C E Hack

Summary

Affiliation: University of Amsterdam
Country: The Netherlands

Publications

  1. ncbi Derangements of coagulation and fibrinolysis in infectious diseases
    C Erik Hack
    Sanquin Research, Department of Immunopathology, VU Medical Center, Department of Clinical Chemistry, Amsterdam, The Netherlands
    Contrib Microbiol 10:18-37. 2003
  2. ncbi Cardiovascular secrets of secretory phospholipase A(2)
    C Erik Hack
    Sanquin Research at CLB, Department of Immunopathology, Amsterdam
    Eur J Clin Invest 32:381-2. 2002
  3. ncbi Fibrinolysis in disseminated intravascular coagulation
    C E Hack
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Laboratory for Experimental and Clinical Immunology, University of Amsterdam, The Netherlands
    Semin Thromb Hemost 27:633-8. 2001
  4. ncbi Tissue factor pathway of coagulation in sepsis
    C E Hack
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Department of Clinical Chemistry, Academic Hospital Vrije Universiteit, Amsterdam
    Crit Care Med 28:S25-30. 2000
  5. ncbi Platelet-activating factor antagonist TCV-309 attenuates the induction of the cytokine network in experimental endotoxemia in chimpanzees
    B Kuipers
    Center of Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, University of Amsterdam, The Netherlands
    J Immunol 152:2438-46. 1994
  6. pmc Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees
    T van der Poll
    Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, University of Amsterdam, The Netherlands
    J Exp Med 179:1253-9. 1994
  7. ncbi Cellular origin and procoagulant properties of microparticles in meningococcal sepsis
    R Nieuwland
    Department of Clinical Chemistry, Leiden University Medical Center, Leiden, The Netherlands
    Blood 95:930-5. 2000
  8. ncbi Interleukin-12 induces sustained activation of multiple host inflammatory mediator systems in chimpanzees
    F N Lauw
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 179:646-52. 1999
  9. ncbi Tissue factor pathway inhibitor does not influence inflammatory pathways during human endotoxemia
    E de Jonge
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands
    J Infect Dis 183:1815-8. 2001
  10. ncbi IC14, an anti-CD14 antibody, inhibits endotoxin-mediated symptoms and inflammatory responses in humans
    A Verbon
    Department of Infectious Diseases, Tropical Medicine, and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 166:3599-605. 2001

Detail Information

Publications93

  1. ncbi Derangements of coagulation and fibrinolysis in infectious diseases
    C Erik Hack
    Sanquin Research, Department of Immunopathology, VU Medical Center, Department of Clinical Chemistry, Amsterdam, The Netherlands
    Contrib Microbiol 10:18-37. 2003
  2. ncbi Cardiovascular secrets of secretory phospholipase A(2)
    C Erik Hack
    Sanquin Research at CLB, Department of Immunopathology, Amsterdam
    Eur J Clin Invest 32:381-2. 2002
  3. ncbi Fibrinolysis in disseminated intravascular coagulation
    C E Hack
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Laboratory for Experimental and Clinical Immunology, University of Amsterdam, The Netherlands
    Semin Thromb Hemost 27:633-8. 2001
    ..Hence we suggest that PAI-1 constitutes an important target for therapy in patients with DIC...
  4. ncbi Tissue factor pathway of coagulation in sepsis
    C E Hack
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Department of Clinical Chemistry, Academic Hospital Vrije Universiteit, Amsterdam
    Crit Care Med 28:S25-30. 2000
    ..To review the role of the tissue factor pathway of coagulation in experimental sepsis...
  5. ncbi Platelet-activating factor antagonist TCV-309 attenuates the induction of the cytokine network in experimental endotoxemia in chimpanzees
    B Kuipers
    Center of Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, University of Amsterdam, The Netherlands
    J Immunol 152:2438-46. 1994
    ..PAF does not seem to be an important intermediate factor in endotoxin-induced neutrophilia or neutrophil degranulation...
  6. pmc Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees
    T van der Poll
    Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, University of Amsterdam, The Netherlands
    J Exp Med 179:1253-9. 1994
    ..IL-6 is, however, an important intermediate factor in activation of coagulation in low grade endotoxemia in chimpanzees...
  7. ncbi Cellular origin and procoagulant properties of microparticles in meningococcal sepsis
    R Nieuwland
    Department of Clinical Chemistry, Leiden University Medical Center, Leiden, The Netherlands
    Blood 95:930-5. 2000
    ..These findings may suggest a novel therapeutic approach to combat clinical conditions with excessive coagulation activation...
