Jeroen Rouwkema

Summary

Affiliation: University of Twente
Country: The Netherlands

Publications

  1. doi request reprint Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks
    Jeroen Rouwkema
    Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA, 02115, USA Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02319, USA Department of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands Electronic address
    Trends Biotechnol 34:733-45. 2016
  2. doi request reprint A medium throughput device to study the effects of combinations of surface strains and fluid-flow shear stresses on cells
    R Sinha
    Department of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Lab Chip 15:429-39. 2015
  3. doi request reprint Vascularization in tissue engineering
    Jeroen Rouwkema
    Department of Tissue Regeneration, University of Twente, Drienerlolaan 5, 7522NB Enschede, The Netherlands
    Trends Biotechnol 26:434-41. 2008
  4. doi request reprint The use of endothelial progenitor cells for prevascularized bone tissue engineering
    Jeroen Rouwkema
    Departments of Biomechanical Engineering, Twente University, Enschede, The Netherlands
    Tissue Eng Part A 15:2015-27. 2009
  5. pmc Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation
    Nicolas C Rivron
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, 7500AE, University of Twente, Enschede, The Netherlands
    Proc Natl Acad Sci U S A 109:4413-8. 2012
  6. pmc Tissue deformation spatially modulates VEGF signaling and angiogenesis
    Nicolas C Rivron
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, 7500 AE Enschede, The Netherlands
    Proc Natl Acad Sci U S A 109:6886-91. 2012
  7. doi request reprint Tissue assembly and organization: developmental mechanisms in microfabricated tissues
    Nicolas C Rivron
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, Zuidhorst, P O Box 217, Enschede 7500 AE, The Netherlands
    Biomaterials 30:4851-8. 2009
  8. doi request reprint Spheroid culture as a tool for creating 3D complex tissues
    Eelco Fennema
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Trends Biotechnol 31:108-15. 2013
  9. pmc Endothelial cell alignment as a result of anisotropic strain and flow induced shear stress combinations
    Ravi Sinha
    Department of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Sci Rep 6:29510. 2016
  10. pmc In vitro platforms for tissue engineering: implications for basic research and clinical translation
    Jeroen Rouwkema
    Department of Biomechanical Engineering, University of Twente, Enschede, The Netherlands
    J Tissue Eng Regen Med 5:e164-7. 2011

