D Hoekstra

Summary

Affiliation: University of Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Membrane dynamics and cell polarity: the role of sphingolipids
    Dick Hoekstra
    University of Groningen, Department of Membrane Cell Biology, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Lipid Res 44:869-77. 2003
  2. ncbi request reprint The subapical compartment: a traffic center in membrane polarity development
    Dick Hoekstra
    Department of Membrane Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Cell Sci 117:2183-92. 2004
  3. ncbi request reprint On the mechanism of protein-induced membrane fusion: from model to biological membranes
    Dick Hoekstra
    University of Groningen, Department of Membrane Cell Biology, Ant Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Cell Mol Biol Lett 7:231-2. 2002
  4. ncbi request reprint Lipid trafficking and sorting: how cholesterol is filling gaps
    D Hoekstra
    Department of Physiological Chemistry, University of Groningen, Groningen, 9713 AV, The Netherlands
    Curr Opin Cell Biol 12:496-502. 2000
  5. pmc PDMP blocks brefeldin A-induced retrograde membrane transport from golgi to ER: evidence for involvement of calcium homeostasis and dissociation from sphingolipid metabolism
    J W Kok
    Department of Physiological Chemistry, University of Groningen, Groningen Institute for Drug Studies GIDS, 9713 AV Groningen, The Netherlands
    J Cell Biol 142:25-38. 1998
  6. pmc An apical-type trafficking pathway is present in cultured oligodendrocytes but the sphingolipid-enriched myelin membrane is the target of a basolateral-type pathway
    H de Vries
    Department of Physiological Chemistry, Faculty of Medical Sciences, University of Groningen, The Netherlands
    Mol Biol Cell 9:599-609. 1998
  7. pmc Efficient cationic lipid-mediated delivery of antisense oligonucleotides into eukaryotic cells: down-regulation of the corticotropin-releasing factor receptor
    F Shi
    Department of Membrane Cell Biology, University of Groningen, Faculty of Medical Sciences, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Nucleic Acids Res 29:2079-87. 2001
  8. ncbi request reprint Gene delivery by cationic lipids: in and out of an endosome
    D Hoekstra
    Department of Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochem Soc Trans 35:68-71. 2007
  9. ncbi request reprint Molecular shape of the cationic lipid controls the structure of cationic lipid/dioleylphosphatidylethanolamine-DNA complexes and the efficiency of gene delivery
    J Smisterová
    Department of Membrane Cell Biology, University of Groningen, Faculty of Medical Sciences, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Biol Chem 276:47615-22. 2001
  10. ncbi request reprint Membrane fusion induced by 11-mer anionic and cationic peptides: a structure-function study
    E I Pecheur
    Department of Physiological Chemistry, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochemistry 37:2361-71. 1998

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Membrane dynamics and cell polarity: the role of sphingolipids
    Dick Hoekstra
    University of Groningen, Department of Membrane Cell Biology, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Lipid Res 44:869-77. 2003
    ..Here, a brief summary is presented of some recent developments in this field, with a particular emphasis on raft assembly and membrane transport in the establishment of membrane polarity...
  2. ncbi request reprint The subapical compartment: a traffic center in membrane polarity development
    Dick Hoekstra
    Department of Membrane Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Cell Sci 117:2183-92. 2004
    ..Furthermore, subcompartmentalization of the SAC appears to be key to its various functions...
  3. ncbi request reprint On the mechanism of protein-induced membrane fusion: from model to biological membranes
    Dick Hoekstra
    University of Groningen, Department of Membrane Cell Biology, Ant Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Cell Mol Biol Lett 7:231-2. 2002
  4. ncbi request reprint Lipid trafficking and sorting: how cholesterol is filling gaps
    D Hoekstra
    Department of Physiological Chemistry, University of Groningen, Groningen, 9713 AV, The Netherlands
    Curr Opin Cell Biol 12:496-502. 2000
    ..Recently, several proteins have been identified that play a role in the flow and sorting of all major lipid classes...
  5. pmc PDMP blocks brefeldin A-induced retrograde membrane transport from golgi to ER: evidence for involvement of calcium homeostasis and dissociation from sphingolipid metabolism
    J W Kok
    Department of Physiological Chemistry, University of Groningen, Groningen Institute for Drug Studies GIDS, 9713 AV Groningen, The Netherlands
    J Cell Biol 142:25-38. 1998
    ..Thus, the biological effects of PDMP revealed a relation between three important physiological processes of multidrug resistance, calcium homeostasis, and membrane flow in the ER/ Golgi system...
