Huib A M Kerstjens

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Effects of short-acting bronchodilators added to maintenance tiotropium therapy
    Huib A M Kerstjens
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Chest 132:1493-9. 2007
  2. pmc Airways inflammation and treatment during acute exacerbations of COPD
    Erik Bathoorn
    Groningen Research Institute for Asthma and COPD GRIAC, Department of Pulmonology, University Medical Center Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 3:217-29. 2008
  3. pmc Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice
    Margaretha van der Deen
    Pulmonology Department, University Medical Center Groningen and University of Groningen, The Netherlands
    Respir Res 8:49. 2007
  4. ncbi request reprint Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:517-27. 2009
  5. doi request reprint Anti-inflammatory effects of combined budesonide/formoterol in COPD exacerbations
    Erik Bathoorn
    Groningen Research Institute for Asthma and COPD, Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    COPD 5:282-90. 2008
  6. pmc Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation
    Erik Bathoorn
    Department of Pulmonology, Groningen Research Institute for Asthma and COPD GRIAC, University Medical Center Groningen, University of Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 4:101-9. 2009
  7. pmc Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
    Eef D Telenga
    Department of Pulmonary Diseases, University Medical Center Groningen, Groningen, Netherlands
    BMC Pulm Med 13:58. 2013
  8. doi request reprint Sputum inflammation predicts exacerbations after cessation of inhaled corticosteroids in COPD
    Jeroen J W Liesker
    Department of Respiratory Diseases and Tuberculosis, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Respir Med 105:1853-60. 2011
  9. pmc Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells?
    Corry Anke Brandsma
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, P, O, Box 30, 001, 9700 RB, Groningen, The Netherlands
    Respir Res 9:17. 2008
  10. doi request reprint Inhaled corticosteroids in chronic obstructive pulmonary disease: a review
    Eef D Telenga
    University Medical Center Groningen, University of Groningen, Department of Pulmonology PO Box 30 001, 9700 RB Groningen, The Netherlands
    Expert Opin Pharmacother 11:405-21. 2010

Detail Information

Publications78

  1. ncbi request reprint Effects of short-acting bronchodilators added to maintenance tiotropium therapy
    Huib A M Kerstjens
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Chest 132:1493-9. 2007
    ..Combining bronchodilators has been shown to be beneficial in patients with COPD. The additive effects of short-acting bronchodilators added to maintenance tiotropium therapy, however, are unknown...
  2. pmc Airways inflammation and treatment during acute exacerbations of COPD
    Erik Bathoorn
    Groningen Research Institute for Asthma and COPD GRIAC, Department of Pulmonology, University Medical Center Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 3:217-29. 2008
    ..It is important to focus on inflammation since it gives insight into the pathological changes causing an exacerbation, thereby possibly providing directions for future therapies which modify inflammation...
  3. pmc Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice
    Margaretha van der Deen
    Pulmonology Department, University Medical Center Groningen and University of Groningen, The Netherlands
    Respir Res 8:49. 2007
    ..Their impaired function may contribute to COPD development by diminished detoxification of noxious compounds in cigarette smoke...
  4. ncbi request reprint Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:517-27. 2009
    ..Inhaled corticosteroids (ICSs) and long-acting beta(2)-agonists (LABAs) are used to treat moderate to severe chronic obstructive pulmonary disease (COPD)...
  5. doi request reprint Anti-inflammatory effects of combined budesonide/formoterol in COPD exacerbations
    Erik Bathoorn
    Groningen Research Institute for Asthma and COPD, Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    COPD 5:282-90. 2008
    ..50). In conclusion, budesonide/formoterol reduces sputum eosinophils and improves symptoms in the treatment of out-patient COPD exacerbations...
  6. pmc Change in inflammation in out-patient COPD patients from stable phase to a subsequent exacerbation
    Erik Bathoorn
    Department of Pulmonology, Groningen Research Institute for Asthma and COPD GRIAC, University Medical Center Groningen, University of Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 4:101-9. 2009
    ..Better identification of these changes will increase our knowledge and potentially guide therapy, for instance by helping with quicker distinction of bacterially induced exacerbations from other causes...