  8. ncbi Interleukin-12 induces sustained activation of multiple host inflammatory mediator systems in chimpanzees
    F N Lauw
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 179:646-52. 1999
    ..These data may contribute to understanding the role of IL-12 in the pathogenesis of sepsis syndrome and the toxicity found after repeated injections of IL-12...
  9. ncbi Tissue factor pathway inhibitor does not influence inflammatory pathways during human endotoxemia
    E de Jonge
    Department of Intensive Care, Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands
    J Infect Dis 183:1815-8. 2001
    ..Thus, complete prevention of coagulation activation by TFPI does not influence activation of inflammatory pathways during human endotoxemia...
  10. ncbi IC14, an anti-CD14 antibody, inhibits endotoxin-mediated symptoms and inflammatory responses in humans
    A Verbon
    Department of Infectious Diseases, Tropical Medicine, and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 166:3599-605. 2001
    ..These data provide the first proof of principle that blockade of CD14 is associated with reduced LPS responsiveness in humans in vivo...
  11. ncbi Vasoactive side effects of intravenous immunoglobulin preparations in a rat model and their treatment with recombinant platelet-activating factor acetylhydrolase
    W K Bleeker
    CLB, Amsterdam, The Netherlands
    Blood 95:1856-61. 2000
    ..If so, rPAF-AH can be used for the treatment of those adverse reactions. (Blood. 2000;95:1856-1861)..
  12. ncbi Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coli
    M C Minnema
    Sanquin Blood Supply Foundation, Amsterdam, The Netherlands the Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands
    Blood 95:1117-23. 2000
    ..Blood. 2000;95:1117-1123)..
  13. ncbi Proinflammatory effects of IL-10 during human endotoxemia
    F N Lauw
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 165:2783-9. 2000
    ..These data indicate that high-dose IL-10 treatment in patients with inflammatory disorders can be associated with undesired proinflammatory effects...
  14. ncbi Intravenous immunoglobulin preparations induce mild activation of neutrophils in vivo via triggering of macrophages--studies in a rat model
    J L Teeling
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory of Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Br J Haematol 112:1031-40. 2001
    ..For this reason, IVIG preparations with a high content of dimers may not always be as harmless as generally believed and may be responsible for some of the side-effects observed during IVIG infusions...
  15. ncbi Interleukin 10 release during endotoxaemia in chimpanzees: role of platelet-activating factor and interleukin 6
    T van der Poll
    Department of Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Scand J Immunol 43:122-5. 1996
    ..IL-10 release elicited by injection of endotoxin is not mediated by PAF or IL6...
  16. ncbi Microparticles from patients with multiple organ dysfunction syndrome and sepsis support coagulation through multiple mechanisms
    K Joop
    Department of Clinical Chemistry, Leiden University Medical Center, The Netherlands
    Thromb Haemost 85:810-20. 2001
    ..62, p = 0.013). CONCLUSIONS: In patients with MODS and sepsis relatively low numbers of MP are present that differ from controls in their cellular origin, numbers and coagulation activation mechanisms...
  17. ncbi Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation
    R J Berckmans
    Department of Clinical Chemistry, Leiden University Medical Center, The Netherlands
    Thromb Haemost 85:639-46. 2001
    ..We conclude that microparticles in blood from healthy individuals support thrombin generation via TF- and FVII-independent pathways, and which may have an anticoagulant function...
  18. ncbi Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant
    R Nieuwland
    Department of Clinical Chemistry, University Hospital Leiden, The Netherlands
    Circulation 96:3534-41. 1997
    ..The aim of the present study was to investigate the procoagulant properties of microparticles generated in vivo...
  19. ncbi Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo
    E H Spaeny-Dekking
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam
    J Immunol 160:3610-6. 1998
    ..Furthermore, these results suggest that granzymes mediate biologic effects beyond their described role in apoptotic cell death...
  20. ncbi Systemic coagulation and fibrinolysis in patients with or at risk for the adult respiratory distress syndrome
    A B Groeneveld
    Medical Intensive Care Unit of the Free University Hospital, Amsterdam, The Netherlands
    Thromb Haemost 78:1444-9. 1997
    ..These data indicate that systemic activation of coagulation and impaired fibrinolysis do not play a major role in ARDS development and outcome in patients with acute lung injury...
