Jan A Gorter

Summary

Affiliation: University of Amsterdam
Country: The Netherlands

Publications

  1. ncbi request reprint Sodium channel beta1-subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Section of Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 16:360-4. 2002
  2. ncbi request reprint Glutamate transporters alterations in the reorganizing dentate gyrus are associated with progressive seizure activity in chronic epileptic rats
    Jan A Gorter
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM, Amsterdam, The Netherlands
    J Comp Neurol 442:365-77. 2002
  3. ncbi request reprint Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Epilepsia 44:647-58. 2003
  4. ncbi request reprint Increased expression of ferritin, an iron-storage protein, in specific regions of the parahippocampal cortex of epileptic rats
    Jan A Gorter
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 46:1371-9. 2005
  5. ncbi request reprint Abnormal plastic changes in a rat model for mesial temporal lobe epilepsy: a short review
    Jan A Gorter
    Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Prog Brain Res 138:61-72. 2002
  6. ncbi request reprint Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy
    Jan A Gorter
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM, Amsterdam, The Netherlands
    J Neurosci 26:11083-110. 2006
  7. ncbi request reprint Differential and long-lasting alterations of high-voltage activated calcium currents in CA1 and dentate granule neurons after status epilepticus
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Eur J Neurosci 16:701-12. 2002
  8. ncbi request reprint Dynamic changes of proteases and protease inhibitors revealed by microarray analysis in CA3 and entorhinal cortex during epileptogenesis in the rat
    Jan A Gorter
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan, Amsterdam, The Netherlands
    Epilepsia 48:53-64. 2007
  9. ncbi request reprint Long-lasting increased excitability differs in dentate gyrus vs. CA1 in freely moving chronic epileptic rats after electrically induced status epilepticus
    Jan A Gorter
    Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    Hippocampus 12:311-24. 2002
  10. ncbi request reprint Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 46:849-57. 2005

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Sodium channel beta1-subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Section of Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Eur J Neurosci 16:360-4. 2002
    ....
  2. ncbi request reprint Glutamate transporters alterations in the reorganizing dentate gyrus are associated with progressive seizure activity in chronic epileptic rats
    Jan A Gorter
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM, Amsterdam, The Netherlands
    J Comp Neurol 442:365-77. 2002
    ..Considering the steady growth of reorganizing mossy fibers in the iml, the absence of a glutamate reuptake mechanism in this region could contribute to progression of spontaneous seizure activity, which occurs with a similar time course...
  3. ncbi request reprint Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands
    Epilepsia 44:647-58. 2003
    ....
  4. ncbi request reprint Increased expression of ferritin, an iron-storage protein, in specific regions of the parahippocampal cortex of epileptic rats
    Jan A Gorter
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 46:1371-9. 2005
    ..In this study we used ferritin as indicator for disturbed iron homeostasis to acquire insight into whether this could play a role in the pathogenesis of temporal lobe epilepsy...
  5. ncbi request reprint Abnormal plastic changes in a rat model for mesial temporal lobe epilepsy: a short review
    Jan A Gorter
    Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Prog Brain Res 138:61-72. 2002
  6. ncbi request reprint Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy
    Jan A Gorter
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM, Amsterdam, The Netherlands
    J Neurosci 26:11083-110. 2006
    ..Especially genes related to the immune response, such as complement factors, interleukins, and genes related to prostaglandin synthesis and coagulation pathway may be interesting targets...
  7. ncbi request reprint Differential and long-lasting alterations of high-voltage activated calcium currents in CA1 and dentate granule neurons after status epilepticus
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM, Amsterdam, The Netherlands
    Eur J Neurosci 16:701-12. 2002
    ..DG cells depended strongly on whether rats had experienced SE and later spontaneous seizure activity. These changes are likely to contribute to regionally different effects on local network excitability...
  8. ncbi request reprint Dynamic changes of proteases and protease inhibitors revealed by microarray analysis in CA3 and entorhinal cortex during epileptogenesis in the rat
    Jan A Gorter
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan, Amsterdam, The Netherlands
    Epilepsia 48:53-64. 2007
    ..The fact that several proteolytic genes were still activated in the chronic epileptic phase makes them interesting candidates to modify and slow down seizure progression...
