Thera P Links

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. pmc ACTH-independent macronodular adrenocortical hyperplasia reveals prevalent aberrant in vivo and in vitro responses to hormonal stimuli and coupling of arginine-vasopressin type 1a receptor to 11β-hydroxylase
    Johannes Hofland
    Department of Internal Medicine, Section of Endocrinology, P, O, Box 2040, Rotterdam, CA, 3000, The Netherlands
    Orphanet J Rare Dis 8:142. 2013
  2. pmc Pancreatic cyst development: insights from von Hippel-Lindau disease
    Sophie J van Asselt
    Department of Endocrinology, University of Groningen, University Medical Center Groningen, PO Box 30, 001, 9700 RB, Groningen, The Netherlands
    Cilia 2:3. 2013
  3. doi request reprint 89Zr-Bevacizumab PET Visualizes Disease Manifestations in Patients with von Hippel-Lindau Disease
    Sjoukje F Oosting
    Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 57:1244-50. 2016
  4. doi request reprint Potential value of EUS in pancreatic surveillance of VHL patients
    Sophie J van Asselt
    Department of EndocrinologyUniversity of Groningen, University Medical Center Groningen, Groningen, The Netherlands Department of Medical OncologyUniversity of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Endocrinol 174:611-20. 2016
  5. doi request reprint No influence of antihypertensive agents on plasma free metanephrines
    Thamara E Osinga
    Department of Endocrinology AA31, University of Groningen, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands Electronic address
    Clin Biochem 49:1368-1371. 2016
  6. doi request reprint 18-fluorodeoxyglucose positron emission tomography in the early diagnostic workup of differentiated thyroid cancer patients with a negative post-therapeutic iodine scan and detectable thyroglobulin
    Deborah van Dijk
    Department of Endocrinology, Groningen University Medical Centre, Groningen, The Netherlands
    Thyroid 23:1003-9. 2013
  7. doi request reprint Additional value of a high sensitive thyroglobulin assay in the follow-up of patients with differentiated thyroid carcinoma
    Andries H Groen
    Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands
    Clin Endocrinol (Oxf) . 2016
  8. pmc Mass spectrometric quantification of salivary metanephrines-A study in healthy subjects
    Thamara E Osinga
    Department of Endocrinology AA31, University of Groningen, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands Electronic address
    Clin Biochem 49:983-8. 2016
  9. doi request reprint Calculating optimal surveillance for detection of von Hippel-Lindau-related manifestations
    Roeliene C Kruizinga
    Departments of Medical Oncology Endocrinology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Endocr Relat Cancer 21:63-71. 2014
  10. doi request reprint Bone Marrow Function After (131)I Therapy in Patients With Differentiated Thyroid Carcinoma
    Hester T Prinsen
    Departments of Endocrinology H T P, E N K H, W J S, A N A v d H S, T P L, Nuclear Medicine and Molecular Imaging A H B, Surgical Oncology J T M P, and Hematology G W v I, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 100:3911-7. 2015

Collaborators

  • Adrienne H Brouwers
  • Wouter W de Herder
  • Sjoukje F Oosting
  • Eelco W Hoving
  • Robert M W Hofstra
  • Ronald R de Krijger
  • Esther Korpershoek
  • Bas Havekes
  • Cécile M Ronckers
  • Karel Pacak
  • Geertruida H de Bock
  • Stephan J L Bakker
  • Ha T T Phan
  • Elisabeth Ge de Vries
