C J Heijnen

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. ncbi The importance of being receptive
    C J Heijnen
    Department of Pediatric Immunology, Wilhelmina Children s Hospital of the University Medical Center Utrecht, Netherlands
    J Neuroimmunol 100:197-202. 1999
  2. ncbi Role and modulation of G protein-coupled receptor signaling in inflammatory processes
    Maria Stella Lombardi
    Department of Immunology, University Medical Center Utrecht, The Netherlands
    Crit Rev Immunol 22:141-63. 2002
  3. ncbi Respiratory distress syndrome-associated inflammation is related to early but not late peri/intraventricular hemorrhage in preterm infants
    Tannette G Krediet
    Department of Neonatology and Laboratory of Psychoneuroimmunology and Perinatology, Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
    J Pediatr 148:740-6. 2006
  4. ncbi Cytokines regulate alpha(1)-adrenergic receptor mRNA expression in human monocytic cells and endothelial cells
    Cobi J Heijnen
    Laboratory for Psychoneuroimmunology, Department of Immunology, University Medical Center Utrecht, Room KC03 068 0, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    J Neuroimmunol 125:66-72. 2002
  5. ncbi Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis
    M S Lombardi
    Department of Immunology, University Hospital for Children and Youth, Het Wilhelmina Kinderziekenhuis, 3584 EA Utrecht, The Netherlands
    FASEB J 13:715-25. 1999
  6. ncbi Disturbed neuroendocrine-immune interactions in chronic fatigue syndrome
    A Kavelaars
    Department of Pediatric Immunology, Wilhelmina Children s Hospital of the University Medical Center Utrecht, The Netherlands
    J Clin Endocrinol Metab 85:692-6. 2000
  7. ncbi Neuroendocrine mediators up-regulate alpha1b- and alpha1d-adrenergic receptor subtypes in human monocytes
    C Rouppe van der Voort
    Department of Immunology, University Hospital for Children and Youth Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands
    J Neuroimmunol 95:165-73. 1999
  8. ncbi Beta 2-adrenergic activation enhances interleukin-8 production by human monocytes
    A Kavelaars
    Department of Immunology, University Hospital for Children and Youth Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands
    J Neuroimmunol 77:211-6. 1997
  9. ncbi Neonatal dexamethasone treatment induces long-lasting changes in T-cell receptor vbeta repertoire in rats
    J M Bakker
    Department of Pediatric Immunology, KC 03 068 0, Wilhelmina Children s Hospital of the University Medical Center Utrecht, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    J Neuroimmunol 112:47-54. 2001
  10. ncbi Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune system
    M S Lombardi
    Department of Pediatric Immunology, Wilhelmina Children s Hospital of the University Medical Center Utrecht, Utrecht, The Netherlands
    J Immunol 166:1635-40. 2001

Collaborators

  • A Kavelaars
  • R E Schmidt
  • C Rouppe van der Voort
  • J M Bakker
  • M S Lombardi
  • F van Bel
  • B C J M Fauser
  • R J Benschop
  • J M Koolhaas
  • J W Bijlsma
  • Graham Aw Rook
  • M J C Eijkemans
  • John Dulos
  • Robert Lefkowitz
  • Annemarie Ledeboer
  • Richard Premont
  • Willem van Eden
  • Enrique Espinosa
  • Anne Vroon
  • Maike ter Wolbeek
  • Lorenz J P van Doornen
  • Evelyn R W van den Tweel
  • Frans B Plötz
  • Floris Groenendaal
  • Wendy Kleibeuker
  • Paula M C Mommersteeg
  • Federico Mayor
  • Manfred Schedlowski
  • Niels Eijkelkamp
  • Cora H A Nijboer
  • H J C Bonestroo
  • Jitske Zijlstra
  • Pieter M Cobelens
  • C M Boomsma
  • Cora H Nijboer
  • Rosa Karemaker
  • Jan Willem Kuiper
  • Michael J May
  • Petronila Penela
  • Maria Jurado-Pueyo
  • Cristina Murga
  • Jan H Houtveen
  • Tannette G Krediet