  9. ncbi request reprint Long-lasting increased excitability differs in dentate gyrus vs. CA1 in freely moving chronic epileptic rats after electrically induced status epilepticus
    Jan A Gorter
    Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    Hippocampus 12:311-24. 2002
    ..These observed changes indicate a lasting increased excitability in CA1 and DG networks that could play a role in the recurrence of spontaneous seizures...
  10. ncbi request reprint Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 46:849-57. 2005
    ..This study investigated the expression and cellular distribution of BCRP in human control and epileptic brain, including a large number of both neoplastic and nonneoplastic specimens from patients with chronic pharmacoresistant epilepsy...
  11. ncbi request reprint Expression and cellular distribution of high- and low-affinity neurotrophin receptors in malformations of cortical development
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Acta Neuropathol 108:422-34. 2004
    ..Further research is necessary to investigate how activation of these specific receptors could contribute to the development and the epileptogenicity of these developmental disorders...
  12. ncbi request reprint Physiological changes in chronic epileptic rats are prominent in superficial layers of the medial entorhinal area
    Else A Tolner
    Swammerdam Institute of Life Sciences, Center for Neuroscience, University of Amsterdam, Graduate School of Neurosciences Amsterdam, Amsterdam, The Netherlands
    Epilepsia 46:72-81. 2005
    ..We investigated whether the functional network properties of the medial entorhinal area (MEA) of the entorhinal cortex were altered in a rat model of chronic epilepsy that is characterized by extensive cell loss in MEA layer III...
  13. pmc Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 β
    Emanuele Zurolo
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam AZ 1105, The Netherlands
    J Neuroinflammation 9:280. 2012
    ..Here, we evaluated the potential effect of inflammatory molecules, such as interleukin-1β (IL-1β) on Kir4.1 mRNA and protein expression...
  14. ncbi request reprint Progression of temporal lobe epilepsy in the rat is associated with immunocytochemical changes in inhibitory interneurons in specific regions of the hippocampal formation
    Erwin A van Vliet
    Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    Exp Neurol 187:367-79. 2004
    ....
  15. pmc Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 52:1645-55. 2011
    ..We hypothesized that dysregulation of ADK is an ubiquitous pathologic hallmark of TLE...
  16. ncbi request reprint Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 45:441-51. 2004
    ....
  17. doi request reprint Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias
    Anand Iyer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 51:1763-73. 2010
    ..In the present study we examined the innate and adaptive immune responses in focal cortical dysplasia (FCD) with different histopathologic and pathogenetic features...
  18. doi request reprint Expression of sodium channel α subunits 1.1, 1.2 and 1.6 in rat hippocampus after kainic acid-induced epilepsy
    Xin Qiao
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsy Res 106:17-28. 2013
    ..This implies that understanding epileptogenesis has to take into account several distinct and type-specific changes in sodium channel expression...
  19. pmc MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response
    Anand Iyer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 7:e44789. 2012
    ..This supports an important role of miR-146a in human neurological disorders associated with chronic inflammation and suggests that this miR may represent a novel target for therapeutic strategies...
  20. doi request reprint Dynamics of evoked local field potentials in the hippocampus of epileptic rats with spontaneous seizures
    Claudio M Queiroz
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    J Neurophysiol 101:1588-97. 2009
    ..Taken together, these results provide evidence that, in this experimental model, DG physiology is more likely to follow the already ongoing seizure activity rather than to contribute to its generation...
  21. doi request reprint Expression patterns of synaptic vesicle protein 2A in focal cortical dysplasia and TSC-cortical tubers
    Sjoukje T Toering
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Epilepsia 50:1409-18. 2009
    ..The aim of the study was to define the expression and cell-specific distribution of SV2A in developmental focal lesions associated with medically intractable epilepsy...
  22. ncbi request reprint Calcium extrusion protein expression in the hippocampal formation of chronic epileptic rats after kainate-induced status epilepticus
    Susan O M Ketelaars
    Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 45:1189-201. 2004
    ..We investigated whether the expression of these calcium-extrusion proteins is altered in the course of epileptogenesis...
