Janine Doorduin

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. doi request reprint Neuroinflammation in schizophrenia-related psychosis: a PET study
    Janine Doorduin
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Nucl Med 50:1801-7. 2009
  2. pmc [11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis
    Janine Doorduin
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    Mol Imaging Biol 11:386-98. 2009
  3. doi request reprint Evaluation of [11C]-DAA1106 for imaging and quantification of neuroinflammation in a rat model of herpes encephalitis
    Janine Doorduin
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Nucl Med Biol 37:9-15. 2010
  4. doi request reprint Can celecoxib affect P-glycoprotein-mediated drug efflux? A microPET study
    Erik F J de Vries
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Nucl Med Biol 35:459-66. 2008
  5. doi request reprint 18F-FEAnGA for PET of β-glucuronidase activity in neuroinflammation
    Inês F Antunes
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 53:451-8. 2012
  6. ncbi request reprint Evaluation of [(11)C]rofecoxib as PET tracer for cyclooxygenase 2 overexpression in rat models of inflammation
    Erik F J de Vries
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Nucl Med Biol 35:35-42. 2008
  7. ncbi request reprint PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders
    Janine Doorduin
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Curr Pharm Des 14:3297-315. 2008
  8. doi request reprint Volume, metabolites and neuroinflammation of the hippocampus in bipolar disorder - A combined magnetic resonance imaging and positron emission tomography study
    Bartholomeus C M Benno Haarman
    University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands Radiology Morphological Solutions, Berkel en Rodenrijs, The Netherlands Electronic address
    Brain Behav Immun 56:21-33. 2016
  9. ncbi request reprint Synthesis and preliminary evaluation of (S)-[11C]-exaprolol, a novel beta-adrenoceptor ligand for PET
    Aren van Waarde
    Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Neurochem Int 52:729-33. 2008
  10. doi request reprint Pharmacokinetic Analysis of 11C-PBR28 in the Rat Model of Herpes Encephalitis: Comparison with (R)-11C-PK11195
    Andrea Parente
    Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 57:785-91. 2016