  6. pmc An apical-type trafficking pathway is present in cultured oligodendrocytes but the sphingolipid-enriched myelin membrane is the target of a basolateral-type pathway
    H de Vries
    Department of Physiological Chemistry, Faculty of Medical Sciences, University of Groningen, The Netherlands
    Mol Biol Cell 9:599-609. 1998
    ..These remarkable results emphasize that polarity and regulation of membrane transport in cultured OLG display features that are quite different from those in polarized cells...
  7. pmc Efficient cationic lipid-mediated delivery of antisense oligonucleotides into eukaryotic cells: down-regulation of the corticotropin-releasing factor receptor
    F Shi
    Department of Membrane Cell Biology, University of Groningen, Faculty of Medical Sciences, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Nucleic Acids Res 29:2079-87. 2001
    ....
  8. ncbi request reprint Gene delivery by cationic lipids: in and out of an endosome
    D Hoekstra
    Department of Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochem Soc Trans 35:68-71. 2007
    ..To further clarify molecular mechanisms and to appreciate and overcome intracellular hurdles in lipoplex-mediated gene delivery, quantification of distinct steps in overall transfection and proper model systems are required...
  9. ncbi request reprint Molecular shape of the cationic lipid controls the structure of cationic lipid/dioleylphosphatidylethanolamine-DNA complexes and the efficiency of gene delivery
    J Smisterová
    Department of Membrane Cell Biology, University of Groningen, Faculty of Medical Sciences, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Biol Chem 276:47615-22. 2001
    ..We conclude that in the DOPE-containing complexes the molecular shape and the nonbilayer preferences of the cationic lipid control the topology of the lipoplex and thereby the transfection efficiency...
  10. ncbi request reprint Membrane fusion induced by 11-mer anionic and cationic peptides: a structure-function study
    E I Pecheur
    Department of Physiological Chemistry, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochemistry 37:2361-71. 1998
    ..The data also reveal a certain degree of sequence specificity in WAE-induced fusion...
  11. pmc Reconstitution of membrane proteins into giant unilamellar vesicles via peptide-induced fusion
    N Kahya
    Ultrafast Laser and Spectroscopy Laboratory, Optical Sciences, Materials Science Centre, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Biophys J 81:1464-74. 2001
    ..2 microm(2)/s. The current procedure offers new opportunities to address issues related to membrane-protein structure and dynamics in a close-to-native state...
  12. pmc Ceramide transport from endoplasmic reticulum to Golgi apparatus is not vesicle-mediated
    J W Kok
    University of Groningen, Department of Physiological Chemistry, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochem J 333:779-86. 1998
    ..These results indicate that [14C]Cer is transferred from ER to Golgi by a non-vesicular mechanism...
  13. ncbi request reprint Cationic lipid-mediated transfection in vitro and in vivo (review)
    S Audouy
    Department of Membrane Cell Biology, Faculty of Medical Sciences, University of Groningen, The Netherlands
    Mol Membr Biol 18:129-43. 2001
    ..Here, most recent advances in cationic lipid-mediated gene delivery are discussed from such a perspective...
  14. ncbi request reprint Membrane domains and polarized trafficking of sphingolipids
    O Maier
    Department of Membrane Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Semin Cell Dev Biol 12:149-61. 2001
    ....
  15. ncbi request reprint On the mechanism of cationic amphiphile-mediated transfection. To fuse or not to fuse: is that the question?
    I S Zuhorn
    Department of Membrane Cell Biology, Faculty of Medical Sciences, University of Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    J Membr Biol 189:167-79. 2002
    ..Ultimately, cationic lipids may be used in gene therapeutic protocols...
  16. ncbi request reprint The function of neurofascin155 in oligodendrocytes is regulated by metalloprotease-mediated cleavage and ectodomain shedding
    Olaf Maier
    University Medical Center Groningen, University of Groningen, Department of Cell Biology Section Membrane Cell Biology, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Exp Cell Res 312:500-11. 2006
    ....
  17. ncbi request reprint Leukemia inhibitory factor is produced by myelin-reactive T cells from multiple sclerosis patients and protects against tumor necrosis factor-alpha-induced oligodendrocyte apoptosis
    Joris Vanderlocht
    Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Hasselt University, Diepenbeek, Belgium
    J Neurosci Res 83:763-74. 2006
    ..This study emphasizes that secretion of LIF may contribute to the neuroprotective effects of autoreactive T cells...