  23. ncbi request reprint GAP-43 mRNA and protein expression in the hippocampal and parahippocampal region during the course of epileptogenesis in rats
    Else A Tolner
    Swammerdam Institute of Life Sciences, Section of Neurobiology, University of Amsterdam, Graduate School of Neurosciences Amsterdam, 1098 SM, Amsterdam, The Netherlands
    Eur J Neurosci 17:2369-80. 2003
    ..Whether reorganization of fibers has occurred in this region after SE needs to be investigated with tools other than GAP-43...
  24. doi request reprint Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy
    Linda Holtman
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 54:589-95. 2013
    ..Moreover, studies in epilepsy animal models have shown that peripheral inflammation may play either a pathogenic or neuroprotective role...
  25. doi request reprint Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation
    Erwin A van Vliet
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 53:1254-63. 2012
    ....
  26. doi request reprint Induction of sodium channel Na(x) (SCN7A) expression in rat and human hippocampus in temporal lobe epilepsy
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 51:1791-800. 2010
    ..Herein we investigated the expression and cellular distribution of SCN7A mRNA and protein in normal and epileptic rat and human hippocampus...
  27. pmc Gene expression analysis of tuberous sclerosis complex cortical tubers reveals increased expression of adhesion and inflammatory factors
    Karin Boer
    Department of Neuro Pathology, Academic Medical Center, Amsterdam, The Netherlands
    Brain Pathol 20:704-19. 2010
    ..Changes in gene expression yield insights into new candidate genes that may contribute to tuber formation or seizure onset, representing new targets for potential therapeutic development...
  28. ncbi request reprint Interleukin-1 beta down-regulates the expression of metabotropic glutamate receptor 5 in cultured human astrocytes
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9 1105 AZ Amsterdam, The Netherlands
    J Neuroimmunol 160:188-94. 2005
    ..Thus, interleukin 1beta may represent an additional pathway through which mGluR5 expression and function can be modulated in astrocytes under different pathological conditions associated with an inflammatory response...
  29. doi request reprint Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats I: Magnetic resonance imaging
    Erwin A van Vliet
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 57:59-69. 2016
    ..To study whether rapamycin mediates this effect via restoration of blood-brain barrier (BBB) dysfunction, contrast-enhanced magnetic resonance imaging (CE-MRI) was used to determine BBB permeability throughout epileptogenesis...
  30. doi request reprint Atorvastatin treatment during epileptogenesis in a rat model for temporal lobe epilepsy
    Erwin A van Vliet
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Science Park 904, Amsterdam, The Netherlands
    Epilepsia 52:1319-30. 2011
    ..If this drug could restore the blood-brain barrier, a reduction of brain inflammation might be expected, thereby delaying or preventing the development of epilepsy...
  31. ncbi request reprint Presubiculum stimulation in vivo evokes distinct oscillations in superficial and deep entorhinal cortex layers in chronic epileptic rats
    Else A Tolner
    Swammerdam Institute of Life Sciences, Center for Neuroscience, University of Amsterdam, Graduate School of Neurosciences, 1098 SM Amsterdam, The Netherlands
    J Neurosci 25:8755-65. 2005
    ..These findings emphasize the significance of the entorhinal cortex in temporal lobe epilepsy and suggest that the superficial cell layers could play an important role in distributing oscillatory activity...
  32. ncbi request reprint Expression and regulation of voltage-gated sodium channel beta1 subunit protein in human gliosis-associated pathologies
    Eleonora Aronica
    Department of Neuro Pathology, H2, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Acta Neuropathol 105:515-23. 2003
    ..These findings demonstrate that the expression of NaCh beta1 subunit protein in astrocytes is plastic, and indicate a novel mechanism for modulation of glial function in gliosis-associated pathologies...
  33. pmc Cellular distribution of vascular endothelial growth factor A (VEGFA) and B (VEGFB) and VEGF receptors 1 and 2 in focal cortical dysplasia type IIB
    Karin Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Acta Neuropathol 115:683-96. 2008
    ..In addition, the expression of VEGFA and its receptors in glial cells within the dysplastic cortex indicates that VEGF-mediated signaling could contribute to astroglial activation and associated inflammatory reactions...
