Dirkje S Postma

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. doi request reprint Revisiting the Dutch hypothesis
    Dirkje S Postma
    University of Groningen, Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands University of Groningen, GRIAC Research Institute, University Medical Center Groningen, Groningen, The Netherlands Electronic address
    J Allergy Clin Immunol 136:521-9. 2015
  2. doi request reprint Risk factors and early origins of chronic obstructive pulmonary disease
    Dirkje S Postma
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Electronic address
    Lancet 385:899-909. 2015
  3. pmc Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD
    Akkelies E Dijkstra
    For lists of the authors affiliations, and the LifeLines Cohort Study group members and their affiliations, see the Acknowledgements section
    Eur Respir J 45:60-75. 2015
  4. pmc Early life microbial exposure and fractional exhaled nitric oxide in school-age children: a prospective birth cohort study
    Lidia Casas
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Environ Health 12:103. 2013
  5. pmc Co-morbidities are the key nominators of the health related quality of life in mild and moderate COPD
    Jukka Koskela
    Clinical Research Unit for Pulmonary Diseases and Division of Pulmonology, Helsinki University Central Hospital, Helsinki, Finland
    BMC Pulm Med 14:102. 2014
  6. pmc ITGB5 and AGFG1 variants are associated with severity of airway responsiveness
    Blanca E Himes
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 14:86. 2013
  7. doi request reprint Asthma and chronic obstructive pulmonary disease: similarities and differences
    Dirkje S Postma
    University of Groningen, Department of Pulmonology, GRIAC Research Institute, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands Electronic address
    Clin Chest Med 35:143-56. 2014
  8. doi request reprint Factor analysis in predominantly severe COPD: identification of disease heterogeneity by easily measurable characteristics
    Dirkje S Postma
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Medicine and Tuberculosis, GRIAC Research Institute, AA11, Hanzeplein, PO Box 30001, 9700 RB Groningen, The Netherlands Electronic address
    Respir Med 107:1939-47. 2013
  9. pmc Rate of progression of CT-quantified emphysema in male current and ex-smokers: a follow-up study
    Firdaus A A Mohamed Hoesein
    Department of Respiratory Medicine, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    Respir Res 14:55. 2013
  10. pmc Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD
    Simona E Budulac
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Res 11:60. 2010

Detail Information

Publications87

  1. doi request reprint Revisiting the Dutch hypothesis
    Dirkje S Postma
    University of Groningen, Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands University of Groningen, GRIAC Research Institute, University Medical Center Groningen, Groningen, The Netherlands Electronic address
    J Allergy Clin Immunol 136:521-9. 2015
    ..This detailed phenotyping can help in understanding these obstructive airway diseases and provide guidance for disease management. ..
  2. doi request reprint Risk factors and early origins of chronic obstructive pulmonary disease
    Dirkje S Postma
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Electronic address
    Lancet 385:899-909. 2015
    ..In this Review, we will discuss the evidence for risk factors for the various phenotypes of chronic obstructive pulmonary disease during different stages of life...
  3. pmc Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD
    Akkelies E Dijkstra
    For lists of the authors affiliations, and the LifeLines Cohort Study group members and their affiliations, see the Acknowledgements section
    Eur Respir J 45:60-75. 2015
    ..57×10(-6), OR 1.48) and with significantly increased MAML3 expression in lung tissue (p=2.59×10(-12)). Our data suggest the potential for differential genetic backgrounds of CMH in individuals with and without COPD. ..
  4. pmc Early life microbial exposure and fractional exhaled nitric oxide in school-age children: a prospective birth cohort study
    Lidia Casas
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Environ Health 12:103. 2013
    ..In the present work we aimed to evaluate the associations between early life microbial exposures, and fractional exhaled nitric oxide (FeNO) at school age...
