Paul J Coffer

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Rapid temporal control of Foxp3 protein degradation by sirtuin-1
    Jorg van Loosdregt
    Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e19047. 2011
  2. pmc SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition
    Stephin J Vervoort
    Department of Cell Biology, University Medical Centre, Utrecht, The Netherlands
    PLoS ONE 8:e53238. 2013
  3. pmc Hepatic autophagy is differentially regulated in periportal and pericentral zones - a general mechanism relevant for other tissues?
    Rolf Gebhardt
    Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Leipzig, Germany
    Cell Commun Signal 11:21. 2013
  4. doi p38 MAP kinase inhibits neutrophil development through phosphorylation of C/EBPalpha on serine 21
    Christian R Geest
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Utrecht, The Netherlands
    Stem Cells 27:2271-82. 2009
  5. ncbi Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis
    Miranda Buitenhuis
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Utrecht, The Netherlands
    Blood 111:112-21. 2008
  6. ncbi Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors
    Christian R Geest
    Molecular Immunology Lab, Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 114:3402-12. 2009
  7. pmc Ectopic expression of C/EBPalpha and ID1 is sufficient to restore defective neutrophil development in low-risk myelodysplasia
    Christian R Geest
    Department of Immunology, University Medical Center, Utrecht, The Netherlands
    Haematologica 94:1075-84. 2009
  8. pmc Mammalian target of rapamycin activity is required for expansion of CD34+ hematopoietic progenitor cells
    Christian R Geest
    Department of Immunology, Molecular Immunology Lab, UMC, Utrecht, The Netherlands
    Haematologica 94:901-10. 2009
  9. ncbi Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2
    Miranda Buitenhuis
    Department of Pulmonary Diseases, University Medical Center, Utrecht, The Netherlands
    Blood 105:4272-81. 2005
  10. doi HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation
    Loes M Kuijk
    Department of General Pediatrics, University Medical Centre, Utrecht, The Netherlands
    Blood 112:3563-73. 2008

Collaborators

Detail Information

Publications44

  1. pmc Rapid temporal control of Foxp3 protein degradation by sirtuin-1
    Jorg van Loosdregt
    Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e19047. 2011
    ..Pharmacological modulation of SIRT1 activity in Treg may therefore provide a novel therapeutic strategy for controlling immune responses...
  2. pmc SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition
    Stephin J Vervoort
    Department of Cell Biology, University Medical Centre, Utrecht, The Netherlands
    PLoS ONE 8:e53238. 2013
    ..Taken together, these data suggest that TGF-b-mediated increased expression of SOX4 is required for the induction of a mesenchymal phenotype during EMT in human mammary epithelial cells...
  3. pmc Hepatic autophagy is differentially regulated in periportal and pericentral zones - a general mechanism relevant for other tissues?
    Rolf Gebhardt
    Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Leipzig, Germany
    Cell Commun Signal 11:21. 2013
    ..Since in liver this mechanism can only be functioning in the pericentral zone it remains unclear how autophagy might be regulated in the rest of liver parenchyma...
  4. doi p38 MAP kinase inhibits neutrophil development through phosphorylation of C/EBPalpha on serine 21
    Christian R Geest
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Utrecht, The Netherlands
    Stem Cells 27:2271-82. 2009
    ..This signaling module may thus provide an important therapeutic target in the treatment of bone marrow failure...
  5. ncbi Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis
    Miranda Buitenhuis
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Utrecht, The Netherlands
    Blood 111:112-21. 2008
    ..These results identify an important novel role for PKB in regulation of cell fate choices during hematopoietic lineage commitment...
  6. ncbi Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors
    Christian R Geest
    Molecular Immunology Lab, Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 114:3402-12. 2009
    ....
  7. pmc Ectopic expression of C/EBPalpha and ID1 is sufficient to restore defective neutrophil development in low-risk myelodysplasia
    Christian R Geest
    Department of Immunology, University Medical Center, Utrecht, The Netherlands
    Haematologica 94:1075-84. 2009
    ..Although a number of genetic defects in myelodysplastic progenitor cells have been described, the intracellular signaling pathways underlying aberrant regulation of myelopoiesis remain relatively undefined...
