Klaas Nico Faber

Summary

Affiliation: University of Groningen
Country: The Netherlands

Publications

  1. ncbi A novel method to determine the topology of peroxisomal membrane proteins in vivo using the tobacco etch virus protease
    K N Faber
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    J Biol Chem 276:36501-7. 2001
  2. ncbi Normal peroxisome development from vesicles induced by truncated Hansenula polymorpha Pex3p
    Klaas Nico Faber
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Postbus 14, 9750 AA Haren, The Netherlands
    J Biol Chem 277:11026-33. 2002
  3. doi Glutathione and antioxidant enzymes serve complementary roles in protecting activated hepatic stellate cells against hydrogen peroxide-induced cell death
    Sandra Dunning
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Biochim Biophys Acta 1832:2027-34. 2013
  4. pmc Angiotensin II protects primary rat hepatocytes against bile salt-induced apoptosis
    Golnar Karimian
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e52647. 2012
  5. doi Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease
    Hans Blokzijl
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands
    J Biol Chem 283:35630-7. 2008
  6. ncbi Hansenula polymorpha Pex3p is a peripheral component of the peroxisomal membrane
    Gert Jan Haan
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    J Biol Chem 277:26609-17. 2002
  7. doi Unconjugated bile salts shuttle through hepatocyte peroxisomes for taurine conjugation
    Krzysztof P Rembacz
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hepatology 52:2167-76. 2010
  8. doi Lipid rafts are essential for peroxisome biogenesis in HepG2 cells
    Jannes Woudenberg
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hepatology 52:623-33. 2010
  9. doi Caveolin-1 is enriched in the peroxisomal membrane of rat hepatocytes
    Jannes Woudenberg
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hepatology 51:1744-53. 2010
  10. pmc Metformin protects rat hepatocytes against bile acid-induced apoptosis
    Titia E Woudenberg-Vrenken
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 8:e71773. 2013

