Peter M Lansdorp

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. pmc Epigenetic differences between sister chromatids?
    Peter M Lansdorp
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada
    Ann N Y Acad Sci 1266:1-6. 2012
  2. pmc Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes
    Geraldine Aubert
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    PLoS Genet 8:e1002696. 2012
  3. pmc RTEL1 contributes to DNA replication and repair and telomere maintenance
    Evert Jan Uringa
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
    Mol Biol Cell 23:2782-92. 2012
  4. doi request reprint Reduced telomere length variation in healthy oldest old
    Julius Halaschek-Wiener
    Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada
    Mech Ageing Dev 129:638-41. 2008
  5. pmc Prolonged self-renewal activity unmasks telomerase control of telomere homeostasis and function of mouse hematopoietic stem cells
    Sanja Sekulovic
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
    Blood 118:1766-73. 2011
  6. pmc Chromosome orientation fluorescence in situ hybridization to study sister chromatid segregation in vivo
    Ester Falconer
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada
    Nat Protoc 5:1362-77. 2010
  7. pmc Identification of sister chromatids by DNA template strand sequences
    Ester Falconer
    Terry Fox Laboratory, B C Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Nature 463:93-7. 2010
  8. pmc DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution
    Ester Falconer
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada
    Nat Methods 9:1107-12. 2012
  9. ncbi request reprint Longitudinal data on telomere length in leukocytes from newborn baboons support a marked drop in stem cell turnover around 1 year of age
    Gabriela M Baerlocher
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada
    Aging Cell 6:121-3. 2007
  10. pmc Detection of G-quadruplex DNA in mammalian cells
    Alexander Henderson
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada, Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, Baltimore, MD 21224, USA, Department of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6100, USA, Division of Hematology, Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada and European Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, A Deusinglaan 1, NL 9713 AV Groningen, The Netherlands
    Nucleic Acids Res 42:860-9. 2014

