Annelien L Bredenoord

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. doi request reprint Nuclear transfer to prevent mitochondrial DNA disorders: revisiting the debate on reproductive cloning
    A L Bredenoord
    Maastricht University and University Medical Center, Utrecht, The Netherlands
    Reprod Biomed Online 22:200-7. 2011
  2. doi request reprint Ethics of intergenerational (father-to-son) sperm donation
    Annelien L Bredenoord
    Julius Center, Department of Medical Ethics, University Medical Center Utrecht, Stratenum 6 131, 3508 GA Utrecht, The Netherlands
    Hum Reprod 27:1286-91. 2012
  3. doi request reprint Feedback of individual genetic results to research participants: in favor of a qualified disclosure policy
    Annelien L Bredenoord
    Department of Medical Ethics, University Medical Center Utrecht, Division Julius Center, Utrecht, The Netherlands
    Hum Mutat 32:861-7. 2011
  4. pmc Preimplantation genetic diagnosis for mitochondrial DNA disorders: ethical guidance for clinical practice
    Annelien Bredenoord
    Department of Health, Ethics and Society, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Eur J Hum Genet 17:1550-9. 2009
  5. doi request reprint Reproductive decision-making in the context of mitochondrial DNA disorders: views and experiences of professionals
    A L Bredenoord
    Maastricht University, Faculty of Health, Medicine and Life Sciences, Health, Ethics and Society, Research Institutes GROW and CAPHRI, Maastricht, The Netherlands
    Clin Genet 77:10-7. 2010
  6. doi request reprint Avoiding transgenerational risks of mitochondrial DNA disorders: a morally acceptable reason for sex selection?
    Annelien L Bredenoord
    Department of Health, Ethics and Society, Faculty of Health, Medicine and Life Sciences, Research Institute GROW and CAPHRI, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Hum Reprod 25:1354-60. 2010
  7. doi request reprint Ethics of modifying the mitochondrial genome
    A L Bredenoord
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum, 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Med Ethics 37:97-100. 2011
  8. doi request reprint Disclosure of individual genetic data to research participants: the debate reconsidered
    Annelien L Bredenoord
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Department of Medical Ethics, Stratenum 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Trends Genet 27:41-7. 2011
  9. pmc Inclusion of residual tissue in biobanks: opt-in or opt-out?
    Noor A A Giesbertz
    Department of Medical Humanities, Julius Center, University Medical Center Utrecht, The Netherlands
    PLoS Biol 10:e1001373. 2012
  10. doi request reprint Participant selection for preventive Regenerative Medicine trials: ethical challenges of selecting individuals at risk
    Sophie L Niemansburg
    Department of Medical Humanities, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Med Ethics 41:914-6. 2015

