Diederick E Grobbee

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Improving clinical trial efficiency by biomarker-guided patient selection
    Ruud Boessen
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Trials 15:103. 2014
  2. pmc Individual and community determinants of neonatal mortality in Ghana: a multilevel analysis
    Gbenga A Kayode
    Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, P, O, Box 85500, Utrecht, GA 3508, The Netherlands
    BMC Pregnancy Childbirth 14:165. 2014
  3. pmc PPAR gamma variant influences angiographic outcome and 10-year cardiovascular risk in male symptomatic coronary artery disease patients
    Jakub J Regieli
    Juliuscenter for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes Care 32:839-44. 2009
  4. pmc No relationship between circulating levels of sex steroids and mammographic breast density: the Prospect-EPIC cohort
    Martijn Verheus
    Julius Center for Health Sciences and Primary Care, Room Str 6, 131, PO Box 85500, University Medical Center Utrecht, Utrecht 3508 GA, The Netherlands
    Breast Cancer Res 9:R53. 2007
  5. pmc Age- and gender-specific risk of death after first hospitalization for heart failure
    I Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Public Health 10:637. 2010
  6. pmc Advantages of the nested case-control design in diagnostic research
    Cornelis J Biesheuvel
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    BMC Med Res Methodol 8:48. 2008
  7. pmc Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsia
    Suhreta Mujakovic
    University Medical Centre Utrecht, Department of Gastroenterology and Hepatology, The Netherlands
    BMC Med Genet 12:140. 2011
  8. pmc Cardiovascular risk factor assessment after pre-eclampsia in primary care
    Marie Elise Nijdam
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Fam Pract 10:77. 2009
  9. pmc Long-term survival after initial hospital admission for peripheral arterial disease in the lower extremities
    I Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Cardiovasc Disord 9:43. 2009
  10. pmc The dynamics of mortality in follow-up time after an acute myocardial infarction, lower extremity arterial disease and ischemic stroke
    Ilonca Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Cardiovasc Disord 10:57. 2010

Collaborators

Detail Information

Publications72

  1. pmc Improving clinical trial efficiency by biomarker-guided patient selection
    Ruud Boessen
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Trials 15:103. 2014
    ..Using such predictive markers to select subjects for inclusion in randomized clinical trials could potentially result in more targeted studies and reduce the number of subjects to recruit...
  2. pmc Individual and community determinants of neonatal mortality in Ghana: a multilevel analysis
    Gbenga A Kayode
    Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, P, O, Box 85500, Utrecht, GA 3508, The Netherlands
    BMC Pregnancy Childbirth 14:165. 2014
    ....
  3. pmc PPAR gamma variant influences angiographic outcome and 10-year cardiovascular risk in male symptomatic coronary artery disease patients
    Jakub J Regieli
    Juliuscenter for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes Care 32:839-44. 2009
    ..We investigated the effects of carriership of the Pro12Ala variant on angiographic and cardiovascular event outcomes in male patients with symptomatic coronary artery disease (CAD)...
  4. pmc No relationship between circulating levels of sex steroids and mammographic breast density: the Prospect-EPIC cohort
    Martijn Verheus
    Julius Center for Health Sciences and Primary Care, Room Str 6, 131, PO Box 85500, University Medical Center Utrecht, Utrecht 3508 GA, The Netherlands
    Breast Cancer Res 9:R53. 2007
    ..The objective of the present study was to study the relation between circulating oestrogens and androgens as well as sex hormone binding globulin (SHBG) in relation to breast density...
  5. pmc Age- and gender-specific risk of death after first hospitalization for heart failure
    I Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Public Health 10:637. 2010
    ..Age and gender are important predictors of mortality in hospitalized HF patients. However, studies assessing short- and long-term risk of death stratified by age and gender are scarce...
