Floris P J G Lafeber

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi request reprint CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid
    Jocea M R van Amelsfort
    University Medical Centre Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 50:2775-85. 2004
  2. doi request reprint Osteoarthritis year 2013 in review: biomarkers; reflecting before moving forward, one step at a time
    F P J G Lafeber
    Rheumatology and Clin Immunol, University Medical Centre Utrecht, The Netherlands Electronic address
    Osteoarthritis Cartilage 21:1452-64. 2013
  3. pmc A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models
    Yvonne H Sniekers
    Department of Orthopaedics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    BMC Musculoskelet Disord 9:20. 2008
  4. doi request reprint Physiopathology of haemophilic arthropathy
    F P J G Lafeber
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Haemophilia 14:3-9. 2008
  5. ncbi request reprint Unloading joints to treat osteoarthritis, including joint distraction
    Floris P J G Lafeber
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands
    Curr Opin Rheumatol 18:519-25. 2006
  6. doi request reprint Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis
    Sarita A Y Hartgring
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 60:2595-605. 2009
  7. doi request reprint Interleukin-10 protects against blood-induced joint damage
    Nathalie W D Jansen
    Rheumatology and Clinical Immunology, UMC Utrecht, The Netherlands
    Br J Haematol 142:953-61. 2008
  8. doi request reprint Thymic stromal lymphopoietin, a novel proinflammatory mediator in rheumatoid arthritis that potently activates CD1c+ myeloid dendritic cells to attract and stimulate T cells
    Fréderique M Moret
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheumatol 66:1176-84. 2014
  9. pmc Persistence of interleukin 7 activity and levels on tumour necrosis factor alpha blockade in patients with rheumatoid arthritis
    Joel A G van Roon
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 66:664-9. 2007
  10. doi request reprint Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators
    Sarita A Y Hartgring
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 62:2716-25. 2010

Collaborators

Detail Information

Publications82

  1. ncbi request reprint CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid
    Jocea M R van Amelsfort
    University Medical Centre Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 50:2775-85. 2004
    ..We investigated the presence, phenotype, and function of CD4(+)CD25(+) regulatory T cells in peripheral blood (PB) and synovial fluid (SF) from patients with rheumatoid arthritis (RA)...
  2. doi request reprint Osteoarthritis year 2013 in review: biomarkers; reflecting before moving forward, one step at a time
    F P J G Lafeber
    Rheumatology and Clin Immunol, University Medical Centre Utrecht, The Netherlands Electronic address
    Osteoarthritis Cartilage 21:1452-64. 2013
    ..Looking ahead, we are optimistic but realistic in our expectations, we believe that the field can be brought forward by critically and cautiously reconsidering our approaches, and making changes forward, one step at a time. ..
  3. pmc A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models
    Yvonne H Sniekers
    Department of Orthopaedics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    BMC Musculoskelet Disord 9:20. 2008
    ..This study evaluates changes in peri-articular bone in two canine models for osteoarthritis: the groove model and the anterior cruciate ligament transection (ACLT) model...
  4. doi request reprint Physiopathology of haemophilic arthropathy
    F P J G Lafeber
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Haemophilia 14:3-9. 2008
    ..Overall, it may be expected that these experimental results will yield new therapeutic strategies capable of effectively preventing the occurrence of this still serious and common complication in patients with severe haemophilia...
  5. ncbi request reprint Unloading joints to treat osteoarthritis, including joint distraction
    Floris P J G Lafeber
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, 3508 GA Utrecht, The Netherlands
    Curr Opin Rheumatol 18:519-25. 2006
    ..This review examines the recent literature on the potential beneficial effects of unloading joints in the treatment of osteoarthritis, with a focus on joint distraction...
  6. doi request reprint Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis
    Sarita A Y Hartgring
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 60:2595-605. 2009
    ..To evaluate the expression and functional ability of the high-affinity interleukin-7 receptor (IL-7Ralpha) in patients with rheumatoid arthritis (RA)...
  7. doi request reprint Interleukin-10 protects against blood-induced joint damage
    Nathalie W D Jansen
    Rheumatology and Clinical Immunology, UMC Utrecht, The Netherlands
    Br J Haematol 142:953-61. 2008
    ..Taken together, although effects were obtained in vitro, IL-10 protects against blood-induced joint damage and might be further evaluated as candidate in treatment of tissue damaging effects of joint haemorrhages...