  18. ncbi request reprint Calmodulin modulates hepatic membrane polarity by protein kinase C-sensitive steps in the basolateral endocytic pathway
    Donatienne Tyteca
    Department of Cell Biology Section Membrane Cell Biology, University Medical Center Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Exp Cell Res 310:293-302. 2005
    ..This interference, although not affecting endocytosis as such, compromises cell polarity by impeding membrane trafficking from early endosomes to the apical membrane...
  19. ncbi request reprint Alteration of the extracellular matrix interferes with raft association of neurofascin in oligodendrocytes. Potential significance for multiple sclerosis?
    Olaf Maier
    Department of Membrane Cell Biology, University of Groningen, Groningen, The Netherlands
    Mol Cell Neurosci 28:390-401. 2005
    ..The results suggest that the association of NF155 to microdomains in the oligodendrocyte membrane is required for its participation in intermolecular interactions, which are important for myelination and/or myelin integrity...
  20. ncbi request reprint Exosome secretion: the art of reutilizing nonrecycled proteins?
    Aude de Gassart
    UMR CNRS 5539, Universite Montpellier II, cc107, 34095 Montpellier, France
    Traffic 5:896-903. 2004
    ..These considerations are mirrored in the context of current knowledge on the mechanism of protein sorting for degradation in lysosomes, and the hijacking of such mechanisms by some retroviruses for particle budding...
  21. pmc Oncostatin M-stimulated apical plasma membrane biogenesis requires p27(Kip1)-regulated cell cycle dynamics
    Sven C D Van IJzendoorn
    Department of Membrane Cell Biology, University of Groningen, 9713 AV, Groningen, The Netherlands
    Mol Biol Cell 15:4105-14. 2004
    ....
  22. pmc Polarized membrane traffic and cell polarity development is dependent on dihydroceramide synthase-regulated sphinganine turnover
    Sven C D Van IJzendoorn
    Department of Cell Biology Section Membrane Cell Biology, University of Groningen, 9713 AV Groningen, The Netherlands
    Mol Biol Cell 15:4115-24. 2004
    ....
  23. pmc Rho kinase, myosin-II, and p42/44 MAPK control extracellular matrix-mediated apical bile canalicular lumen morphogenesis in HepG2 cells
    Hilde Herrema
    Membrane Cell Biology and Electron Microscopy, Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
    Mol Biol Cell 17:3291-303. 2006
    ....
  24. pmc Efficient trafficking of MDR1/P-glycoprotein to apical canalicular plasma membranes in HepG2 cells requires PKA-RIIalpha anchoring and glucosylceramide
    Kacper A Wojtal
    Section of Membrane Cell Biology, Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
    Mol Biol Cell 17:3638-50. 2006
    ....
  25. doi request reprint cAMP-dependent protein kinase A and the dynamics of epithelial cell surface domains: moving membranes to keep in shape
    Kacper A Wojtal
    Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland
    Bioessays 30:146-55. 2008
    ..Here, we review recent developments with regard to the role of cAMP/PKA in the regulation of intracellular membrane trafficking in relation to the dynamics of epithelial surface domains...
  26. doi request reprint Polarity development in oligodendrocytes: sorting and trafficking of myelin components
    Olaf Maier
    Department of Cell Biology Section Membrane Cell Biology, University Medical Center Groningen, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Mol Neurosci 35:35-53. 2008
    ....
  27. ncbi request reprint Sorting signals and regulation of cognate basolateral trafficking in myelin biogenesis
    Bert Klunder
    University Medical Center Groningen, University of Groningen, Department of Cell Biology, Section of Membrane Cell Biology, Groningen, The Netherlands
    J Neurosci Res 86:1007-16. 2008
    ..These data imply that several distinctly regulated pathways operate in myelin sheet directed-transport that at least partly rely on a cognate basolateral sorting signal...
  28. pmc Anchoring of protein kinase A-regulatory subunit IIalpha to subapically positioned centrosomes mediates apical bile canalicular lumen development in response to oncostatin M but not cAMP
    Kacper A Wojtal
    Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Mol Biol Cell 18:2745-54. 2007
    ..The results also imply that multiple PKA-mediated signaling pathways control apical lumen development and that subapical centrosome positioning is important in some of these pathways...
  29. ncbi request reprint Reduced raft-association of NF155 in active MS-lesions is accompanied by the disruption of the paranodal junction
    Olaf Maier
    Department of Cell Biology Section Membrane Cell Biology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Glia 55:885-95. 2007
    ....