  6. pmc Advantages of the nested case-control design in diagnostic research
    Cornelis J Biesheuvel
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    BMC Med Res Methodol 8:48. 2008
    ..Despite its benefits, it is uncommon to apply the nested case-control design in diagnostic research. We aim to show advantages of this design for diagnostic accuracy studies...
  7. pmc Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsia
    Suhreta Mujakovic
    University Medical Centre Utrecht, Department of Gastroenterology and Hepatology, The Netherlands
    BMC Med Genet 12:140. 2011
    ..We investigated the association between these functional polymorphisms and dyspeptic symptom severity...
  8. pmc Cardiovascular risk factor assessment after pre-eclampsia in primary care
    Marie Elise Nijdam
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Fam Pract 10:77. 2009
    ..It is not known how general practitioners in the Netherlands care for these women after delivery with respect to cardiovascular risk factor management...
  9. pmc Long-term survival after initial hospital admission for peripheral arterial disease in the lower extremities
    I Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Cardiovasc Disord 9:43. 2009
    ..Insights in absolute mortality risks following admission for PAD in the lower extremities can be useful to improve awareness as they are easy to interpret...
  10. pmc The dynamics of mortality in follow-up time after an acute myocardial infarction, lower extremity arterial disease and ischemic stroke
    Ilonca Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Cardiovasc Disord 10:57. 2010
    ..Therefore, our objective was to determine risk of death after first hospital admission for atherosclerotic disease located at different sites...
  11. pmc Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study
    Annemieke W J Opstal-van Winden
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    BMC Cancer 11:381. 2011
    ..We present for the first time pre-diagnostic serum protein profiles in relation to breast cancer, using the Prospect-EPIC (European Prospective Investigation into Cancer and nutrition) cohort...
  12. ncbi request reprint Relations between body composition, functional and hormonal parameters and quality of life in healthy postmenopausal women
    Corinne E I Lebrun
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
    Maturitas 55:82-92. 2006
    ..To investigate whether body composition, functional status and serum hormone levels are associated with quality of life in healthy postmenopausal women...
  13. ncbi request reprint PTPN1 polymorphisms are associated with total and low-density lipoprotein cholesterol
    Florianne Bauer
    Department of Medical Genetics DBG, Complex Genetics Section, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 17:28-34. 2010
    ..Our aim was to investigate the association between single nucleotide polymorphisms (SNPs) of the PTPN1 gene and metabolic endophenotypes and insulin sensitivity...
  14. ncbi request reprint Cumulative genetic defects in carcinogen metabolism may increase breast cancer risk (The Netherlands)
    Olga L van der Hel
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Cancer Causes Control 16:675-81. 2005
    ..45 (95% CI 1.24-4.86), compared to women with zero putative at risk genotypes. In conclusion, the results of this study suggest that presence of three or more putative at risk genotypes increases breast cancer risk...
  15. ncbi request reprint GSTM1 null genotype, red meat consumption and breast cancer risk (The Netherlands)
    Olga L van der Hel
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Cancer Causes Control 15:295-303. 2004
    ..We studied whether polymorphisms in N-acetyltransferase 1 and 2 and Glutathione S-transferase M1 and T1 genes modify the association between meat consumption and breast cancer...
  16. ncbi request reprint Reproductive factors, metabolic factors, and coronary artery calcification in older women
    Femke Atsma
    Department of Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Menopause 15:899-904. 2008
    ..This cohort study investigated the relationship between reproductive factors and coronary artery calcification in elderly women and whether this relationship could be explained by metabolic disturbances...
  17. ncbi request reprint Noninvasive arterial measurements of vascular damage in healthy young adults: relation to coronary heart disease risk
    Marijke J C A van Trijp
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Dept of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
    Ann Epidemiol 16:71-7. 2006
    ..Our aim was to study whether AIx is related to coronary heart disease (CHD) risk and to compare the strength of the relations of AIx, PWV, and CIMT with cardiovascular risk in healthy young adults...