  8. doi request reprint Thymic stromal lymphopoietin, a novel proinflammatory mediator in rheumatoid arthritis that potently activates CD1c+ myeloid dendritic cells to attract and stimulate T cells
    Fréderique M Moret
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheumatol 66:1176-84. 2014
    ....
  9. pmc Persistence of interleukin 7 activity and levels on tumour necrosis factor alpha blockade in patients with rheumatoid arthritis
    Joel A G van Roon
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 66:664-9. 2007
    ..In addition, the effect of TNFalpha blockade on IL7 activity and on IL7 levels was studied...
  10. doi request reprint Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators
    Sarita A Y Hartgring
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 62:2716-25. 2010
    ..To study the effects of interleukin-7 receptor α-chain (IL-7Rα) blockade on collagen-induced arthritis (CIA) and to investigate the effects on T cell numbers, T cell activity, and levels of proinflammatory mediators...
  11. ncbi request reprint Initiation of degenerative joint damage by experimental bleeding combined with loading of the joint: a possible mechanism of hemophilic arthropathy
    Michel J J Hooiveld
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 50:2024-31. 2004
    ..To investigate the effect of a limited number of experimental joint bleedings, combined with loading of the affected joint, on the development of progressive degenerative joint damage...
  12. ncbi request reprint Increased intraarticular interleukin-7 in rheumatoid arthritis patients stimulates cell contact-dependent activation of CD4(+) T cells and macrophages
    Joel A G van Roon
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 52:1700-10. 2005
    ..To determine the level of intraarticular expression of interleukin-7 (IL-7) in patients with rheumatoid arthritis (RA) and to investigate the mechanisms by which IL-7 facilitates activation of CD4(+) T cells and monocyte/macrophages in RA...
  13. ncbi request reprint Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis
    Jocea M R van Amelsfort
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 56:732-42. 2007
    ..The purpose of the present study was to investigate whether particular proinflammatory mediators that are associated with RA could abrogate CD4+,CD25+ Treg-mediated suppression...
  14. doi request reprint The combination of the biomarkers urinary C-terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy
    Nathalie W D Jansen
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 60:290-8. 2009
    ....
  15. ncbi request reprint A shift in the balance of inhibitory and activating Fcgamma receptors on monocytes toward the inhibitory Fcgamma receptor IIb is associated with prevention of monocyte activation in rheumatoid arthritis
    Siska Wijngaarden
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 50:3878-87. 2004
    ....
  16. doi request reprint Increase of body mass index in a tight controlled methotrexate-based strategy with prednisone in early rheumatoid arthritis: side effect of the prednisone or better control of disease activity?
    Maud S Jurgens
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Care Res (Hoboken) 65:88-93. 2013
    ....
  17. doi request reprint IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7Rα
    Angela Bikker
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Rheumatology (Oxford) 51:996-1005. 2012
    ....
  18. doi request reprint Misclassification of disease activity when assessing individual patients with early rheumatoid arthritis using disease activity indices that do not include joints of feet
    Marije F Bakker
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 71:830-5. 2012
    ....
  19. ncbi request reprint Oral or nasal antigen induces regulatory T cells that suppress arthritis and proliferation of arthritogenic T cells in joint draining lymph nodes
    Femke Broere
    Division of Immunology, Institute of Infectious Diseases and Immunology, University of Utrecht, Utrecht, The Netherlands
    J Immunol 181:899-906. 2008
    ..Herein we show that both oral and nasal Ag application induced Tr cells, which had a direct inhibitory effect on already established pathogenic B and T cell responses...
  20. doi request reprint Do radiographic joint damage and disease activity influence functional disability through different mechanisms? Direct and indirect effects of disease activity in established rheumatoid arthritis
    Sandhya C Nair
    From the Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Rheumatol 40:1505-12. 2013
    ....
  21. doi request reprint Haemarthrosis stimulates the synovial fibrinolytic system in haemophilic mice
    Laurens Nieuwenhuizen
    Department of Internal Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands
    Thromb Haemost 110:173-83. 2013
    ....