  7. pmc Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
    Eef D Telenga
    Department of Pulmonary Diseases, University Medical Center Groningen, Groningen, Netherlands
    BMC Pulm Med 13:58. 2013
    ..We investigated differences in blood and sputum inflammatory profiles between ex-, current-, and never-smokers and assessed their ICS treatment response after 2-week and 1-year treatment...
  8. doi request reprint Sputum inflammation predicts exacerbations after cessation of inhaled corticosteroids in COPD
    Jeroen J W Liesker
    Department of Respiratory Diseases and Tuberculosis, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Respir Med 105:1853-60. 2011
    ..Unfortunately, physicians do not know in which patients they can stop ICS treatment safely...
  9. pmc Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells?
    Corry Anke Brandsma
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, P, O, Box 30, 001, 9700 RB, Groningen, The Netherlands
    Respir Res 9:17. 2008
    ..The effects of HO-1 modulation on cigarette smoke induced inflammation and emphysema were tested in a smoking mouse model...
  10. doi request reprint Inhaled corticosteroids in chronic obstructive pulmonary disease: a review
    Eef D Telenga
    University Medical Center Groningen, University of Groningen, Department of Pulmonology PO Box 30 001, 9700 RB Groningen, The Netherlands
    Expert Opin Pharmacother 11:405-21. 2010
    ..Although widely used, the efficacy of inhaled corticosteroids (ICS) in the treatment of COPD remains a matter of debate...
  11. ncbi request reprint Nitrogen dioxide exposure attenuates cigarette smoke-induced cytokine production in mice
    Corry Anke Brandsma
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Inhal Toxicol 20:183-9. 2008
    ..The next step is to translate these findings of combined, controlled exposure in animals to the human situation...
  12. pmc Increased levels of (class switched) memory B cells in peripheral blood of current smokers
    Corry Anke Brandsma
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands
    Respir Res 10:108. 2009
    ..Future studies focusing on the presence of these (class switched) memory B cells in the lung, their antigen specificity and their interaction with Tregs are necessary to further elucidate the specific B-cell response in COPD...
  13. doi request reprint Muscarinic M₃ receptors contribute to allergen-induced airway remodeling in mice
    Loes E M Kistemaker
    1 Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands
    Am J Respir Cell Mol Biol 50:690-8. 2014
    ..No stimulatory role for muscarinic M3 receptors in allergic inflammation was observed, suggesting that the role of acetylcholine in remodeling is independent of the allergic inflammatory response, and may involve bronchoconstriction. ..
  14. pmc Induction of autoantibodies against lung matrix proteins and smoke-induced inflammation in mice
    Corry Anke Brandsma
    Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    BMC Pulm Med 10:64. 2010
    ..Whether the presence of these autoantibodies contributes to the pathogenesis of COPD is unclear...
  15. doi request reprint β-Catenin signaling is required for TGF-β1-induced extracellular matrix production by airway smooth muscle cells
    Hoeke A Baarsma
    Department of Molecular Pharmacology, University of Groningen, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 301:L956-65. 2011
    ..Targeting β-catenin-dependent gene transcription may therefore hold promise as a therapeutic intervention in airway remodeling in both asthma and COPD...
  16. doi request reprint Tiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trial
    Huib A M Kerstjens
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 128:308-14. 2011
    ..Some patients with severe asthma remain symptomatic and obstructed despite maximal recommended treatment. Tiotropium, a long-acting inhaled anticholinergic agent, might be an effective bronchodilator in such patients...
  17. pmc Inhaled corticosteroids and long-acting beta-agonists in adult asthma: a winning combination in all?
    Dirkje S Postma
    Department of Pulmonology, University Medical Center, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 378:203-15. 2008
    ..Clinical effectiveness in the real world now has to be established, since this approach likely improves compliance with regular maintenance therapy...