  30. ncbi request reprint Fibronectin impedes "myelin" sheet-directed flow in oligodendrocytes: a role for a beta 1 integrin-mediated PKC signaling pathway in vesicular trafficking
    Zuzana Siskova
    Department of Membrane Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Mol Cell Neurosci 33:150-9. 2006
    ..e., that leakage of fibronectin across the blood-brain barrier may impede myelination by interference with intracellular myelin sheet-directed membrane transport...
  31. ncbi request reprint Rafts in oligodendrocytes: evidence and structure-function relationship
    Ellen Gielen
    Biomedical Research Institute, Hasselt University and Transnationale Universiteit Limburg, Agoralaan, B 3590 Diepenbeek, Belgium
    Glia 54:499-512. 2006
    ..The current picture of rafts in oligodendrocytes is mainly based on detergent methods. The robustness of such data is discussed and alternative methods that may provide complementary data are indicated...
  32. doi request reprint IGF binding protein alterations on periplaque oligodendrocytes in multiple sclerosis: implications for remyelination
    Nadine Wilczak
    Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    Neurochem Int 52:1431-5. 2008
    ....
  33. pmc Cell polarity development and protein trafficking in hepatocytes lacking E-cadherin/beta-catenin-based adherens junctions
    Delphine Théard
    Section of Membrane Cell Biology, Department of Cell Biology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
    Mol Biol Cell 18:2313-21. 2007
    ..In addition, we suggest a possible requirement for E-cadherin/beta-catenin-based adherens junctions with regard to the indirect apical trafficking of specific proteins in hepatocytes...
  34. ncbi request reprint Sphingolipid trafficking and protein sorting in epithelial cells
    Tounsia Ait Slimane
    University of Groningen, Department of Membrane Cell Biology, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    FEBS Lett 529:54-9. 2002
    ..Next to the trans Golgi network, a subapical compartment called SAC or common endosome appears instrumental in regulating these sorting events...
  35. ncbi request reprint Spatial organization of bacteriorhodopsin in model membranes. Light-induced mobility changes
    Nicoletta Kahya
    Ultrafast Laser and Spectroscopy Laboratory, Optical Sciences, Materials Science Centre, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    J Biol Chem 277:39304-11. 2002
    ..These observations are fully supported by freeze-fracture electron microscopy, and the size of the clusters during photoactivation was estimated to consist of two or three trimers...
  36. ncbi request reprint Phospholipid species act as modulators in p97/p47-mediated fusion of Golgi membranes
    Eve Isabelle Pécheur
    Department of Membrane Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochemistry 41:9813-23. 2002
    ..We therefore propose that at physiological conditions PE-induced conformational changes in p97/p47 are relevant in triggering this activity...
  37. ncbi request reprint Trans-Golgi network and subapical compartment of HepG2 cells display different properties in sorting and exiting of sphingolipids
    Olaf Maier
    Department of Membrane Cell Biology, Faculty of Medical Sciences, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Biol Chem 278:164-73. 2003
    ..The results indicate that in HepG2 cells sphingolipids are mainly sorted in the SAC membrane and that the release of SM from SAC and TGN is differentially regulated...
  38. pmc Oncostatin M regulates membrane traffic and stimulates bile canalicular membrane biogenesis in HepG2 cells
    Johanna M Van Der Wouden
    Department of Membrane Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands
    EMBO J 21:6409-18. 2002
    ..These data provide a clue for a molecular mechanism that couples the biogenesis of an apical plasma membrane domain to the regulation of intracellular transport in response to an extracellular, basolaterally localized stimulus...
  39. ncbi request reprint In search of lipid translocases and their biological functions
    Dick Hoekstra
    Department of Membrane Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Dev Cell 4:8-9. 2003
    ..Recent work identified novel lipid translocators in yeast, and their activity was functionally correlated to endocytosis, thus boosting investigations on identity, mechanism, and function of lipid translocases...
  40. ncbi request reprint Membrane fusion induced by the major lipid-binding domain of the cytoskeletal protein talin
    Gerhard Isenberg
    Department of Biophysics E22, Technical University Munich, James Franck Str, D 85748 Garching, Germany
    Biochem Biophys Res Commun 295:636-43. 2002
    ..This is the first example of a cytoskeletal protein domain that can trigger membrane fusion that might be of importance for understanding membrane targeting and motile events at the leading edge of the cell...