  5. pmc Co-morbidities are the key nominators of the health related quality of life in mild and moderate COPD
    Jukka Koskela
    Clinical Research Unit for Pulmonary Diseases and Division of Pulmonology, Helsinki University Central Hospital, Helsinki, Finland
    BMC Pulm Med 14:102. 2014
    ..Co-morbidities are common in chronic obstructive pulmonary disease (COPD). We assessed the contribution of common co-morbidities on health related quality of life (HRQoL) among COPD patients...
  6. pmc ITGB5 and AGFG1 variants are associated with severity of airway responsiveness
    Blanca E Himes
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 14:86. 2013
    ..We sought to determine whether common genetic variants were associated with AHR severity...
  7. doi request reprint Asthma and chronic obstructive pulmonary disease: similarities and differences
    Dirkje S Postma
    University of Groningen, Department of Pulmonology, GRIAC Research Institute, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands Electronic address
    Clin Chest Med 35:143-56. 2014
    ....
  8. doi request reprint Factor analysis in predominantly severe COPD: identification of disease heterogeneity by easily measurable characteristics
    Dirkje S Postma
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Medicine and Tuberculosis, GRIAC Research Institute, AA11, Hanzeplein, PO Box 30001, 9700 RB Groningen, The Netherlands Electronic address
    Respir Med 107:1939-47. 2013
    ..A post-hoc analysis of five randomised studies in patients with a history of previous exacerbations examined the clinical and demographic characteristics describing moderate-to-very-severe COPD...
  9. pmc Rate of progression of CT-quantified emphysema in male current and ex-smokers: a follow-up study
    Firdaus A A Mohamed Hoesein
    Department of Respiratory Medicine, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    Respir Res 14:55. 2013
    ..The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and FEV1-decline in male heavy smokers...
  10. pmc Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD
    Simona E Budulac
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Res 11:60. 2010
    ..The aim of our study was to assess the associations of MRP1 SNPs with FEV1 level, MRP1 protein levels and inflammatory markers in bronchial biopsies and sputum of COPD patients...
  11. doi request reprint Anti-inflammatory effects of combined budesonide/formoterol in COPD exacerbations
    Erik Bathoorn
    Groningen Research Institute for Asthma and COPD, Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    COPD 5:282-90. 2008
    ..50). In conclusion, budesonide/formoterol reduces sputum eosinophils and improves symptoms in the treatment of out-patient COPD exacerbations...
  12. doi request reprint Airway epithelial changes in smokers but not in ex-smokers with asthma
    Martine Broekema
    Dept of Pathology, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Am J Respir Crit Care Med 180:1170-8. 2009
    ..This results in accelerated lung function decline. The underlying pathological process of smoke-induced deterioration of asthma is unknown...
  13. pmc Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
    Eef D Telenga
    Department of Pulmonary Diseases, University Medical Center Groningen, Groningen, Netherlands
    BMC Pulm Med 13:58. 2013
    ..We investigated differences in blood and sputum inflammatory profiles between ex-, current-, and never-smokers and assessed their ICS treatment response after 2-week and 1-year treatment...
  14. pmc Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells?
    Corry Anke Brandsma
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, P, O, Box 30, 001, 9700 RB, Groningen, The Netherlands
    Respir Res 9:17. 2008
    ..The effects of HO-1 modulation on cigarette smoke induced inflammation and emphysema were tested in a smoking mouse model...
  15. doi request reprint Gene-gene interaction in regulatory T-cell function in atopy and asthma development in childhood
    Renske W B Bottema
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 126:338-46, 346.e1-10. 2010
    ..Therefore, we hypothesized that single nucleotide polymorphisms in genes involved in the development and function of regulatory T cells are associated with atopy and asthma development...
  16. doi request reprint Inhaled corticosteroids in chronic obstructive pulmonary disease: a review
    Eef D Telenga
    University Medical Center Groningen, University of Groningen, Department of Pulmonology PO Box 30 001, 9700 RB Groningen, The Netherlands
    Expert Opin Pharmacother 11:405-21. 2010
    ..Although widely used, the efficacy of inhaled corticosteroids (ICS) in the treatment of COPD remains a matter of debate...