  8. pmc Mammalian target of rapamycin activity is required for expansion of CD34+ hematopoietic progenitor cells
    Christian R Geest
    Department of Immunology, Molecular Immunology Lab, UMC, Utrecht, The Netherlands
    Haematologica 94:901-10. 2009
    ....
  9. ncbi Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2
    Miranda Buitenhuis
    Department of Pulmonary Diseases, University Medical Center, Utrecht, The Netherlands
    Blood 105:4272-81. 2005
    ..These data demonstrate that both Id1 and Id2 play a critical, although differential role in granulopoiesis...
  10. doi HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation
    Loes M Kuijk
    Department of General Pediatrics, University Medical Centre, Utrecht, The Netherlands
    Blood 112:3563-73. 2008
    ..These data suggest that pharmacologic inhibition of Rac1 could provide a novel therapeutic strategy for treatment of MKD...
  11. doi Survival, but not maturation, is affected in neutrophil progenitors from GSD-1b patients
    Gepke Visser
    Department of Metabolic Diseases, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    J Inherit Metab Dis 35:287-300. 2012
    ....
  12. doi Signal inhibitory receptor on leukocytes-1 (SIRL-1) negatively regulates the oxidative burst in human phagocytes
    Tessa A M Steevels
    Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Immunol 43:1297-308. 2013
    ..We propose that SIRL-1 on phagocytes sets an activation threshold to prevent inappropriate production of oxygen radicals. Upon infection, SIRL-1 expression is downregulated, allowing microbial killing and clearance of the pathogen...
  13. doi Protein kinase B (PKB/c-akt) regulates homing of hematopoietic progenitors through modulation of their adhesive and migratory properties
    Miranda Buitenhuis
    Molecular Immunology Laboratory, Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 116:2373-84. 2010
    ..These results indicate that transient inhibition of PKB activity may provide a means for ex vivo stem cell manipulation to improve bone marrow transplantation regimes...
  14. doi Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output
    Jeffrey M Beekman
    Molecular Immunology Laboratory, Department of Immunology, Wilhelmina Childrens Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands
    Blood 114:3917-27. 2009
    ..These data demonstrate that cytokine-specific functions can be transduced by unique receptor alpha-chain-associating adapter proteins...
  15. ncbi Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function
    Sandra Verploegen
    Molecular Immunology Lab, Department of Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Blood 106:1076-83. 2005
    ..These findings suggest a critical role for CKLiK in modulating chemoattractant-induced functional responses in human granulocytes...
  16. doi Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
    Jorg van Loosdregt
    Molecular Immunology Lab, Department of Immunology, Wilhelmina Children s Hospital, Utrecht, The Netherlands
    Blood 115:965-74. 2010
    ..Manipulating Foxp3 acetylation levels could therefore provide a new therapeutic strategy to control inappropriate (auto)immune responses...
  17. pmc Co-expression of the collagen receptors leukocyte-associated immunoglobulin-like receptor-1 and glycoprotein VI on a subset of megakaryoblasts
    Tessa A M Steevels
    Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Haematologica 95:2005-12. 2010
    ..Thus far, the cellular expression of glycoprotein VI and leukocyte-associated immunoglobulin-like receptor-1 appears mutually exclusive...
  18. pmc Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation
    Marije Bartels
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Haematologica 95:1052-60. 2010
    ..Nonetheless, little is currently known concerning their effects on myelopoiesis...
  19. doi Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity
    Jorg van Loosdregt
    Department of Immunology, University Medical Center Utrecht, Utrecht 3584EA, The Netherlands
    Immunity 39:259-71. 2013
    ..Our data reveal a molecular mechanism in which rapid temporal control of Foxp3 expression in Treg cells can be regulated by USP7, thereby modulating Treg cell numbers and function. ..
  20. ncbi Chronic protein kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation
    Ankie G M van Gorp
    Molecular Immunology Laboratory, Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cancer Res 66:10760-9. 2006
    ..Taken together, our data provide novel insights into the molecular consequences of uncontrolled PKB activation...