  41. ncbi request reprint Peptide-induced fusion of liposomes
    Eve Isabelle Pécheur
    Department of Physiological Chemistry, Faculty of Medical Sciences, University of Groningen, Groningen, The Netherlands
    Methods Mol Biol 199:31-48. 2002
  42. ncbi request reprint Adhesion receptors mediate efficient non-viral gene delivery
    Inge S Zuhorn
    BiOMaDe Technology Foundation, Nijenborgh, Groningen, The Netherlands
    Mol Ther 15:946-53. 2007
    ..Moreover, the finding that adhesion receptors mediate efficient non-viral gene delivery paves the way for the optimization of (standard) transfection procedures as well as ex vivo gene therapy protocols using non-viral vectors...
  43. ncbi request reprint Insulin-like growth factor-binding protein 6 inhibits survival and differentiation of rat oligodendrocyte precursor cells
    Nicole M Kühl
    Department of Neurology, Academic Hospital Groningen, Groningen, The Netherlands
    Glia 44:91-101. 2003
    ..In addition, IGFBP-6 reduced the IGF-stimulated expression of two myelin proteins, CNPase and MAG. Taken together, the data show that IGFBP-6 is a new negative effector of oligodendrocyte survival and differentiation...
  44. ncbi request reprint Role of rab proteins in epithelial membrane traffic
    Sven C D Van IJzendoorn
    Department of Membrane Cell Biology, University of Groningen, Groningen 9713AV, The Netherlands
    Int Rev Cytol 232:59-88. 2003
    ..This review discusses the role of rabs in epithelial membrane transport...
  45. ncbi request reprint Adhesion characteristics and stability assessment of lectin-modified liposomes for site-specific drug delivery
    Heike Bakowsky
    Department of Physiological Chemistry, Medical Faculty, Martin Luther University Halle Wittenberg, 06114 Halle, Germany
    Biochim Biophys Acta 1778:242-9. 2008
    ..Moreover, our studies enabled us to establish quartz crystal microbalance and atomic force microscopy as powerful and complementary methods to characterize adhesion properties of targeted drug delivery systems...
  46. ncbi request reprint Lipoplex-mediated transfection of mammalian cells occurs through the cholesterol-dependent clathrin-mediated pathway of endocytosis
    Inge S Zuhorn
    Department of Membrane Cell Biology, University of Groningen, A Deusinglaan 1, Groningen 9713 AV, The Netherlands
    J Biol Chem 277:18021-8. 2002
    ....
  47. ncbi request reprint The influence of physicochemical parameters on the efficacy of non-viral DNA transfection complexes: a comparative study
    Carsten Kneuer
    Department of Pharmaceutical Technology, Philipps University Marburg, 35032 Marburg, Germany
    J Nanosci Nanotechnol 6:2776-82. 2006
    ..In conclusion, transfection efficiency (i) seems to require a positive or neutral zeta potential, (ii) is depending on size, e.g., is higher for smaller particles, and (iii) requires a vector that is stable in serum...
  48. ncbi request reprint Lipoplex assembly visualized by atomic force microscopy
    Volker Oberle
    Department of Membrane Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Methods Enzymol 373:281-97. 2003
  49. ncbi request reprint Insulin-like growth factor binding proteins-1 and -2 differentially inhibit rat oligodendrocyte precursor cell survival and differentiation in vitro
    Nicole M Kühl
    Department Membrane Cell Biology, University Groningen, Groningen, The Netherlands
    J Neurosci Res 69:207-16. 2002
    ..Accordingly, the role of IGFBPs should be explicitly taken into account when investigating IGF-1 effects on oligodendrocytes, especially in the context of therapeutic purposes...
  50. ncbi request reprint Interference of serum with lipoplex-cell interaction: modulation of intracellular processing
    Inge S Zuhorn
    University of Groningen, Department of Membrane Cell Biology, The Netherlands
    Biochim Biophys Acta 1560:25-36. 2002
    ..By extrapolation, we propose that serum may regulate these parameters in an amphiphile-dependent manner, by complex 'penetration' and modulation of DNA conformation...
  51. ncbi request reprint Fluorescent lipid probes: some properties and applications (a review)
    Olaf Maier
    Department of Membrane Cell Biology, Faculty of Medical Sciences, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Chem Phys Lipids 116:3-18. 2002
    ..Here we provide a brief overview of the application of several lipid probes in cell biological and biophysical research, and critically analyze their validity in the various fields...