  22. pmc Interleukin-7-aggravated joint inflammation and tissue destruction in collagen-induced arthritis is associated with T-cell and B-cell activation
    Sarita A Y Hartgring
    Department of Rheumatology and Clinical Immunology, UMC Utrecht, Heidelberglaan 100, Utrecht, PO Box 85500 F02, 127 3508 GA, The Netherlands
    Arthritis Res Ther 14:R137. 2012
    ..We sought to investigate the capacity of interleukin (IL)-7 to enhance collagen-induced arthritis and to study by what mechanisms this is achieved...
  23. doi request reprint Clinical efficacy of leflunomide in primary Sjogren's syndrome is associated with regulation of T-cell activity and upregulation of IL-7 receptor α expression
    Angela Bikker
    Department of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 71:1934-41. 2012
    ..To investigate whether the immunomodulatory capacities of leflunomide are associated with clinical efficacy in the treatment of primary Sjögren's syndrome (SS) in a phase II pilot study...
  24. doi request reprint Coagulation aggravates blood-induced joint damage in dogs
    Monique E R van Meegeren
    Van Creveld Clinic and University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 64:3231-9. 2012
    ....
  25. pmc Tissue structure modification in knee osteoarthritis by use of joint distraction: an open 1-year pilot study
    Femke Intema
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 70:1441-6. 2011
    ..Modification of joint tissue damage is challenging in late-stage osteoarthritis (OA). Few options are available for treating end-stage knee OA other than joint replacement...
  26. ncbi request reprint Selective elimination of synovial inflammatory macrophages in rheumatoid arthritis by an Fcgamma receptor I-directed immunotoxin
    Joel A G van Roon
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 48:1229-38. 2003
    ....
  27. doi request reprint Intra-articular glucocorticoid injections decrease the number of steroid hormone receptor positive cells in synovial tissue of patients with persistent knee arthritis
    Marlies C van der Goes
    Department of Rheumatology and Clinical Immunology F02 127, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 71:1552-8. 2012
    ....
  28. doi request reprint Identifying phenotypes of knee osteoarthritis by separate quantitative radiographic features may improve patient selection for more targeted treatment
    Margot B Kinds
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Rheumatol 40:891-902. 2013
    ..Our objective was to identify phenotypes of progression of radiographic knee OA using separate quantitative features...
  29. doi request reprint A single intra-articular injection with IL-4 plus IL-10 ameliorates blood-induced cartilage degeneration in haemophilic mice
    Monique E R van Meegeren
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Br J Haematol 160:515-20. 2013
    ..Improved bioavailability (half-life) of both cytokines might improve their protective ability in the development of cartilage degeneration, and probably also inflammation...
  30. doi request reprint Elevation of cartilage AGEs does not accelerate initiation of canine experimental osteoarthritis upon mild surgical damage
    Petra A J M Vos
    Rheumatology and Clinical Immunology F02 127, University Medical Centre Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Orthop Res 30:1398-404. 2012
    ..As such, elevated AGEs do not unambiguously accelerate the development of early canine OA upon minimal surgical damage...
  31. doi request reprint Understanding haemophilic arthropathy: an exploration of current open issues
    Nathalie W D Jansen
    Rheumatology and Clinical Immunology, University Medical Center UMC Utrecht, Utrecht, The Netherlands
    Br J Haematol 143:632-40. 2008
    ..These subsequently influence each other: the synovial inflammatory changes enhancing cartilage damage and vice versa. Consequently, effective treatment strategies will have to affect both pathways...
  32. doi request reprint Personalized biological treatment for rheumatoid arthritis: a systematic review with a focus on clinical applicability
    Bart V J Cuppen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Rheumatology (Oxford) 55:826-39. 2016
    ..To review studies that address prediction of response to biologic treatment in RA and to explore the clinical utility of the studied (bio)markers...
  33. doi request reprint Alternative Ways to Quantify Sustained Remission: Applying the Continuity Rewarded Score and Patient Vector Graph
    Maud S Jurgens
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Care Res (Hoboken) 67:1471-4. 2015
    ..Furthermore, we investigated whether the patient vector graph, which plots on patient level, would add visual information on remission compared to a conventional box plot only, which displays data on the group level...
  34. doi request reprint IL-1β, in contrast to TNFα, is pivotal in blood-induced cartilage damage and is a potential target for therapy
    Lize F D van Vulpen
    Van Creveldkliniek and Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 126:2239-46. 2015
    ..This hierarchical position of IL-1β in blood-induced joint damage warrants studies on targeting IL-1β to potentially prevent joint degeneration after a joint bleed. ..