  17. pmc Can AMP induce sputum eosinophils, even in subjects with complete asthma remission?
    Franke Volbeda
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, The Netherlands
    Respir Res 11:106. 2010
    ....
  18. ncbi request reprint Nitrogen dioxide exposure attenuates cigarette smoke-induced cytokine production in mice
    Corry Anke Brandsma
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Inhal Toxicol 20:183-9. 2008
    ..The next step is to translate these findings of combined, controlled exposure in animals to the human situation...
  19. doi request reprint Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation
    Henk Koning
    Beatrix Children s Hospital, University Medical Center Groningen, Groningen, The Netherlands
    FASEB J 26:439-48. 2012
    ..In summary, PCDH1 transcripts display remarkable variability in expression of conserved intracellular signaling domains. Enhanced PCDH1 expression levels strongly correlate with differentiation of bronchial epithelial cells...
  20. pmc Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation
    Erik Bathoorn
    Department of Pulmonology, Groningen Research Institute for Asthma and COPD GRIAC, University Medical Center Groningen, University of Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 4:101-9. 2009
    ..Better identification of these changes will increase our knowledge and potentially guide therapy, for instance by helping with quicker distinction of bacterially induced exacerbations from other causes...
  21. doi request reprint Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes
    Marjan Kerkhof
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands GRIAC Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Electronic address
    J Allergy Clin Immunol 133:68-76.e1-4. 2014
    ..Little is known about whether subjects genetically predisposed to COPD show their first symptoms or reduced lung function in childhood...
  22. doi request reprint Skin-blanching is associated with FEV(1), allergy, age and gender in asthma families
    Eef D Telenga
    Department of Pulmonology, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Med 106:1376-82. 2012
    ..Finally, we assessed which clinical and inflammatory parameters influence the variability in skin-blanching response...
  23. doi request reprint Protocadherin-1 polymorphisms are associated with eczema in two Dutch birth cohorts
    Henk Koning
    Pediatric Pulmonology and Pediatric Allergology, Beatrix Children s Hospital, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Pediatr Allergy Immunol 23:270-7. 2012
    ..We determined whether PCDH1 polymorphisms, previously associated with asthma or BHR, also associated with questionnaire and UK Working Party (UKWP) defined eczema...
  24. doi request reprint Sputum inflammation predicts exacerbations after cessation of inhaled corticosteroids in COPD
    Jeroen J W Liesker
    Department of Respiratory Diseases and Tuberculosis, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Respir Med 105:1853-60. 2011
    ..Unfortunately, physicians do not know in which patients they can stop ICS treatment safely...
  25. ncbi request reprint Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma
    Irene H Heijink
    Department of Allergology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Int Arch Allergy Immunol 145:111-21. 2008
    ....
  26. pmc Low-dose CT measurements of airway dimensions and emphysema associated with airflow limitation in heavy smokers: a cross sectional study
    Akkelies E Dijkstra
    University of Groningen, Department of Pulmonary Diseases, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands
    Respir Res 14:11. 2013
    ..Advances in computed tomography (CT) post-processing imaging allow to quantify these features. The aim of this Dutch population study is to assess the relationships between AWT, lung function, emphysema and respiratory symptoms...
  27. pmc Induction of autoantibodies against lung matrix proteins and smoke-induced inflammation in mice
    Corry Anke Brandsma
    Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    BMC Pulm Med 10:64. 2010
    ..Whether the presence of these autoantibodies contributes to the pathogenesis of COPD is unclear...
  28. pmc Increased levels of (class switched) memory B cells in peripheral blood of current smokers
    Corry Anke Brandsma
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands
    Respir Res 10:108. 2009
    ..Future studies focusing on the presence of these (class switched) memory B cells in the lung, their antigen specificity and their interaction with Tregs are necessary to further elucidate the specific B-cell response in COPD...