  52. ncbi request reprint Gene delivery by cationic lipid vectors: overcoming cellular barriers
    Inge S Zuhorn
    Department of Cell Biology, Section Membrane Cell Biology, University Medical Center Groningen, Groningen, The Netherlands
    Eur Biophys J 36:349-62. 2007
    ....
  53. ncbi request reprint Gene transfer by means of lipo- and polyplexes: role of clathrin and caveolae-mediated endocytosis
    Joanna Rejman
    Institute for Experimental Treatment of Cystic Fibrosis, San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milano, Italy
    J Liposome Res 16:237-47. 2006
    ....
  54. ncbi request reprint Effective intracellular delivery of oligonucleotides in order to make sense of antisense
    Fuxin Shi
    Department of Membrane Cell Biology, Faculty of Medical Sciences, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Control Release 97:189-209. 2004
    ..Here, consideration will also be given to antisense design and chemistry, and the challenge of extra- and intracellular barriers to be overcome in the delivery process...
  55. pmc Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis
    Joanna Rejman
    Department of Membrane Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochem J 377:159-69. 2004
    ..200 nm, and kinetic parameters may determine the almost exclusive internalization of such particles along this pathway rather than via caveolae...
  56. ncbi request reprint Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection efficiency
    Inge S Zuhorn
    Department of Membrane Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Mol Ther 11:801-10. 2005
    ....
  57. ncbi request reprint Sunfish cationic amphiphiles: toward an adaptative lipoplex morphology
    Marco Scarzello
    Physical Organic Chemistry Unit, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    J Am Chem Soc 127:10420-9. 2005
    ....
  58. ncbi request reprint Membrane dynamics and the regulation of epithelial cell polarity
    Johanna M Van Der Wouden
    Department of Membrane Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands
    Int Rev Cytol 226:127-64. 2003
    ....
  59. pmc Raft-mediated trafficking of apical resident proteins occurs in both direct and transcytotic pathways in polarized hepatic cells: role of distinct lipid microdomains
    Tounsia Ait Slimane
    Department of Membrane Cell Biology, University of Groningen, The Netherlands
    Mol Biol Cell 14:611-24. 2003
    ..Furthermore, raft-cargo likely distinguishing single vs. multispanning membrane anchors, rather than rafts per se (co)determine the sorting pathway...
  60. ncbi request reprint In vivo characteristics of cationic liposomes as delivery vectors for gene therapy
    Sandrine A L Audouy
    Department of Membrane Cell Biology, Groningen University Institute for Drug Exploration, Groningen, The Netherlands
    Pharm Res 19:1599-605. 2002
    ..Increasing understanding of lipoplex behavior and gene transfer capacities in vivo offers new possibilities to enhance their efficiency and paves the path to more extensive clinical applications in the future...
  61. ncbi request reprint Transfection mediated by pH-sensitive sugar-based gemini surfactants; potential for in vivo gene therapy applications
    Luc Wasungu
    Department of Cell Biology Section Membrane Cell Biology, University Medical Center Groningen, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    J Mol Med (Berl) 84:774-84. 2006
    ..This potential of avoiding 'preliminary capture' in the lungs may, thus, be further exploited in developing devices for specific targeting of gemini lipoplexes...
  62. ncbi request reprint Characterization and transfection properties of lipoplexes stabilized with novel exchangeable polyethylene glycol-lipid conjugates
    Joanna Rejman
    Department of Membrane Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochim Biophys Acta 1660:41-52. 2004
    ..Lipoplexes targeted to cell-surface epithelial glycoprotein 2, by means of a covalently coupled monoclonal antibody, were specifically internalized by cells expressing this antigen...
  63. ncbi request reprint Lipoplexes formed from sugar-based gemini surfactants undergo a lamellar-to-micellar phase transition at acidic pH. Evidence for a non-inverted membrane-destabilizing hexagonal phase of lipoplexes
    Luc Wasungu
    Department of Cell Biology Section Membrane Cell Biology, University Medical Center Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochim Biophys Acta 1758:1677-84. 2006
    ....
  64. ncbi request reprint Cationic lipids, lipoplexes and intracellular delivery of genes
    Luc Wasungu
    Department of Cell Biology, Section Membrane Cell Biology, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Control Release 116:255-64. 2006
    ..The effect of DOPE on lipoplex assembly and the relevance of the structural properties of the lipoplexes in destabilizing endosomal membranes and mediating endosomal escape of DNA will be discussed...