  35. doi request reprint Contribution of the subjective components of the disease activity score to the response to biologic treatment in rheumatoid arthritis
    Maud S Jurgens
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Care Res (Hoboken) 67:923-8. 2015
    ..The secondary aim was to examine whether the value of this subjective contribution at baseline affects the response to treatment...
  36. doi request reprint Deferasirox limits cartilage damage following haemarthrosis in haemophilic mice
    Laurens Nieuwenhuizen
    Laurens Nieuwenhuizen, MD, Department of Internal Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands, E mail
    Thromb Haemost 112:1044-50. 2014
    ..This study demonstrates the role of iron in blood-induced cartilage damage. Moreover, these data indicate that iron chelation may be a potential prevention option to limit the development of haemophilic arthropathy. ..
  37. doi request reprint Hemarthrosis in hemophilic mice results in alterations in M1-M2 monocyte/macrophage polarization
    Laurens Nieuwenhuizen
    Rheumatology and Clinical Immunology, University Medical Center, Utrecht, The Netherlands Hematology and Van Creveldkliniek, University Medical Center, Utrecht, The Netherlands Electronic address
    Thromb Res 133:390-5. 2014
    ..Joint bleedings result in iron-mediated synovitis and cartilage destruction. Monocyte/macrophage polarization affects their role in iron homeostasis. This study evaluates the effects of hemarthrosis on monocyte/macrophage polarization...
  38. doi request reprint Quantitative radiographic features of early knee osteoarthritis: development over 5 years and relationship with symptoms in the CHECK cohort
    Margot B Kinds
    Rheumatology and Clinical Immunology, the Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Rheumatol 40:58-65. 2013
    ....
  39. pmc Performance of a multi-biomarker score measuring rheumatoid arthritis disease activity in the CAMERA tight control study
    Marije F Bakker
    Correspondence to Marije F Bakker, UMC Utrecht, Department of Rheumatology and Clinical Immunology, Utrecht PO BOX 85500, The Netherlands
    Ann Rheum Dis 71:1692-7. 2012
    ....
  40. pmc Celecoxib: considerations regarding its potential disease-modifying properties in osteoarthritis
    Manon C Zweers
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, F02, 127, 3508 GA Utrecht, The Netherlands
    Arthritis Res Ther 13:239. 2011
    ..Can celecoxib be considered a disease-modifying osteoarthritic drug? In this review, these direct effects of celecoxib on cartilage, bone, and synoviocytes in OA treatment are discussed...
  41. doi request reprint Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: a randomized trial
    Marije F Bakker
    Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht, The Netherlands
    Ann Intern Med 156:329-39. 2012
    ..Treatment strategies for tight control of early rheumatoid arthritis (RA) are highly effective but can be improved...
  42. pmc The relation between cartilage biomarkers (C2C, C1,2C, CS846, and CPII) and the long-term outcome of rheumatoid arthritis patients within the CAMERA trial
    Marije F Bakker
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Arthritis Res Ther 13:R70. 2011
    ....
  43. ncbi request reprint Clinical benefit of joint distraction in the treatment of ankle osteoarthritis
    Anne C A Marijnissen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, P O Box 85500 F02 127, 3508 GA Utrecht, The Netherlands
    Foot Ankle Clin 8:335-46. 2003
    ..In the light of increased aging, and the limited life span of an endoprosthesis, evaluation of joint distraction in the case of knee and hip osteoarthritis is justified...
  44. ncbi request reprint Diversity of regulatory T cells to control arthritis
    Joel A G van Roon
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Best Pract Res Clin Rheumatol 20:897-913. 2006
    ....
  45. ncbi request reprint Exposure of human cartilage tissue to low concentrations of blood for a short period of time leads to prolonged cartilage damage: an in vitro study
    Nathalie W D Jansen
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 56:199-207. 2007
    ..This study was carried out to test the in vitro thresholds of exposure time and concentration that lead to irreversible joint damage, to add to the discussion on the usefulness of aspiration of the joint after a hemorrhage...
