Hilgo Bruining

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Dissecting the clinical heterogeneity of autism spectrum disorders through defined genotypes
    Hilgo Bruining
    Department of Children and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 5:e10887. 2010
  2. doi request reprint Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development
    Hilgo Bruining
    Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands Electronic address
    Biol Psychiatry 78:485-95. 2015
  3. doi request reprint Paradoxical Benzodiazepine Response: A Rationale for Bumetanide in Neurodevelopmental Disorders?
    Hilgo Bruining
    Departments of Translational Neuroscience, Psychiatry, and
    Pediatrics 136:e539-43. 2015
  4. pmc Behavioral signatures related to genetic disorders in autism
    Hilgo Bruining
    Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center, Postbus 85500, Heidelberglaan 100 3508 GA, Utrecht, The Netherlands
    Mol Autism 5:11. 2014
  5. doi request reprint Psychiatric characteristics in a self-selected sample of boys with Klinefelter syndrome
    Hilgo Bruining
    University Medical Centre Utrecht, Department of Child and Adolescent Psychiatry, Heidelberglaan 100, Postbus 85500, 3508 GA, Utrecht, Netherlands
    Pediatrics 123:e865-70. 2009
  6. pmc The parent-of-origin of the extra X chromosome may differentially affect psychopathology in Klinefelter syndrome
    Hilgo Bruining
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Biol Psychiatry 68:1156-62. 2010
  7. doi request reprint In search for significant cognitive features in Klinefelter syndrome through cross-species comparison of a supernumerary X chromosome
    H Bruining
    Department of Psychiatry Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University of Utrecht, The Netherlands
    Genes Brain Behav 10:658-62. 2011
  8. pmc Limited impact of Cntn4 mutation on autism-related traits in developing and adult C57BL/6J mice
    Remco T Molenhuis
    Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
    J Neurodev Disord 8:6. 2016
  9. pmc Sex-dependent novelty response in neurexin-1α mutant mice
    Marijke C Laarakker
    Department of Neurosciences and Pharmacology, Division of Neuroscience, Rudolf Magnus Institute, University Medical Center Utrecht, The Netherlands
    PLoS ONE 7:e31503. 2012

Collaborators

Detail Information

Publications9

  1. pmc Dissecting the clinical heterogeneity of autism spectrum disorders through defined genotypes
    Hilgo Bruining
    Department of Children and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    PLoS ONE 5:e10887. 2010
    ..Here, a first attempt is made to assess whether genetically more homogeneous ASD groups are associated with decreased phenotypic heterogeneity with respect to their autistic symptom profile...
  2. doi request reprint Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development
    Hilgo Bruining
    Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands Electronic address
    Biol Psychiatry 78:485-95. 2015
    ..Here, we analyzed genetic contributions to single-trial, long-term social and nonsocial recognition and subsequently studied the functional impact of an identified candidate gene on behavioral development...
  3. doi request reprint Paradoxical Benzodiazepine Response: A Rationale for Bumetanide in Neurodevelopmental Disorders?
    Hilgo Bruining
    Departments of Translational Neuroscience, Psychiatry, and
    Pediatrics 136:e539-43. 2015
    ..This case highlights that a paradoxical behavioral response to GABA-enforcing drugs may constitute a framework for targeted treatment with bumetanide. ..
  4. pmc Behavioral signatures related to genetic disorders in autism
    Hilgo Bruining
    Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center, Postbus 85500, Heidelberglaan 100 3508 GA, Utrecht, The Netherlands
    Mol Autism 5:11. 2014
    ..Autism spectrum disorder (ASD) is well recognized to be genetically heterogeneous. It is assumed that the genetic risk factors give rise to a broad spectrum of indistinguishable behavioral presentations...
  5. doi request reprint Psychiatric characteristics in a self-selected sample of boys with Klinefelter syndrome
    Hilgo Bruining
    University Medical Centre Utrecht, Department of Child and Adolescent Psychiatry, Heidelberglaan 100, Postbus 85500, 3508 GA, Utrecht, Netherlands
    Pediatrics 123:e865-70. 2009
    ..To our knowledge, the only data available are from psychiatric inventories of adults with Klinefelter syndrome...
  6. pmc The parent-of-origin of the extra X chromosome may differentially affect psychopathology in Klinefelter syndrome
    Hilgo Bruining
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Biol Psychiatry 68:1156-62. 2010
    ..Here, we investigated whether the parent-of-origin of the supernumerary X chromosome influences autistic and schizotypal symptom profiles in KS...
  7. doi request reprint In search for significant cognitive features in Klinefelter syndrome through cross-species comparison of a supernumerary X chromosome
    H Bruining
    Department of Psychiatry Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University of Utrecht, The Netherlands
    Genes Brain Behav 10:658-62. 2011
    ..Similar cross-species evaluations of standard mouse behavioral paradigms in different genetic contexts may be powerful tools to optimize genotype-phenotype relationships...
  8. pmc Limited impact of Cntn4 mutation on autism-related traits in developing and adult C57BL/6J mice
    Remco T Molenhuis
    Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
    J Neurodev Disord 8:6. 2016
    ..Here, we used our recently established developmental test battery to characterize the consequences of disruption of contactin 4 (Cntn4) on neurological, sensory, cognitive, and behavioral phenotypes across different developmental stages...
  9. pmc Sex-dependent novelty response in neurexin-1α mutant mice
    Marijke C Laarakker
    Department of Neurosciences and Pharmacology, Division of Neuroscience, Rudolf Magnus Institute, University Medical Center Utrecht, The Netherlands
    PLoS ONE 7:e31503. 2012
    ..However, this effect was mainly observed in male mice, strongly suggesting that gender-specific mechanisms play an important role in Nrxn1α-induced phenotypes...