  18. pmc Azithromycin and cough-specific health status in patients with chronic obstructive pulmonary disease and chronic cough: a randomised controlled trial
    Farida F Berkhof
    Department of Pulmonary Diseases, Isala, Dr, van Heesweg 2, 8025AB, Zwolle, The Netherlands
    Respir Res 14:125. 2013
    ..Their effects on health status has not been assessed as primary outcome and is less clear. This study assessed the effects of prophylactic azithromycin on cough-specific health status in COPD-patients with chronic productive cough...
  19. ncbi request reprint Bronchoscopic lung volume reduction coil treatment of patients with severe heterogeneous emphysema
    Dirk Jan Slebos
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands d
    Chest 142:574-82. 2012
    ..We investigated the safety and efficacy of LVR-coil treatment in patients with heterogeneous emphysema...
  20. doi request reprint Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells
    Loes E M Kistemaker
    Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Thorax 70:668-76. 2015
    ..In vivo studies have demonstrated an indirect role for acetylcholine in epithelial cell differentiation. Here, we aimed to investigate direct effects of endogenous non-neuronal acetylcholine on epithelial cell differentiation...
  21. doi request reprint Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD
    Maarten van den Berge
    Dept of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Eur Respir J 40:1098-105. 2012
    ..Our findings indicate that BHR is an independent trait in COPD and provides important information on phenotype heterogeneity and disease activity...
  22. pmc Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice
    Loes E M Kistemaker
    Department of Molecular Pharmacology, University of Groningen, The Netherlands GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 308:L96-103. 2015
    ..This effect is probably not mediated via KC release, but may involve altered adhesion and transmigration of neutrophils via fibrinogen-α and CD177...
  23. pmc Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: I. Effects on lung remodeling and pathology
    Hoeke A Baarsma
    Department of Molecular Pharmacology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Respir Res 14:113. 2013
    ..The kinase acts as a negative regulator in β-catenin signalling and is critically involved in the smad pathway. Activation of both pathways may contribute to pulmonary features of chronic obstructive pulmonary disease (COPD)...
  24. ncbi request reprint Dissociation of lung function and airway inflammation in chronic obstructive pulmonary disease
    Thérèse S Lapperre
    Lung Function Lab, C2 P, Department of Pulmonology, Leiden University Medical Center, Albinusdreef 2, P O Box 9600 2300 RC Leiden, The Netherlands
    Am J Respir Crit Care Med 170:499-504. 2004
    ..We conclude that airflow limitation, airway inflammation, and features commonly associated with asthma are separate and largely independent factors in the pathophysiology of COPD...
  25. pmc Glycogen synthase kinase-3 (GSK-3) regulates TGF-β₁-induced differentiation of pulmonary fibroblasts
    Hoeke A Baarsma
    Department of Molecular Pharmacology, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands
    Br J Pharmacol 169:590-603. 2013
    ..Glycogen synthase kinase-3 (GSK-3) regulates various intracellular signalling pathways; its role in TGF-β₁-induced myofibroblast differentiation is currently largely unknown...
  26. ncbi request reprint Tiotropium in asthma poorly controlled with standard combination therapy
    Huib A M Kerstjens
    University of Groningen and the Department of Pulmonary Medicine and Tuberculosis, University Medical Center Groningen, and Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands
    N Engl J Med 367:1198-207. 2012
    ..Some patients with asthma have frequent exacerbations and persistent airflow obstruction despite treatment with inhaled glucocorticoids and long-acting beta-agonists (LABAs)...
  27. pmc Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease
    Hoeke A Baarsma
    Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands
    PLoS ONE 6:e25450. 2011
    ..We determined WNT-pathway gene expression in pulmonary fibroblasts of individuals with and without COPD and disentangled the role of β-catenin in fibroblast phenotype and function...
  28. doi request reprint Chemical labeling and enrichment of nitrotyrosine-containing peptides
    Nicolas Abello
    Department of Pharmacy, Analytical Biochemistry, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Talanta 80:1503-12. 2010
    ..The approach presented here is well adapted to peptide analysis, for instance in shotgun proteomics...