  46. ncbi request reprint Necessity of TNF-alpha inhibitor discontinuation in rheumatoid arthritis is predicted by smoking and number of previously used biological DMARDs
    Bart V J Cuppen
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    Clin Exp Rheumatol . 2016
    ..Prediction thereof would be clinically relevant and guide the decision whether to start TNFi treatment...
  47. pmc Determining the Lowest Optimally Effective Methotrexate Dose for Individual RA Patients Using Their Dose Response Relation in a Tight Control Treatment Approach
    Sandhya C Nair
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    PLoS ONE 11:e0148791. 2016
    ..To determine the optimal methotrexate dose in individual patients and to explore whether this optimal dose and the level of disease activity at that dose could be predicted...
  48. pmc The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade
    Maarten R Hillen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 10:e0130830. 2015
    ..In addition, the effects of IL-7 and TSLP in human RA dendritic cell (DC)/T-cell co-cultures were studied...
  49. pmc Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study
    Simon C Mastbergen
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Res Ther 8:R2. 2006
    ..NSAIDs with low COX-2/COX-1 selectivity exhibit adverse direct effects on OA cartilage, whereas high COX-2/COX-1 selective NSAIDs did not show such effects and might even have cartilage reparative properties...
  50. doi request reprint A short time window to profit from protection of blood-induced cartilage damage by IL-4 plus IL-10
    Monique E R van Meegeren
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Rheumatology (Oxford) 52:1563-71. 2013
    ....
  51. doi request reprint Associations of CTX-II with biochemical markers of bone turnover raise questions on its tissue origin: data from CHECK, a cohort study of early osteoarthritis
    Willem E van Spil
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 72:29-36. 2013
    ..In this study, the authors describe similarities between CTX-II and bone markers arguing against CTX-II as a marker of (solely) cartilage degradation...
  52. pmc Exploring the Inflammatory Metabolomic Profile to Predict Response to TNF-α Inhibitors in Rheumatoid Arthritis
    Bart V J Cuppen
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 11:e0163087. 2016
    ..Associations between metabolites and disease activity may help elucidate additional pathologic mechanisms behind RA. ..
  53. doi request reprint Cohort Profile: Cohort Hip and Cohort Knee (CHECK) study
    Janet Wesseling
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Int J Epidemiol 45:36-44. 2016
    ..The CHECK steering group welcomes collaboration with national and international colleagues. Requests for collaboration or access to data can be sent to [checkreu@umcutrecht.nl]. ..
  54. doi request reprint Does disease activity add to functional disability in estimation of utility for rheumatoid arthritis patients on biologic treatment?
    Sandhya C Nair
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht
    Rheumatology (Oxford) 55:94-102. 2016
    ..Our aim was to develop and validate a model that uses a combination of disease activity (DAS28) and HAQs to estimate EuroQoL 5-dimension scale (EQ5D) utilities...
  55. ncbi request reprint Blood-induced joint damage in hemophilia
    Goris Roosendaal
    Van Creveldkliniek and National Hemophilia Center, Division of Internal Medicine, University Medical Center Utrecht, The Netherlands
    Semin Thromb Hemost 29:37-42. 2003
    ..Thus, both processes occur in parallel, and although they influence each other they probably do not depend on each other. This concept resembles degenerative joint damage as found in osteoarthritis...
  56. doi request reprint Evidence of cartilage repair by joint distraction in a canine model of osteoarthritis
    Karen Wiegant
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheumatol 67:465-74. 2015
    ..The purpose of this study was to evaluate cartilage tissue repair directly by histologic and biochemical assessments after joint distraction treatment...
  57. ncbi request reprint Is radiation synovectomy for arthritis of the knee more effective than intraarticular treatment with glucocorticoids? Results of an eighteen-month, randomized, double-blind, placebo-controlled, crossover trial
    Zalima N Jahangier
    Dept of Rheumatology and Clinical Immunology F02 127, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Arthritis Rheum 52:3391-402. 2005
    ....
  58. pmc Interleukin-7 and Toll-like receptor 7 induce synergistic B cell and T cell activation
    Angela Bikker
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 9:e94756. 2014
    ..To investigate the potential synergy of IL-7-driven T cell-dependent and TLR7-mediated B cell activation and to assess the additive effects of monocyte/macrophages in this respect...