  29. pmc Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity
    Maarten van den Berge
    Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Thorax 69:14-23. 2014
    ....
  30. pmc Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease
    Simona E Budulac
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 7:e43124. 2012
    ....
  31. doi request reprint Multidrug resistance-associated protein 1 and lung function decline with or without long-term corticosteroids treatment in COPD
    Simona E Budulac
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
    Eur J Pharmacol 696:136-42. 2012
    ..None of the variants was associated with FEV(1) decline. Our unique study suggests a role of MRP1 protein expression in bronchial biopsies in FEV(1) decline occurring selectively in COPD patients with long-term (30-month) ICS therapy...
  32. doi request reprint Persisting remodeling and less airway wall eosinophil activation in complete remission of asthma
    Martine Broekema
    Department of Pulmonology, University Medical Center Groningen, RB Groningen, The Netherlands
    Am J Respir Crit Care Med 183:310-6. 2011
    ..It is uncertain whether this associates with remission of all inflammatory and remodeling asthma features...
  33. pmc Association of mast cells with lung function in chronic obstructive pulmonary disease
    Margot M E Gosman
    Department of Pulmonology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Respir Res 9:64. 2008
    ..We compared MC-T and MC-C distributions in COPD and controls without airflow limitation, and determined their relation with lung function...
  34. doi request reprint Risk factors for chronic mucus hypersecretion in individuals with and without COPD: influence of smoking and job exposure on CMH
    Akkelies E Dijkstra
    Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Occup Environ Med 71:346-52. 2014
    ..Several risk factors contribute to CMH and to COPD. It is, however, unknown if risk factors for CMH are similar in persons with and without COPD...
  35. ncbi request reprint Down-regulation of E-cadherin in human bronchial epithelial cells leads to epidermal growth factor receptor-dependent Th2 cell-promoting activity
    Irene H Heijink
    Department of Allergology, University Medical Center, University of Groningen, Groningen, The Netherlands
    J Immunol 178:7678-85. 2007
    ..Thus, disruption of intercellular epithelial contacts may specifically promote Th2 cell recruitment in allergic asthma...
  36. doi request reprint Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD
    Maarten van den Berge
    Dept of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Eur Respir J 40:1098-105. 2012
    ..Our findings indicate that BHR is an independent trait in COPD and provides important information on phenotype heterogeneity and disease activity...
  37. doi request reprint Gender differences in asthma development and remission during transition through puberty: the TRacking Adolescents' Individual Lives Survey (TRAILS) study
    Nienke M Vink
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 126:498-504.e1-6. 2010
    ..During puberty, a gender shift in asthma prevalence occurs, with a preponderance of boys before puberty. The mechanisms underlying this gender shift are unclear...
  38. doi request reprint House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epithelium
    Irene H Heijink
    Department of Allergology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Am J Respir Cell Mol Biol 42:69-79. 2010
    ..We propose that TGF-beta secretion and dysregulated EGFR signaling may increase epithelial vulnerability to allergens and trigger the induction of EMT, a hitherto unrecognized contributor to airway remodeling in asthma...
  39. pmc Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD
    Simona E Budulac
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e33386. 2012
    ....
  40. ncbi request reprint Cigarette smoke extract affects functional activity of MRP1 in bronchial epithelial cells
    Margaretha van der Deen
    Department of Medical Oncology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
    J Biochem Mol Toxicol 21:243-51. 2007
    ..Inhibition of MRP1 in turn results in higher CSE toxicity. We propose that MRP1 may be a protective protein for COPD development...
  41. doi request reprint Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA
    Olga E Savenije
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 127:1505-12.e14. 2011
    ..It is unclear whether these phenotypes can be replicated in other birth cohorts...
  42. pmc A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology
    Margot M E Gosman
    Department of Pulmonology, University Medical Centre Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Thorax 62:242-7. 2007
    ..Single-nucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) gene have been associated with AHR and COPD...