Collaborators

Detail Information

Publications20

  1. doi request reprint Neuroinflammation in schizophrenia-related psychosis: a PET study
    Janine Doorduin
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Nucl Med 50:1801-7. 2009
    ....
  2. pmc [11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis
    Janine Doorduin
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    Mol Imaging Biol 11:386-98. 2009
    ..In this study, we evaluated the PET tracers [(11)C]-DPA-713 and [(18)F]-DPA-714 as agents for imaging of activated microglia in a rat model of herpes encephalitis...
  3. doi request reprint Evaluation of [11C]-DAA1106 for imaging and quantification of neuroinflammation in a rat model of herpes encephalitis
    Janine Doorduin
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Nucl Med Biol 37:9-15. 2010
    ..As a potentially more sensitive PET tracer for neuroinflammation, [(11)C]-N-(2,5-dimethoxybenzyl)-N-(4-fluoro-2-phenoxyphenyl)-acetamide (DAA1106) was evaluated in a rat model of herpes encephalitis...
  4. doi request reprint Can celecoxib affect P-glycoprotein-mediated drug efflux? A microPET study
    Erik F J de Vries
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Nucl Med Biol 35:459-66. 2008
    ..To clarify whether Pgp is involved in the sensitizing effect of celecoxib, we investigated in vivo whether celecoxib is a substrate of Pgp and whether it can affect the efflux activity of the pump...
  5. doi request reprint 18F-FEAnGA for PET of β-glucuronidase activity in neuroinflammation
    Inês F Antunes
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 53:451-8. 2012
    ..In this study, we investigated whether the PET tracer (18)F-FEAnGA was able to detect β-glucuronidase release during neuroinflammation in a rat model of herpes encephalitis...
  6. ncbi request reprint Evaluation of [(11)C]rofecoxib as PET tracer for cyclooxygenase 2 overexpression in rat models of inflammation
    Erik F J de Vries
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Nucl Med Biol 35:35-42. 2008
    ..This study aims to investigate [(11)C]rofecoxib as a positron emission tomography (PET) tracer for COX-2 expression...
  7. ncbi request reprint PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders
    Janine Doorduin
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Curr Pharm Des 14:3297-315. 2008
    ..The imaging studies published so far showed that the PBR can be an important target for monitoring disease progression, therapy response and determining the optimal drug dose...
  8. doi request reprint Volume, metabolites and neuroinflammation of the hippocampus in bipolar disorder - A combined magnetic resonance imaging and positron emission tomography study
    Bartholomeus C M Benno Haarman
    University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands Radiology Morphological Solutions, Berkel en Rodenrijs, The Netherlands Electronic address
    Brain Behav Immun 56:21-33. 2016
    ....
  9. ncbi request reprint Synthesis and preliminary evaluation of (S)-[11C]-exaprolol, a novel beta-adrenoceptor ligand for PET
    Aren van Waarde
    Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Neurochem Int 52:729-33. 2008
    ..The observed inhibition of tracer uptake in lung, spleen and erythrocytes seems due to an interaction of propranolol with amine transporters rather than beta-adrenoceptors...
  10. doi request reprint Pharmacokinetic Analysis of 11C-PBR28 in the Rat Model of Herpes Encephalitis: Comparison with (R)-11C-PK11195
    Andrea Parente
    Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 57:785-91. 2016
    ..These results suggest that (11)C-PBR28 should be able to detect more subtle changes in microglial activation in preclinical models of neuroinflammation. ..
  11. pmc Evaluation of [(11)C]CB184 for imaging and quantification of TSPO overexpression in a rat model of herpes encephalitis
    David Vállez Garcia
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB, Groningen, The Netherlands
    Eur J Nucl Med Mol Imaging 42:1106-18. 2015
    ..11)C]PK11195 PET imaging has been widely used for this purpose. However, it has a low sensitivity and a poor signal-to-noise ratio. For these reasons, [(11)C]CB184 was evaluated as a potentially more sensitive PET tracer...
  12. pmc Novel Approach to Repeated Arterial Blood Sampling in Small Animal PET: Application in a Test-Retest Study with the Adenosine A1 Receptor Ligand [(11)C]MPDX
    Jurgen W A Sijbesma
    University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Mol Imaging Biol 18:715-23. 2016
    ..This often requires rapid arterial blood sampling. However, current catheterization procedures do not allow repeated blood sampling. We have developed a procedure which allows arterial sampling on repeated occasions in the same animal...
  13. ncbi request reprint Three Month Follow-Up of Rat Mild Traumatic Brain Injury: A Combined [18F]FDG and [11C]PK11195 Positron Emission Study
    David Vállez Garcia
    1 Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Neurotrauma 33:1855-1865. 2016
    ....
  14. pmc Altered Regional Cerebral Blood Flow in Chronic Whiplash Associated Disorders
    David Vállez Garcia
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Huispostcode EB50, Postbus 30001, 9700 RB Groningen, The Netherlands Electronic address
    EBioMedicine 10:249-57. 2016
    ....
  15. doi request reprint P-glycoprotein activity in the blood-brain barrier is affected by virus-induced neuroinflammation and antipsychotic treatment
    Janine Doorduin
    Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands Electronic address
    Neuropharmacology 85:548-53. 2014
    ..This finding is of importance for the understanding of treatment resistance in schizophrenia, and warrants further investigation of the underlying mechanism and the importance in clinical practice...
  16. doi request reprint Cerebral adenosine A₁ receptors are upregulated in rodent encephalitis
    Soumen Paul
    University of Groningen, University Medical Center Groningen, Nuclear Medicine and Molecular Imaging, Hanzeplein 1, 9713GZ Groningen, The Netherlands
    Neuroimage 92:83-9. 2014
    ..Both the quantitative PET data and immunohistochemical analysis indicate that A1Rs are upregulated in brain areas where active virus is present...
  17. doi request reprint Neuroinflammation in bipolar disorder - A [(11)C]-(R)-PK11195 positron emission tomography study
    Bartholomeus C M Benno Haarman
    University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands Electronic address
    Brain Behav Immun 40:219-25. 2014
    ..We aim to determine if there is increased [(11)C]-(R)-PK11195 binding to activated microglia in the hippocampus of patients with bipolar I disorder when compared to healthy controls...
  18. doi request reprint In vivo imaging of brain estrogen receptors in rats: a 16α-18F-fluoro-17β-estradiol PET study
    Mohammed A Khayum
    Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Nucl Med 55:481-7. 2014
    ....
  19. doi request reprint Manipulation of [11C]-5-hydroxytryptophan and 6-[18F]fluoro-3,4-dihydroxy-L-phenylalanine accumulation in neuroendocrine tumor cells
    Oliver C Neels
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Cancer Res 68:7183-90. 2008
    ..This could be a consequence of the serotonin saturation of BON cells in the in vivo model...
  20. pmc A standardized method for the construction of tracer specific PET and SPECT rat brain templates: validation and implementation of a toolbox
    David Vállez Garcia
    Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 10:e0122363. 2015
    ..The templates and the SAMIT package will be freely available for the research community [corrected]...