  18. ncbi request reprint Prediction rule for cardiovascular events and mortality in peripheral arterial disease patients: data from the prospective Second Manifestations of ARTerial disease (SMART) cohort study
    Ralf W Sprengers
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Surg 50:1369-76. 2009
    ..Stratifying PAD patients according to their risk of secondary events could aid in achieving optimal therapy compliance. To this end we developed a prediction model for secondary cardiovascular events in PAD patients...
  19. ncbi request reprint Long term consequences of the 1944-1945 Dutch famine on the insulin-like growth factor axis
    Sjoerd G Elias
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Int J Cancer 108:628-30. 2004
    ..These results are opposite to immediate responses seen under starvation and we hypothesize that this could indicate a permanent overshoot upon improvement of nutritional status after the famine...
  20. ncbi request reprint Influence of estrogen receptor alpha and progesterone receptor polymorphisms on the effects of hormone therapy on mammographic density
    Franzel J B van Duijnhoven
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Mail drop Str 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 15:462-7. 2006
    ..In conclusion, our results suggest that specific polymorphisms in the ESR1 and PGR genes may make women more susceptible to the effects of hormone therapy use on mammographic density...
  21. ncbi request reprint Biologically implausible carotid intima-media thickness measurement values: effects on rate of change over time
    Sanne A E Peters
    University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Med Res Opin 28:891-9. 2012
    ..It is currently unclear to what extent biologically implausible values affect treatment effects. We evaluated the impact of biologically implausible CIMT values on the estimated rate of change in CIMT...
  22. ncbi request reprint Analysis of case-cohort data: a comparison of different methods
    N Charlotte Onland-Moret
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Epidemiol 60:350-5. 2007
    ..However, adaptation of the model is necessary because of the sampling. We compared three methods that were proposed in the literature, which differ in weighting of study subjects: Prentice's, Barlow's, and Self and Prentice's method...
  23. ncbi request reprint The association of depression with cardiovascular mortality is partly explained by health status. The FINE Study
    Marjolein H Kamphuis
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 114:184-92. 2009
    ..We investigated to what extent subjective health status explained the apparent association between depressive symptoms and cardiovascular mortality in older European men...
  24. ncbi request reprint Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trial
    Marielle H Emmelot-Vonk
    Department of Geriatric Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    JAMA 299:39-52. 2008
    ..Serum testosterone levels decline significantly with aging. Testosterone supplementation to older men might beneficially affect the aging processes...
  25. pmc Peroxisome proliferator-activated receptor gamma-2 P12A polymorphism and risk of acute myocardial infarction, coronary heart disease and ischemic stroke: a case-cohort study and meta-analyses
    Mohammad Hadi Zafarmand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, Str 6 131, 3584 CX, Utrecht, The Netherlands
    Vasc Health Risk Manag 4:427-36. 2008
    ..Yet, the risk relation has not been confirmed, and data on ischemic stroke (IS) is scarce. We therefore investigated the role of this polymorphism on occurrence of AMI, coronary heart disease (CHD) and IS...
  26. ncbi request reprint No increased incidence of diabetes in antidepressant users
    Mirjam J Knol
    Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    Int Clin Psychopharmacol 22:382-6. 2007
    ..12-1.68) for AD and BD users compared with no AD and no BD users. We did not find an increased risk of diabetes in individuals using ADs. The association between BD use and diabetes was partly explained by chronic somatic comorbidity...
  27. ncbi request reprint Common genetic variation of insulin-like growth factor-binding protein 1 (IGFBP-1), IGFBP-3, and acid labile subunit in relation to serum IGF-I levels and mammographic density
    Cornelia W Taverne
    Julius Center for Health Sciences and Primary Care, University Medical Center, Room Str 6 131, PO Box 85500, Utrecht, 3508, GA, The Netherlands
    Breast Cancer Res Treat 123:843-55. 2010
    ..These findings suggest that common genetic variation in the IGFBP1 gene is weakly related to IGF-I levels and mammographic density. Our results do not provide support for such a role of genetic variants in the IGFBP3 and ALS genes...