  59. doi request reprint Pathophysiology of hemophilic arthropathy and potential targets for therapy
    Astrid E Pulles
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands Van Creveldkliniek, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands Electronic address
    Pharmacol Res 115:192-199. 2016
    ..The most important challenges are: establishing a universal outcome measure to predict efficacy in humans, and determination of the optimal route and timing to administer disease modifying therapy...
  60. pmc Can baseline serum microRNAs predict response to TNF-alpha inhibitors in rheumatoid arthritis?
    Bart V J Cuppen
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Arthritis Res Ther 18:189. 2016
    ..This study aims to discover miRNAs that predict response and aims to replicate results of two previous studies addressing this topic...
  61. doi request reprint The detrimental effects of iron on the joint: a comparison between haemochromatosis and haemophilia
    Lize F D van Vulpen
    Van Creveldkliniek, University Medical Center Utrecht, Utrecht, The Netherlands Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Pathol 68:592-600. 2015
    ..Additional research is needed to further specify the role of iron as a specific target in treating these types of arthropathy. ..
  62. pmc Differentiation of naive CD4+ T cells towards T helper 2 cells is not impaired in rheumatoid arthritis patients
    Joel A G van Roon
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    Arthritis Res Ther 5:R269-76. 2003
    ..The perpetuation of arthritogenic T-cell activity in RA therefore seems not to be the result of intrinsic defects of naive CD4+ T cells to develop towards suppressive memory Th2 cells...
  63. doi request reprint The prognostic value of routinely performed minor salivary gland assessments in primary Sjögren's syndrome
    Anna P Risselada
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 73:1537-40. 2014
    ..To investigate the prognostic value of the lymphocytic focus score (LFS) and the percentages of IgA+, IgM+ and IgG+ plasma cells for disease severity of primary Sjögren syndrome (pSS)...
  64. doi request reprint Functional articular cartilage repair: here, near, or is the best approach not yet clear?
    Simon C Mastbergen
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Nat Rev Rheumatol 9:277-90. 2013
    ..Only with such rational and integrated assessment of outcomes will the promising results of these approaches be consolidated in clinical practice...
  65. ncbi request reprint Interleukin-7: a key mediator in T cell-driven autoimmunity, inflammation, and tissue destruction
    Angela Bikker
    Dept of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, The Netherlands
    Curr Pharm Des 18:2347-56. 2012
    ....
  66. ncbi request reprint Immature articular cartilage is more susceptible to blood-induced damage than mature articular cartilage: an in vivo animal study
    Michel J J Hooiveld
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 48:396-403. 2003
    ....
  67. doi request reprint Numbers of CD25+Foxp3+ T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients
    Joel A G van Roon
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Rheumatology (Oxford) 49:2084-9. 2010
    ..To investigate numbers and function of CD25(+) regulatory T cells (Tregs) that lack IL-7 receptor (CD127) expression in RA...
  68. ncbi request reprint Clinical benefit of joint distraction in the treatment of severe osteoarthritis of the ankle: proof of concept in an open prospective study and in a randomized controlled study
    Anne C A Marijnissen
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 46:2893-902. 2002
    ....
  69. ncbi request reprint Suppression of inflammation and joint destruction in rheumatoid arthritis may require a concerted action of Th2 cytokines
    Joel A G van Roon
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    Curr Opin Investig Drugs 3:1011-6. 2002
    ..Based on a thorough evaluation of the actions of IL-4 and IL-10 in these studies, it is hypothesized that disease suppression of RA may require the concerted action of suppressive Th2 cytokines or Th2 activity...
  70. doi request reprint Osteoarthritis: an update with relevance for clinical practice
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Netherlands
    Lancet 377:2115-26. 2011
    ..In the coming years, a better definition of osteoarthritis is expected by delineating different phenotypes of the disease. Treatment targeted more specifically at these phenotypes might lead to improved outcomes...
  71. ncbi request reprint Antigen-specific T cell suppression by human CD4+CD25+ regulatory T cells
    Leonie S Taams
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Immunol 32:1621-30. 2002
    ..This would provide a mechanism for the generation of regulatory cells that induce tolerance to a wide array of antigens that may not be encountered in the thymus...