  • Johannes A A Meijer
  • Catarina Eloy
  • Paula Soares
  • Anouk N A van der Horst-Schrivers
  • Wim J Sluiter
  • Sophie J van Asselt
  • Thamara E Osinga
  • Ido P Kema
  • John T M Plukker
  • Esther N Klein Hesselink
  • Robin P F Dullaart
  • Michiel N Kerstens
  • Roeliene C Kruizinga
  • Anneke C Muller Kobold
  • Mariëlle S Klein Hesselink
  • Annemiek M E Walenkamp
  • Hendrik M van Dullemen
  • Hans H G Verbeek
  • Bruce H R Wolffenbuttel
  • Joop D Lefrandt
  • Bernard A Zonnenberg
  • Helle Brit Fiebrich
  • Karin Eijkelenkamp
  • Andries H Groen
  • Martijn van Faassen
  • Hanneke J C M Wouters
  • Klaas P Koopmans
  • Johannes G M Burgerhof
  • Henri J Timmers
  • Eric J van der Jagt
  • Johan R de Jong
  • Hester T Prinsen
  • Lars C Steggink
  • John Th M Plukker
  • Wilhelmina H A de Jong
  • Melanie M van der Klauw
  • Hannah C M van Loon
  • Alfons H H Bongaerts
  • Richard A Feelders
  • Ron T Gansevoort
  • Elise I Klaver
  • Deborah van Dijk
  • Johannes Hofland
  • Rachel H Giles
  • Margriet M De Vries
  • Carlijn Frantzen
  • Mirjam M de Jong
  • Marloes Nies
  • Denise M S van Marion
  • Johannes W A Smit
  • Rob B van der Luijt
  • Graham R Williams
  • Gianni Bocca
  • Eef G W M Lentjes
  • Wilfred F A den Dunnen
  • Piet L Jager
  • Hetty Timmer-Bosscha
  • Robin P Peeters
  • Anneke Muller Kobold
  • Alfons H Bongaerts
  • Rob P Coppes
  • Marry M van den Heuvel-Eibrink
  • Kurt W Schmid
  • Martin F Elderson
  • Eveline W C M van Dam
  • Wim J E Tissing
  • Eleonora P M Corssmit
  • Romana T Netea-Maier
  • Hanneke M van Santen
  • Rosalie P H Derks
  • Arjan Vissink
  • Chantal Cornelissen
  • Jan C de Groot
  • Leontien C M Kremer
  • Sandra N Slagter
  • Heleen J H van der Pal

Detail Information

Publications30

  1. pmc ACTH-independent macronodular adrenocortical hyperplasia reveals prevalent aberrant in vivo and in vitro responses to hormonal stimuli and coupling of arginine-vasopressin type 1a receptor to 11β-hydroxylase
    Johannes Hofland
    Department of Internal Medicine, Section of Endocrinology, P, O, Box 2040, Rotterdam, CA, 3000, The Netherlands
    Orphanet J Rare Dis 8:142. 2013
    ..We investigated the prevalence of adrenocortical reactions to these stimuli in a large cohort of AIMAH patients, both in vivo and in vitro...
  2. pmc Pancreatic cyst development: insights from von Hippel-Lindau disease
    Sophie J van Asselt
    Department of Endocrinology, University of Groningen, University Medical Center Groningen, PO Box 30, 001, 9700 RB, Groningen, The Netherlands
    Cilia 2:3. 2013
    ..Based on preclinical studies, cilia loss in ductal cells is probably an important early event in pancreatic cyst development...
  3. doi request reprint 89Zr-Bevacizumab PET Visualizes Disease Manifestations in Patients with von Hippel-Lindau Disease
    Sjoukje F Oosting
    Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 57:1244-50. 2016
    ..We aimed to assess whether VHL manifestations can be visualized with (89)Zr-bevacizumab PET and to explore whether (89)Zr-bevacizumab PET can differentiate progressive from nonprogressive lesions...
  4. doi request reprint Potential value of EUS in pancreatic surveillance of VHL patients
    Sophie J van Asselt
    Department of EndocrinologyUniversity of Groningen, University Medical Center Groningen, Groningen, The Netherlands Department of Medical OncologyUniversity of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Endocrinol 174:611-20. 2016
    ....