  21. ncbi Coagulopathy following major liver resection: the effect of rBPI21 and the role of decreased synthesis of regulating proteins by the liver
    C Meijer
    Department of Surgery, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Shock 15:261-71. 2001
    ..Prevention of t-PA release by rBPI21 may have important clinical implications. Decreased availability of alpha2-M may be a factor in post-operative DIC...
  22. doi Complement activation on the surface of cell-derived microparticles during cardiac surgery with cardiopulmonary bypass - is retransfusion of pericardial blood harmful?
    E Biro
    Dept of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Perfusion 26:21-9. 2011
    ....
  23. ncbi Intravenous infusion of erythromycin inhibits CXC chemokine production, but augments neutrophil degranulation in whole blood stimulated with Streptococcus pneumoniae
    M J Schultz
    Laboratory of Experimental Internal Medicine, Department of Intensive Care, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Antimicrob Chemother 46:235-40. 2000
    ..05). These results indicate the ability of erythromycin to reduce CXC chemokine production and to enhance neutrophil degranulation in human blood...
  24. ncbi The effect of pseudomonas exotoxin A on cytokine production in whole blood exposed to Pseudomonas aeruginosa
    M J Schultz
    Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, The Netherlands
    FEMS Immunol Med Microbiol 29:227-32. 2000
    ..The effect of P-ExA on cytokine production may offer a disadvantage to the host with respect to clearance of the infection...
  25. ncbi Accelerated autoantibody clearance by intravenous immunoglobulin therapy: studies in experimental models to determine the magnitude and time course of the effect
    W K Bleeker
    Department of Immunopathology, Central Laboratory of the Blood Transfusion Service, Amsterdam, The Netherlands
    Blood 98:3136-42. 2001
    ..Hence, IVIG can also reduce autoantibody levels through mechanisms such as down-regulation of antibody production or neutralization by anti-idiotypic antibodies...
  26. ncbi The potentiation of human C1-inhibitor by dextran sulphate is transient in vivo: studies in a rat model
    I G Bos
    Department of Immunopathology, CLB and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, The Netherlands
    Int Immunopharmacol 1:1583-95. 2001
    ..We conclude that the enhanced inhibitory capacity of C1-Inh complexed to dextran sulphate is transient in vivo. Hence, co-administration of these compounds seems a feasible approach to achieve short-term inhibition of complement in vivo...
  27. ncbi Upregulation of ICAM-1 on cardiomyocytes in jeopardized human myocardium during infarction
    H W Niessen
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    Cardiovasc Res 41:603-10. 1999
    ..Impaired perfusion of the myocardium induces a local inflammatory response. In animal models, there is ample evidence that polymorphonuclear leucocytes (PMNs) infiltrating infarcted myocardium contribute significantly to infarct size...
  28. ncbi Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria
    F N Lauw
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 182:206-13. 2000
    ..The interaction between the cytokine network and granzymes may play an important immunoregulatory role during bacterial infections...
  29. ncbi Proinflammatory cytokines and elastase-alpha-1-antitrypsin in Argentine hemorrhagic fever
    R F Marta
    Central Laboratory of the Blood Transfusion Service, Amsterdam, The Netherlands
    Am J Trop Med Hyg 60:85-9. 1999
    ..This study shows that IL-8 plays an essential role in neutrophil activation in AHF patients as demonstrated in other infectious diseases...
  30. ncbi Complement activation in patients with rheumatoid arthritis mediated in part by C-reactive protein
    E T Molenaar
    Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 44:997-1002. 2001
    ..CONCLUSION: Part of the activation of complement in RA is mediated by CRP and is correlated with disease activity. We suggest that this activation is involved in the pathogenesis of RA...
  31. ncbi Interferon-gamma in healthy subjects: selective modulation of inflammatory mediators
    J de Metz
    Department of Endocrinology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Eur J Clin Invest 31:536-43. 2001
    ..05). CONCLUSION: We conclude that IFN-gamma selectively affects host inflammatory mediators in humans...
  32. pmc Circulating inflammatory mediators in patients with fever: predicting bloodstream infection
    A B Groeneveld
    Medical Intensive Care Unit, Department of Internal Medicine, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands
    Clin Diagn Lab Immunol 8:1189-95. 2001
    ..This may help in the designing of entry criteria for therapeutic intervention studies...
  33. ncbi Complement activation induced by ischemia-reperfusion in humans: a study in patients undergoing partial hepatectomy
    I H Straatsburg
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Hepatol 32:783-91. 2000
    ..Whether I/R also induces complement activation in humans is not known. Here, we investigated complement activation in patients undergoing major liver resection...