  72. doi request reprint Identifying Trajectories of Pain Severity in Early Symptomatic Knee Osteoarthritis: A 5-year Followup of the Cohort Hip and Cohort Knee (CHECK) Study
    Janet Wesseling
    From Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht Department of General Practice, Department of Orthopedics, Erasmus MC University Medical Center Rotterdam, Rotterdam Department of Rheumatology, Kennemer Gasthuis Haarlem, Haarlem Department of Rheumatology and Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands J Wesseling, PhD, Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht A N Bastick, MD, Department of General Practice, Erasmus MC University Medical Center Rotterdam S ten Wolde, MD, PhD, Department of Rheumatology, Kennemer Gasthuis Haarlem M Kloppenburg, MD, PhD, Department of Rheumatology and Department of Clinical Epidemiology, Leiden University Medical Centre F P Lafeber, PhD, Professor, Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht S M Bierma Zeinstra, PhD, Professor, Department of General Practice, and Department of Orthopedics, Erasmus MC University Medical Center Rotterdam J W Bijlsma, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht
    J Rheumatol 42:1470-7. 2015
    ..To identify subgroups of pain trajectories in patients with symptomatic knee osteoarthritis (OA), and to explain these different trajectories by patient characteristics, lifestyle, and coping factors, as well as radiographic features...
  73. ncbi request reprint Interleukin 10 treatment of patients with rheumatoid arthritis enhances Fc gamma receptor expression on monocytes and responsiveness to immune complex stimulation
    Joel van Roon
    Department of Reumatology and Clinical Immunology, University Medical Centre Utrecht, The Netherlands
    J Rheumatol 30:648-51. 2003
    ..We evaluated the upregulation of Fc gamma receptor (Fc gamma R) expression on monocytes/macrophages (and granulocytes) in patients with RA receiving different dosages of IL-10...
  74. ncbi request reprint Glucocorticoid receptor downregulation in early diagnosed rheumatoid arthritis
    A Margriet Huisman
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    Ann N Y Acad Sci 966:64-7. 2002
    ..Since normal glucocorticoid receptor expression was found in the male population with early-diagnosed RA, it remains questionable if glucocorticoid receptor expression is causally involved in pathogenesis of RA...
  75. pmc Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells
    Leonie S Taams
    Infection and Immunity Research Group, Franklin Wilkins Building, King s College London, UK
    Hum Immunol 66:222-30. 2005
    ..Together, these data demonstrate that CD4+CD25+ Tregs can exert direct suppressive effects on monocytes/macrophages, thereby affecting subsequent innate and adaptive immune responses...
  76. ncbi request reprint Profiling of endogenous peptides in human synovial fluid by NanoLC-MS: method validation and peptide identification
    Jurre J Kamphorst
    Division of Analytical Biosciences, LACDR, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    J Proteome Res 6:4388-96. 2007
    ....
  77. pmc Role of interleukin-7 in degenerative and inflammatory joint diseases
    Joel A G van Roon
    Arthritis Res Ther 10:107. 2008
    ..This indicates that IL-7, indirectly via immune activation, but also by a direct action on cartilage, contributes to joint destruction in rheumatic diseases...
  78. ncbi request reprint Joint distraction as an alternative for the treatment of osteoarthritis
    Peter M Van Roermund
    Department of Orthopaedic Surgery, University Medical Centre, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Foot Ankle Clin 7:515-27. 2002
    ....
  79. ncbi request reprint Glucosamine sulfate in osteoarthritis: the jury is still out
    Johannes W J Bijlsma
    Ann Intern Med 148:315-6. 2008
  80. ncbi request reprint Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis
    Nicole Verzijl
    TNO Prevention and Health, Leiden, The Netherlands
    Arthritis Rheum 46:114-23. 2002
    ..We studied the effect of AGE crosslinking on the stiffness of the collagen network in human articular cartilage...
  81. ncbi request reprint Accumulation of advanced glycation end products as a molecular mechanism for aging as a risk factor in osteoarthritis
    Jeroen Degroot
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Arthritis Rheum 50:1207-15. 2004
    ....
  82. ncbi request reprint Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes
    Marjan M C Steenvoorden
    TNO Quality of Life TNO Pharma, and Leiden University Medical Center, 2301 CE Leiden, The Netherlands
    Arthritis Rheum 54:253-63. 2006
    ..We undertook this study to investigate the role of the receptor for AGEs (RAGE) in mediating the cellular effects of AGEs on chondrocytes and fibroblast-like synoviocytes (FLS)...