  29. doi request reprint Tiotropium improves lung function, exacerbation rate, and asthma control, independent of baseline characteristics including age, degree of airway obstruction, and allergic status
    Huib A M Kerstjens
    University of Groningen, Department of Pulmonary Medicine, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, Postbox 30 001, 9700 RB Groningen, The Netherlands Electronic address
    Respir Med 117:198-206. 2016
    ..Tiotropium add-on to ICS plus a LABA has been shown to improve lung function and reduce exacerbation risk in patients with symptomatic asthma...
  30. doi request reprint Asthma in patients climbing to high and extreme altitudes in the Tibetan Everest region
    Henrike K Huismans
    Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Asthma 47:614-9. 2010
    ..The aim of this study was to investigate the behavior of asthma in patients traveling to high and extreme altitudes...
  31. ncbi request reprint The role of endogenous and exogenous AMP in asthma and chronic obstructive pulmonary disease
    Maarten van den Berge
    Department of Pulmonology, University Hospital Groningen, The Netherlands
    J Allergy Clin Immunol 114:737-46. 2004
    ..The aim of this article was to review the literature assessing AMP's value in asthma and chronic obstructive pulmonary disease...
  32. doi request reprint The Severe Respiratory Insufficiency Questionnaire scored best in the assessment of health-related quality of life in chronic obstructive pulmonary disease
    Fransien M Struik
    Department of Pulmonology Center for Home Mechanical Ventilation, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
    J Clin Epidemiol 66:1166-74. 2013
    ....
  33. doi request reprint Endobronchial Valves for Emphysema without Interlobar Collateral Ventilation
    Karin Klooster
    From the Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen K K, N H T H, J E H, H A M K, D J S, and the Department of Radiology and Nuclear Medicine, Radboud University Medical Center Nijmegen, Nijmegen E M R both in the Netherlands
    N Engl J Med 373:2325-35. 2015
    ..To date, the benefits have been modest but have been hypothesized to be much larger in patients without interlobar collateral ventilation than in those with collateral ventilation...
  34. doi request reprint Short- and long-term effects of a physical activity counselling programme in COPD: a randomized controlled trial
    Wytske A Altenburg
    University of Groningen, University Medical Centre Groningen, Department of Pulmonary Diseases, Groningen, The Netherlands University of Groningen, University Medical Centre Groningen, Centre for Rehabilitation, Groningen, The Netherlands University of Groningen, University Medical Centre Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands Electronic address
    Respir Med 109:112-21. 2015
    ..We were interested in the effects of a physical activity (PA) counselling programme in three groups of COPD patients from general practice (primary care), outpatient clinic (secondary care) and pulmonary rehabilitation (PR)...
  35. doi request reprint Poly(ethylene glycol)-based stable isotope labeling reagents for the quantitative analysis of low molecular weight metabolites by LC-MS
    Nicolas Abello
    Department of Analytical Biochemistry, University of Groningen, Groningen, The Netherlands
    Anal Chem 80:9171-80. 2008
    ..g., glutathione) decreased although disulfide bond formation was not increased. These labeling reagents should also prove useful for the labeling of peptides and other compounds containing primary amine functionalities...
  36. pmc Day-to-day measurement of patient-reported outcomes in exacerbations of chronic obstructive pulmonary disease
    Jan Willem H Kocks
    Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Int J Chron Obstruct Pulmon Dis 8:273-86. 2013
    ..This study aims to describe the day-to-day course of patient-reported health status during exacerbations of COPD and to assess its value in predicting clinical outcomes...
  37. pmc Health status in routine clinical practice: validity of the clinical COPD questionnaire at the individual patient level
    Janwillem W H Kocks
    Department of General Practice, University Medical Center Groningen, University of Groningen, A, Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Health Qual Life Outcomes 8:135. 2010
    ..This study examines a new method, using patient interviews, to validate a short health status questionnaire, the Clinical COPD Questionnaire (CCQ), at the individual patient level...