  • M Carmen Jiménez-Sainz
  • Volker Limmroth
  • Marc G Caron
  • Katharina Haerter
  • Harriet A Vreugdenhil
  • Hans Van Vught
  • Harriet A E Vreugdenhil
  • Marc A T Teunis
  • Louis Bont
  • P M Cobelens
  • C E Hack
  • C H A Nijboer
  • C T J van Velthoven
  • H van Middendorp
  • E G Lentjes
  • N S Macklon
  • A B Johan Groeneveld
  • Wim Baerts
  • Ivette Aymerich
  • Francisco Sanchez-Madrid
  • Rosanna R Vaschetto
  • Marijke Tersteeg-Kamperman
  • Onno E Janssen
  • Pieter Sipkema
  • W Kuis
  • Gerard H A Visser
  • Hans W M Niessen
  • Amanda M G Versteilen
  • Sylvia Veen
  • Olga Barreiro
  • Catalina Ribas
  • Jannie F Samsom
  • Elise M van de Putte
  • Linda R Watkins
  • Steven F Maier
  • Anna M Aragay
  • Beate F Krakstad
  • Hendrik J Vreman
  • Cora Nijboer
  • Anne Marie van Dam
  • Marion U Goebel
  • Sigrid Elsenbruch
  • S Kamphuis
  • Burkhard Lachmann
  • Adrianus J van Vught
  • Koos J Jansen
  • Jack J Haitsma

Detail Information

Publications57

  1. ncbi The importance of being receptive
    C J Heijnen
    Department of Pediatric Immunology, Wilhelmina Children s Hospital of the University Medical Center Utrecht, Netherlands
    J Neuroimmunol 100:197-202. 1999
    ..This review describes the role of regulated expression and function of receptors for hormones and neurotransmitters within the immune system in neuroendocrine-immune communication...
  2. ncbi Role and modulation of G protein-coupled receptor signaling in inflammatory processes
    Maria Stella Lombardi
    Department of Immunology, University Medical Center Utrecht, The Netherlands
    Crit Rev Immunol 22:141-63. 2002
    ..Since altered regulation of GPCR signaling can influence disease states, the molecules involved in this process can also represent attractive therapeutic targets...
  3. ncbi Respiratory distress syndrome-associated inflammation is related to early but not late peri/intraventricular hemorrhage in preterm infants
    Tannette G Krediet
    Department of Neonatology and Laboratory of Psychoneuroimmunology and Perinatology, Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
    J Pediatr 148:740-6. 2006
    ....
  4. ncbi Cytokines regulate alpha(1)-adrenergic receptor mRNA expression in human monocytic cells and endothelial cells
    Cobi J Heijnen
    Laboratory for Psychoneuroimmunology, Department of Immunology, University Medical Center Utrecht, Room KC03 068 0, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    J Neuroimmunol 125:66-72. 2002
    ..Our data demonstrate that TNF-alpha and IL-1beta can regulate expression of alpha(1)-AR mRNA and that cytokine regulation of alpha(1)-AR expression is subtype- and tissue-specific...
  5. ncbi Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis
    M S Lombardi
    Department of Immunology, University Hospital for Children and Youth, Het Wilhelmina Kinderziekenhuis, 3584 EA Utrecht, The Netherlands
    FASEB J 13:715-25. 1999
    ....
  6. ncbi Disturbed neuroendocrine-immune interactions in chronic fatigue syndrome
    A Kavelaars
    Department of Pediatric Immunology, Wilhelmina Children s Hospital of the University Medical Center Utrecht, The Netherlands
    J Clin Endocrinol Metab 85:692-6. 2000
    ..Based on these data, we suggest CFS should be viewed as a disease of deficient neuroendocrine-immune communication...
  7. ncbi Neuroendocrine mediators up-regulate alpha1b- and alpha1d-adrenergic receptor subtypes in human monocytes
    C Rouppe van der Voort
    Department of Immunology, University Hospital for Children and Youth Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands
    J Neuroimmunol 95:165-73. 1999
    ..This study describes for the first time regulated expression of alpha1-AR subtypes in human monocytes...