  28. ncbi request reprint Vasomotor symptoms, estradiol levels and cardiovascular risk profile in women
    Gerrie Cor M Gast
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Maturitas 66:285-90. 2010
    ..Furthermore, we examined the association between estradiol levels and VMS, and whether an association between VMS and cardiovascular risk factors can be explained by estradiol levels...
  29. ncbi request reprint Vasomotor menopausal symptoms are associated with increased risk of coronary heart disease
    Gerrie Cor M Gast
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Menopause 18:146-51. 2011
    ..We investigated whether VMS are related to an increased risk of future coronary heart disease (CHD) and whether possible associations can be explained by CVD risk factors...
  30. ncbi request reprint Algorithms to measure carotid intima-media thickness in trials: a comparison of reproducibility, rate of progression and treatment effect
    Soner Dogan
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Hypertens 29:2181-93. 2011
    ....
  31. ncbi request reprint Multiple imputation of missing repeated outcome measurements did not add to linear mixed-effects models
    Sanne A E Peters
    Julius Center for Health Sciences and Primary Care, Stratenum 6 131, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    J Clin Epidemiol 65:686-95. 2012
    ..To assess the added value of multiple imputation (MI) of missing repeated outcomes measures in longitudinal data sets analyzed with linear mixed-effects (LME) models...
  32. ncbi request reprint High dietary glycemic load and glycemic index increase risk of cardiovascular disease among middle-aged women: a population-based follow-up study
    Joline W J Beulens
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Coll Cardiol 50:14-21. 2007
    ..The goal of this work was to assess whether high dietary glycemic load and glycemic index are associated with an increased risk of cardiovascular disease (CVD)...
  33. ncbi request reprint Risk and determinants of myocardial injury during off-pump coronary artery bypass grafting
    Hendrik M Nathoe
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Cardiol 97:1482-6. 2006
    ..Patients with perioperative myocardial injury during off-pump surgery were at a higher risk of adverse cardiac outcomes at 1 year...
  34. ncbi request reprint Ultrasound protocols to measure carotid intima-media thickness in trials; comparison of reproducibility, rate of progression, and effect of intervention in subjects with familial hypercholesterolemia and subjects with mixed dyslipidemia
    Soner Dogan
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Med 42:447-64. 2010
    ..Participants were randomized to torcetrapib or placebo on top of optimal atorvastatin therapy...
  35. ncbi request reprint Vascular status and physical functioning: the association between vascular status and physical functioning in middle-aged and elderly men: a cross-sectional study
    Ilse E M A Arts
    Faculty Chair Care for the Chronically Ill and Elderly, Hogeschool Utrecht, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 17:211-6. 2010
    ..The aim of this study was to investigate the association of vascular status with muscle strength and physical functioning in middle aged and elderly men...
  36. ncbi request reprint Lifetime endogenous estrogen exposure and electrocardiographic frontal T axis changes in postmenopausal women
    Femke Atsma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Maturitas 63:347-51. 2009
    ..The aim of this study was to investigate the relation between reproductive factors and the electrocardiographic frontal T axis in postmenopausal women...
  37. ncbi request reprint The diagnostic value of physical examination and additional testing in primary care patients with suspected heart failure
    Johannes C Kelder
    Julius Center for Health Sciences and Primary Care, Room 6 101, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Circulation 124:2865-73. 2011
    ..Early diagnosis of nonacute heart failure is crucial because prompt initiation of evidence-based treatment can prevent or slow down further progression. To diagnose new-onset heart failure in primary care is challenging...
  38. ncbi request reprint Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis
    Femke Atsma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Menopause 13:265-79. 2006
    ..The aim was to obtain valid estimates of the cardiovascular disease risk associated with postmenopausal status and early menopause...