  38. ncbi request reprint Cognitive performance in patients with COPD
    Jeroen J W Liesker
    Department of Pulmonary Diseases, University Hospital Groningen, Hanzeplein 1, Postbox 30001 NL 9700 RB, Groningen, The Netherlands
    Respir Med 98:351-6. 2004
    ..These neuropsychological impairments are related to the degree of hypoxemia. So far, cognitive performance has not been tested in non-hypoxemic patients with COPD...
  39. doi request reprint Determining the Role of Dynamic Hyperinflation in Patients with Severe Chronic Obstructive Pulmonary Disease
    Karin Klooster
    Research Institute for Asthma and COPD, University Medical Center Groningen, Department of Pulmonary Diseases, University of Groningen, Groningen, The Netherlands
    Respiration 90:306-13. 2015
    ..Dynamic hyperinflation due to increased respiratory frequency during exercise is associated with limitations in exercise capacity in patients with moderately severe chronic obstructive pulmonary disease (COPD)...
  40. pmc COPD exacerbations in general practice: variability in oral prednisolone courses
    Marianne de Vries
    Department of General Practice, University Medical Centre Groningen, University of Groningen, Antonius Deusinglaan 1, FA 20, 9700 AD Groningen, The Netherlands
    BMC Fam Pract 13:3. 2012
    ..It also investigates the number of general practitioners (GPs) who adjust their treatment according to the presence of diabetic co-morbidity...
  41. doi request reprint Beneficial effects of treatment with anti-IgE antibodies (Omalizumab) in a patient with severe asthma and negative skin-prick test results
    Maarten van den Berge
    Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands
    Chest 139:190-3. 2011
    ....
  42. ncbi request reprint Oral or IV prednisolone in the treatment of COPD exacerbations: a randomized, controlled, double-blind study
    Ynze P de Jong
    Department of Pulmonology, Isala Klinieken, Pulmonology, PO Box 10500, Zwolle 8000 GM, The Netherlands
    Chest 132:1741-7. 2007
    ..We conducted a study to demonstrate that therapy with oral prednisolone was not inferior to therapy with IV prednisolone using a double-blind, double-dummy design...
  43. doi request reprint Functional and psychological variables both affect daily physical activity in COPD: a structural equations model
    Wytske A Altenburg
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, P O Box 30001, Internal mail address AA11, 9700 RB Groningen, The Netherlands University of Groningen, University Medical Center Groningen, Center for Rehabilitation, Groningen, P O Box 30002, Internal Mail Address CD24, 9750 RA Haren, The Netherlands University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, P O Box 30001, Internal Mail Address FA40, 9700RB Groningen, The Netherlands Electronic address
    Respir Med 107:1740-7. 2013
    ..Daily physical activity (DPA) level is reduced in patients with COPD. The aim of this study was to investigate the association of DPA with functional and psychological variables in these patients...
  44. doi request reprint Protein tyrosine nitration: selectivity, physicochemical and biological consequences, denitration, and proteomics methods for the identification of tyrosine-nitrated proteins
    Nicolas Abello
    Department of Analytical Biochemistry, Center for Pharmacy, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Proteome Res 8:3222-38. 2009
    ..The second part of this review article focuses on analytical methods to determine this post-translational modification in complex proteomes, which remains a major challenge...
  45. ncbi request reprint [Experiences of combined heart-lung transplantations in the University Medical Center Groningen]
    Johan Brügemann
    Universitair Medisch Centrum Groningen, Groningen, The Netherlands
    Ned Tijdschr Geneeskd 153:B98. 2009
    ..Reporting the results of combined heart-lung transplantation in the University Medical Center Groningen (UMCG), the Netherlands...
  46. doi request reprint Validity and Predictive Value of a Portable Two-Channel Sleep-Screening Tool in the Identification of Sleep Apnea in Patients With Heart Failure
    Grietje E de Vries
    Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Card Fail 21:848-55. 2015
    ..We assessed the validity of a portable 2-channel sleep-screening tool for the identification of sleep apnea in patients with HF...