  5. doi request reprint No influence of antihypertensive agents on plasma free metanephrines
    Thamara E Osinga
    Department of Endocrinology AA31, University of Groningen, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands Electronic address
    Clin Biochem 49:1368-1371. 2016
    ..The aim of this study was to determine whether commonly prescribed antihypertensive drugs can falsely elevate plasma free metanephrines concentrations measured by LC-MS/MS analysis...
  6. doi request reprint 18-fluorodeoxyglucose positron emission tomography in the early diagnostic workup of differentiated thyroid cancer patients with a negative post-therapeutic iodine scan and detectable thyroglobulin
    Deborah van Dijk
    Department of Endocrinology, Groningen University Medical Centre, Groningen, The Netherlands
    Thyroid 23:1003-9. 2013
    ..The yield of (18)F-FDG-PET imaging and clinical usefulness of a Tg-off cutoff value to predict a positive scan were assessed...
  7. doi request reprint Additional value of a high sensitive thyroglobulin assay in the follow-up of patients with differentiated thyroid carcinoma
    Andries H Groen
    Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands
    Clin Endocrinol (Oxf) . 2016
    ..The aim of this study was to investigate the additional value of unstimulated hs-Tg measurements (Tg-on) compared to stimulated IRMA-Tg measurements (Tg-off) in the follow-up of patients with DTC...
  8. pmc Mass spectrometric quantification of salivary metanephrines-A study in healthy subjects
    Thamara E Osinga
    Department of Endocrinology AA31, University of Groningen, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands Electronic address
    Clin Biochem 49:983-8. 2016
    ..Determination of metanephrine (MN), normetanephrine (NMN), and 3-methoxytyramine (3-MT) in saliva may offer potential diagnostic advantages in diagnosing pheochromocytoma...
  9. doi request reprint Calculating optimal surveillance for detection of von Hippel-Lindau-related manifestations
    Roeliene C Kruizinga
    Departments of Medical Oncology Endocrinology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Endocr Relat Cancer 21:63-71. 2014
    ..To attain a 5% detection probability rate per organ, our mathematical model indicates that several modifications of current VHL surveillance guidelines should be considered. ..
  10. doi request reprint Bone Marrow Function After (131)I Therapy in Patients With Differentiated Thyroid Carcinoma
    Hester T Prinsen
    Departments of Endocrinology H T P, E N K H, W J S, A N A v d H S, T P L, Nuclear Medicine and Molecular Imaging A H B, Surgical Oncology J T M P, and Hematology G W v I, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 100:3911-7. 2015
    ..The secondary objective was to define characteristics of patients at risk for impaired bone marrow function after (131)I treatment...
  11. doi request reprint Catecholamine-Synthesizing Enzymes Are Expressed in Parasympathetic Head and Neck Paraganglioma Tissue
    Thamara E Osinga
    Department of Endocrinology and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Neuroendocrinology 101:289-95. 2015
    ..Therefore, our aim was to demonstrate the presence of catecholamine-synthesizing enzymes, i.e. tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC) and dopamine β-hydroxylase (DBH) in HNPGL tissue...
  12. doi request reprint Everolimus Reduces (89)Zr-Bevacizumab Tumor Uptake in Patients with Neuroendocrine Tumors
    Sophie J van Asselt
    Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 55:1087-92. 2014
    ..Therefore, we aimed to investigate the effect of everolimus on tumor uptake of the radioactive-labeled VEGF-A antibody bevacizumab with PET in NET patients...
  13. ncbi request reprint Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study
    Esther N Klein Hesselink
    Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 57:1685-1691. 2016
    ....
  14. pmc Calculating the optimal surveillance for head and neck paraganglioma in SDHB-mutation carriers
    Karin Eijkelenkamp
    Department of Endocrinology and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Fam Cancer 16:123-130. 2017
    ..These results may give rise to reconsider the current guidelines regarding the screening of these mutation carriers...