Collaborators

Detail Information

Publications16

  1. doi request reprint Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks
    Jeroen Rouwkema
    Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA, 02115, USA Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02319, USA Department of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands Electronic address
    Trends Biotechnol 34:733-45. 2016
    ..This review will give an overview of recent efforts, and will propose future perspectives to engineer the optimal, functional vascular network. ..
  2. doi request reprint A medium throughput device to study the effects of combinations of surface strains and fluid-flow shear stresses on cells
    R Sinha
    Department of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Lab Chip 15:429-39. 2015
    ..Uniform equibiaxial strains up to 20% and shear stresses up to 0.3 Pa can be generated. Compatibility of the device with cell culture and end point fixation, staining and imaging is shown using C2C12 mouse myoblast cells. ..
  3. doi request reprint Vascularization in tissue engineering
    Jeroen Rouwkema
    Department of Tissue Regeneration, University of Twente, Drienerlolaan 5, 7522NB Enschede, The Netherlands
    Trends Biotechnol 26:434-41. 2008
    ..We will illustrate that combining the efforts of different research lines might be necessary to obtain optimal results in the field...
  4. doi request reprint The use of endothelial progenitor cells for prevascularized bone tissue engineering
    Jeroen Rouwkema
    Departments of Biomechanical Engineering, Twente University, Enschede, The Netherlands
    Tissue Eng Part A 15:2015-27. 2009
    ..The degree of organization, however, was higher. We conclude that EPC can be used for complex tissue engineering applications, but the differentiation stage of these cells is important...
  5. pmc Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation
    Nicolas C Rivron
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, 7500AE, University of Twente, Enschede, The Netherlands
    Proc Natl Acad Sci U S A 109:4413-8. 2012
    ..These findings open the door for new strategies to treat large bone defects by closely mimicking natural endochondral bone repair...
  6. pmc Tissue deformation spatially modulates VEGF signaling and angiogenesis
    Nicolas C Rivron
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, 7500 AE Enschede, The Netherlands
    Proc Natl Acad Sci U S A 109:6886-91. 2012
    ..We suggest that tissue contractility and deformation can induce the formation of gradients of angiogenic microenvironments which could contribute to the long-range patterning of the vascular system...
  7. doi request reprint Tissue assembly and organization: developmental mechanisms in microfabricated tissues
    Nicolas C Rivron
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, Zuidhorst, P O Box 217, Enschede 7500 AE, The Netherlands
    Biomaterials 30:4851-8. 2009
    ....
  8. doi request reprint Spheroid culture as a tool for creating 3D complex tissues
    Eelco Fennema
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Trends Biotechnol 31:108-15. 2013
    ..Here, we review new possibilities that combine the strengths of spheroid culture with new microenvironment fabrication methods that allow for the creation of large numbers of highly reproducible, complex tissues...
  9. pmc Endothelial cell alignment as a result of anisotropic strain and flow induced shear stress combinations
    Ravi Sinha
    Department of Biomechanical Engineering, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands
    Sci Rep 6:29510. 2016
    ..Studying EC response to such combined physiological mechanical stimuli was not possible with existing platforms and to our best knowledge, has not been reported before. ..
  10. pmc In vitro platforms for tissue engineering: implications for basic research and clinical translation
    Jeroen Rouwkema
    Department of Biomechanical Engineering, University of Twente, Enschede, The Netherlands
    J Tissue Eng Regen Med 5:e164-7. 2011
    ..Here we summarize the current status and future development of in vitro tissue models, based on the findings presented at this symposium...
  11. ncbi request reprint Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct
    Jeroen Rouwkema
    Institute for Biomedical Technology, University of Twente, Prof Bronkhorstlaan 10D, Bilthoven 3723MB, The Netherlands
    Tissue Eng 12:2685-93. 2006
    ..This finding is a strong indication that in vitro prevascularization is a promising strategy to improve implant vascularization in bone tissue engineering...
  12. pmc Advancing Tissue Engineering: A Tale of Nano-, Micro-, and Macroscale Integration
    Jeroen Leijten
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
    Small 12:2130-45. 2016
    ..Here we review the role, function and progress of a wide range of nano- and microtechnologies that are driving the advancements in the field of tissue engineering. ..
  13. doi request reprint Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response
    Ajaykumar Vishwakarma
    Department of Medicine, Biomaterials Innovation Research Center, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02115, USA Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02319, USA
    Trends Biotechnol 34:470-82. 2016
    ..Biomaterial-based immunomodulation strategies can significantly ameliorate the outcomes of medical implants and tissue engineering therapies. ..
  14. doi request reprint Biological and Tribological Assessment of Poly(Ethylene Oxide Terephthalate)/Poly(Butylene Terephthalate), Polycaprolactone, and Poly (L\DL) Lactic Acid Plotted Scaffolds for Skeletal Tissue Regeneration
    Wilhelmus J Hendrikson
    Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, 7500, AE, The Netherlands
    Adv Healthc Mater 5:232-43. 2016
    ..Taken together, our studies show that PEOT/PBT scaffolds support better skeletal differentiation of seeded stromal cells and lower friction coefficient compared to PCL and P(L/DL)A scaffolds. ..
  15. ncbi request reprint Supply of nutrients to cells in engineered tissues
    Jeroen Rouwkema
    Department of Biomechanical Engineering, Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    Biotechnol Genet Eng Rev 26:163-78. 2010
    ..Based on these concepts, the main strategies that have been developed to enhance the supply of nutrients to cells in engineered tissues will be discussed...
  16. ncbi request reprint Engineering vascularized skeletal muscle tissue
    Shulamit Levenberg
    Department of Biomedical Engineering, Technion 32000, Haifa, Israel
    Nat Biotechnol 23:879-84. 2005
    ..Prevascularization improved the vascularization, blood perfusion and survival of the muscle tissue constructs after transplantation...