Cora H Nijboer

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies
    Elke Kooijman
    Division of Internal Medicine, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Neuroinflammation 11:2. 2014
  2. doi request reprint Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage
    Cora H Nijboer
    Laboratory of Neuroimmunology and Developmental Origins of Disease NIDOD, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurobiol Dis 54:432-44. 2013
  3. pmc Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage
    Cora H Nijboer
    Laboratory of Neuroimmunology and Developmental Origins of Disease NIDOD, University Medical Center Utrecht, KC03 068 0, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    Neurobiol Dis 54:206-15. 2013
  4. doi request reprint Inhibition of the JNK/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury
    Cora H Nijboer
    Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Brain Behav Immun 24:812-21. 2010
  5. doi request reprint Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia
    Cora H Nijboer
    Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 40:3362-8. 2009
  6. pmc Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice
    Cora H Nijboer
    Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Brain Behav Immun 24:420-6. 2010
  7. doi request reprint Targeting the p53 pathway to protect the neonatal ischemic brain
    Cora H Nijboer
    Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Neurol 70:255-64. 2011
  8. pmc The endogenous regenerative capacity of the damaged newborn brain: boosting neurogenesis with mesenchymal stem cell treatment
    Vanessa Donega
    Laboratory of Neuroimmunology and Developmental Origins of Disease NIDOD, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 33:625-34. 2013
  9. pmc Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvement
    Vanessa Donega
    Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e51253. 2013
  10. doi request reprint NF-kappaB inhibition after neonatal cerebral hypoxia-ischemia improves long-term motor and cognitive outcome in rats
    Michael A van der Kooij
    Department of Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurobiol Dis 38:266-72. 2010

