Lianne S M Boesten

Summary

Affiliation: TNO Prevention and Health
Country: The Netherlands

Publications

  1. ncbi request reprint Tumor necrosis factor-alpha promotes atherosclerotic lesion progression in APOE*3-Leiden transgenic mice
    Lianne S M Boesten
    Department of General Internal Medicine, Leiden University Medical Center, The Netherlands
    Cardiovasc Res 66:179-85. 2005
  2. doi request reprint Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice
    Lianne S M Boesten
    Dept of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Atherosclerosis 207:399-404. 2009
  3. ncbi request reprint Dual PPARalpha/gamma agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE*3Leiden mice
    A Susanne M Zadelaar
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 26:2560-6. 2006
  4. ncbi request reprint Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice
    Lianne S M Boesten
    Department of General Internal Medicine, Leiden University Medical Center, c o TNO Quality of Life, Gaubius Laboratory, Zernikedreef 9, P O Box 2215, Leiden 2301 CE, The Netherlands
    FASEB J 20:953-5. 2006
  5. ncbi request reprint Increased vulnerability of pre-existing atherosclerosis in ApoE-deficient mice following adenovirus-mediated Fas ligand gene transfer
    A Susanne M Zadelaar
    Department of Cardiology, Leiden University Medical Center c o TNO Prevention and Health, Gaubius Laboratory, Zernikedreef 9, P O Box 2215, 2301 CE Leiden, The Netherlands
    Atherosclerosis 183:244-50. 2005
  6. ncbi request reprint Local Cre-mediated gene recombination in vascular smooth muscle cells in mice
    Susanne M Zadelaar
    Department of Cardiology, p o TNO Quality of Life Gaubius Laboratory, Leiden University Medical Centre, Zernikedreef 9, P O Box 2215, 2301 CE, Leiden, The Netherlands
    Transgenic Res 15:31-6. 2006
  7. ncbi request reprint Tumor necrosis factor-alpha plays an important role in restenosis development
    Pascalle S Monraats
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    FASEB J 19:1998-2004. 2005
  8. ncbi request reprint Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol
    Sonia M S Espirito Santo
    TNO Prevention and Health, Leiden, The Netherlands
    Blood 103:3777-82. 2004

Collaborators

  • Bob van de Water
  • Paul H A Quax
  • Jos Jonkers
  • J W Jukema
  • Wei Ping Li
  • JOACHIM J HERZ
  • Johannes Waltenberger
  • Susanne M Zadelaar
  • A Susanne M Zadelaar
  • Louis M Havekes
  • Bart J M van Vlijmen
  • Pascalle S Monraats
  • Nuno M M Pires
  • Sonia M S Espirito Santo
  • Erik Lundholm
  • Jef J Emeis
  • German Camejo
  • Teake Kooistra
  • Erik A L Biessen
  • Marjan A Versnel
  • Abbey Schepers
  • Leen M 't Hart
  • Jan H von der Thüsen
  • Rob C Hoeben
  • Mark M Kockx
  • Pieter A F M Doevendans
  • Willem R P Agema
  • Moniek P M de Maat
  • Margreet R De Vries
  • Rune R Frants
  • Theo J C Van Berkel
  • Aeilko H Zwinderman
  • Arnoud van der Laarse
  • Robbert J de Winter
  • Rene A Tio
  • Ernst E van der Wall
  • Andre Bensadoun
  • Hans M G Princen
  • Niels Bovenschen
  • Ko Willems van Dijk
  • Gery Gerritsen

Detail Information

Publications8

  1. ncbi request reprint Tumor necrosis factor-alpha promotes atherosclerotic lesion progression in APOE*3-Leiden transgenic mice
    Lianne S M Boesten
    Department of General Internal Medicine, Leiden University Medical Center, The Netherlands
    Cardiovasc Res 66:179-85. 2005
    ..Studies in mice indicated that TNFalpha affects atherosclerosis minimally or not under conditions that allow fatty streak formation. Here, we examined the possible role of TNFalpha in advanced and complex atherosclerotic lesions...
  2. doi request reprint Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice
    Lianne S M Boesten
    Dept of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Atherosclerosis 207:399-404. 2009
    ..Our data demonstrate that macrophage p53 is an important regulator of macrophage apoptosis, thereby preventing necrotic death of lesional macrophages. The regulation of this cell death balance directly affects lesion composition...
  3. ncbi request reprint Dual PPARalpha/gamma agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE*3Leiden mice
    A Susanne M Zadelaar
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 26:2560-6. 2006
    ..We investigated whether the dual PPARalpha/gamma agonist tesaglitazar has anti-atherogenic effects in ApoE*3Leiden mice with reduced insulin sensitivity...
  4. ncbi request reprint Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice
    Lianne S M Boesten
    Department of General Internal Medicine, Leiden University Medical Center, c o TNO Quality of Life, Gaubius Laboratory, Zernikedreef 9, P O Box 2215, Leiden 2301 CE, The Netherlands
    FASEB J 20:953-5. 2006
    ..6-fold increase in lesional macrophage proliferation was observed. These studies demonstrate that macrophage Rb is a suppressing factor in the progression of atherosclerosis by reducing macrophage proliferation...
  5. ncbi request reprint Increased vulnerability of pre-existing atherosclerosis in ApoE-deficient mice following adenovirus-mediated Fas ligand gene transfer
    A Susanne M Zadelaar
    Department of Cardiology, Leiden University Medical Center c o TNO Prevention and Health, Gaubius Laboratory, Zernikedreef 9, P O Box 2215, 2301 CE Leiden, The Netherlands
    Atherosclerosis 183:244-50. 2005
    ..In the present study, we investigated whether overexpression of FasL in pre-existing atherosclerotic lesions can induce lesion remodelling and rupture-related events...
  6. ncbi request reprint Local Cre-mediated gene recombination in vascular smooth muscle cells in mice
    Susanne M Zadelaar
    Department of Cardiology, p o TNO Quality of Life Gaubius Laboratory, Leiden University Medical Centre, Zernikedreef 9, P O Box 2215, 2301 CE, Leiden, The Netherlands
    Transgenic Res 15:31-6. 2006
    ..Thus, local application of a 4-OHT-eluting PDD results in vascular SMC-specific Cre-mediated recombination in SM-CreER(T2)(ki)/rosa26 mice without affecting additional SMCs...
  7. ncbi request reprint Tumor necrosis factor-alpha plays an important role in restenosis development
    Pascalle S Monraats
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    FASEB J 19:1998-2004. 2005
    ..Therefore, TNFalpha genotype may be used as a risk marker for restenosis and may contribute to individual patient screening prior to PCI in clinical practice. Inhibition of TNFalpha may be an anti-restenotic target strategy...
  8. ncbi request reprint Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol
    Sonia M S Espirito Santo
    TNO Prevention and Health, Leiden, The Netherlands
    Blood 103:3777-82. 2004
    ..1 vs 219.1 +/- 86.0 10(3)microm(2), P =.003). Our data indicate that hepatic LRP plays a clear protective role in atherogenesis independent of plasma cholesterol, possibly due to maintaining low levels of its proatherogenic ligands...