  34. ncbi The endothelium in sepsis: source of and a target for inflammation
    C E Hack
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam
    Crit Care Med 29:S21-7. 2001
    ..Identification of the molecular mechanisms that contribute to endothelial dysfunction or damage is likely to provide novel targets for the treatment of sepsis...
  35. ncbi Heparin-protamine complexes and C-reactive protein induce activation of the classical complement pathway: studies in patients undergoing cardiac surgery and in vitro
    P Bruins
    Department of Anesthesiology, Academic Medical Centre, Amsterdam, The Netherlands
    Thromb Haemost 84:237-43. 2000
    ..Protamine administration during cardiac surgery induces complement activation which in part is CRP-dependent, and correlates with postoperative arrhythmia...
  36. ncbi Activation of clotting factors XI and IX in patients with acute myocardial infarction
    M C Minnema
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 20:2489-93. 2000
    ..Because these clotting factors are considered to be important for continuous thrombin generation and clot stability, their activation might have clinical and therapeutic consequences...
  37. doi Two novel inhibitory anti-human factor XI antibodies prevent cessation of blood flow in a murine venous thrombosis model
    M L van Montfoort
    Joost C M Meijers, Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands, Tel 31 20 5662825, Fax 31 20 6916972, E mail
    Thromb Haemost 110:1065-73. 2013
    ..05). Neither antibody caused severe blood loss in a tail bleeding assay. In conclusion, the two inhibitory antibodies against FXI prevented cessation of blood flow in a murine thrombosis model without inducing a bleeding tendency. ..
  38. ncbi Activation of coagulation factor XI, without detectable contact activation in dengue haemorrhagic fever
    E C van Gorp
    Department of Internal Medicine Slotervaart Hospital, Amsterdam, The Netherlands
    Br J Haematol 113:94-9. 2001
    ..These findings in a human viral infection model are in accordance with earlier findings in bacterial sepsis...
  39. pmc Thalidomide inhibits granulocyte responses in healthy humans after ex vivo stimulation with bacterial antigens
    N P Juffermans
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Antimicrob Agents Chemother 45:1547-9. 2001
    ..A single oral dose of thalidomide attenuates neutrophil activation upon ex vivo stimulation with bacterial antigens...
  40. doi Immunoglobulin M, C-reactive protein and complement activation in rat hepatic ischemia-reperfusion injury
    G M P Diepenhorst
    Surgical Laboratory, Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Eur Surg Res 52:50-62. 2014
    ..However, the time course of CRP- and IgM-mediated complement activation and the relation to hepatocellular injury and inflammation in liver I/R are unknown...
  41. doi Secretory type II phospholipase A2 in culprit coronary lesions is associated with myocardial infarction
    R Nijmeijer
    Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Eur J Clin Invest 38:205-10. 2008
    ..We have studied the presence of sPLA(2)-II in culprit lesions in the coronary arteries of patients with acute myocardial infarction (AMI) or angina pectoris...
  42. ncbi Cell-derived microparticles and complement activation in preeclampsia versus normal pregnancy
    E Biro
    Department of Clinical Chemistry, F 1 219, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD, Amsterdam, The Netherlands
    Placenta 28:928-35. 2007
    ..Inflammation plays a major role in the vascular dysfunction seen in preeclampsia, and several studies suggest involvement of the complement system...
  43. pmc Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model
    B H M Heijnen
    Department of Surgery, Surgical Laboratory, Academic Medical Centre, Amsterdam, The Netherlands
    Clin Exp Immunol 143:15-23. 2006
    ..Pre-ischaemic administration of C1-inh is an effective pharmacological intervention to protect against liver I/R injury...
  44. ncbi Tissue factor serum levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study
    T T Keller
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Thromb Haemost 4:2391-6. 2006
    ..High levels of circulating TF are found in patients with acute atherothrombotic events. Whether high serum TF levels predict risk of future CAD independent of known risk factors remains unknown...
  45. pmc Localization and identification of granzymes A and B-expressing cells in normal human lymphoid tissue and peripheral blood
    J A Kummer
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam
    Clin Exp Immunol 100:164-72. 1995
    ..These results indicate that in normal lymphoid tissue the predominant cytolytic cell population is formed by the NK cells, and activated CTL are rare...