  8. ncbi Beta 2-adrenergic activation enhances interleukin-8 production by human monocytes
    A Kavelaars
    Department of Immunology, University Hospital for Children and Youth Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands
    J Neuroimmunol 77:211-6. 1997
    ..We conclude that enhancement of IL-8 production is one of the pathways via which beta 2-adrenergic agonists such as catecholamines can influence inflammatory responses...
  9. ncbi Neonatal dexamethasone treatment induces long-lasting changes in T-cell receptor vbeta repertoire in rats
    J M Bakker
    Department of Pediatric Immunology, KC 03 068 0, Wilhelmina Children s Hospital of the University Medical Center Utrecht, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    J Neuroimmunol 112:47-54. 2001
    ..In conclusion, changes in T cell Vbeta repertoire after neonatal glucocorticoid treatment may contribute to altered immune reactivity in later life...
  10. ncbi Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune system
    M S Lombardi
    Department of Pediatric Immunology, Wilhelmina Children s Hospital of the University Medical Center Utrecht, Utrecht, The Netherlands
    J Immunol 166:1635-40. 2001
    ..In conclusion, we demonstrate in this study, for the first time, that an inflammatory process in vivo induces a tissue-specific down-regulation of GRKs in the immune system...
  11. ncbi Expression of preproenkephalin mRNA and production and secretion of enkephalins by human thymocytes
    A Kavelaars
    Department of Pediatric Immunology, Room KC 03 068 0, Wilhelmina Children Hospital, University Medical Center Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Ann N Y Acad Sci 917:778-83. 2000
    ..Cytokines IL-1 beta and IL-10 increase the expression of PPE mRNA in 50% of the thymuses tested, whereas IFN-gamma does not induce changes in PPE mRNA expression...
  12. ncbi Noradrenaline induces phosphorylation of ERK-2 in human peripheral blood mononuclear cells after induction of alpha(1)-adrenergic receptors
    C Rouppe van der Voort
    Department of Pediatric Immunology, Wilhelmina Children Hospital of the University Medical Center Utrecht, Lundlaan 6 3584 EA, Utrecht, The Netherlands
    J Neuroimmunol 108:82-91. 2000
    ..Our results demonstrate that functional alpha(1)-ARs can be induced on PBMCs and that these alpha(1)-ARs mediate NA-induced activation of ERK-2...
  13. pmc The effects of beta-adrenoceptor stimulation on adhesion of human natural killer cells to cultured endothelium
    R J Benschop
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Br J Pharmacol 113:1311-6. 1994
    ..7. Together, these results show that stimulation of beta2-adrenoceptors on NK cells negatively influences their capacity to adhere to EC, and that beta2-adrenoceptors on EC play a negligible role in this phenomenon...
  14. doi Cerebral and hepatic inflammatory response after neonatal hypoxia-ischemia in newborn rats
    H J C Bonestroo
    Laboratory of Neuroimmunology and Developmental Origins of Disease NIDOD, University Medical Center Utrecht, Utrecht, The Netherlands
    Dev Neurosci 35:197-211. 2013
    ..The aim of the present study was to investigate the effect of neonatal HI on the inflammatory response in the liver in comparison to inflammation in the brain...
  15. ncbi Dynamics of mycobacterial HSP65-induced T-cell cytokine expression during oral tolerance induction in adjuvant arthritis
    P M Cobelens
    Department of Immunology, Wilhelmina Children s Hospital of the University Medical Center Utrecht, The Netherlands
    Rheumatology (Oxford) 41:775-9. 2002
    ..To investigate whether oral administration of mycobacterial heat-shock protein 65 (HSP65) during adjuvant arthritis (AA) induces regulatory cells and cytokines...
  16. ncbi The reactivity of the cardiovascular system and immunomodulation by catecholamines in juvenile chronic arthritis
    A Kavelaars
    Department of Immunology, University Hospital for Children, Utrecht, The Netherlands
    Ann N Y Acad Sci 840:698-704. 1998
    ..In addition, catecholamines induce the production of IL-6 by leukocytes of these patients, via triggering of alpha 1-adrenergic receptors. Healthy controls do not express functional alpha 1-adrenergic receptors...