Collaborators

Detail Information

Publications30

  1. pmc Epigenetic differences between sister chromatids?
    Peter M Lansdorp
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada
    Ann N Y Acad Sci 1266:1-6. 2012
    ....
  2. pmc Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes
    Geraldine Aubert
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    PLoS Genet 8:e1002696. 2012
    ....
  3. pmc RTEL1 contributes to DNA replication and repair and telomere maintenance
    Evert Jan Uringa
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
    Mol Biol Cell 23:2782-92. 2012
    ..We propose that mRtel1 is a key protein for DNA replication, recombination, and repair and efficient elongation of telomeres by telomerase...
  4. doi request reprint Reduced telomere length variation in healthy oldest old
    Julius Halaschek-Wiener
    Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada
    Mech Ageing Dev 129:638-41. 2008
    ..Selection of individuals and/or cells that have an optimal telomere repeat length could contribute to disease resistance and promote healthy aging...
  5. pmc Prolonged self-renewal activity unmasks telomerase control of telomere homeostasis and function of mouse hematopoietic stem cells
    Sanja Sekulovic
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
    Blood 118:1766-73. 2011
    ..These findings document a role of telomerase in telomere homeostasis, and in preserving HSC functional integrity on prolonged self-renewal stimulation...
  6. pmc Chromosome orientation fluorescence in situ hybridization to study sister chromatid segregation in vivo
    Ester Falconer
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada
    Nat Protoc 5:1362-77. 2010
    ..This procedure requires 4 d for in vivo mouse tissues and 2 d for in vitro-cultured cells...
  7. pmc Identification of sister chromatids by DNA template strand sequences
    Ester Falconer
    Terry Fox Laboratory, B C Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    Nature 463:93-7. 2010
    ..Our results establish that DNA template sequences can be used to distinguish sister chromatids and follow their mitotic segregation in vivo...
  8. pmc DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution
    Ester Falconer
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada
    Nat Methods 9:1107-12. 2012
    ..The ability to map SCE events at high resolution and fine-tune reference genomes by Strand-seq dramatically expands the scope of single-cell sequencing...
  9. ncbi request reprint Longitudinal data on telomere length in leukocytes from newborn baboons support a marked drop in stem cell turnover around 1 year of age
    Gabriela M Baerlocher
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada
    Aging Cell 6:121-3. 2007
    ..These observations suggest that hematopoietic stem cells, after an initial phase of rapid expansion, switch at around 1 year of age to a different functional mode characterized by a markedly decreased turnover rate...
  10. pmc Detection of G-quadruplex DNA in mammalian cells
    Alexander Henderson
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada, Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, Baltimore, MD 21224, USA, Department of Chemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6100, USA, Division of Hematology, Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada and European Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen, A Deusinglaan 1, NL 9713 AV Groningen, The Netherlands
    Nucleic Acids Res 42:860-9. 2014
    ..We conclude that monoclonal antibody 1H6 is a valuable tool for further studies on the role of G4 DNA in cell and molecular biology. ..
  11. pmc Telomeres, stem cells, and hematology
    Peter M Lansdorp
    Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC
    Blood 111:1759-66. 2008
    ..Here, the role of telomeres and telomerase in human biology is reviewed from a personal historical perspective...
  12. doi request reprint Telomere length in Hutchinson-Gilford progeria syndrome
    Michelle L Decker
    Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, BC, Canada
    Mech Ageing Dev 130:377-83. 2009
    ..Our results suggest that mutant lamin A decreases telomere length via a direct effect and that expression of mutant LMNA is necessary for telomere loss in HGPS...
  13. pmc Analysis of repetitive DNA in chromosomes by flow cytometry
    Julie Brind'amour
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Nat Methods 8:484-6. 2011
    ..Using CFF we also identified parental homologs of human chromosome 18 with different amounts of repetitive DNA...
  14. pmc Strand-seq: a unifying tool for studies of chromosome segregation
    Ester Falconer
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada
    Semin Cell Dev Biol 24:643-52. 2013
    ..This method is expected to help unify the field by testing previous claims of non-random segregation in an unbiased way in many model systems in vitro and in vivo. ..
  15. pmc Telomeres and disease
    Peter M Lansdorp
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada
    EMBO J 28:2532-40. 2009
    ..It is proposed that the variable phenotype and penetrance of heritable human telomerase deficiencies result from additional environmental, genetic and stochastic factors or combinations thereof...
  16. ncbi request reprint Role of telomerase in hematopoietic stem cells
    Peter M Lansdorp
    Terry Fox Laboratory, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada
    Ann N Y Acad Sci 1044:220-7. 2005
    ..Here, the role of telomerase in human HSC biology is reviewed, and it is proposed that telomerase has an important role in the repair of G-rich DNA...
  17. doi request reprint Short telomeres resulting from heritable mutations in the telomerase reverse transcriptase gene predispose for a variety of malignancies
    Mark Hills
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada
    Ann N Y Acad Sci 1176:178-90. 2009
    ..Our findings point to an intimate connection between senescence and cancer and highlight the important role of telomeres in the biology of normal and malignant human cells...
  18. ncbi request reprint Flow cytometry and FISH to measure the average length of telomeres (flow FISH)
    Gabriela M Baerlocher
    Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia, V5Z 1L3, Canada
    Nat Protoc 1:2365-76. 2006
    ..The basic protocol for the analysis of nucleated blood cells from 22 different individuals takes about 12 h spread over 2-3 days...
  19. pmc Telomere length measurement-caveats and a critical assessment of the available technologies and tools
    Geraldine Aubert
    Terry Fox Laboratory, BC Cancer Agency, Vancouver BC, Canada
    Mutat Res 730:59-67. 2012
    ..The information in this review should facilitate the selection of the most suitable method to address specific research question about telomeres in either model organisms or human subjects...
  20. ncbi request reprint Immortal strands? Give me a break
    Peter M Lansdorp
    Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
    Cell 129:1244-7. 2007
    ..As I describe in this Essay, such a possibility seems unlikely. An alternative explanation is that asymmetric cell divisions and cell fate are codirected by epigenetic differences between sister chromatids...
  21. ncbi request reprint Telomere length in paroxysmal nocturnal hemoglobinuria correlates with clone size
    Gabriela M Baerlocher
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
    Exp Hematol 35:1777-81. 2007
    ..To study if telomere length can be used as a surrogate marker for the mitotic history in normal and affected hematopoietic cells from patients with paroxysmal nocturnal hemoglobinuria (PNH)...
  22. doi request reprint Telomeres and aging
    Geraldine Aubert
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Physiol Rev 88:557-79. 2008
    ..Here the role of telomeres and telomerase in human aging and aging-associated diseases is reviewed...
  23. pmc High incidence of rapid telomere loss in telomerase-deficient Caenorhabditis elegans
    Iris Cheung
    Terry Fox Laboratory, BC Cancer Agency Avenue, Vancouver, BC, Canada V5Z 1L3
    Nucleic Acids Res 34:96-103. 2006
    ..We speculate that, apart from maintaining the average telomere length, telomerase is required to prevent or repair sporadic telomere truncations that are unrelated to the typical 'end-replication' problems...
  24. pmc Probing the mitotic history and developmental stage of hematopoietic cells using single telomere length analysis (STELA)
    Mark Hills
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
    Blood 113:5765-75. 2009
    ..These results indicate extensive self-renewal divisions of human hematopoietic stem cells are the primary cause of telomere erosion upon transplantation rather than added cell divisions in downstream progenitors...
  25. pmc Resolution of telomere associations by TRF1 cleavage in mouse embryonic stem cells
    Kathleen Lisaingo
    Terry Fox Laboratory, BC Cancer Research Centre, University of British Columbia, Vancouver, BC V5Z 1L3, Canada
    Mol Biol Cell 25:1958-68. 2014
    ..This study provides novel insight into the formation and resolution of telomere associations...
  26. pmc RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination
    Evert Jan Uringa
    Terry Fox Laboratory, BC Cancer Agency, Avenue, Vancouver, BC, V5Z 1L3, Canada
    Nucleic Acids Res 39:1647-55. 2011
    ..Here, we review the role of RTEL1 in telomere maintenance and homologous recombination and discuss models linking RTEL1's enzymatic activity to its function in telomere maintenance and DNA repair...
  27. ncbi request reprint Telomere length in human natural killer cell subsets
    Qin Ouyang
    Terry Fox Laboratory, BC Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC, Canada, V5Z 1L3
    Ann N Y Acad Sci 1106:240-52. 2007
    ..Telomere attrition in NK cells is a plausible cause for diminished NK cell function in the elderly...
  28. ncbi request reprint Stress, social rank and leukocyte telomere length
    Peter M Lansdorp
    Terry Fox Laboratory, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Aging Cell 5:583-4. 2006
    ....
  29. ncbi request reprint Major cutbacks at chromosome ends
    Peter M Lansdorp
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, V5Z 1L3, Canada
    Trends Biochem Sci 30:388-95. 2005
    ..Differences in telomere-erosion pathways between normal and malignant cells provide novel targets for the prevention and therapy of disease...
  30. pmc Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERT
    Alexander Roth
    Terry Fox Laboratory, British Columbia Cancer Agency, 12th Floor, 675 W 10th Ave, Vancouver, BC, V5Z 1L3, Canada
    Blood 106:43-50. 2005
    ..We conclude that overexpression of hTERT in CD4+ T cells provides a proliferative advantage independent of the average telomere length but does not prevent eventual genetic instability and replicative senescence...