Collaborators

Detail Information

Publications31

  1. doi request reprint Nuclear transfer to prevent mitochondrial DNA disorders: revisiting the debate on reproductive cloning
    A L Bredenoord
    Maastricht University and University Medical Center, Utrecht, The Netherlands
    Reprod Biomed Online 22:200-7. 2011
    ..Nevertheless, as it may lead to more complex ethical appraisals than the other variants, researchers should initially focus on the development of the other types of nuclear transfer to prevent mtDNA disorders...
  2. doi request reprint Ethics of intergenerational (father-to-son) sperm donation
    Annelien L Bredenoord
    Julius Center, Department of Medical Ethics, University Medical Center Utrecht, Stratenum 6 131, 3508 GA Utrecht, The Netherlands
    Hum Reprod 27:1286-91. 2012
    ..We will conclude the paper with recommendations for a morally sound practice of IMAR...
  3. doi request reprint Feedback of individual genetic results to research participants: in favor of a qualified disclosure policy
    Annelien L Bredenoord
    Department of Medical Ethics, University Medical Center Utrecht, Division Julius Center, Utrecht, The Netherlands
    Hum Mutat 32:861-7. 2011
    ..We appeal to the genetics community to make a joint effort to further refine the packages and set thresholds for result selection...
  4. pmc Preimplantation genetic diagnosis for mitochondrial DNA disorders: ethical guidance for clinical practice
    Annelien Bredenoord
    Department of Health, Ethics and Society, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Eur J Hum Genet 17:1550-9. 2009
    ..Fifth, we discuss whether follow-up studies should be conducted, particularly the genetic testing of children born after IVF/PGD. Finally, we offer the main information that is required to obtain a truly informed consent...
  5. doi request reprint Reproductive decision-making in the context of mitochondrial DNA disorders: views and experiences of professionals
    A L Bredenoord
    Maastricht University, Faculty of Health, Medicine and Life Sciences, Health, Ethics and Society, Research Institutes GROW and CAPHRI, Maastricht, The Netherlands
    Clin Genet 77:10-7. 2010
    ..Insight into the experiences of professionals may contribute to a further improvement of reproductive genetic counseling in the context of mtDNA disorders...
  6. doi request reprint Avoiding transgenerational risks of mitochondrial DNA disorders: a morally acceptable reason for sex selection?
    Annelien L Bredenoord
    Department of Health, Ethics and Society, Faculty of Health, Medicine and Life Sciences, Research Institute GROW and CAPHRI, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Hum Reprod 25:1354-60. 2010
    ..To start an IVF/PGD-cycle especially for this purpose would be disproportional. The alternative approach of preconceptional sex selection may be morally justified as a means to increase the chances of obtaining male embryos...
  7. doi request reprint Ethics of modifying the mitochondrial genome
    A L Bredenoord
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum, 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Med Ethics 37:97-100. 2011
    ..If nuclear transfer to prevent mtDNA disorders becomes safe and effective, then dismissing it because it involves germ-line modification is unjustified...
  8. doi request reprint Disclosure of individual genetic data to research participants: the debate reconsidered
    Annelien L Bredenoord
    University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Department of Medical Ethics, Stratenum 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Trends Genet 27:41-7. 2011
    ....
  9. pmc Inclusion of residual tissue in biobanks: opt-in or opt-out?
    Noor A A Giesbertz
    Department of Medical Humanities, Julius Center, University Medical Center Utrecht, The Netherlands
    PLoS Biol 10:e1001373. 2012
    ..We suggest that further interdisciplinary debate should answer the question when to opt-in or when to opt-out...
  10. doi request reprint Participant selection for preventive Regenerative Medicine trials: ethical challenges of selecting individuals at risk
    Sophie L Niemansburg
    Department of Medical Humanities, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Med Ethics 41:914-6. 2015
    ....
  11. doi request reprint Ethical, legal, and counseling challenges surrounding the return of genetic results in oncology
    Martijn P Lolkema
    University Medical Center Utrecht, The Netherlands
    J Clin Oncol 31:1842-8. 2013
    ..We also provide a framework for returning these genetic results by proposing a design for a qualified disclosure policy...
  12. doi request reprint Reconsidering the ethics of sham interventions in an era of emerging technologies
    Sophie L Niemansburg
    Department of Medical Humanities, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands Electronic address
    Surgery 157:801-10. 2015
    ..Second, the increased awareness of the lack of systematic research in surgery stresses the need to discuss the necessity and acceptability of sham-controlled clinical trials...
  13. doi request reprint Societal impacts of regenerative medicine: reflections on the views of orthopedic professionals
    Sophie L Niemansburg
    Department of Medical Humanities, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584CG Utrecht, The Netherlands
    Regen Med 10:17-24. 2015
    ..This is important as they can co-shape the societal impacts during the developmental process of technologies and thereby stimulate responsible innovation. ..
  14. doi request reprint Am I My Family's Keeper? Disclosure Dilemmas in Next-Generation Sequencing
    Roel H P Wouters
    Department of Medical Humanities, Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Mutat 37:1257-1262. 2016
    ..Commitment of all parties is needed to ensure adequate dissemination of results in the NGS era...
  15. doi request reprint Studying the lay of the land: views and experiences of professionals in the translational pluripotent stem cell field
    Michelle G J L Habets
    Department of Medical Humanities, Julius Center for Primary Care and Health Services, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Regen Med 11:63-71. 2016
    ..Conducting parallel bioethics research based on experiences and views of professionals in the stem cell field is therefore important...