  17. ncbi Neonatal dexamethasone treatment increases susceptibility to experimental autoimmune disease in adult rats
    J M Bakker
    Departments of Pediatric Immunology and Neonatology, Wilhelmina Children s Hospital of the University Medical Center, and Rudolf Magnus Institute, Utrecht, The Netherlands
    J Immunol 165:5932-7. 2000
    ..In view of the frequent clinical application of glucocorticoids to preterm infants, our data demonstrate that neonatal glucocorticoid treatment may be a risk factor for the development of (auto)immune disease in man...
  18. ncbi T helper 2 cytokines induce preproenkephalin mRNA expression and proenkephalin A in human peripheral blood mononuclear cells
    S Kamphuis
    Department of Immunology, University Hospital for Children and Youth, Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands
    J Neuroimmunol 79:91-9. 1997
    ..IL-4 and IL-10 do not induce PPE mRNA via the same pathways. We could observe that PKA is involved in IL-4 mediated PPE mRNA induction, whereas IL-10 apparently uses another route...
  19. ncbi Individual behavioral characteristics of wild-type rats predict susceptibility to experimental autoimmune encephalomyelitis
    A Kavelaars
    Department of Immunology, University Children Hospital, Het Wilhelmina Kinderziekenhuis, 3051 CA, Utrecht, The Netherlands
    Brain Behav Immun 13:279-86. 1999
    ..These data, obtained in an unselected strain of wild-type rats, demonstrate that behavioral response patterns of individual animals can in part predict susceptibility to autoimmune disease...
  20. doi Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF
    C M Boomsma
    Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, F05 126, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Hum Reprod 24:1427-35. 2009
    ....
  21. ncbi Neonatal glucocorticoids and the developing brain: short-term treatment with life-long consequences?
    J M Bakker
    Dept of Neonatology, Wilhelmina Children s Hospital of the University Medical Center, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    Trends Neurosci 24:649-53. 2001
    ..Altered functioning of the hypothalamo-pituitary-adrenal axis, and/or changes at higher brain levels might underlie alterations in disease susceptibility...
  22. ncbi Psychological adjustment of adolescent girls with chronic fatigue syndrome
    H van Middendorp
    Department of Pediatric Psychology, University Medical Center Utrecht, Wilhelmina Children's Hospital, The Netherlands
    Pediatrics 107:E35. 2001
    ..Our results on adjustment and coping strategies may be helpful to implement (individual) rehabilitation programs...
  23. ncbi Longitudinal analysis of pro- and anti-inflammatory cytokine production in severely fatigued adolescents
    Maike ter Wolbeek
    Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands
    Brain Behav Immun 21:1063-74. 2007
    ..These results show that, although overlap in symptomatology between the general population and patients with CFS was observed, only CFS patients show a skewing of the cytokine balance towards an anti-inflammatory profile...
  24. ncbi CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines
    John Dulos
    University Medical Center Utrecht, The Netherlands
    Arthritis Rheum 52:770-8. 2005
    ..The purpose of this study was to investigate the presence of 7alpha-OH-DHEA in synovial samples and the cytokine regulation of CYP7B activity in fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA)...
  25. ncbi Immune and endocrine function in burnout syndrome
    Paula M C Mommersteeg
    Department of Health Psychology, Utrecht University, Utrecht, The Netherlands
    Psychosom Med 68:879-86. 2006
    ..It is associated with a higher incidence of infections possibly pointing to a compromised immune system. In the present study, endocrine and ex vivo immune function of severe cases of burnout were investigated...
  26. ncbi Ventilator-induced heat shock protein 70 and cytokine mRNA expression in a model of lipopolysaccharide-induced lung inflammation
    Harriet A Vreugdenhil
    Pediatric Intensive Care Unit, University Medical Center Utrecht, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    Intensive Care Med 29:915-22. 2003
    ..To investigate the effect of mechanical ventilation with no PEEP (ZEEP) and 4 cmH(2)O PEEP on heat shock protein 70 (HSP70) and pulmonary inflammatory cytokine expression in a model of lipopolysaccharide (LPS) induced lung inflammation...