  15. doi request reprint EUS is superior for detection of pancreatic lesions compared with standard imaging in patients with multiple endocrine neoplasia type 1
    Sophie J van Asselt
    Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Gastrointest Endosc 81:159-167.e2. 2015
    ..In multiple endocrine neoplasia type 1 (MEN1), pancreatic neuroendocrine tumors (pNETs) are the leading MEN1-related cause of death...
  16. ncbi request reprint No Effect of the Thr92Ala Polymorphism of Deiodinase-2 on Thyroid Hormone Parameters, Health-Related Quality of Life, and Cognitive Functioning in a Large Population-Based Cohort Study
    Hanneke J C M Wouters
    1 Department of Endocrinology and Metabolism, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
    Thyroid . 2016
    ..It was hypothesized that homozygous carriers of the D2-92Ala allele have different thyroid hormone parameters, and reduced health-related quality of life (HRQoL) and cognitive functioning...
  17. pmc Recombinant TSH stimulated remnant ablation therapy in thyroid cancer: the success rate depends on the definition of ablation success--an observational study
    Anouk N A van der Horst-Schrivers
    Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 10:e0120184. 2015
    ..Using a strict definition, we performed an observational study aiming to determine the efficacy of rhTSH as preparation for remnant ablation...
  18. doi request reprint Unilateral and bilateral adrenalectomy for pheochromocytoma requires adjustment of urinary and plasma metanephrine reference ranges
    Thamara E Osinga
    Department of Endocrinology and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 98:1076-83. 2013
    ..During follow-up, plasma and/or urinary metanephrine (MN) and normetanephrine (NMN) are interpreted using reference ranges obtained in healthy subjects...
  19. doi request reprint Endocrine tumours: progressive metastatic medullary thyroid carcinoma: first- and second-line strategies
    Thera P Links
    Department of EndocrinologyUniversity Medical Centre Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The NetherlandsDepartment of GeneticsErasmus Medical Centre, Rotterdam, The NetherlandsDepartment of Surgical OncologyUniversity Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Endocrinol 172:R241-51. 2015
    ..Combining several agents would seem to be more promising, in particular agents that target RET with those that independently target RET signalling pathways or the more general mechanism of tumour progression. ..
  20. doi request reprint Increased Risk of Atrial Fibrillation After Treatment for Differentiated Thyroid Carcinoma
    Esther N Klein Hesselink
    University of Groningen, University Medical Center Groningen, Departments of Vascular Medicine E N K H, J D L, E P S, Endocrinology E N K H, B G, A N A v d H S, R P F D, T P L, Epidemiology J G M B, Nephrology R T G, Cardiology I C V G, M R, and Nuclear Medicine and Molecular Imaging A H B, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 100:4563-9. 2015
    ..The aim of this study was to evaluate whether there is an increased risk of atrial fibrillation (AF) in DTC patients and whether AF occurrence is related to DTC treatment...
  21. doi request reprint Long-term cardiovascular mortality in patients with differentiated thyroid carcinoma: an observational study
    Esther N Klein Hesselink
    All authors University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Clin Oncol 31:4046-53. 2013
    ..Secondary aims were to evaluate all-cause mortality and explore the relation between thyroid-stimulating hormone (TSH; also known as thyrotropin) level and these outcome parameters...
  22. doi request reprint RET/PTC rearrangement is prevalent in follicular Hürthle cell carcinomas
    Margriet M De Vries
    Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Histopathology 61:833-43. 2012
    ..In an attempt to clarify this issue, we analysed a series of Hürthle cell tumours for the presence of RET/PTC and PAX8/PPARG rearrangements and BRAF, HRAS and NRAS mutations...
  23. doi request reprint Fewer cancer reoperations for medullary thyroid cancer after initial surgery according to ATA guidelines
    Hans H G Verbeek
    Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands
    Ann Surg Oncol 22:1207-13. 2015
    ..We evaluated clinical outcome in patients with locoregional MTC with regard to adequacy of treatment following ATA guidelines and number of sessions to first intended curative surgery in different hospitals...