  47. pmc Two-year home-based nocturnal noninvasive ventilation added to rehabilitation in chronic obstructive pulmonary disease patients: a randomized controlled trial
    Marieke L Duiverman
    Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Respir Res 12:112. 2011
    ..The aim was to compare the outcome of 2-year home-based nocturnal NIPPV in addition to rehabilitation (NIPPV + PR) with rehabilitation alone (PR) in COPD patients with chronic hypercapnic respiratory failure...
  48. doi request reprint Selecting the increment size for a maximal incremental cycle test in patients with COPD
    Jorine E Hartman
    Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Respirology 20:352-5. 2015
    ..This study shows that simple measures like forced expiratory volume in 1 s, chair-stand test and modified Medical Research Council dyspnoea score may improve the accuracy of the predicted maximum workload in COPD patients...
  49. doi request reprint Telemedicine, the effect of nurse-initiated telephone follow up, on health status and health-care utilization in COPD patients: a randomized trial
    Farida F Berkhof
    Department of Pulmonary Diseases, Isala Klinieken, Zwolle, The Netherlands
    Respirology 20:279-85. 2015
    ..This pilot study determined the effects of telemedicine on health-care utilization and health status of chronic obstructive pulmonary disease (COPD) patients...
  50. pmc Health status in patients with coexistent COPD and heart failure: a validation and comparison between the Clinical COPD Questionnaire and the Minnesota Living with Heart Failure Questionnaire
    Farida F Berkhof
    Department of Pulmonary Diseases, Isala Hospital, Zwolle, The Netherlands
    Int J Chron Obstruct Pulmon Dis 9:999-1008. 2014
    ..This study validated and compared which questionnaire, ie, the CCQ or the MLHF-Q, is suited best for patients with coexistent COPD and HF...
  51. doi request reprint Lung volume reduction coil treatment in chronic obstructive pulmonary disease patients with homogeneous emphysema: a prospective feasibility trial
    Karin Klooster
    Department of Pulmonary Diseases, University Medical Center Groningen, Groningen, The Netherlands
    Respiration 88:116-25. 2014
    ..Bronchoscopic LVR coil treatment has been shown to be effective in patients with heterogeneous emphysema, but this treatment has not been exclusively investigated in homogeneous emphysema...
  52. pmc Treatment of bronchiectasis in adults
    Nick H T ten Hacken
    Pulmonary Department, University Medical Centre Groningen, University of Groningen, Postbox 30001, 9700 RB Groningen, Netherlands
    BMJ 335:1089-93. 2007
  53. doi request reprint Glycogen synthase kinase-3 regulates cigarette smoke extract- and IL-1β-induced cytokine secretion by airway smooth muscle
    Hoeke A Baarsma
    Department of Molecular Pharmacology, University of Groningen, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 300:L910-9. 2011
    ..Furthermore, we show that GSK-3 regulates the release of these cytokines induced by CSE and IL-1β by promoting NF-κB-dependent gene transcription...
  54. pmc Putting health status guided COPD management to the test: protocol of the MARCH study
    Janwillem Kocks
    Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    BMC Pulm Med 13:41. 2013
    ....
  55. doi request reprint Definitions of exacerbations: does it really matter in clinical trials on COPD?
    Tanja W Effing
    Medisch Spectrum Twente, Department of Pulmonology, Haaksbergerstraat 55, 7513 ER Enschede, The Netherlands
    Chest 136:918-23. 2009
    ..Also, the exact definition to be used in a study should be specified in the protocol...
  56. doi request reprint Functional status measurement in COPD: a review of available methods and their feasibility in primary care
    Janwillem W H Kocks
    Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Prim Care Respir J 20:269-75. 2011
    ..This review aims to categorize systematically the available tools based on their construct (i.e. what the tool intends to measure) and to rate the tools for use in the primary care setting...