  27. ncbi Changes in the G-protein-coupled receptor desensitization machinery during relapsing-progressive experimental allergic encephalomyelitis
    Anne Vroon
    Laboratory for Psychoneuroimmunology, Department of Immunology, University Medical Center Utrecht, Room KC03 068 0, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    J Neuroimmunol 137:79-86. 2003
    ..Downregulation of GRK2 was restricted to the spleen and mesenteric lymph nodes and was not observed in peritoneal macrophages. Furthermore, EAE did not induce alterations in GRK2 expression in heart, liver and pituitary...
  28. ncbi Inhibition of nNOS and iNOS following hypoxia-ischaemia improves long-term outcome but does not influence the inflammatory response in the neonatal rat brain
    Evelyn R W van den Tweel
    Department of Neonatology, Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
    Dev Neurosci 24:389-95. 2002
    ..Combined inhibition of nNOS and iNOS did not induce any change in cytokine expression. We conclude that the long-term neuroprotective effects of combined nNOS and iNOS inhibition were not achieved by an altered cytokine response...
  29. ncbi A role for G protein-coupled receptor kinase 2 in mechanical allodynia
    Wendy Kleibeuker
    University Medical Center Utrecht, Laboratory of Psychoneuroimmunology, KC03 068 0, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    Eur J Neurosci 25:1696-704. 2007
    ..We propose cytokine-induced down-regulation of spinal cord neuronal GRK2 expression as a novel mechanism that contributes to increased neuronal signalling in mechanical allodynia...
  30. ncbi Down-regulation of GRK2 after oxygen and glucose deprivation in rat hippocampal slices: role of the PI3-kinase pathway
    Maria Stella Lombardi
    Laboratory for Psycho neuro immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Neurochem 102:731-40. 2007
    ..In conclusion, OGD-induced phosphoinositide-3-kinase-dependent phosphorylation of GRK2 on Ser670 is a novel mechanism leading to down-regulation of GRK2 protein via a proteasome-dependent pathway...
  31. ncbi Mechanical ventilation alters the immune response in children without lung pathology
    Frans B Plötz
    Pediatric Intensive Care Unit, University Medical Center Utrecht, The Netherlands
    Intensive Care Med 28:486-92. 2002
    ..This study was undertaken to examine the hypothesis that mechanical ventilation in association with anesthesia would alter the cytokine profile in infants without preexisting lung pathology...
  32. ncbi Heterogeneous medically unexplained symptoms and immune function
    Jan H Houtveen
    Department of Clinical and Health Psychology, Utrecht University, Faculty of Social and Behavioural Sciences, P O Box 80 140, 3508 TC Utrecht, The Netherlands
    Brain Behav Immun 21:1075-82. 2007
    ..Nonetheless, no support was found for the hypothesized immunological dysregulation in peripheral blood leukocyte function of MUS patients...
  33. ncbi Physiological changes in GRK2 regulate CCL2-induced signaling to ERK1/2 and Akt but not to MEK1/2 and calcium
    Wendy Kleibeuker
    University Medical Center Utrecht, Laboratory of Psychoneuroimmunology, Utrecht, The Netherlands
    J Neurochem 104:979-92. 2008
    ....
  34. ncbi The HPA-axis and immune function in burnout
    Paula M C Mommersteeg
    Laboratory for Psychoneuroimmunology, Division of Perinatology and Gynaecology, University Medical Center Utrecht, 3508 AB, Utrecht, The Netherlands
    Prog Brain Res 167:281-5. 2008
    ..The increased IL-10 level may be related to an increased sensitivity for infections...