  43. doi request reprint Interleukin 13 and interleukin 4 receptor-α polymorphisms in rhinitis and asthma
    Renske W B Bottema
    Department of Pulmonology, University Medical Center, University of Groningen, Groningen, The Netherlands
    Int Arch Allergy Immunol 153:259-67. 2010
    ..IL13 and IL4R polymorphisms are associated with asthma and show gene-gene interaction in asthma. Their role in rhinitis has not been extensively studied...
  44. pmc Acute effects of cigarette smoking on inflammation in healthy intermittent smokers
    Hester van der Vaart
    Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands
    Respir Res 6:22. 2005
    ..Knowledge on the response to the initial smoke exposures might enhance the understanding of changes due to chronic smoking, since repetitive acute smoke effects may cumulate and lead to irreversible lung damage...
  45. doi request reprint Smoking and nonsmoking asthma: differences in clinical outcome and pathogenesis
    Fatemeh Fattahi
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Expert Rev Respir Med 5:93-105. 2011
    ..Possible pathogenetic mechanisms that may explain the links between cigarette smoking and changes in the clinical expression of asthma will be discussed, as well as the beneficial effects of smoking cessation...
  46. pmc Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD
    Irene H Heijink
    Laboratory of Allergology and Pulmonary Diseases, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, The Netherlands
    Respir Res 12:110. 2011
    ....
  47. doi request reprint A chronic obstructive pulmonary disease related signature in squamous cell lung cancer
    Mirjam C Boelens
    Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Lung Cancer 72:177-83. 2011
    ....
  48. pmc Prediction and course of symptoms and lung function around an exacerbation in chronic obstructive pulmonary disease
    Maarten van den Berge
    Department of Respiratory Medicine, University Medical Center Groningen, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands
    Respir Res 13:44. 2012
    ..We investigated the course of exacerbations in the published COSMIC study that investigated the effects of 1-year withdrawal of fluticasone after a 3-month run-in treatment period with salmeterol/fluticasone in patients with COPD...
  49. doi request reprint Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease
    Irene H Heijink
    Department of Pathology and Medical Biology, Lab of Allergology and Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Thorax 68:709-16. 2013
    ..We investigated whether lung epithelial expression of WNT ligands, receptors (frizzled; FZD) or target genes is dysregulated on cigarette smoking and/or in chronic obstructive pulmonary disease (COPD)...
  50. doi request reprint Predicting who will have asthma at school age among preschool children
    Olga E M Savenije
    Department of Epidemiology, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 130:325-31. 2012
    ..In the future, biomarkers and genomic risk profiles to develop personalized medicine might further improve asthma prediction, treatment, and prevention...
  51. doi request reprint Small airway disease in asthma and COPD: clinical implications
    Maarten van den Berge
    Department of Pulmonary, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Chest 139:412-23. 2011
    ..The first studies in COPD are promising, and results from new studies are eagerly awaited...
  52. doi request reprint A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis
    Anita I R Spanjer
    Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands Groningen Research Institute for Asthma and COPD GRIAC, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Thorax 71:312-22. 2016
    ..Here, we investigated if the Frizzled-8 receptor has a functional role in airway inflammation associated with chronic bronchitis...
  53. pmc Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD
    Susan J M Hoonhorst
    Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Respir Res 15:121. 2014
    ..This study aimed to investigate if acute systemic and local immune responses to cigarette smoke differentiate between individuals susceptible or non-susceptible to develop COPD, both at young (18-40 years) and old (40-75 years) age...
  54. doi request reprint Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels
    Kim de Jong
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Groningen Research Institute for Asthma and COPD GRIAC, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 136:1664-72.e1-14. 2015
    ....
  55. doi request reprint Effects of IL-4 and IL-13 on adenosine receptor expression and responsiveness of the human mast cell line 1
    Mieke Versluis
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int Immunopharmacol 8:866-73. 2008
    ..Bronchoconstriction upon AMP inhalation is thought to occur by histamine release and subsequent binding to receptors on airway smooth muscle cells...