  46. ncbi Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins
    J A Kummer
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam
    J Immunol Methods 163:77-83. 1993
    ..The availability of these mAb may facilitate studies on the role of human cytotoxic cells in various immune reactions and may contribute to a better understanding of the role of granzymes A and B in the cytotoxic response in vivo...
  47. pmc Local activation of coagulation and inhibition of fibrinolysis in the lung during ventilator associated pneumonia
    M J Schultz
    Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thorax 59:130-5. 2004
    ....
  48. ncbi Inflammatory markers in late-life depression: results from a population-based study
    M A Bremmer
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    J Affect Disord 106:249-55. 2008
    ..The association between inflammation and depression may depend on the presence of specific chronic diseases or be relevant in specific sub-groups of depressed patients only...
  49. pmc Biosynthesis of normal and low-molecular-mass complement component C1q by cultured human monocytes and macrophages
    R Hoekzema
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam
    Biochem J 257:477-86. 1989
    ..By contrast, secretion of C1q and LMM-C1q by cells from healthy individuals was clearly co-ordinate, indicating that LMM-C1q in serum may provide a unique marker of C1q synthesis in vivo...
  50. ncbi Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia
    J L Teeling
    Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Academical Medical Center, University of Amsterdam, The Netherlands
    Blood 98:1095-9. 2001
    ..In this model, it is shown that IgG dimers present in IVIG preparations are responsible for the increase in platelet counts. (Blood. 2001;98:1095-1099)..
  51. pmc A pilot study to evaluate the effects of C1 esterase inhibitor on the toxicity of high-dose interleukin 2
    A C Ogilvie
    Department of Medical Oncology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 69:596-8. 1994
    ..1 +/- 8.4 nmol l-1) or escalating-dose (18.3 +/- 2.9 nmol l-1) IL-2. This study demonstrates that C1-INH administration during IL-2 treatment is safe and warrants further study to evaluate its ability to ameliorate IL-2-induced toxicity...
  52. pmc Infliximab treatment reduces complement activation in patients with rheumatoid arthritis
    A Familian
    Department of Immunopathology, Sanquin Research at the CLB, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Ann Rheum Dis 64:1003-8. 2005
    ..Tumour necrosis factor (TNF) blocking agents decrease C reactive protein (CRP) levels in rheumatoid arthritis (RA). It has been shown that CRP may contribute to complement activation in RA...
  53. ncbi Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner
    E Biro
    Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, The Netherlands
    J Thromb Haemost 1:2561-8. 2003
    ..To what extent these microparticles contribute to coagulation in vivo is unknown...
  54. ncbi Ischemia induces nuclear NOX2 expression in cardiomyocytes and subsequently activates apoptosis
    C Meischl
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Apoptosis 11:913-21. 2006
    ..To the best of our knowledge, this is the first demonstration of nuclear NOX2 expression and its involvement in cardiomyocyte apoptosis...
  55. ncbi Structural and functional aspects of C1-inhibitor
    Ineke G A Bos
    Dept Immunopathology, Academical Medical Centre, University of Amsterdam, The Netherlands
    Immunobiology 205:518-33. 2002
    ..This model gives insight into a possible potentiation mechanism of C1-Inh and based on this model the essential residues for efficient inhibition by C1-Inh are discussed...
  56. ncbi Novel strategy for the selection of human recombinant Fab fragments to membrane proteins from a phage-display library
    Aran F Labrijn
    Department of Immunopathology, CLB and Laboratory of Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol Methods 261:37-48. 2002
    ..Hence, the novel panning strategy described here may be applicable for selection of phage-libraries against membrane proteins...
  57. ncbi Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia
    Judith Branger
    Department of Infectious Disease, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 101:4446-8. 2003
    ..Activation of p38 MAPK plays an important role in the procoagulant and endothelial cell response after in vivo exposure to LPS...
  58. ncbi P-selectin- and CD63-exposing platelet microparticles reflect platelet activation in peripheral arterial disease and myocardial infarction
    P Marc van der Zee
    Department of Cardiology and Laboratory of Experimental Clinical Chemistry, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    Clin Chem 52:657-64. 2006
    ..Platelet-derived microparticles (PMPs) are generally considered a marker of platelet activation in cardiovascular disease. We studied the extent to which PMP subpopulations parallel platelet activation in vitro and in vivo...
  59. ncbi Evaluation of classical complement pathway activation in rheumatoid arthritis: measurement of C1q-C4 complexes as novel activation products
    Diana Wouters
    Department of Immunopathology, Sanquin Research at CLB and Academic Medical Centre, Amsterdam, The Netherlands
    Arthritis Rheum 54:1143-50. 2006
    ....