  39. ncbi request reprint Hormone therapy and coronary heart disease risk by vasomotor menopausal symptoms
    Gerrie Cor M Gast
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Maturitas 70:373-8. 2011
    ..We examined whether the association between hormone therapy (HT) use and coronary heart disease (CHD) risk differed between women with and without vasomotor symptoms (VMS)...
  40. ncbi request reprint Higher dietary intake of lignans is associated with better cognitive performance in postmenopausal women
    Oscar H Franco
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    J Nutr 135:1190-5. 2005
    ..02 (1.11-3.71)]. Isoflavone intake was not related to cognitive function. From our results we conclude that higher dietary intake of lignans is associated with better cognitive function in postmenopausal women...
  41. ncbi request reprint Change in abdominal obesity and risk of coronary calcification
    Siamak Sabour
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Epidemiol Community Health 65:287-8. 2011
    ..A prospective follow-up study was conducted to examine the relationship between 9 year change in abdominal obesity and risk of coronary artery calcification (CAC)...
  42. ncbi request reprint Sample size requirements in trials using repeated measurements and the impact of trial design
    Sanne A E Peters
    University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Med Res Opin 28:681-8. 2012
    ..However, this approach neglects the impact of differences in trial design. We studied the effects of variations in trial design on the required sample size...
  43. ncbi request reprint The prediction of functional decline in older hospitalised patients
    Jita G Hoogerduijn
    Faculty of Health Care, University of Applied Sciences Utrecht, Utrecht, The Netherlands
    Age Ageing 41:381-7. 2012
    ..First step in prevention is the identification of patients at risk...
  44. ncbi request reprint High dietary menaquinone intake is associated with reduced coronary calcification
    Joline W J Beulens
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Atherosclerosis 203:489-93. 2009
    ..This may be due to different effects of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone, MK), but few studies included both...
  45. ncbi request reprint Association of endogenous sex hormone with C-reactive protein levels in middle-aged and elderly men
    Hamid Reza Nakhai Pour
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Clin Endocrinol (Oxf) 66:394-8. 2007
    ..Whether endogenous sex hormone levels in men are also related to systemic subclinical inflammation is still unknown...
  46. ncbi request reprint Alcohol and endogenous sex steroid levels in postmenopausal women: a cross-sectional study
    N Charlotte Onland-Moret
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Endocrinol Metab 90:1414-9. 2005
    ..This finding supports the hypothesis that alcohol use may increase breast cancer risk at least partially through an effect on sex steroid levels...
  47. ncbi request reprint Dietary phytoestrogen intake and cognitive function in older women
    Sanne Kreijkamp-Kaspers
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:556-62. 2007
    ..Aging is associated with a decline in cognitive function; we explored the possible influence of dietary phytoestrogens on this decline...
  48. ncbi request reprint Soy protein containing isoflavones and mammographic density in a randomized controlled trial in postmenopausal women
    Martijn Verheus
    Julius Center for Health Sciences and Primary Care, University Medical Center, Room Str 6 131, P O Box 85500, Utrecht 3508 GA, Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 17:2632-8. 2008
    ..The aim of the present study was to determine the effect of daily soy supplementation on mammographic density, one of the strongest known risk factors for breast cancer...
  49. ncbi request reprint Breast cancer risk after caloric restriction during the 1944-1945 Dutch famine
    Sjoerd G Elias
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Natl Cancer Inst 96:539-46. 2004
    ..We examined whether caloric restriction imposed as a consequence of the 1944-1945 Dutch famine reduced the risk of breast cancer in women participating in a Dutch breast cancer screening program...
  50. ncbi request reprint Asymmetrical distribution of atherosclerosis in the carotid artery: identical patterns across age, race, and gender
    Parvin Tajik
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Prev Cardiol 19:687-97. 2012
    ....