  34. ncbi request reprint Expression and cell distribution of group I and group II metabotropic glutamate receptor subtypes in taylor-type focal cortical dysplasia
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 44:785-95. 2003
    ..Because recent studies indicate that metabotropic glutamate receptor subtypes (mGluRs) play a role in epileptogenesis, we investigated the expression and cellular distribution pattern of mGluRs in FCD specimens...
  35. doi request reprint Different subsets of newborn granule cells: a possible role in epileptogenesis?
    Pascal Bielefeld
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands
    Eur J Neurosci 39:1-11. 2014
    ..This hypothesis may clarify previously contradictory data in the literature, and could thereby aid in our understanding of the role of neurogenesis in epileptogenesis, and open up promising avenues for therapeutic intervention. ..
  36. ncbi request reprint Gene expression profile in temporal lobe epilepsy
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Neuroscientist 13:100-8. 2007
    ....
  37. ncbi request reprint Overexpression of the human major vault protein in gangliogliomas
    Eleonora Aronica
    Department of Neuro Pathology, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 44:1166-75. 2003
    ..We investigated the expression and cellular localization of MVP in gangliogliomas (GGs), which are increasingly recognized causes of chronic pharmacoresistant epilepsy...
  38. doi request reprint Ontogenetic modifications of neuronal excitability during brain maturation: developmental changes of neurotransmitter receptors
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Epilepsia 52:3-5. 2011
    ..We will also briefly discuss recent evidence on the involvement of the endocannabinoid signaling in the regulation of neuronal excitability during early brain development....
  39. doi request reprint Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats II: Potential mechanisms
    Erwin A van Vliet
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 57:70-8. 2016
    ..Given rapamycin's role in growth and immune response, the potential therapeutic effects of rapamycin after status epilepticus with emphasis on brain inflammation and brain vasculature were investigated...
  40. doi request reprint Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy
    Linda Holtman
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    Epilepsy Res 91:49-56. 2010
    ..Here we have investigated the effects of cox-2 inhibition on epileptogenesis, spontaneous seizures and PHT treatment in a rat model for temporal lobe epilepsy (TLE)...
  41. doi request reprint Effects of rapamycin and curcumin treatment on the development of epilepsy after electrically induced status epilepticus in rats
    Cato M Drion
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 57:688-97. 2016
    ..Here we aim to elucidate whether mTOR inhibition has antiepileptogenic and/or antiseizure effects using different treatment strategies in the electrogenic post-status epilepticus (SE) rat model...
  42. doi request reprint Glutathione pegylated liposomal methylprednisolone administration after the early phase of status epilepticus did not modify epileptogenesis in the rat
    Linda Holtman
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    Epilepsy Res 108:396-404. 2014
    ..Our study shows that the selected GSH-PEG liposomal MP treatment regimen that was administered beyond the acute SE phase does not reduce brain inflammation and development of temporal lobe epilepsy. ..
  43. doi request reprint Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy
    Jan A Gorter
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, The Netherlands SEIN Stichting Epilepsie Instellingen Nederland, Heemstede, The Netherlands
    Neurobiol Dis 62:508-20. 2014
    ..These include miRNAs that regulate the ErbB and Wnt pathways and focal adhesion, which may represent interesting new targets for therapeutic interventions. ..
  44. doi request reprint Cerebral expression of drug transporters in epilepsy
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    Adv Drug Deliv Rev 64:919-29. 2012
    ..Knowledge of the cerebral expression patterns of drug transporters in normal and epileptogenic brain will provide relevant information to guide strategies attempting to overcome drug resistance by targeting specific transporters...
  45. doi request reprint Status epilepticus, blood-brain barrier disruption, inflammation, and epileptogenesis
    Jan A Gorter
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands Electronic address
    Epilepsy Behav 49:13-6. 2015
    ..2014; Vezzani et al., 2011) [3-7]. Here, we discuss how the BBB is disrupted as a consequence of SE and how this BBB breakdown may be involved in epileptogenesis. This article is part of a Special Issue entitled "Status Epilepticus"...
