Carola W N Damen

Summary

Affiliation: Slotervaart Hospital
Country: The Netherlands

Publications

  1. doi Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
    Anal Bioanal Chem 394:1171-82. 2009
  2. ncbi Quantitative aspects of the analysis of the monoclonal antibody trastuzumab using high-performance liquid chromatography coupled with electrospray mass spectrometry
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    J Pharm Biomed Anal 46:449-55. 2008
  3. doi Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Am Soc Mass Spectrom 20:2021-33. 2009
  4. doi Bioanalytical methods for the quantification of therapeutic monoclonal antibodies and their application in clinical pharmacokinetic studies
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Hum Antibodies 18:47-73. 2009
  5. doi High-performance liquid chromatography coupled with mass spectrometry for the quantitative analysis of vinca-alkaloids in biological matrices: a concise survey from the literature
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Biomed Chromatogr 24:83-90. 2010
  6. doi The bioanalysis of trastuzumab in human serum using precipitate-enhanced ellipsometry
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Anal Biochem 393:73-9. 2009
  7. doi The bioanalysis of vinorelbine and 4-O-deacetylvinorelbine in human and mouse plasma using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass-spectrometry
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Biomed Chromatogr 23:1316-25. 2009
  8. doi The bioanalysis of the monoclonal antibody trastuzumab by high-performance liquid chromatography with fluorescence detection after immuno-affinity purification from human serum
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    J Pharm Biomed Anal 50:861-6. 2009
  9. doi Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tandem ma
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Rapid Commun Mass Spectrom 23:763-74. 2009
  10. doi A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 868:102-9. 2008

Detail Information

Publications12

  1. doi Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
    Anal Bioanal Chem 394:1171-82. 2009
    ..The assay can now be used to support clinical pharmacologic studies with vincristine and actinomycin-D...
  2. ncbi Quantitative aspects of the analysis of the monoclonal antibody trastuzumab using high-performance liquid chromatography coupled with electrospray mass spectrometry
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    J Pharm Biomed Anal 46:449-55. 2008
    ..The sensitivity loss during analysis could be reduced by lowering the MS source temperature. This parameter is critical in creating a robust LC-MS system for the quantitative analysis of trastuzumab...
  3. doi Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Am Soc Mass Spectrom 20:2021-33. 2009
    ..The results show that each batch of trastuzumab shares the same types of glycoforms but relative abundance of each glycoforms is varied...
  4. doi Bioanalytical methods for the quantification of therapeutic monoclonal antibodies and their application in clinical pharmacokinetic studies
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Hum Antibodies 18:47-73. 2009
    ..We conclude that immunoassays are still the analytical technique of first choice for the analysis of mAbs, but that, unfortunately, the provided information in the literature about method performance is scarce...
  5. doi High-performance liquid chromatography coupled with mass spectrometry for the quantitative analysis of vinca-alkaloids in biological matrices: a concise survey from the literature
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Biomed Chromatogr 24:83-90. 2010
    ..These problems encounter carry-over and absorption effects and solutions will be provided how to circumvent these problems...
  6. doi The bioanalysis of trastuzumab in human serum using precipitate-enhanced ellipsometry
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Anal Biochem 393:73-9. 2009
    ..The prototype ellipsometer is still in development, and from the data obtained in this study, improvements will be implemented...
  7. doi The bioanalysis of vinorelbine and 4-O-deacetylvinorelbine in human and mouse plasma using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass-spectrometry
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Biomed Chromatogr 23:1316-25. 2009
    ..The assay is now in use to support (pre-)clinical pharmacologic studies with vinorelbine in humans and mice...
  8. doi The bioanalysis of the monoclonal antibody trastuzumab by high-performance liquid chromatography with fluorescence detection after immuno-affinity purification from human serum
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    J Pharm Biomed Anal 50:861-6. 2009
    ..These anti-idiotype antibodies are also used in ELISA and as ELISA is more sensitive and less labor-intensive, ELISA probably remains the analytical technique of first choice...
  9. doi Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tandem ma
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Rapid Commun Mass Spectrom 23:763-74. 2009
    ..The assays are now in use to support clinical pharmacological studies in children treated with vincristine and actinomycin-D...
  10. doi A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 868:102-9. 2008
    ..The lower limit of quantification in mouse plasma is 0.8 ng/mL. This assay is used to support preclinical and clinical pharmacologic studies with vinorelbine...
  11. ncbi P-glycoprotein, multidrug-resistance associated protein 2, Cyp3a, and carboxylesterase affect the oral availability and metabolism of vinorelbine
    Jurjen S Lagas
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Mol Pharmacol 82:636-44. 2012
    ..Nonetheless, P-gp, Mrp2, Cyp3a, and Ces2a clearly restricted vinorelbine availability in mice. Variation in activity of their human homologs may also affect vinorelbine pharmacokinetics in patients...
  12. doi Development and validation of an enzyme-linked immunosorbent assay for the quantification of trastuzumab in human serum and plasma
    Carola W N Damen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, 1066 EC Amsterdam, The Netherlands
    Anal Biochem 391:114-20. 2009
    ..Validation results demonstrate that trastuzumab can be accurately and precisely quantified in human serum and plasma. The assay is now used to support pharmacokinetic studies with trastuzumab in human serum and plasma...