  57. doi request reprint Bronchodilators delivered by nebuliser versus pMDI with spacer or DPI for exacerbations of COPD
    Wouter H van Geffen
    Department of Pulmonary Diseases and Tuberculosis, University of Groningen, University Medical Center Groningen, Hanzeplein 1, Groningen, Netherlands, 9713 GZ
    Cochrane Database Syst Rev . 2016
    ..We assessed the available randomised controlled trials (RCTs) to help guide practice in a more uniform way...
  58. doi request reprint Increased neutrophil expression of pattern recognition receptors during COPD exacerbations
    Simon D Pouwels
    Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Respirology . 2016
    ..Together, these data indicate that increased DAMP signalling contributes to activation of neutrophils during COPD exacerbations...
  59. doi request reprint Revisiting the Dutch hypothesis
    Dirkje S Postma
    University of Groningen, Department of Pulmonology, University Medical Center Groningen, Groningen, The Netherlands University of Groningen, GRIAC Research Institute, University Medical Center Groningen, Groningen, The Netherlands Electronic address
    J Allergy Clin Immunol 136:521-9. 2015
    ..This detailed phenotyping can help in understanding these obstructive airway diseases and provide guidance for disease management. ..
  60. doi request reprint Tiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group, active-comparator, randomised trials
    Huib A M Kerstjens
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Medicine and Tuberculosis, and Groningen Research Institute for Asthma and COPD, Groningen, Netherlands Electronic address
    Lancet Respir Med 3:367-76. 2015
    ..We aimed to assess the safety and efficacy of tiotropium in patients with moderate asthma who were symptomatic despite treatment with medium-dose inhaled corticosteroids...
  61. doi request reprint Efficacy of a new pulmonary cyclosporine a powder formulation for prevention of transplant rejection in rats
    Gerrit S Zijlstra
    Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands
    J Heart Lung Transplant 28:486-92. 2009
    ..The aim of this pilot study was to determine the pharmacokinetics of cyclosporine A powder for inhalation (iCsA) and its rejection prevention efficacy in an experimental lung transplantation model in rats...
  62. ncbi request reprint Safety of sputum induction during exacerbations of COPD
    Erik Bathoorn
    Department of Pulmonology, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, The Netherlands
    Chest 131:432-8. 2007
    ..We concluded that SI can be safely carried out in patients with mild-to-moderate COPD who experience an exacerbation, and this occurs with no greater risk than in stable patients with COPD...
  63. ncbi request reprint Initial improvements in lung function and bronchial hyperresponsiveness are maintained during 5 years of treatment with inhaled beclomethasone dipropionate and terbutaline
    W Rob Douma
    Department of Pulmonology, University Hospital Groningen, Groningen, The Netherlands
    Chest 121:151-7. 2002
    ....
  64. doi request reprint Diagnosing viral and bacterial respiratory infections in acute COPD exacerbations by an electronic nose: a pilot study
    Wouter H van Geffen
    University of Groningen, Department of Pulmonary Diseases, University Medical Center Groningen, The Netherlands
    J Breath Res 10:036001. 2016
    ..Validation of these results using a new and large cohort is required before introduction into clinical practice. ..
  65. pmc Tolerability and Pharmacokinetic Evaluation of Inhaled Dry Powder Tobramycin Free Base in Non-Cystic Fibrosis Bronchiectasis Patients
    Marcel Hoppentocht
    Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands
    PLoS ONE 11:e0149768. 2016
    ..The presence of Pseudomonas aeruginosa in bronchiectasis is associated with a higher hospitalisation frequency and a reduced quality of life, requiring frequent and adequate treatment with antibiotics...
  66. ncbi request reprint A systematic review of the effects of bronchodilators on exercise capacity in patients with COPD
    Jeroen J W Liesker
    Department of Pulmonary Diseases, University Hospital Groningen, Groningen, The Netherlands
    Chest 121:597-608. 2002
    ..The majority of studies reporting a measure of dyspnea found improvements, even in the absence of improvement in exercise capacity...
  67. pmc The validity and precision of the Leicester Cough Questionnaire in COPD patients with chronic cough
    Farida F Berkhof
    Isala Klinieken, Department of Pulmonary Diseases, Zwolle, The Netherlands
    Health Qual Life Outcomes 10:4. 2012
    ..We examined the psychometric performance of the LCQ in patients with COPD and chronic productive cough...