  46. doi request reprint Which insights have we gained from the kindling and post-status epilepticus models?
    Jan A Gorter
    Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands Electronic address
    J Neurosci Methods 260:96-108. 2016
    ..Finally, we shortly discuss the advantages and disadvantages of these models. ..
  47. ncbi request reprint Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance
    Massimo Rizzi
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
    J Neurosci 22:5833-9. 2002
    ..P-gp alterations significantly affect antiepileptic drugs concentrations in the brain, suggesting that seizure-induced mdr mRNA expression contributes to MDR in epilepsy...
  48. ncbi request reprint Semaphorins: contributors to structural stability of hippocampal networks?
    Anthony J G D Holtmaat
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Prog Brain Res 138:17-38. 2002
  49. ncbi request reprint Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Eur J Neurosci 17:2106-18. 2003
    ....
  50. ncbi request reprint Transient downregulation of Sema3A mRNA in a rat model for temporal lobe epilepsy. A novel molecular event potentially contributing to mossy fiber sprouting
    Anthony J G D Holtmaat
    Graduate School of Neuroscience, Netherlands Institute for Brain Research, Amsterdam, Netherlands
    Exp Neurol 182:142-50. 2003
    ....
  51. ncbi request reprint Upregulation of neuronal nitric oxide synthase in in vitro stellate astrocytes and in vivo reactive astrocytes after electrically induced status epilepticus
    Maria Vincenza Catania
    Institute of Neurological Sciences, National Research Council, Section of Catania, Vl Regina Margherita 6, 95125 Catania, Italy
    Neurochem Res 28:607-15. 2003
    ..Thus, nNOS upregulation occurs in both in vitro stellate and in vivo reactive astrocytes, suggesting a possible involvement of glial nNOS in neurological diseases characterized by reactive gliosis...
  52. ncbi request reprint Expression and cellular distribution of major vault protein: a putative marker for pharmacoresistance in a rat model for temporal lobe epilepsy
    Erwin A van Vliet
    Stichting Epilepsie Instellingen Nederland, Heemstede, The Netherlands
    Epilepsia 45:1506-16. 2004
    ..Because drug transporters might play a role in the development of multidrug resistance (MDR), we investigated the expression of a vesicular drug transporter, the major vault protein (MVP), in a rat model for temporal lobe epilepsy...
  53. ncbi request reprint Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats
    Erwin A van Vliet
    Epilepsy Institute of the Netherlands SEIN, Heemstede, The Netherlands
    Epilepsia 46:1569-80. 2005
    ..In the present study, we investigated the expression of different multidrug transporters during epileptogenesis in the rat. In addition, we determined whether these transporters affected phenytoin (PHT) distribution in the brain...
  54. ncbi request reprint Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats
    Erwin A van Vliet
    Epilepsy Institute of the Netherlands SEIN, Heemstede, The Netherlands
    Epilepsia 47:672-80. 2006
    ..Here we tested whether P-gp contributes to pharmacoresistance to phenytoin (PHT) by using a specific P-gp inhibitor in a model of spontaneous seizures in rats...
  55. doi request reprint Development of tolerance to levetiracetam in rats with chronic epilepsy
    Erwin A van Vliet
    Epilepsy Institute of the Netherlands SEIN, Heemstede, The Netherlands
    Epilepsia 49:1151-9. 2008
    ..Since it has been suggested that levetiracetam (LEV) is no substrate for MDTs, we hypothesized that LEV would more adequately control seizures in this rat model...
  56. ncbi request reprint Synaptic responses in superficial layers of medial entorhinal cortex from rats with kainate-induced epilepsy
    Else A Tolner
    Johannes Müller Institute of Physiology at the Charité, Humboldt University Berlin, Tucholskystr 2, 10117 Berlin, Germany
    Neurobiol Dis 26:419-38. 2007
    ..In conclusion, hyperexcitability in superficial MEC neurons is not due to loss of GABAergic interneurons and probably results from alterations in synaptic connectivity within superficial MEC...