  21. doi Valproic acid treatment is associated with altered leukocyte subset development
    Marije Bartels
    Department of Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Psychopharmacol 32:832-4. 2012
    ..In this study, we demonstrate that in a large patient population treated for neurological or psychiatric disorders, VPA treatment affects neutrophil as well as lymphocyte subset counts...
  22. ncbi FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1
    Kim U Birkenkamp
    Molecular Immunology Laboratory, Department of Immunology, University Medical Center, KC 02 085 2, Lundiaan 6, 3584 CX Utrecht, The Netherlands
    J Biol Chem 282:2211-20. 2007
    ..Taken together our data strongly suggest that high expression of Id1, through PKB-mediated inhibition of FOXO3a, is critical for maintenance of the leukemic phenotype...
  23. ncbi Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation
    Miranda Buitenhuis
    Molecular Immunology Lab, Department of Immunology, University Medical Center, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Cancer Res 67:3759-66. 2007
    ....
  24. doi Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy
    Kristan E van der Vos
    Department of Immunology, University Medical Center Utrecht, Utrecht 3584CX, The Netherlands
    Nat Cell Biol 14:829-37. 2012
    ..These findings reveal a growth-factor-responsive network that can directly modulate autophagy through the regulation of glutamine metabolism...
  25. doi Canonical Wnt signaling negatively modulates regulatory T cell function
    Jorg van Loosdregt
    Department of Immunology, University Medical Center Utrecht, Utrecht 3584EA, The Netherlands
    Immunity 39:298-310. 2013
    ..We propose a model in which Wnt produced under inflammatory conditions represses Treg cell function, allowing a productive immune response, but, if uncontrolled, could lead to the development of autoimmunity. ..
  26. pmc STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass
    Petrus R de Jong
    Department of Pediatric Intensive Care, University Medical Center Utrecht, Wilhelmina Children s Hospital, Utrecht, The Netherlands
    PLoS ONE 7:e35070. 2012
    ..The purpose of this study was to identify the major signaling pathway involved in plasma-mediated inhibition of LPS-induced tumor necrosis factor (TNF)-α production by monocytes...
  27. ncbi Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells
    Miranda Buitenhuis
    Department of Pulmonary Diseases, University Medical Center, Utrecht, The Netherlands
    Blood 101:134-42. 2003
    ..These results demonstrate that STAT5 plays a critical role in eosinophil differentiation of primary human hematopoietic cells...
  28. ncbi Forkhead-box transcription factors and their role in the immune system
    Paul J Coffer
    Department of Pulmonary Diseases, University Medical Centre, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Nat Rev Immunol 4:889-99. 2004
    ..This review focuses on FOXP3, FOXN1, FOXJ1 and members of the FOXO subfamily and their function in the immune system...
  29. doi The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity
    Ismayil Taşdelen
    Department of Metabolic Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands
    Biochem J 451:45-53. 2013
    ..These findings qualify the phosphatase PPM1B as a novel selective modulator of PPARγ activity...
  30. ncbi Functional analysis of the interleukin-5 receptor antagonist peptide, AF18748
    Marcela Rosas
    Department of Pulmonary Diseases, G03 550, University Medical Centre, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Cytokine 26:247-54. 2004
    ..In each case the AF18748 functioned as an antagonist. These data suggest that AF18748 may be useful to specifically modulate eosinophil function in vivo...
  31. ncbi Differential expression of leukocyte-associated Ig-like receptor-1 during neutrophil differentiation and activation
    Annelies Verbrugge
    Department of Immunology, University Medical Center Utrecht, Room KC02 085 2, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    J Leukoc Biol 79:828-36. 2006
    ..Our studies suggest that LAIR-1 may play a regulatory role in differentiation and function of human granulocytes...
  32. ncbi MAPK signaling pathways in the regulation of hematopoiesis
    Christian R Geest
    Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Leukoc Biol 86:237-50. 2009
    ..In addition, the consequences of aberrant MAPK activation in the pathogenesis of various myeloid malignancies will be discussed...