  56. pmc Reticular basement membrane in asthma and COPD: similar thickness, yet different composition
    Jeroen J W Liesker
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 4:127-35. 2009
    ..Reticular basement membrane (RBM) thickening has been variably associated with asthma and chronic obstructive pulmonary disease (COPD). Even if RBM thickness is similar in both diseases, its composition might still differ...
  57. pmc Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD
    Andre Zandvoort
    Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Res 9:83. 2008
    ..We address the following hypothesis: fibroblasts have abnormal expression of genes in the Smad pathway in COPD, resulting in abnormal proteoglycan modulation, the ground substance of ECM...
  58. pmc GST-omega genes interact with environmental tobacco smoke on adult level of lung function
    Kim de Jong
    University of Groningen, University Medical Center Groningen UMCG, Department of Epidemiology, Groningen, The Netherlands
    Respir Res 14:83. 2013
    ..This study aimed to assess if GSTO SNPs interact with ETS exposure in utero and during adulthood on the level of lung function during adulthood...
  59. ncbi request reprint First study of infliximab treatment in patients with chronic obstructive pulmonary disease
    Hester van der Vaart
    Department of Pulmonology, University Medical Center Groningen, P O Box 30 001, NL 9700 RB, Groningen, The Netherlands
    Am J Respir Crit Care Med 172:465-9. 2005
    ..Tumor necrosis factor-alpha is believed to be important in the induction and maintenance of airway inflammation in chronic obstructive pulmonary disease...
  60. ncbi request reprint Different modulation of decorin production by lung fibroblasts from patients with mild and severe emphysema
    Jacobien A Noordhoek
    Department of Pulmonology, University Medical Center Groningen, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    COPD 2:17-25. 2005
    ..This dysregulation of decorin production may contribute to the impaired lung tissue repair, present in patients with emphysema, since these alterations in the extracellular matrix may cause diminished cytokine binding and neutralization...
  61. pmc Inhaled corticosteroids and long-acting beta-agonists in adult asthma: a winning combination in all?
    Dirkje S Postma
    Department of Pulmonology, University Medical Center, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 378:203-15. 2008
    ..Clinical effectiveness in the real world now has to be established, since this approach likely improves compliance with regular maintenance therapy...
  62. pmc Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease
    Hoeke A Baarsma
    Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e25450. 2011
    ..We determined WNT-pathway gene expression in pulmonary fibroblasts of individuals with and without COPD and disentangled the role of β-catenin in fibroblast phenotype and function...
  63. doi request reprint Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood
    Olga E M Savenije
    Departments of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 127:750-6.e1-5. 2011
    ..Single nucleotide polymorphisms (SNPs) in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies...
  64. doi request reprint Advanced glycation end products in the skin are enhanced in COPD
    Susan J M Hoonhorst
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands
    Metabolism 63:1149-56. 2014
    ..In this study we assessed whether AGE accumulation in the skin is elevated in COPD and associates with disease severity...
  65. doi request reprint Localization and quantification of regional and segmental air trapping in asthma
    Judith Cohen
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, The Netherlands
    J Comput Assist Tomogr 32:562-9. 2008
    ..To assess the feasibility of volumetric and densitometric software to localize and quantify signs of regional air trapping after methacholine bronchoprovocations in asthma...
  66. ncbi request reprint Rationale for the Dutch hypothesis. Allergy and airway hyperresponsiveness as genetic factors and their interaction with environment in the development of asthma and COPD
    Dirkje S Postma
    Department of Pulmonology, University Hospital, University of Groningen, Postbus 30001, Hanseplein 1, 9700 RB Groningen, The Netherlands
    Chest 126:96S-104S; discussion 159S-161S. 2004
    ..Such studies must include subjects who have airway obstruction that does not necessarily meet the current strict definitions of asthma or COPD (ie, the extremes of these conditions) that are used in clinical studies...