Collaborators

Detail Information

Publications21

  1. pmc The rodent endovascular puncture model of subarachnoid hemorrhage: mechanisms of brain damage and therapeutic strategies
    Elke Kooijman
    Division of Internal Medicine, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Neuroinflammation 11:2. 2014
    ..We propose the endovascular puncture model as a suitable animal model which resembles the human pathology of SAH and which could be applied to investigate novel therapeutic therapies to combat this debilitating insult. ..
  2. doi request reprint Mitochondrial JNK phosphorylation as a novel therapeutic target to inhibit neuroinflammation and apoptosis after neonatal ischemic brain damage
    Cora H Nijboer
    Laboratory of Neuroimmunology and Developmental Origins of Disease NIDOD, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurobiol Dis 54:432-44. 2013
    ..Moreover we show the crucial role of upregulation of mitochondrial anti-apoptotic proteins to maintain neuroprotection...
  3. pmc Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage
    Cora H Nijboer
    Laboratory of Neuroimmunology and Developmental Origins of Disease NIDOD, University Medical Center Utrecht, KC03 068 0, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    Neurobiol Dis 54:206-15. 2013
    ..These findings underline the critical role of GRK2 regulation in astrocytes for dampening the extent of brain damage after ischemia...
  4. doi request reprint Inhibition of the JNK/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury
    Cora H Nijboer
    Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Brain Behav Immun 24:812-21. 2010
    ..We propose that inhibition of mitochondrial Smac/DIABLO release and calpain activation contribute to neuroprotection by TAT-JBD...
  5. doi request reprint Alternate pathways preserve tumor necrosis factor-alpha production after nuclear factor-kappaB inhibition in neonatal cerebral hypoxia-ischemia
    Cora H Nijboer
    Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 40:3362-8. 2009
    ..We investigated how tumor necrosis factor-alpha (TNF-alpha) production is maintained after NF-kappaB inhibition and whether TNF-alpha contributes to brain damage...
  6. pmc Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice
    Cora H Nijboer
    Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Brain Behav Immun 24:420-6. 2010
    ..The level of GRK2 in neurons is crucial for determining the ultimate severity of HI damage in the newborn brain...
  7. doi request reprint Targeting the p53 pathway to protect the neonatal ischemic brain
    Cora H Nijboer
    Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Neurol 70:255-64. 2011
    ..To investigate whether inhibition of mitochondrial p53 association using pifithrin-μ (PFT-μ) represents a potential novel neuroprotective strategy to combat perinatal hypoxic-ischemic (HI) brain damage...
  8. pmc The endogenous regenerative capacity of the damaged newborn brain: boosting neurogenesis with mesenchymal stem cell treatment
    Vanessa Donega
    Laboratory of Neuroimmunology and Developmental Origins of Disease NIDOD, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 33:625-34. 2013
    ..Furthermore, we will consider the potential to use stem cell transplantation as a means to boost endogenous neurogenesis and restore brain function...
  9. pmc Intranasal mesenchymal stem cell treatment for neonatal brain damage: long-term cognitive and sensorimotor improvement
    Vanessa Donega
    Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e51253. 2013
    ..Our data strongly indicate that intranasal MSC treatment may become a promising non-invasive therapeutic tool to effectively reduce neonatal encephalopathy...
  10. doi request reprint NF-kappaB inhibition after neonatal cerebral hypoxia-ischemia improves long-term motor and cognitive outcome in rats
    Michael A van der Kooij
    Department of Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurobiol Dis 38:266-72. 2010
    ..In conclusion, the almost complete reduction in lesion size observed after TAT-NBD treatment was associated with long-lasting normalization of sensorimotor and cognitive functions...
  11. pmc Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse
    Vanessa Donega
    Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, The Netherlands
    Pediatr Res 78:520-6. 2015
    ..Furthermore, the long-term effects of MSCs on behavior and lesion size were determined...
  12. doi request reprint Intranasally administered mesenchymal stem cells promote a regenerative niche for repair of neonatal ischemic brain injury
    Vanessa Donega
    Lab of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, The Netherlands
    Exp Neurol 261:53-64. 2014
    ....
  13. pmc Intranasal administration of human MSC for ischemic brain injury in the mouse: in vitro and in vivo neuroregenerative functions
    Vanessa Donega
    Lab of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 9:e112339. 2014
    ..The results described in this work also tempt us to contemplate hMSCs not only as a potential treatment option for neonatal encephalopathy, but also for a plethora of degenerative and traumatic injuries of the nervous system...
  14. doi request reprint Development of cerebral gray and white matter injury and cerebral inflammation over time after inflammatory perinatal asphyxia
    Hilde J C Bonestroo
    Laboratory of Neuroimmunology and Developmental Origins of Disease NIDOD, University Medical Center Utrecht, Utrecht, The Netherlands
    Dev Neurosci 37:78-94. 2015
    ....
  15. doi request reprint The neonatal brain is not protected by osteopontin peptide treatment after hypoxia-ischemia
    Hilde J C Bonestroo
    Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, The Netherlands
    Dev Neurosci 37:142-52. 2015
    ..Our data show that administration of the TAT-OPN peptide did not exert neuroprotective effects on neonatal HI-induced brain injury or sensorimotor behavioral deficits...
  16. doi request reprint Impaired oligodendrocyte maturation in preterm infants: Potential therapeutic targets
    Erik van Tilborg
    Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, The Netherlands
    Prog Neurobiol 136:28-49. 2016
    ....
  17. pmc Long-term functional consequences and ongoing cerebral inflammation after subarachnoid hemorrhage in the rat
    Elke Kooijman
    Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 9:e90584. 2014
    ..In conclusion, we are the first to show that SAH induces ongoing cortical inflammation. Moreover, SAH induces mainly cortical long-term brain damage, which is associated with long-term sensorimotor damage. ..
  18. doi request reprint Delayed administration of neural stem cells after hypoxia-ischemia reduces sensorimotor deficits, cerebral lesion size, and neuroinflammation in neonatal mice
    Luca Braccioli
    Laboratory of Neuroimmunology and Developmental Origins of Disease NIDOD, University Medical Center Utrecht, Utrecht, The Netherlands
    Pediatr Res 81:127-135. 2017
    ..Here, we explored whether delayed transplantation of allogenic neural stem cells (NSCs) at 10 d after HI could be a tool to repair HI brain injury and improve behavioral impairments...
  19. pmc Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-μ
    Karen Krukowski
    aLaboratory of Neuroimmunology, Department Symptom Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA bLaboratory of Neuroimmunology and Developmental Origins of Disease NIDOD, University Medical Center Utrecht, Utrecht, The Netherlands
    Pain 156:2184-92. 2015
    ..These data are the first to identify PFT-μ as a potential therapeutic strategy for prevention of CIPN to combat one of the most devastating side effects of chemotherapy. ..
  20. doi request reprint A dual role of the NF-kappaB pathway in neonatal hypoxic-ischemic brain damage
    Cora H Nijboer
    University Medical Center Utrecht, KC03 068 0, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Stroke 39:2578-86. 2008
    ..We hypothesize that timing and duration of NF-kappaB inhibition will be a major factor in determining outcome...
  21. doi request reprint Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity
    Maurits P A van Meer
    Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    J Neurosci 32:4495-507. 2012
    ....