ....
  18. doi request reprint Beneficial effects of treatment with anti-IgE antibodies (Omalizumab) in a patient with severe asthma and negative skin-prick test results
    Maarten van den Berge
    Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands
    Chest 139:190-3. 2011
    ....
  19. doi request reprint Revisiting the Dutch hypothesis
    Dirkje S Postma
    University of Groningen, Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands University of Groningen, GRIAC Research Institute, University Medical Center Groningen, Groningen, The Netherlands Electronic address
    J Allergy Clin Immunol 136:521-9. 2015
    ..This detailed phenotyping can help in understanding these obstructive airway diseases and provide guidance for disease management. ..
  20. doi request reprint Glucocorticoids induce the production of the chemoattractant CCL20 in airway epithelium
    G Jan Zijlstra
    University of Groningen, University Medical Center Groningen, Dept of Pathology and Medical Biology, Experimental Pulmonology and Inflammation Research, Groningen University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen University of Groningen, University Medical Center Groningen, Dept of Pulmonology, Groningen
    Eur Respir J 44:361-70. 2014
    ..We show that glucocorticoids enhance CCL20 production by bronchial epithelium, which may constitute a novel mechanism in Th17-mediated glucocorticoid-insensitive inflammation in asthma. ..
  21. pmc Susceptibility to COPD: differential proteomic profiling after acute smoking
    Lorenza Franciosi
    University of Groningen, Department of Pharmacy, Analytical Biochemistry, Groningen, The Netherlands
    PLoS ONE 9:e102037. 2014
    ..Our data suggest that SerpinB3 and Uteroglobin could be interesting proteins in understanding the processes leading to COPD. ..
  22. pmc Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice
    Loes E M Kistemaker
    Department of Molecular Pharmacology, University of Groningen, The Netherlands GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 308:L96-103. 2015
    ..This effect is probably not mediated via KC release, but may involve altered adhesion and transmigration of neutrophils via fibrinogen-α and CD177...
  23. pmc Lower corticosteroid skin blanching response is associated with severe COPD
    Susan J M Hoonhorst
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands
    PLoS ONE 9:e91788. 2014
    ..The underlying mechanisms are yet unclear. This study aimed to assess whether skin corticosteroid insensitivity is associated with COPD and COPD severity using the corticosteroid skin blanching test...
  24. doi request reprint A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD
    Corry Anke Brandsma
    Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands
    Thorax 70:21-32. 2015
    ..Unbiased analysis of genome-wide gene expression profiles in lung tissue provides a powerful tool to investigate this...
  25. doi request reprint Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease
    Irene H Heijink
    Department of Pathology and Medical Biology, Lab of Allergology and Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Thorax 68:709-16. 2013
    ..We investigated whether lung epithelial expression of WNT ligands, receptors (frizzled; FZD) or target genes is dysregulated on cigarette smoking and/or in chronic obstructive pulmonary disease (COPD)...
  26. doi request reprint Quantification of free and total desmosine and isodesmosine in human urine by liquid chromatography tandem mass spectrometry: a comparison of the surrogate-analyte and the surrogate-matrix approach for quantitation
    Sara Ongay
    University of Groningen, Department of Pharmacy, Analytical Biochemistry, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Chromatogr A 1326:13-9. 2014
    ..Results indicate that the presented methods have the necessary quality and level of validation to assess the potential of urinary DES and IDS levels as biomarkers for the progression of COPD and the effect of therapeutic interventions. ..
  27. ncbi request reprint Role of adenosine receptors in the treatment of asthma and chronic obstructive pulmonary disease: recent developments
    Maarten van den Berge
    Department of Pulmonology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Drugs R D 8:13-23. 2007
    ..A therapeutic potential for adenosine receptor modulation has even been anticipated. This review focuses on the role of adenosine and adenosine receptors in the treatment of asthma and COPD...
  28. pmc Chronic Obstructive Pulmonary Disease Is Not Associated with KRAS Mutations in Non-Small Cell Lung Cancer
    Ali Saber
    Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 11:e0152317. 2016
    ..8%). In conclusion, KRAS mutations are more common in females and smokers, but are not associated with COPD-status in NSCLC patients. EGFR mutations are more common in non-smoking NSCLC patients. ..
  29. pmc Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis
    Joanna Smolonska
    Dept of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Dept of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands GRIAC Research Institute, Groningen University Medical Center, University of Groningen, Groningen, The Netherlands
    Eur Respir J 44:860-72. 2014
    ..g. lifestyle and occupation in different countries and continents, which may have obscured the genetic common contribution. ..
  30. doi request reprint Risk factors and early origins of chronic obstructive pulmonary disease
    Dirkje S Postma
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Electronic address
    Lancet 385:899-909. 2015
    ..In this Review, we will discuss the evidence for risk factors for the various phenotypes of chronic obstructive pulmonary disease during different stages of life...