  67. doi request reprint Beneficial effects of treatment with anti-IgE antibodies (Omalizumab) in a patient with severe asthma and negative skin-prick test results
    Maarten van den Berge
    Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands
    Chest 139:190-3. 2011
    ....
  68. pmc Development, validity and responsiveness of the Clinical COPD Questionnaire
    Thys van der Molen
    Department of General Practice, University of Groningen, Groningen, The Netherlands
    Health Qual Life Outcomes 1:13. 2003
    ..So far no validated questionnaires are available to measure symptom and functional state in daily clinical practice. The aim of this study was to develop and validate the Clinical COPD Questionnaire (CCQ)...
  69. doi request reprint Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood
    Olga E Savenije
    University of Groningen, University Medical Center Groningen, Department of Epidemiology, GRIAC Research Institute, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, Department of Pediatrics, Beatrix Children s Hospital, GRIAC Research Institute, Groningen, The Netherlands
    J Allergy Clin Immunol 134:170-7. 2014
    ..Genome-wide association studies identified IL33 and IL-1 receptor-like 1 (IL1RL1)/IL18R1 as asthma susceptibility loci. IL33 and IL1RL1 constitute a single ligand-receptor pathway...
  70. doi request reprint Difference between patient-reported side effects of ciclesonide versus fluticasone propionate
    Thys van der Molen
    Department of General Practice, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Respir Med 104:1825-33. 2010
    ..Further to asthma control and quality of life, self-reported side effects of treatment can be assessed with the validated Inhaled Corticosteroid Questionnaire (ICQ)...
  71. pmc Decorin and TGF-beta1 polymorphisms and development of COPD in a general population
    Cleo C van Diemen
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Res 7:89. 2006
    ..Interestingly, they act as each other's feedback regulator. We investigated whether single nucleotide polymorphisms (SNPs) in decorin and TGF-beta1 underlie accelerated decline in FEV1 and development of COPD in the general population...
  72. pmc Glycogen synthase kinase-3 (GSK-3) regulates TGF-β₁-induced differentiation of pulmonary fibroblasts
    Hoeke A Baarsma
    Department of Molecular Pharmacology, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands
    Br J Pharmacol 169:590-603. 2013
    ..Glycogen synthase kinase-3 (GSK-3) regulates various intracellular signalling pathways; its role in TGF-β₁-induced myofibroblast differentiation is currently largely unknown...
  73. doi request reprint Comparison of the effect of low-dose ciclesonide and fixed-dose fluticasone propionate and salmeterol combination on long-term asthma control
    Dirkje S Postma
    Department of Pulmonary Diseases, University Medical Center Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Chest 139:311-8. 2011
    ..We compared benefits of first-line treatment with ciclesonide and a combination of fluticasone and salmeterol in patients with mild asthma...
  74. pmc ADAM33 gene polymorphisms and mortality. A prospective cohort study
    Sylwia M Figarska
    University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands
    PLoS ONE 8:e67768. 2013
    ..8 (0.9 to 16.3), ever smokers 3.6 (1.8 to 7.2). This study shows for the first time that ADAM33 is a pleiotropic gene that is associated with all-cause, COPD and cardiovascular mortality, independent of potential confounders. ..
  75. doi request reprint Basal or stress-induced cortisol and asthma development: the TRAILS study
    Nienke M Vink
    University of Groningen, University Medical Center Groningen, Groninger Research Institute for Asthma and COPD, Groningen, The Netherlands
    Eur Respir J 41:846-52. 2013
    ..We found no evidence supporting a role for cortisol in asthma and asthma development...
  76. doi request reprint Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma: a systematic review
    Erica van der Wiel
    Department of Pulmonary Medicine and Tuberculosis and the GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 131:646-57. 2013
    ..It is important to develop simpler and more reliable tools (eg, questionnaires or bronchial provocation tests with small-particle stimuli) to assess the presence and extent of small-airways dysfunction in daily clinical practice...