  60. ncbi Factor XIII in severe sepsis and septic shock
    Sacha Zeerleder
    Sanquin Research at CLB, Amsterdam, The Netherlands
    Thromb Res 119:311-8. 2007
    ..Activated FXIII (FXIIIa) forms stable fibrin clots by covalently cross-linking fibrin monomers. Therefore, we investigated the impact of FXIII antigen and activity levels on disease severity and fatality in sepsis patients...
  61. ncbi Disseminated intravascular coagulation in sepsis
    Sacha Zeerleder
    Central Hematology Laboratory, University Hospital, Berne, Switzerland
    Chest 128:2864-75. 2005
    ..Moreover, therapeutic concepts as well as the three randomized, double-blind, placebo-controlled studies are discussed...
  62. ncbi Detection of a soluble form of BACE-1 in human cerebrospinal fluid by a sensitive activity assay
    Jan H Verheijen
    TNO Quality of Life, Biomedical Research, Leiden, The Netherlands
    Clin Chem 52:1168-74. 2006
    ..Inhibition of BACE-1 is thought to be a therapeutic approach to AD. Measuring BACE-1 activity in biological samples would be useful to elucidate the mechanism of AD and for development of AD drugs...
  63. ncbi Regulation of complement activation by C-reactive protein: targeting of the inhibitory activity of C4b-binding protein
    Andreas P Sjöberg
    Department of Laboratory Medicine, Section of Clinical Chemistry, Wallenberg Laboratory, University Hospital Malmo, Lund University, Sweden
    J Immunol 176:7612-20. 2006
    ..We hypothesize that CRP limits excessive complement activation on targets via its interactions with both factor H and C4BP...
  64. ncbi Inhibition of sPLA2-IIA, C-reactive protein or complement: new therapy for patients with acute myocardial infarction?
    Paul A J Krijnen
    VU Medical Center, Department of Pathology, Room nr 1B116, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Cardiovasc Hematol Disord Drug Targets 6:113-23. 2006
    ..This review will focus on the pathogenic effects of sPLA2-IIA, CRP and complement and on the putative therapeutic effects of inhibitors of these inflammatory mediators in acute myocardial infarction...
  65. ncbi Pharmaceutical proteins from methylotrophic yeasts
    Eric C de Bruin
    Department of Immunopathology, Sanquin Research at CLB, Amsterdam, The Netherlands
    Methods Mol Biol 308:65-76. 2005
  66. pmc Activated complement components and complement activator molecules on the surface of cell-derived microparticles in patients with rheumatoid arthritis and healthy individuals
    Eva Bíró
    Department of Clinical Chemistry, F 1 219, Academic Medical Center, University of Amsterdam, PO Box 22660, 1100 DD, Amsterdam, Netherlands
    Ann Rheum Dis 66:1085-92. 2007
    ..We therefore investigated the presence of activated complement components and complement activator molecules on the surface of cell-derived microparticles of RA patients and healthy individuals...
  67. ncbi Recombinant human C1-inhibitor in the treatment of acute angioedema attacks
    Goda Choi
    Department of Internal Medicine, Academic Medical Center, Free University Medical Center, Amsterdam, The Netherlands
    Transfusion 47:1028-32. 2007
    ..This study was undertaken to investigate the effects of rHuC1INH in the treatment of acute angioedema attacks in patients with a hereditary C1-inhibitor deficiency...
  68. doi Intravenous immunoglobulin (IVIG) treatment for modulation of immune activation in human immunodeficiency virus type 1 infected therapy-naive individuals
    Joost N Vermeulen
    IATEC, c o Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
    AIDS Res Hum Retroviruses 23:1348-53. 2007
    ..Our results support the hypothesis that T cell activation, rather than direct HIV-1 infection, mediates the loss of CD4+ T cells and suggest that immunomodulating therapy in HIV-1 infection could indeed be effective...
  69. ncbi C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice
    Petra J G Zwijnenburg
    Department of Pediatrics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Infect Dis 196:115-23. 2007
    ..C1-inh treatment increased bacterial clearance, possibly through an up-regulation of CR3. Hence, C1-inh may be a useful agent in the treatment of pneumococcal meningitis...
  70. ncbi Hemostatic markers in healthy postmenopausal women during intranasal and oral hormone therapy: a randomized trial
    Majoie Hemelaar
    Vrije Universiteit, Amsterdam, The Netherlands
    Menopause 15:248-55. 2008
    ..A wide range of markers of coagulation and fibrinolysis associated with coronary artery disease was tested...