  33. doi Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells
    Ellen J Wehrens
    Center for Molecular and Cellular Intervention, Department of Immunology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 118:3538-48. 2011
    ..Furthermore, these findings suggest that for a Treg enhancing strategy to be successful in the treatment of autoimmune inflammation, resistance because of PKB/c-akt hyperactivation should be targeted as well...
  34. doi Signal inhibitory receptor on leukocytes-1 is a novel functional inhibitory immune receptor expressed on human phagocytes
    Tessa A M Steevels
    Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Immunol 184:4741-8. 2010
    ..Thus, SIRL-1 is a novel inhibitory immune receptor belonging to the growing family of ITIM-bearing receptors that is implied in the regulation of phagocytes...
  35. doi The extending network of FOXO transcriptional target genes
    Kristan E van der Vos
    Molecular Immunology Lab, Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Antioxid Redox Signal 14:579-92. 2011
    ..In this review we describe the functional consequences of FOXO activation based on our current knowledge of transcriptional targets...
  36. doi Statin synergizes with LPS to induce IL-1beta release by THP-1 cells through activation of caspase-1
    Loes M Kuijk
    Department of General Pediatrics, Division of Pediatrics, University Medical Center, Utrecht, The Netherlands
    Mol Immunol 45:2158-65. 2008
    ..These findings suggest that MKD patients may have overactive caspase-1, causing enhanced IL-1beta processing and subsequent inflammation in response to bacterial components...
  37. doi Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis
    Wilco de Jager
    Department of Pediatrics, Centre for Cellular and Molecular Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 60:2782-93. 2009
    ..Since IL-18 can drive NK cell function, we examined how the high plasma levels of this cytokine are related to the documented NK cell failure in these patients...
  38. ncbi Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions. Comparison with the role of phosphotidylinositol-3 kinase
    Sandra Verploegen
    Department of Pulmonary Diseases, University Medical Center Utrecht, The Netherlands
    Eur J Biochem 269:4625-34. 2002
    ....
  39. pmc Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion
    Robert van der Burgh
    From the Department of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht, Wilhelmina Children s Hospital, 3584 EA Utrecht, The Netherlands
    J Biol Chem 289:5000-12. 2014
    ..Together, these results indicate that defective autophagy can prime monocytes for mitochondria-mediated NLRP3 inflammasome activation, thereby contributing to hypersecretion of IL-1β in mevalonate kinase deficiency. ..
  40. ncbi FOXO transcription factors as regulators of immune homeostasis: molecules to die for?
    Kim U Birkenkamp
    Department of Pulmonary Diseases, University Medical Center, Utrecht, The Netherlands
    J Immunol 171:1623-9. 2003
    ..A greater understanding of the regulation and function of this signaling pathway in lymphocytes may provide novel therapeutic opportunities for immune diseases...
  41. pmc Differential effects of nitrostyrene derivatives on myelopoiesis involve regulation of C/EBPα and p38MAPK activity
    Marije Bartels
    Department of Cell Biology, University Medical Center Utrecht, Utrecht, The Netherlands Division of Pediatrics, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 9:e90586. 2014
    ....
  42. doi c-Jun activating binding protein 1 binds to the IgA receptor and modulates protein levels of FcalphaRI and FcRgamma-chain
    Jantine E Bakema
    The Immunotherapy laboratory, Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Immunol 40:2035-40. 2010
    ..These data functionally link JAB1 with controlling protein expression levels of FcalphaRI-FcR gamma-chain protein complex...
  43. doi The ins and outs of syntenin, a multifunctional intracellular adaptor protein
    Jeffrey M Beekman
    Department of Immunology and Pediatric Immunology, Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
    J Cell Sci 121:1349-55. 2008
    ..Here we assimilate and discuss current data that support a role for syntenin in regulating transmembrane-receptor trafficking, tumour-cell metastasis and neuronal-synapse function...
  44. pmc Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors
    Geert J P L Kops
    Department of Physiological Chemistry, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    Mol Cell Biol 22:2025-36. 2002
    ..We therefore propose that Forkhead inactivation by PKB signaling in quiescent cells is a crucial step in cell cycle reentry and contributes to the processes of transformation and regeneration...