Collaborators

Detail Information

Publications32

  1. ncbi A novel method to determine the topology of peroxisomal membrane proteins in vivo using the tobacco etch virus protease
    K N Faber
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    J Biol Chem 276:36501-7. 2001
    ..SKL revealed that the C termini of Pex3p and Pex10p are exposed to the cytosol. Additional applications of the TEV protease to study peroxisome biogenesis are discussed...
  2. ncbi Normal peroxisome development from vesicles induced by truncated Hansenula polymorpha Pex3p
    Klaas Nico Faber
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Postbus 14, 9750 AA Haren, The Netherlands
    J Biol Chem 277:11026-33. 2002
    ..We discuss the significance of this finding in relation to peroxisome reintroduction, e.g. in case peroxisomes are lost due to failure in inheritance...
  3. doi Glutathione and antioxidant enzymes serve complementary roles in protecting activated hepatic stellate cells against hydrogen peroxide-induced cell death
    Sandra Dunning
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Biochim Biophys Acta 1832:2027-34. 2013
    ..Therefore, activated hepatic stellate cells need to harbor highly effective anti-oxidants to protect against the toxic effects of ROS...
  4. pmc Angiotensin II protects primary rat hepatocytes against bile salt-induced apoptosis
    Golnar Karimian
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e52647. 2012
    ..Moreover, AT-II prevented the GCDCA-induced expression of CHOP (the marker of the ER-mediated apoptosis)...
  5. doi Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease
    Hans Blokzijl
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands
    J Biol Chem 283:35630-7. 2008
    ..These data show that MRP1 protects intestinal epithelial cells against inflammation-induced apoptotic cell death and provides a functional role for MRP1 in the inflamed intestinal epithelium of IBD patients...
  6. ncbi Hansenula polymorpha Pex3p is a peripheral component of the peroxisomal membrane
    Gert Jan Haan
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    J Biol Chem 277:26609-17. 2002
    ..Taken together, our data suggest that HpPex3p does not span the peroxisomal membrane but instead is tightly associated to the cytosolic face of the organelle where it may be present in focal protein clusters...
  7. doi Unconjugated bile salts shuttle through hepatocyte peroxisomes for taurine conjugation
    Krzysztof P Rembacz
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hepatology 52:2167-76. 2010
    ..D(4)TCA was detected in fractions of purified peroxisomes, which did not contain D(4)CA and D(4)GCA...
  8. doi Lipid rafts are essential for peroxisome biogenesis in HepG2 cells
    Jannes Woudenberg
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hepatology 52:623-33. 2010
    ..Repletion of cholesterol to these cells efficiently reestablished the peroxisomal sorting of catalase but not ALDP...
  9. doi Caveolin-1 is enriched in the peroxisomal membrane of rat hepatocytes
    Jannes Woudenberg
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hepatology 51:1744-53. 2010
    ..Targeting of peroxisomal matrix proteins and peroxisome number and shape were not altered in rat hepatocytes with 70%-80% reduced caveolin-1 levels and in livers of caveolin-1 knockout mice...
  10. pmc Metformin protects rat hepatocytes against bile acid-induced apoptosis
    Titia E Woudenberg-Vrenken
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 8:e71773. 2013
    ..AMPK is an inhibitor of mammalian target of rapamycin (mTOR). Both AMPK and mTOR are able to modulate cell death...
  11. ncbi Import of assembled PTS1 proteins into peroxisomes of the yeast Hansenula polymorpha: yes and no!
    Klaas Nico Faber
    Eukaryotic Microbiology, GBB, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Biochim Biophys Acta 1591:157-162. 2002
    ..SKL and dimeric DHAS. This shows that import of oligomeric proteins is not a universal pathway for peroxisomal matrix proteins...
  12. doi Superoxide anions and hydrogen peroxide inhibit proliferation of activated rat stellate cells and induce different modes of cell death
    Sandra Dunning
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Liver Int 29:922-32. 2009
    ..Oxidative stress has been implicated as a driving force of HSC activation and proliferation, although contradictory results have been described...
  13. doi Low retinol levels differentially modulate bile salt-induced expression of human and mouse hepatic bile salt transporters
    Martijn O Hoeke
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hepatology 49:151-9. 2009
    ..Ntcp protein expression was strongly reduced in CA-fed VAD mice, whereas mRNA levels were normal. CA-fed control and VAD mice had similarly increased serum bile salt levels...
  14. pmc Pertussis toxin, an inhibitor of G(αi) PCR, inhibits bile acid- and cytokine-induced apoptosis in primary rat hepatocytes
    Golnar Karimian
    Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 7:e43156. 2012
    ....
  15. doi Anti-oxidants do not prevent bile acid-induced cell death in rat hepatocytes
    Titia E Woudenberg-Vrenken
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Liver Int 30:1511-21. 2010
    ....
  16. doi The active metabolite of leflunomide, A77 1726, protects rat hepatocytes against bile acid-induced apoptosis
    Titia E Vrenken
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    J Hepatol 49:799-809. 2008
    ..Both cell protective and cytotoxic effects of leflunomide have been described. Since leflunomide affects pathways involved in hepatocyte cell survival, we examined the effects of A77 1726 on hepatocyte cell death...
  17. doi Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells
    Rebekka A Hannivoort
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hepatology 48:624-34. 2008