  68. pmc Usage of positional therapy in adults with obstructive sleep apnea
    Grietje E de Vries
    University of Groningen, University Medical Center Groningen, Department of Pulmonary Medicine and Tuberculosis, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands
    J Clin Sleep Med 11:131-7. 2015
    ....
  69. ncbi request reprint Cigarette smoke-induced emphysema: A role for the B cell?
    Barry W A van der Strate
    Department of Respiratory Medicine, University Medical Center Groningen, Postbox 30 001, NL 9700 RB Groningen, The Netherlands
    Am J Respir Crit Care Med 173:751-8. 2006
    ..Little is known about what drives the inflammatory reaction in the development of chronic obstructive lung disease. B cells have been found...
  70. ncbi request reprint Selective acylation of primary amines in peptides and proteins
    Nicolas Abello
    Department of Analytical Biochemistry, Center for Pharmacy, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Proteome Res 6:4770-6. 2007
    ..In conclusion, the present method allows the selective acylation of primary amines by NHS esters and constitutes a valuable alternative to the treatment with hydroxylamine under alkaline conditions...
  71. ncbi request reprint Discriminating asthma and COPD based on bronchodilator data: an improvement of the methods
    Dick M Goedhart
    Cardialysis BV, Westblaak 92, 3012 KM Rotterdam, The Netherlands
    Physiol Meas 26:1115-23. 2005
    ..628/0.730, 0.592/0.737 and 0.709/0.749. This increase in discriminatory power is obtained in the optimal use of all available information, especially age, which is not used in the increase of the predicted/baseline FEV1 rule...
  72. ncbi request reprint Phosphodiesterase 4 inhibitors: antiinflammatory therapy for chronic obstructive pulmonary disease at last?
    Huib A M Kerstjens
    Am J Respir Crit Care Med 168:914-5. 2003
  73. ncbi request reprint Short-term smoke exposure attenuates ovalbumin-induced airway inflammation in allergic mice
    Barbro N Melgert
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    Am J Respir Cell Mol Biol 30:880-5. 2004
    ..This effect of smoking may be different for long-term smoking, in which remodeling effects of smoking can be expected to interrelate with remodeling changes caused by asthmatic disease...
  74. ncbi request reprint Perimenstrual asthma: a syndrome without known cause or cure
    Annelike Vrieze
    Department of Pulmonary Medicine, University Hospital Groningen, The Netherlands
    J Allergy Clin Immunol 112:271-82. 2003
    ..In light of these positive case reports, well-designed, double-blind studies of sufficient sample size should now be performed to give treatment of PMA an evidence base...
  75. ncbi request reprint Obtaining optimal control in mild asthma: theory and practice
    Louise Watson
    Department of Worldwide Epidemiology, GlaxoSmithKline, Greenford, Middlesex, UK
    Fam Pract 22:305-10. 2005
    ..Studies have shown that asthma severity is easily under-estimated and as a result, patients may be under-treated with reduced asthma control...
  76. ncbi request reprint The GOLD classification has not advanced understanding of COPD
    Huib A M Kerstjens
    Am J Respir Crit Care Med 170:212-3; discussion 214. 2004
  77. ncbi request reprint Bidirectionality in the relationship between asthma and smoking in adolescents: a population-based cohort study
    Monique O M van de Ven
    Behavioural Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands
    J Adolesc Health 41:444-54. 2007
    ..This study examines whether these cross-sectional results are caused by higher smoking onset among adolescents with asthma, or by the development of asthma after smoking onset...
  78. ncbi request reprint Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study
    Johan C Kips
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium
    Am J Respir Crit Care Med 167:1655-9. 2003
    ..We conclude that SCH55700 is a biologically active anti-human IL-5 antibody that can be safely used in severe steroid-treated asthma. Its therapeutic potential needs to be addressed in specifically designed efficacy trials...