  71. ncbi Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation
    Merel C M Strik
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Mol Immunol 44:3462-72. 2007
    ..We conclude that granzyme B is expressed and released by human mast cells upon physiologic stimulation. This suggests a role for granzyme B as a novel mediator in mast cell biology...
  72. ncbi TAFI and PAI-1 levels in human sepsis
    Sacha Zeerleder
    Department of Hematology and Central Hematology Laboratory, Inselspital, Bern, Switzerland
    Thromb Res 118:205-12. 2006
    ..Plasminogen activator inhibitor type-1 (PAI-1) is considered to be the main inhibitor of fibrinolysis in sepsis. However, the contribution of TAFI to the inhibition of fibrinolysis in sepsis is currently unknown...
  73. ncbi Recombinant human C1-inhibitor produced in Pichia pastoris has the same inhibitory capacity as plasma C1-inhibitor
    Ineke G A Bos
    Dept of Immunopathology, Sanquin Research at CLB, and Landsteiner Laboratory, Academical Medical Centre, University of Amsterdam, The Netherlands
    Biochim Biophys Acta 1648:75-83. 2003
    ..We conclude that the P. pastoris system is capable of high-level production of functionally and structurally intact human C1 inhibitor...
  74. ncbi C-reactive protein and the risk of cardiovascular mortality
    Hans W M Niessen
    Am J Med 114:241-2. 2003
  75. ncbi Effects of IC14, an anti-CD14 antibody, on coagulation and fibrinolysis during low-grade endotoxemia in humans
    Annelies Verbon
    Department of Infectious Diseases, Tropical Medicine, and AIDS, Academic Medical Center, University of Amsterdam, The Netherlands
    J Infect Dis 187:55-61. 2003
    ..These results suggest that different hemostatic responses during endotoxemia may proceed via CD14-dependent and -independent pathways...
  76. ncbi Cell-derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII-dependent mechanism
    René J Berckmans
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 46:2857-66. 2002
    ..To determine the cellular origin of synovial microparticles, their procoagulant properties, and their relationship to local hypercoagulation...
  77. ncbi Therapeutic inhibition of the early phase of complement activation
    Anja Roos
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Immunobiology 205:595-609. 2002
    ..The potential value of these molecules for the development of therapeutically active complement inhibitors is discussed...
  78. ncbi In vivo interaction of endotoxin and recombinant bactericidal/permeability-increasing protein (rBPI23): hemodynamic effects in a human endotoxemia model
    Wilbert T Jellema
    Department of Internal Medicine and Cardiology, Cardiovascular Research Institute Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    J Lab Clin Med 140:228-35. 2002
    ..The monitoring of continuous cardiac output allows for the detection of rapid effects on systemic flow and conductance that go unnoticed in a recording of arterial pressure...
  79. ncbi Impaired fibrinolysis in the pathogenesis of dengue hemorrhagic fever
    Eric C M van Gorp
    Department of Internal Medicine, Slotervaart Hospital, Amsterdam, Netherlands
    J Med Virol 67:549-54. 2002
    ..The present study is the first to demonstrate such a mechanism in a viral infection. This imbalance between coagulation and fibrinolysis may be used as a prognostic marker, but it may also be a target for future therapeutic intervention...
  80. ncbi Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia
    Judith Branger
    Department of Infectious Diseases, Tropical Medicine, and AIDS, Academic Medical Center, and CLB and Laboratory for Clinical and Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 168:4070-7. 2002
    ..Furthermore, the anti-inflammatory potential of an oral p38 MAPK inhibitor in humans in vivo suggests that p38 MAPK inhibitors may provide a new therapeutic option in the treatment of inflammatory diseases...
  81. ncbi The role of cytokines in activation of coagulation and fibrinolysis in dengue shock syndrome
    Catharina Suharti
    Department of Medicine, Faculty of Medicine, Diponegoro University and Dr Kariadi Hospital, Semarang, Indonesia
    Thromb Haemost 87:42-6. 2002
    ..03) and fibrinolysis (PAPc; p = 0.002). Our data are in line with studies in bacterial sepsis. In severe dengue virus infection the same cytokines are involved in the onset and regulation of hemostasis...