  24. doi request reprint Pediatric Differentiated Thyroid Carcinoma in The Netherlands: A Nationwide Follow-Up Study
    Mariëlle S Klein Hesselink
    Departments of Endocrinology M S K H, M N, T P L, Nuclear Medicine and Molecular Imaging A H B, Epidemiology J G M B, and Surgical Oncology J T M P, University of Groningen, University Medical Center Groningen, and Departments of Pediatric Endocrinology G B and Pediatric Oncology W J E T, Beatrix Children s Hospital, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands Department of Internal Medicine E W C M v D, VU University Medical Center, 1007 MB Amsterdam, The Netherlands Department of Internal Medicine B H, Division of Endocrinology, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands Department of Pediatric Oncology M M v d H E, Sophia Children s Hospital, Erasmus Medical Center, 3000 CB Rotterdam, The Netherlands Department of Internal Medicine E P M C, Division of Endocrinology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands Department of Pediatric Oncology L C M K, H J H v d P, C M R, Emma Children s Hospital, Academic Medical Center, 1100 DD Amsterdam, The Netherlands Department of Internal Medicine R T N M, J W A S, Division of Endocrinology, Radboud University Medical Center, 6500 HB Nijmegen, France
    J Clin Endocrinol Metab 101:2031-9. 2016
    ..Our objective was to evaluate presentation, treatment-related complications, and long-term outcome in patients with pediatric DTC in The Netherlands...
  25. doi request reprint Tailored imaging of islet cell tumors of the pancreas amidst increasing options
    Helle Brit Fiebrich
    Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Crit Rev Oncol Hematol 82:213-26. 2012
    ..LOEs are weak for all imaging techniques. Analyses indicate a prominent role for endoscopic ultrasound for all three indications...
  26. doi request reprint Clinical relevance of 18F-FDG PET and 18F-DOPA PET in recurrent medullary thyroid carcinoma
    Hans H G Verbeek
    Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 53:1863-71. 2012
    ..We compared (18)F-FDG PET and (18)F-dihydroxyphenylanaline ((18)F-DOPA) PET with biochemical parameters and survival to assess whether these imaging modalities could be of value in detecting progressive disease...
  27. pmc Difference in CXCR4 expression between sporadic and VHL-related hemangioblastoma
    Roeliene C Kruizinga
    Department of Medical Oncology, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    Fam Cancer 15:607-16. 2016
    ..Compared to normal surrounding tissue CXCR4, CXCL12, and VEGFA were overexpressed in hemangioblastomas. Most interestingly, sporadic hemangioblastomas overexpress CXCR4 compared to VHL-related hemangioblastoma. ..
  28. doi request reprint Survival in anaplastic thyroid cancer in relation to pre-existing goiter: a population-based study
    Lars C Steggink
    Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, The Netherlands
    Am J Surg 209:1013-9. 2015
    ..We investigated whether pre-existent goiter and well-differentiated thyroid cancer (WDTC) are associated with survival in anaplastic thyroid carcinoma (ATC)...
  29. pmc Thyroid hormone status and health-related quality of life in the LifeLines Cohort Study
    Elise I Klaver
    1 Department of Endocrinology, University of Groningen, Groningen, The Netherlands
    Thyroid 23:1066-73. 2013
    ..We hypothesize that health-related quality of life (HR-QOL) is more severely impaired in subjects with more abnormal thyroid hormone function tests...
  30. doi request reprint Pregnancy-related hemangioblastoma progression and complications in von Hippel-Lindau disease
    Carlijn Frantzen
    Department of Endocrinology, University Medical Centre Groningen, Groningen, The Netherlands
    Neurology 79:793-6. 2012
    ..We studied the reciprocal effect of pregnancy and von Hippel-Lindau (VHL) disease by analyzing the influence of pregnancy on VHL disease-related lesions and VHL disease on pregnancy outcome...