  16. pmc Personalized assent for pediatric biobanks
    Noor A A Giesbertz
    Department of Medical Humanities, Division Julius Center, University Medical Center Utrecht, Office Stratenum 6 131, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    BMC Med Ethics 17:59. 2016
    ..Implementing personalized assent will both respect the child and support biobank research...
  17. pmc Unsolicited findings of next-generation sequencing for tumor analysis within a Dutch consortium: clinical daily practice reconsidered
    Rhodé M Bijlsma
    Department of Medical Oncology, University Medical Center Utrecht, Cancer Center, Utrecht, The Netherlands
    Eur J Hum Genet 24:1496-500. 2016
    ....
  18. pmc When Children Become Adults: Should Biobanks Re-Contact?
    Noor A A Giesbertz
    Department of Medical Humanities Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS Med 13:e1001959. 2016
    ..Noor Giesbertz and colleagues consider different re-contact policy designs that could be used by biobanks to obtain permission for the continued use of samples collected from children. ..
  19. doi request reprint Postmortem disclosure of genetic information to family members: active or passive?
    Sarah N Boers
    Department of Medical Humanities, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Str 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands Electronic address
    Trends Mol Med 21:148-53. 2015
    ..We conclude that there are valid reasons to communicate some subsets of genetic information to family members after death, and we propose a passive postmortem disclosure policy. ..
  20. pmc Stem cell trials for cardiovascular medicine: ethical rationale
    Sophie L Niemansburg
    1 Department of Medical Humanities, Julius Center, University Medical Center Utercht, The Netherlands
    Tissue Eng Part A 20:2567-74. 2014
    ....
  21. pmc Clarifying assent in pediatric research
    Noor A A Giesbertz
    Department of Medical Humanities, Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Hum Genet 22:266-9. 2014
    ..This can be referred to as personalized assent. Personalized assent is an appeal to the moral responsibility and integrity of the researcher. ..
  22. doi request reprint Consent in psychiatric biobanks for pharmacogenetic research
    Frederieke H van der Baan
    Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Int J Neuropsychopharmacol 16:677-82. 2013
    ..Nevertheless, such a procedure is not the traditional exhaustive informed consent procedure, since this is not feasible in the case of biobanking...
  23. pmc Whole-exome sequencing in pediatrics: parents' considerations toward return of unsolicited findings for their child
    Candice Cornelis
    Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Hum Genet 24:1681-1687. 2016
    ..How parents can be aided in contemplating different scenarios regarding their child's future development also deserves further inquiry...
  24. pmc Big Data in medical research and EU data protection law: challenges to the consent or anonymise approach
    Menno Mostert
    Department of Medical Humanities, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Hum Genet 24:956-60. 2016
    ....
  25. doi request reprint Moral Duties of Genomics Researchers: Why Personalized Medicine Requires a Collective Approach
    Shoko Vos
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands Electronic address
    Trends Genet . 2016
    ..In this review we provide a comprehensive assembly of moral duties that have been attributed to genomics researchers and offer suggestions for responsible advancement of personalized genomic cancer care...
  26. pmc Potential conflicts of interest of editorial board members from five leading spine journals
    Stein J Janssen
    Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 10:e0127362. 2015
    ..Academia and medical journals in particular should be aware of this and strive to improve transparency of the review process. We emphasize recommendations that contribute to achieving this goal. ..
  27. pmc The social value of clinical research
    Michelle G J L Habets
    Department of Medical Humanities, Julius Center for Primary Care and Health Sciences, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    BMC Med Ethics 15:66. 2014
    ..The concept social value is ambiguous by nature and is used in numerous ways in the research ethics literature. Because social value justifies involving human participants, especially in early human trials, this is problematic...
  28. doi request reprint Ethical implications of regenerative medicine in orthopedics: an empirical study with surgeons and scientists in the field
    Sophie L Niemansburg
    Department of Medical Humanities, Julius Center, University Medical Center Utrecht, Heidelberglaan 100, 3584 CG, Utrecht, The Netherlands Electronic address
    Spine J 14:1029-35. 2014
    ..However, no empirical studies that have systematically described the attitudes, opinions, and experiences of experts in the field of orthopedic RM concerning these challenges exist...
  29. doi request reprint Ooplasmic and nuclear transfer to prevent mitochondrial DNA disorders: conceptual and normative issues
    A L Bredenoord
    Maastricht University, Health, Ethics and Society and Research Institute GROW, Maastricht, The Netherlands
    Hum Reprod Update 14:669-78. 2008
    ..Both OT and NT are radical in the sense that they do not entail genetic selection, but genetic intervention to correct the genetic cause of the disease...
  30. doi request reprint PGD to reduce reproductive risk: the case of mitochondrial DNA disorders
    A L Bredenoord
    Maastricht University, Health, Ethics and Society, Maastricht, The Netherlands
    Hum Reprod 23:2392-401. 2008
    ..Nevertheless, introducing this new application of PGD in clinical practice will raise further complex issues of determining conditions for its responsible use...
  31. ncbi request reprint Dealing with uncertainties: ethics of prenatal diagnosis and preimplantation genetic diagnosis to prevent mitochondrial disorders
    A L Bredenoord
    Department of Health, Ethics and Society, Faculty of Health, Medicine and Life Sciences, Maastricht University, The Netherlands
    Hum Reprod Update 14:83-94. 2008
    ....