Heidi M B Lesscher

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Amygdala protein kinase C epsilon controls alcohol consumption
    H M B Lesscher
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA, USA
    Genes Brain Behav 8:493-9. 2009
  2. doi request reprint A grandparent-influenced locus for alcohol preference on mouse chromosome 2
    Heidi M B Lesscher
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Pharmacogenet Genomics 19:719-29. 2009
  3. doi request reprint Inflexible and indifferent alcohol drinking in male mice
    Heidi M B Lesscher
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, The Netherlands
    Alcohol Clin Exp Res 34:1219-25. 2010
  4. pmc Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current
    Doo Sup Choi
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:11890-9. 2008
  5. ncbi request reprint Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization
    Heidi M B Lesscher
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur Neuropsychopharmacol 15:31-7. 2005
  6. doi request reprint Dopaminergic neurotransmission in ventral and dorsal striatum differentially modulates alcohol reinforcement
    Marcia Spoelder
    Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, The Netherlands
    Eur J Neurosci . 2016
  7. doi request reprint Individual Variation in Alcohol Intake Predicts Reinforcement, Motivation, and Compulsive Alcohol Use in Rats
    Marcia Spoelder
    Faculty of Veterinary Medicine, Department of Animals in Science and Society, Division of Behavioural Neuroscience, Utrecht University, Utrecht, The Netherlands
    Alcohol Clin Exp Res 39:2427-37. 2015
  8. pmc Amygdala 14-3-3ζ as a novel modulator of escalating alcohol intake in mice
    Heidi M B Lesscher
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e37999. 2012
  9. pmc Dopamine receptor agonists modulate voluntary alcohol intake independently of individual levels of alcohol intake in rats
    Marcia Spoelder
    Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, The Netherlands
    Psychopharmacology (Berl) 233:2715-25. 2016
  10. pmc Altered performance in a rat gambling task after acute and repeated alcohol exposure
    Marcia Spoelder
    Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, The Netherlands
    Psychopharmacology (Berl) 232:3649-62. 2015

Collaborators

  • Louk J M J Vanderschuren
  • J Peter H Burbach
  • Jeremy J Clark
  • Frank C P Holstege
  • Jan M Van Ree
  • A W Lasek
  • Marcia Spoelder
  • Annemarie M Baars
  • Peter Hesseling
  • José G Lozeman-van 't Klooster
  • Marthe D Rotte
  • Doo Sup Choi
  • D S Mathon
  • Matthew Styles
  • José G Lozeman-van t Klooster
  • Kimberly T Tsutsui
  • Rob Mijnsbergen
  • Werner Sieghart
  • Viktor N Kharazia
  • Robert O Messing
  • Istvan Mody
  • Kevan M Shokat
  • Thomas McMahon
  • Weizheng Wei
  • Dan Wang
  • J Kevin Deitchman
  • Chao Zhang
  • Zhan Heng Qi
  • M P Smidt
  • B M Spruijt
  • A G P Schuller
  • A Kamal
  • J E Pintar
  • M A F M Gerrits
  • G M J Ramakers