  35. ncbi Mechanical ventilation and multiple organ failure
    Frans B Plötz
    Lancet 361:1654. 2003
  36. pmc G protein-coupled receptor kinase 2 positively regulates epithelial cell migration
    Petronila Penela
    Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Madrid, Spain
    EMBO J 27:1206-18. 2008
    ..Furthermore, decreased GRK2 levels in hemizygous mice result in delayed wound healing rate in vivo, consistent with a physiological role of GRK2 as a regulator of coordinated integrin and GPCR-directed epithelial cell migration...
  37. doi Neonatal dexamethasone treatment for chronic lung disease of prematurity alters the hypothalamus-pituitary-adrenal axis and immune system activity at school age
    Rosa Karemaker
    Department of Neonatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Pediatrics 121:e870-8. 2008
    ..To compare long-term effects of neonatal treatment with dexamethasone or hydrocortisone for chronic lung disease of prematurity on the hypothalamus-pituitary-adrenal axis and the immune response in children at school age...
  38. doi A dual role of the NF-kappaB pathway in neonatal hypoxic-ischemic brain damage
    Cora H Nijboer
    University Medical Center Utrecht, KC03 068 0, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Stroke 39:2578-86. 2008
    ..We hypothesize that timing and duration of NF-kappaB inhibition will be a major factor in determining outcome...
  39. doi Strong neuroprotection by inhibition of NF-kappaB after neonatal hypoxia-ischemia involves apoptotic mechanisms but is independent of cytokines
    Cora H A Nijboer
    University Medical Center Utrecht, Laboratory of Psychoneuroimmunology, Lundlaan 6, KC 03 068 0, 3584 EA Utrecht, The Netherlands
    Stroke 39:2129-37. 2008
    ....
  40. doi Production of endothelin-1 and reduced blood flow in the rat kidney during lung-injurious mechanical ventilation
    Jan Willem Kuiper
    VU Medical Center, Department of Pediatric Intensive Care, P O Box 7057, 1007, Ambsterdam, The Netherlands
    Anesth Analg 107:1276-83. 2008
    ....
  41. ncbi Can nerve damage disrupt neuroendocrine immune homeostasis? Leprosy as a case in point
    Graham A W Rook
    Dept Medical Microbiology, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, 46 Cleveland Street, W1P 6DB, London, UK
    Trends Immunol 23:18-22. 2002
    ....
  42. ncbi Oxidative stress decreases G protein-coupled receptor kinase 2 in lymphocytes via a calpain-dependent mechanism
    Maria Stella Lombardi
    Department of Immunology, Laboratory of Psychoneuroimmunology, University Medical Center, Utrecht, The Netherlands
    Mol Pharmacol 62:379-88. 2002
    ..Moreover, our data demonstrate that oxidative stress may change the functioning of GPCRs via calpain-dependent regulation of GRK2 levels...
  43. ncbi Receptor regulation in neuroendocrine-immune communication: current knowledge and future perspectives
    Cobi J Heijnen
    Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Brain Behav Immun 21:1-8. 2007
    ..Finally, consequences of alterations in GRK2 during (neuro)-inflammatory diseases are discussed...
  44. ncbi Maternal deprivation of rat pups increases clinical symptoms of experimental autoimmune encephalomyelitis at adult age
    Marc A T Teunis
    Laboratory for Psychoneuroimmunology, Department of Immunology, Wilhelmina Children s Hospital of the University Medical Center Utrecht, Utrecht, The Netherlands
    J Neuroimmunol 133:30-8. 2002
    ..We conclude that short-lasting neonatal maternal deprivation of rat pups has long-lasting consequences for macrophage activity and for susceptibility to the inflammatory autoimmune disease EAE...
  45. ncbi Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6
    Annemieke Kavelaars
    Laboratory for Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Immunol 171:6128-34. 2003
    ..In conclusion, GRK6 deficiency leads to prolonged BLT1 signaling and increased neutrophil migration...
  46. ncbi In vitro adrenergic modulation of cellular immune functions in experimental autoimmune encephalomyelitis
    Katharina Haerter
    Department of Medical Psychology, University of Essen Medical School, Hufelandstr 55, 45122 Essen, Germany
    J Neuroimmunol 146:126-32. 2004
    ..To analyze the effects in vitro of alpha- and beta-adrenoceptor agonists on splenocyte proliferation and on proinflammatory cytokine production in splenocytes and peritoneal macrophages (MF) in different stages of EAE...