  51. ncbi request reprint Determinants of daily insulin use in Type 1 diabetes
    Marian J Muis
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands Department of Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    J Diabetes Complications 20:356-60. 2006
    ..Insulin need for a given degree of glucose control varies markedly among individuals. We examined which factors determine daily insulin use in patients with Type 1 diabetes...
  52. ncbi request reprint No association of PTPN1 polymorphisms with macronutrient intake and measures of adiposity
    Florianne Bauer
    Complex Genetics Section, Department of Medical Genetics DBG, University Medical Center Utrecht, Utrecht, The Netherlands
    Obesity (Silver Spring) 16:2767-71. 2008
    ..Associations were studied using linear regression analysis. There were no statistically significant associations of SNPs in the PTPN1 gene with dietary phenotypes or measures of obesity...
  53. ncbi request reprint Serum ferritin is a risk factor for stroke in postmenopausal women
    Daphne L van der A
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, HP Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Stroke 36:1637-41. 2005
    ..Iron is an essential element for the human body. It has, however, been suggested that excessive iron stores may increase the risk of vascular disease. So far, epidemiologic studies on stroke are sparse...
  54. ncbi request reprint Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention
    Jakub J Regieli
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Coll Cardiol 54:1238-45. 2009
    ..We investigated the effects of paraoxonase (PON)-1 variants on long-term clinical outcome in patients with coronary artery disease (CAD)...
  55. ncbi request reprint Age at menopause, cause-specific mortality and total life expectancy
    Marlies E Ossewaarde
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Epidemiology 16:556-62. 2005
    ..The net effect on mortality is unclear. We determined the association of age at menopause with longevity and with the balance between cardiovascular and cancer mortality...
  56. ncbi request reprint Striking increases in carotid artery wall thickness in healthy subjects
    Rudy Meijer
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Cerebrovasc Dis 30:448-55. 2010
    ..We studied the occurrence of temporarily impressive thickenings of the carotid arterial wall in a cohort of healthy postmenopausal women who were followed up for 3 years with regular carotid ultrasound examinations...
  57. ncbi request reprint The M235T variant of the angiotensinogen gene is related to development of self-reported hypertension during pregnancy: the Prospect-EPIC cohort study
    Mohammad Hadi Zafarmand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, Str 6 131, 3584 CX, Utrecht, The Netherlands
    Hypertens Res 31:1299-305. 2008
    ..The findings of this study among Caucasian Dutch women, aged 49 to 70 years, demonstrated that the presence of the T allele of the M235T polymorphism in the AGT is associated with self-reported hypertensive disorders in pregnancy...
  58. ncbi request reprint Pulse pressure amplification and risk of cardiovascular disease
    Marie Elise Nijdam
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hypertens 21:388-92. 2008
    ..The purpose of this study was to investigate the relationship between PPA and cardiovascular risk factors and cardiovascular risk in a population-based sample of 40- to 80-year old men...
  59. ncbi request reprint Heart disease risk determines menopausal age rather than the reverse
    Helen S Kok
    Julius Center for Health Sciences and Primary Care, Utrecht University, Utrecht, The Netherlands
    J Am Coll Cardiol 47:1976-83. 2006
    ..The purpose of this study was to investigate whether a harmful cardiovascular risk profile accelerates menopause...
  60. ncbi request reprint Prediction model for hypertension in pregnancy in nulliparous women using information obtained at the first antenatal visit
    Marie Elise Nijdam
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Hypertens 28:119-26. 2010
    ..To develop a prediction model for the occurrence of hypertension in pregnancy using clinical variables obtained routinely at the antenatal booking visit prior to 16 weeks gestation...
  61. ncbi request reprint Lower birth weight predicts metabolic syndrome in young adults: the Atherosclerosis Risk in Young Adults (ARYA)-study
    Made K Ramadhani
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Atherosclerosis 184:21-7. 2006
    ..To study the relationship between intrauterine growth and the metabolic syndrome, particularly fasting serum lipids in young adulthood...