Detail Information

Publications16

  1. pmc Amygdala protein kinase C epsilon controls alcohol consumption
    H M B Lesscher
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA, USA
    Genes Brain Behav 8:493-9. 2009
    ..These mice have a >50% reduction in the abundance of PKCepsilon in the amygdala compared with wild-type mice. We conclude that amygdala PKCepsilon is important for ethanol consumption in mice...
  2. doi request reprint A grandparent-influenced locus for alcohol preference on mouse chromosome 2
    Heidi M B Lesscher
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    Pharmacogenet Genomics 19:719-29. 2009
    ..In addition, mouse chromosome substitution strains were used to further evaluate the contribution of chromosome 2 to ethanol consumption...
  3. doi request reprint Inflexible and indifferent alcohol drinking in male mice
    Heidi M B Lesscher
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, The Netherlands
    Alcohol Clin Exp Res 34:1219-25. 2010
    ....
  4. pmc Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current
    Doo Sup Choi
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 28:11890-9. 2008
    ..These findings indicate that PKCdelta contributes to a high level of behavioral response to ethanol, which is negatively associated with risk of developing an alcohol use disorder in humans...
  5. ncbi request reprint Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization
    Heidi M B Lesscher
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Eur Neuropsychopharmacol 15:31-7. 2005
    ..These findings suggest that CB1 receptors are not involved in acute cocaine reinforcement nor in cocaine-induced behavioural sensitization...
  6. doi request reprint Dopaminergic neurotransmission in ventral and dorsal striatum differentially modulates alcohol reinforcement
    Marcia Spoelder
    Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, The Netherlands
    Eur J Neurosci . 2016
    ..In conclusion, dopaminergic neurotransmission acts in concert in subregions of the striatum to modulate different aspects of alcohol-directed behaviour...
  7. doi request reprint Individual Variation in Alcohol Intake Predicts Reinforcement, Motivation, and Compulsive Alcohol Use in Rats
    Marcia Spoelder
    Faculty of Veterinary Medicine, Department of Animals in Science and Society, Division of Behavioural Neuroscience, Utrecht University, Utrecht, The Netherlands
    Alcohol Clin Exp Res 39:2427-37. 2015
    ..To understand the individual vulnerability for AUD, models that capture both the individual variability in alcohol consumption and the transition from casual to compulsive alcohol use are essential...
  8. pmc Amygdala 14-3-3ζ as a novel modulator of escalating alcohol intake in mice
    Heidi M B Lesscher
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e37999. 2012
    ..This study identifies amygdala 14-3-3ζ as a novel key modulator that is engaged during escalation of alcohol use...
  9. pmc Dopamine receptor agonists modulate voluntary alcohol intake independently of individual levels of alcohol intake in rats
    Marcia Spoelder
    Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, The Netherlands
    Psychopharmacology (Berl) 233:2715-25. 2016
    ..Individual susceptibility to alcohol use disorder has been related to functional changes in dopaminergic neurotransmission...
  10. pmc Altered performance in a rat gambling task after acute and repeated alcohol exposure
    Marcia Spoelder
    Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, The Netherlands
    Psychopharmacology (Berl) 232:3649-62. 2015
    ..However, the mechanisms by which neurocognitive impairments predispose to, or result from AUD remain incompletely understood...
  11. pmc Adolescent Alcohol Exposure Amplifies the Incentive Value of Reward-Predictive Cues Through Potentiation of Phasic Dopamine Signaling
    Marcia Spoelder
    Department of Animals in Science and Society, Division of Behavioral Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Neuropsychopharmacology 40:2873-85. 2015
    ..This pattern of phasic dopamine signaling and the associated bias in learning may provide a mechanism for the well-documented vulnerability of individuals with early-life alcohol use for alcohol use disorders in adulthood. ..
  12. doi request reprint Compulsive drug use and its neural substrates
    Heidi M B Lesscher
    Department of Animals in Science and Society, Utrecht University, Utrecht, The Netherlands
    Rev Neurosci 23:731-45. 2012
    ..The studies discussed here provide a promising line of research that will advance our knowledge of the neural circuits involved in the self-destructive behavior that characterizes drug addiction...
  13. ncbi request reprint Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior
    H M B Lesscher
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA 94608, USA
    Genes Brain Behav 7:323-33. 2008
    ..These results are consistent with a novel mechanism of PKCepsilon control over anxiety-like behavior through regulation of CRF in the amygdala...
  14. doi request reprint Early social isolation augments alcohol consumption in rats
    Heidi M B Lesscher
    aDepartment of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University bDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
    Behav Pharmacol 26:673-80. 2015
    ..This implies that early social experience may be a protective factor against excessive alcohol use. ..
  15. ncbi request reprint Mu-opioid receptors are not involved in acute cocaine-induced locomotor activity nor in development of cocaine-induced behavioral sensitization in mice
    Heidi M B Lesscher
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Stratenum, Universiteitsweg 100, Utrecht, The Netherlands
    Neuropsychopharmacology 30:278-85. 2005
    ..The present findings suggest that mu-opioid receptors are not required for the acute locomotor response to cocaine nor are they essential for the development of cocaine-induced behavioral sensitization...
  16. ncbi request reprint Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice
    D S Mathon
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Neuroscience 130:359-67. 2005
    ....