  47. ncbi Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4
    Anne Vroon
    Laboratory for Psychoneuroimmunology, University Medical Center Utrecht, The Netherlands
    J Leukoc Biol 75:901-9. 2004
    ....
  48. ncbi Hypoxia/ischemia modulates G protein-coupled receptor kinase 2 and beta-arrestin-1 levels in the neonatal rat brain
    Maria Stella Lombardi
    Laboratory for Psychoneuroimmunology, University Medical Center Utrecht, Netherlands
    Stroke 35:981-6. 2004
    ..We analyzed GRK and beta-arrestin expression after cerebral hypoxia/ischemia (HI)...
  49. ncbi Changes in innate and acquired immune responses in mice with targeted deletion of the dopamine transporter gene
    Annemieke Kavelaars
    Laboratory for Psychoneuroimmunology, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht Box KC03 063 0, The Netherlands
    J Neuroimmunol 161:162-8. 2005
    ..In conclusion, we show in the present study that interfering with the dopaminergic system has major consequences for both the acquired and the innate immune response...
  50. ncbi The beta 2-adrenergic agonist salbutamol potentiates oral induction of tolerance, suppressing adjuvant arthritis and antigen-specific immunity
    Pieter M Cobelens
    Department of Immunology, Laboratory for Psychoneuroimmunology, University Medical Center Utrecht, The Netherlands
    J Immunol 169:5028-35. 2002
    ..In conclusion, salbutamol can be of great clinical benefit for the treatment of autoimmune diseases by promoting oral tolerance induction...
  51. ncbi G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis
    Anne Vroon
    Laboratory for Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Immunol 174:4400-6. 2005
    ..We conclude that down-regulation of GRK2 expression may have important consequences for the onset and progression of MS...
  52. ncbi Expression of nitric oxide synthase isoforms and nitrotyrosine formation after hypoxia-ischemia in the neonatal rat brain
    Evelyn R W van den Tweel
    Department of Neonatology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    J Neuroimmunol 167:64-71. 2005
    ..The aim of this study was to analyze changes in expression of nNOS, iNOS and endothelial NOS (eNOS), and nitrotyrosine (NT) formation in proteins in neonatal rats up to 48 h after cerebral hypoxia-ischemia...
  53. pmc G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits
    M Carmen Jiménez-Sainz
    Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Mol Biol Cell 17:25-31. 2006
    ..These results suggest an important role for GRK2 in the control of chemokine induction of ERK activation at the level of the MEK-ERK interface...
  54. ncbi Bilateral molecular changes in a neonatal rat model of unilateral hypoxic-ischemic brain damage
    Evelyn R W van den Tweel
    Department of Neonatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Pediatr Res 59:434-9. 2006
    ..We conclude that during HI, hypoxia is sufficient to regulate multiple molecular mediators that may contribute, but are not sufficient, to induce long-term neuronal damage...
  55. ncbi Natural reinfection with respiratory syncytial virus does not boost virus-specific T-cell immunity
    Louis Bont
    Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
    Pediatr Res 52:363-7. 2002
    ..Moreover, reinfection did not boost RSV-specific T-cell proliferation. To explain both findings, it is hypothesized that RSV-specific T cells fail to expand in vivo upon reinfection...
  56. ncbi GRKs and arrestins: regulators of migration and inflammation
    Anne Vroon
    Department of Psychoneuroimmunology, Room KC03 063 0, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    J Leukoc Biol 80:1214-21. 2006
    ....
  57. doi Glucocorticoid sensitivity of immune cells in severely fatigued adolescent girls: a longitudinal study
    Maike ter Wolbeek
    Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, The Netherlands
    Psychoneuroendocrinology 33:375-85. 2008
    ..These results show that although fatigued participants had severe (comorbid) complaints, only in the case when symptoms persisted, altered GC sensitivity of immune cells was observed...