    ..Cytokines induced Mdr1b expression only. Oxidative stress was not a major regulator of Mdr and Mrp transporter expression. Activated HSCs became necrotic when exposed to the Mrp inhibitors...
  18. doi The ATG16L1-T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients
    Mehdi Sadaghian Sadabad
    Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Gut 64:1546-52. 2015
    ..We investigated the effect of inflammation on the composition of microbiota in the ileal mucosa of CD patients in relation to the ATG16L1 risk status...
  19. pmc A simple coculture system shows mutualism between anaerobic faecalibacteria and epithelial Caco-2 cells
    Mehdi Sadaghian Sadabad
    Departments of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Sci Rep 5:17906. 2015
    ....
  20. pmc Human FXR regulates SHP expression through direct binding to an LRH-1 binding site, independent of an IR-1 and LRH-1
    Martijn O Hoeke
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 9:e88011. 2014
    ..Still, most FXR/RXRα target genes are maximally expressed in the presence of both ligands, including the small heterodimer partner (SHP). Here, we revisited the FXR/RXRα-mediated regulation of human SHP...
  21. ncbi Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport
    Antonella Pellicoro
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hepatology 45:340-8. 2007
    ..When expressed in fibroblasts, GFP-tagged hBAAT localized to the cytosol, confirming earlier observations...
  22. ncbi Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels
    Hans Blokzijl
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Inflamm Bowel Dis 13:710-20. 2007
    ..Here we compared intestinal MDR1 mRNA and protein expression in uninflamed and inflamed intestinal epithelium (IE) of patients with gastrointestinal inflammatory disorders to healthy controls...
  23. doi Suppression of p21Rac signaling and increased innate immunity mediate remission in Crohn's disease
    Kaushal Parikh
    Department of Cell Biology, University Medical Center Groningen, University of Groningen, Deusinglaan 1, NL 9713 AV Groningen, The Netherlands
    Sci Transl Med 6:233ra53. 2014
    ..Thus, suppression of p21Rac activity assists innate immunity in bactericidal activity and may induce remission in IBD. ..
  24. doi Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase
    Shiva Shajari
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Pineal Res 59:391-401. 2015
    ..We conclude that melatonin directly suppresses HSC activation via RORα-mediated inhibition of Alox5 expression, which provides novel drug targets to treat liver fibrosis. ..
  25. pmc Hormesis in Cholestatic Liver Disease; Preconditioning with Low Bile Acid Concentrations Protects against Bile Acid-Induced Toxicity
    Esther M Verhaag
    Department of Gastroenterology and Hepatology, Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 11:e0149782. 2016
    ..This may be explained by a hormetic response in hepatocytes that limits cell death during cholestasis...
  26. ncbi LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process
    Marieke G L Elferink
    Department Pharmacokinetics and Drug Delivery, University of Groningen, 9713 AV Groningen, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 287:G1008-16. 2004
    ..In conclusion, we show that posttranscriptional mechanisms play a more prominent role in LPS-induced regulation of human MRP2 and BSEP compared with the rat transporter proteins...
  27. pmc Targeting pathogen metabolism without collateral damage to the host
    Jurgen R Haanstra
    University of Groningen, University Medical Center Groningen, Department of Pediatrics and Systems Biology Centre for Energy Metabolism and Ageing, Center for Liver, Digestive and Metabolic Diseases, Groningen, The Netherlands
    Sci Rep 7:40406. 2017
    ..Computational predictions were validated experimentally in a novel parasite-erythrocytes co-culture system. Glucose-transport inhibitors killed trypanosomes without killing erythrocytes, neurons or liver cells...
  28. pmc Impact of human granulocyte and monocyte isolation procedures on functional studies
    Lu Zhou
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Vaccine Immunol 19:1065-74. 2012
    ....
  29. doi Effects of active and passive smoking on disease course of Crohn's disease and ulcerative colitis
    Frans van der Heide
    Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Inflamm Bowel Dis 15:1199-207. 2009
    ..We studied the effects of active and passive smoking in Dutch IBD patients...
  30. ncbi Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump
    Jacqueline R M Plass
    Center for Liver, Digestive, and Metabolic Diseases, University Hospital Groningen, 9700 RB Groningen, The Netherlands
    Hepatology 35:589-96. 2002
    ..In conclusion, these results show that FXR is required for the bile salt-dependent transcriptional control of the human ABCB11 gene and that the cellular amount of FXR is critical for the level of activation of ABCB11 transcription...
  31. ncbi Drug transport proteins in the liver
    Klaas Nico Faber
    Department of Gastroenterology and Hepatology, State University Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Adv Drug Deliv Rev 55:107-24. 2003
    ..Adverse drug reactions may be caused by genetic or disease-induced variations of transporter expression or drug-drug interactions at the level of these transporters...
  32. ncbi A progressive familial intrahepatic cholestasis type 2 mutation causes an unstable, temperature-sensitive bile salt export pump
    Jacqueline R M Plass
    Department of Gastroenterology and Hepatology, Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Hepatol 40:24-30. 2004
    ..The disease is caused by mutations in the bile salt export pump (BSEP). Ten different missense mutations have been described. In this study, we analysed the effect of the D482G PFIC-2 mutation on BSEP function...