  82. ncbi The functional integrity of the serpin domain of C1-inhibitor depends on the unique N-terminal domain, as revealed by a pathological mutant
    Ineke G A Bos
    Department of Immunopathology, Sanquin Research at CLB, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 278:29463-70. 2003
    ....
  83. pmc Administration of C1 inhibitor reduces neutrophil activation in patients with sepsis
    Sacha Zeerleder
    Central Hematology Laboratory, Inselspital, Bern, Switzerland
    Clin Diagn Lab Immunol 10:529-35. 2003
    ..The effect of C1 inhibitor therapy on neutrophils may provide an explanation for the beneficial, although mild, effects of this treatment on organ dysfunction in sepsis...
  84. ncbi Activated cytotoxic T cells and NK cells in severe sepsis and septic shock and their role in multiple organ dysfunction
    Sacha Zeerleder
    Central Hematology Laboratory, Inselspital, Bern, Switzerland
    Clin Immunol 116:158-65. 2005
    ..Activated cytotoxic cells reflected by elevated granzymes A and/or B were found in 50% of our sepsis patients. This group showed a higher mortality and a worse organ function...
  85. ncbi Complexes between C1q and C3 or C4: novel and specific markers for classical complement pathway activation
    Diana Wouters
    Department of Immunopathology, Sanquin Research and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, Amsterdam, Netherlands
    J Immunol Methods 298:35-45. 2005
    ..We conclude that complexes between C1q and C4 or C3 are specific markers of classical complement pathway activation...
  86. ncbi Subcutaneous injection of interleukin 12 induces systemic inflammatory responses in humans: implications for the use of IL-12 as vaccine adjuvant
    Johanna E A Portielje
    Department of Medical Oncology, Erasmus Medical Center, Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands
    Cancer Immunol Immunother 54:37-43. 2005
    ..rHuIL-12, when administered at a dose of 0.1 microg/kg, showed minimal systemic effects. In conclusion, when IL-12 is used as an adjuvant, doses should not exceed 0.1 microg/kg, in order to avoid severe systemic inflammatory responses...
  87. ncbi Serum levels of type II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 25:839-46. 2005
    ..To study the prospective relationship between serum levels of type II secretory phospholipase A2 (sPLA2) and the risk of future coronary artery disease (CAD) in apparently healthy men and women...
  88. ncbi IL-8 plasma concentrations and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 24:1503-8. 2004
    ..To study the role of IL-8 in predicting future coronary artery disease (CAD) in apparently healthy men and women...
  89. ncbi Effect of reactive site loop elongation on the inhibitory activity of C1-inhibitor
    Ineke G A Bos
    Department of Immunopathology, Sanquin Research at CLB, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Biochim Biophys Acta 1699:139-44. 2004
    ..These data suggest that the relatively weak inhibitory activity of C1-Inh is not the result of its short RSL. The short RSL of C1-Inh has, surprisingly, the optimal length for inhibition...
  90. ncbi N(omega)-(carboxymethyl)lysine depositions in human aortic heart valves: similarities with atherosclerotic blood vessels
    Alexi Baidoshvili
    Department of Cardiac Surgery, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Atherosclerosis 174:287-92. 2004
    ..Our data support the hypothesis that the process of degeneration of aortic valves resembles that of atherosclerosis in blood vessels. They suggest that CML also plays a role in the process of atherosclerosis in aortic valves...
  91. ncbi Inhibition of plasmin activity by tranexamic acid does not influence inflammatory pathways during human endotoxemia
    Rosemarijn Renckens
    Laboratory of Experimental Internal Medicine, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 24:483-8. 2004
    ..Lipopolysaccharide (LPS) administration to healthy humans results in a rapid generation of plasmin activity, accompanied by activation of a number of inflammatory systems...
  92. ncbi Production, characterization, and use of serpin antibodies
    J Alain Kummer
    Department of Pathology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Methods 32:141-9. 2004
    ..This review summarizes the techniques we have used to obtain and screen antibodies against extra- and intracellular serpins, as well as the use of these antibodies for some of the above-mentioned purposes...
  93. ncbi Secretory type II phospholipase A(2) binds to ischemic myocardium during myocardial infarction in humans
    Remco Nijmeijer
    Department of Pathology, VU Medical Center Amsterdam, Room No PA002, De Boelelaan 1117, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Cardiovasc Res 53:138-46. 2002
    ..Therefore, we studied the course of circulating sPLA(2), in patients with acute myocardial infarction (AMI) or unstable angina pectoris (UAP), and investigated the presence of sPLA(2) in infarcted myocardial tissue...