G J Offerhaus

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc A novel pathogenic MLH1 missense mutation, c.112A > C, p.Asn38His, in six families with Lynch syndrome
    Els Van Riel
    Department of Medical Genetics, University Medical Centre Utrecht, Lundlaan 6, Utrecht, The Netherlands
    Hered Cancer Clin Pract 8:7. 2010
  2. pmc Neoadjuvant chemoradiation followed by surgery versus surgery alone for patients with adenocarcinoma or squamous cell carcinoma of the esophagus (CROSS)
    M van Heijl
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    BMC Surg 8:21. 2008
  3. ncbi request reprint Grading gastrointestinal dysplasia and what to call it when you don't know what it is
    G J Offerhaus
    Department of Pathology, University Medical Center Utrecht, PB 85500, 3508 GA, Utrecht, The Netherlands
    J Pathol 212:121-3. 2007
  4. ncbi request reprint No evidence for functional inactivation of wild-type p53 protein by MDM2 overexpression in gastric carcinogenesis
    P Blok
    Department of Pathology, Westeinde Ziekenhuis, The Hague, The Netherlands
    J Pathol 186:36-40. 1998
  5. ncbi request reprint K-ras mutations in gastric stump carcinomas and in carcinomas from the non-operated stomach
    B P van Rees
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Hepatogastroenterology 46:2063-8. 1999
  6. ncbi request reprint Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis
    J J Keller
    Department of Pathology, Academic Medical Center, 1100 DD Amsterdam, The Netherlands
    Clin Cancer Res 7:4000-7. 2001
  7. ncbi request reprint Small cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases
    A Maitra
    Departments of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Surg Pathol 25:595-601. 2001
  8. ncbi request reprint [Cystadenomas with ovarian stroma in liver and pancreas: indications of embryonic migration of the gonadal epithelium]
    M Poelma
    Academisch Medisch Centrum Universiteit van Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 148:320-5. 2004
  9. ncbi request reprint Narrow-band imaging compared with conventional colonoscopy for the detection of dysplasia in patients with longstanding ulcerative colitis
    E Dekker
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Endoscopy 39:216-21. 2007

Collaborators

  • J J Keller
  • R H Hruban
  • Els Van Riel
  • M van Heijl
  • E Dekker
  • M Poelma
  • P Drillenburg
  • A Maitra
  • Fred H Menko
  • Margreet Gem Ausems
  • Johan Jp Gille
  • Frans Bl Hogervorst
  • Yvonne J Vos
  • Karen Scheidel-Jacobse
  • Eric Fam Hennekam
  • Jeanne van Echtelt
  • Irma Kluijt
  • Rein P Stulp
  • Marielle E van Gijn
  • E W Steyerberg
  • L B Koppert
  • B P L Wijnhoven
  • M I van Berge Henegouwen
  • C C E Koning
  • H van Dekken
  • K Muller
  • J J B van Lanschot
  • A van der Gaast
  • D J Richel
  • H W Tilanus
  • B P van Rees
  • J F Bartelsman
  • O R C Busch
  • P Fockens
  • F J van den Broek
  • S J van Deventer
  • J C Hardwick
  • D W Hommes
  • J B Reitsma
  • M E Craanen
  • P Blok
  • D J Gouma
  • W H Lamers
  • T M van Gulik
  • J Albores-Saavedra
  • M Tascilar
  • D Chibowski
  • W Polkowski
  • E Caspers
  • A Musler
  • W Dekker
  • G N Tytgat

Detail Information

Publications9

  1. pmc A novel pathogenic MLH1 missense mutation, c.112A > C, p.Asn38His, in six families with Lynch syndrome
    Els Van Riel
    Department of Medical Genetics, University Medical Centre Utrecht, Lundlaan 6, Utrecht, The Netherlands
    Hered Cancer Clin Pract 8:7. 2010
    ..The pathogenicity of this variant was unknown. We aim to elucidate the pathogenicity of this MLH1 variant in order to counsel these families adequately and to enable predictive testing in healthy at-risk relatives...
  2. pmc Neoadjuvant chemoradiation followed by surgery versus surgery alone for patients with adenocarcinoma or squamous cell carcinoma of the esophagus (CROSS)
    M van Heijl
    Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    BMC Surg 8:21. 2008
    ..The concept that this neoadjuvant chemoradiotherapy regimen improves overall survival has, however, to be proven in a randomized phase III trial...
  3. ncbi request reprint Grading gastrointestinal dysplasia and what to call it when you don't know what it is
    G J Offerhaus
    Department of Pathology, University Medical Center Utrecht, PB 85500, 3508 GA, Utrecht, The Netherlands
    J Pathol 212:121-3. 2007
    ..Research in this field needs to focus on a combination of biomarkers representing genetic instability, clonal mutations, and genetic clonal divergence...
  4. ncbi request reprint No evidence for functional inactivation of wild-type p53 protein by MDM2 overexpression in gastric carcinogenesis
    P Blok
    Department of Pathology, Westeinde Ziekenhuis, The Hague, The Netherlands
    J Pathol 186:36-40. 1998
    ..In conclusion, it appears that functional inactivation of wild-type p53 by MDM2 protein overexpression plays no role in (early) gastric carcinogenesis...
  5. ncbi request reprint K-ras mutations in gastric stump carcinomas and in carcinomas from the non-operated stomach
    B P van Rees
    Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Hepatogastroenterology 46:2063-8. 1999
    ..The aim of this study was to compare the prevalence of K-ras codon 12 point mutations in gastric stump carcinomas with those in conventional carcinomas from the non-operated stomach...
  6. ncbi request reprint Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis
    J J Keller
    Department of Pathology, Academic Medical Center, 1100 DD Amsterdam, The Netherlands
    Clin Cancer Res 7:4000-7. 2001
    ..Therefore, we investigated molecular alterations in adenomas from FAP patients with complete adenoma regression on sulindac (responsive patients) and from FAP patients with sulindac-resistant adenomas (resistant patients)...
  7. ncbi request reprint Small cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases
    A Maitra
    Departments of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Surg Pathol 25:595-601. 2001
    ..In contrast to pulmonary small cell carcinomas, p16INK4a function appears to be abrogated more frequently in these carcinomas...
  8. ncbi request reprint [Cystadenomas with ovarian stroma in liver and pancreas: indications of embryonic migration of the gonadal epithelium]
    M Poelma
    Academisch Medisch Centrum Universiteit van Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 148:320-5. 2004
    ..To provide an embryological explanation for the presence of ovarian stroma in cystadenomas of the liver and pancreas...
  9. ncbi request reprint Narrow-band imaging compared with conventional colonoscopy for the detection of dysplasia in patients with longstanding ulcerative colitis
    E Dekker
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Endoscopy 39:216-21. 2007
    ..The aim of this study was to compare the accuracy of narrow-band imaging (NBI), a new imaging technique, with standard colonoscopy for the detection of neoplasia in patients with longstanding ulcerative colitis...