Genomes and Genes
Lianne S M Boesten
Affiliation: TNO Prevention and Health
Country: The Netherlands
- Tumor necrosis factor-alpha promotes atherosclerotic lesion progression in APOE*3-Leiden transgenic miceLianne S M Boesten
Department of General Internal Medicine, Leiden University Medical Center, The Netherlands
Cardiovasc Res 66:179-85. 2005..Studies in mice indicated that TNFalpha affects atherosclerosis minimally or not under conditions that allow fatty streak formation. Here, we examined the possible role of TNFalpha in advanced and complex atherosclerotic lesions...
- Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient miceLianne S M Boesten
Dept of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
Atherosclerosis 207:399-404. 2009..Our data demonstrate that macrophage p53 is an important regulator of macrophage apoptosis, thereby preventing necrotic death of lesional macrophages. The regulation of this cell death balance directly affects lesion composition...
- Dual PPARalpha/gamma agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE*3Leiden miceA Susanne M Zadelaar
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
Arterioscler Thromb Vasc Biol 26:2560-6. 2006..We investigated whether the dual PPARalpha/gamma agonist tesaglitazar has anti-atherogenic effects in ApoE*3Leiden mice with reduced insulin sensitivity...
- Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient miceLianne S M Boesten
Department of General Internal Medicine, Leiden University Medical Center, c o TNO Quality of Life, Gaubius Laboratory, Zernikedreef 9, P O Box 2215, Leiden 2301 CE, The Netherlands
FASEB J 20:953-5. 2006..6-fold increase in lesional macrophage proliferation was observed. These studies demonstrate that macrophage Rb is a suppressing factor in the progression of atherosclerosis by reducing macrophage proliferation...
- Increased vulnerability of pre-existing atherosclerosis in ApoE-deficient mice following adenovirus-mediated Fas ligand gene transferA Susanne M Zadelaar
Department of Cardiology, Leiden University Medical Center c o TNO Prevention and Health, Gaubius Laboratory, Zernikedreef 9, P O Box 2215, 2301 CE Leiden, The Netherlands
Atherosclerosis 183:244-50. 2005..In the present study, we investigated whether overexpression of FasL in pre-existing atherosclerotic lesions can induce lesion remodelling and rupture-related events...
- Local Cre-mediated gene recombination in vascular smooth muscle cells in miceSusanne M Zadelaar
Department of Cardiology, p o TNO Quality of Life Gaubius Laboratory, Leiden University Medical Centre, Zernikedreef 9, P O Box 2215, 2301 CE, Leiden, The Netherlands
Transgenic Res 15:31-6. 2006..Thus, local application of a 4-OHT-eluting PDD results in vascular SMC-specific Cre-mediated recombination in SM-CreER(T2)(ki)/rosa26 mice without affecting additional SMCs...
- Tumor necrosis factor-alpha plays an important role in restenosis developmentPascalle S Monraats
Department of Cardiology, Leiden University Medical Center, The Netherlands
FASEB J 19:1998-2004. 2005..Therefore, TNFalpha genotype may be used as a risk marker for restenosis and may contribute to individual patient screening prior to PCI in clinical practice. Inhibition of TNFalpha may be an anti-restenotic target strategy...
- Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterolSonia M S Espirito Santo
TNO Prevention and Health, Leiden, The Netherlands
Blood 103:3777-82. 2004..1 vs 219.1 +/- 86.0 10(3)microm(2), P =.003). Our data indicate that hepatic LRP plays a clear protective role in atherogenesis independent of plasma cholesterol, possibly due to maintaining low levels of its proatherogenic ligands...