  77. pmc Steroid resistance in COPD? Overlap and differential anti-inflammatory effects in smokers and ex-smokers
    Susan J M Hoonhorst
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands
    PLoS ONE 9:e87443. 2014
    ..The literature suggests that cigarette smoking causes ICS insensitivity. The aim of this study is to compare anti-inflammatory effects of ICS in persistent smokers and persistent ex-smokers in a post-hoc analysis of the GLUCOLD study...
  78. pmc Atopy is a risk factor for respiratory symptoms in COPD patients: results from the EUROSCOP study
    Fatemeh Fattahi
    Department of Pulmonology, University of Groningen, University Medical Center Groningen, PO Box 196 9700 AD, Groningen, The Netherlands
    Respir Res 14:10. 2013
    ..So far effects of atopy on the long-term course of COPD have not been elucidated...
  79. pmc Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis
    Joanna Smolonska
    Dept of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Dept of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands GRIAC Research Institute, Groningen University Medical Center, University of Groningen, Groningen, The Netherlands
    Eur Respir J 44:860-72. 2014
    ..g. lifestyle and occupation in different countries and continents, which may have obscured the genetic common contribution. ..
  80. doi request reprint Expression of ADAMs ("a disintegrin and metalloprotease") in the human lung
    Antoon Dijkstra
    Department of Pulmonology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Virchows Arch 454:441-9. 2009
    ..As most ADAMs are involved in release of (pro-) inflammatory mediators and growth factors, they may play an important role in the first line of defense and in initiation of repair events in the airways...
  81. pmc Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness
    Gerard H Koppelman
    Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    Am J Respir Crit Care Med 180:929-35. 2009
    ..Bronchial hyperresponsiveness (BHR) is a hallmark of asthma and results from increased sensitivity of the airways to physical or chemical stimulants. BHR and asthma are linked to chromosome 5q31-q33...
  82. doi request reprint E-cadherin: gatekeeper of airway mucosa and allergic sensitization
    Martijn C Nawijn
    Department of Pathology and Medical Biology, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Trends Immunol 32:248-55. 2011
    ..Here, we discuss this novel role for E-cadherin in mediating the crucial immunological decision between maintenance of tolerance versus induction of innate and adaptive immunity...
  83. doi request reprint Parental eczema increases the risk of double-blind, placebo-controlled reactions to milk but not to egg, peanut or hazelnut
    Marten E van den Berg
    Faculty of Medical Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int Arch Allergy Immunol 158:77-83. 2012
    ..While genetic factors are known to be important in the development of sensitization to foods, it is not known whether they also play a role in clinical allergic reactivity to foods...
  84. pmc Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population
    Mateusz Siedlinski
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Res 10:73. 2009
    ..We assessed the impact of Single Nucleotide Polymorphisms (SNPs) in both genes on the level and longitudinal course of Forced Expiratory Volume in 1 second (FEV1) in the general population...
  85. doi request reprint Asthma and chronic obstructive pulmonary disease: common genes, common environments?
    Dirkje S Postma
    Department of Pulmonology, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands
    Am J Respir Crit Care Med 183:1588-94. 2011
    ..The genetic predisposition to the derailment of certain pathways may further help to define subgroups of asthma and COPD. In the end this may lead to stratification of patients by their genetic make-up and open new therapeutic prospects...
  86. pmc Lower corticosteroid skin blanching response is associated with severe COPD
    Susan J M Hoonhorst
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands
    PLoS ONE 9:e91788. 2014
    ..The underlying mechanisms are yet unclear. This study aimed to assess whether skin corticosteroid insensitivity is associated with COPD and COPD severity using the corticosteroid skin blanching test...
  87. pmc Susceptibility to chronic mucus hypersecretion, a genome wide association study
    Akkelies E Dijkstra
    University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands
    PLoS ONE 9:e91621. 2014
    ..A plausible explanation for this phenomenon is a predisposing genetic constitution. Therefore, we performed a genome wide association (GWA) study of CMH in Caucasian populations...