  62. ncbi request reprint The potential yield of ECG screening of hypertensive patients: the Utrecht Health Project
    Tjarda Scheltens
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Hypertens 28:1527-33. 2010
    ..We estimated the prevalence of clinically relevant ECG abnormalities and the number needed to screen (NNS) with a routine ECG to prevent the occurrence of one death in the next 10 years conditional on adequate treatment and follow-up...
  63. ncbi request reprint Postmenopausal hormone therapy and changes in mammographic density
    Franzel J B van Duijnhoven
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Oncol 25:1323-8. 2007
    ..We explored the underlying mechanism further by determining the effects of HT on mammographic density, a measure of dense tissue in the breast and a consistent breast cancer risk factor...
  64. ncbi request reprint Role of coronary collaterals in off-pump and on-pump coronary bypass surgery
    Hendrik M Nathoe
    Department of Cardiology, Heart Lung Center Utrecht, Utrecht, The Netherlands
    Circulation 110:1738-42. 2004
    ..The role of collaterals has not been studied in patients undergoing off-pump or on-pump bypass surgery...
  65. ncbi request reprint Extensive or restricted ultrasound protocols to measure carotid intima-media thickness: analysis of completeness rates and impact on observed rates of change over time
    Sanne A E Peters
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Soc Echocardiogr 25:91-100. 2012
    ..These issues were addressed in this study using data from Measuring Effects on Intima-Media Thickness: An Evaluation of Rosuvastatin (METEOR)...
  66. ncbi request reprint Effects of dehydroepiandrosterone and atamestane supplementation on frailty in elderly men
    Majon Muller
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Stratenum 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Endocrinol Metab 91:3988-91. 2006
    ..Therefore, hormone replacement might improve the course of frailty by increasing lean body mass and muscle strength, decreasing fat mass, and improving the subjective quality of life...
  67. ncbi request reprint ABCA1 impacts athero-thrombotic risk and 10-year survival in a contemporary secondary prevention setting
    Jakub J Regieli
    Department of Cardiology, University Medical Center, Utrecht, The Netherlands
    Atherosclerosis 218:457-63. 2011
    ..We prospectively investigated the effects of ATP-binding cassette protein-1 (ABCA1) variants on long-term clinical outcome in patients with coronary artery disease (CAD)...
  68. ncbi request reprint Prediction of mortality risk in the elderly
    Stefan Störk
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Med 119:519-25. 2006
    ..We set out to estimate the incremental prognostic utility of inflammation and atherosclerosis markers in the prediction of all-cause and CV mortality in elderly men...
  69. ncbi request reprint Autonomic dysfunction: a link between depression and cardiovascular mortality? The FINE Study
    Marjolein H Kamphuis
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 14:796-802. 2007
    ..Depression is associated with an increased risk of cardiovascular diseases (CVD) in vascular patients as well as in the general population. We investigated whether autonomic dysfunction could explain this relationship...
  70. pmc Unrequested information from routine diagnostic chest CT predicts future cardiovascular events
    Peter C Jacobs
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Universiteitsweg 100, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Eur Radiol 21:1577-85. 2011
    ..This is the first follow-up study to investigate the prognostic relevance of subclinical coronary (CAC) and aortic calcification (TAC) as contained in routine diagnostic chest CT in a clinical care population...
  71. ncbi request reprint Carotid intima-media thickness measurement in cardiovascular screening programmes
    Yvonne Plantinga
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 16:639-44. 2009
    ..At present it seems that the published evidence to quantitatively support the use of a CIMT measurement to help in risk stratification on top of a risk function is limited...
  72. ncbi request reprint Elevated blood pressure and electrocardiographic frontal T axis and spatial QRS-T angle changes in postmenopausal women
    Femke Atsma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Electrocardiol 41:360-4. 2008
    ..We determined whether increased blood pressure is a risk factor for changes in these parameters in postmenopausal women free of left ventricular hypertrophy...