Anneke Brand

Summary

Affiliation: Sanquin Research
Country: The Netherlands

Publications

  1. doi request reprint Immunological complications of blood transfusions
    Anneke Brand
    Leiden University Medical Centre and Sanquin blood supply, Leiden, Netherlands Electronic address
    Presse Med 45:e313-24. 2016
  2. doi request reprint On the role of HLA antibodies in hematopoietic stem cell transplantation
    A Brand
    Europdonor Foundation, Leiden, The Netherlands
    Tissue Antigens 81:1-11. 2013
  3. pmc Long-term outcome in relationship to neonatal transfusion volume in extremely premature infants: a comparative cohort study
    Jeannette S von Lindern
    Division of Neonatology J6 S, Department of Pediatrics, Leiden University Medical Center, 2300RC Leiden, The Netherlands
    BMC Pediatr 11:48. 2011
  4. pmc PATCH: platelet transfusion in cerebral haemorrhage: study protocol for a multicentre, randomised, controlled trial
    Koen de Gans
    Department of Neurology, Academic Medical Centre, H2 222, PO Box 22660 1100 DD Amsterdam, The Netherlands
    BMC Neurol 10:19. 2010
  5. ncbi request reprint Viability does not necessarily reflect the hematopoietic progenitor cell potency of a cord blood unit: results of an interlaboratory exercise
    Anneke Brand
    Leiden Cord Bloodbank, Sanquin, The Netherlands
    Transfusion 48:546-9. 2008
  6. doi request reprint Patient blood management in elective total hip- and knee-replacement surgery (part 2): a randomized controlled trial on blood salvage as transfusion alternative using a restrictive transfusion policy in patients with a preoperative hemoglobin above 13 g/d
    Cynthia So-Osman
    From the Department Center of Clinical Transfusion Research, Sanquin Blood Supply, Leiden, The Netherlands C S O, J A V H, and A B Department of Orthopedic Surgery, Leiden University Medical Center LUMC, Leiden, The Netherlands R G H H N Department of Anaesthesiology, Albert Schweitzer Hospital, Dordrecht, The Netherlands A W M M K v G Department of Anaesthesiology, Slotervaart Hospital, Amsterdam, The Netherlands E K Department of Orthopedic Surgery, Slotervaart Hospital, and VU University Medical Center, Amsterdam, The Netherlands R G P Department of Orthopedic Surgery, Groene Hart Hospital, Gouda, The Netherlands R O Department of Medical Statistics and BioInformatics, LUMC, Leiden, The Netherlands T M J W and R B Department of Medical Decision Making, LUMC, Leiden, The Netherlands W B v d H and Department of Immunohaematology and Blood Transfusion Service, LUMC, Leiden, The Netherlands A B
    Anesthesiology 120:852-60. 2014
  7. doi request reprint High anti-HLA response in women exposed to intrauterine transfusions for severe alloimmune hemolytic disease is associated with mother-child HLA triplet mismatches, high anti-D titer, and new red blood cell antibody formation
    Esther P Verduin
    Sanquin LUMC Jon J van Rood Center for Clinical Transfusion Research and the Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 53:939-47. 2013
  8. ncbi request reprint Differential effect of pretransplant blood transfusions on immune effector and regulatory compartments in HLA-sensitized and nonsensitized recipients
    Michael Eikmans
    Department of Immunohematology and Blood Transfusion, Leiden UniversityMedical Center, Leiden, The Netherlands
    Transplantation 90:1192-9. 2010
  9. doi request reprint Photodynamic treatment with mono-phenyl-tri-(N-methyl-4-pyridyl)-porphyrin for pathogen inactivation in cord blood stem cell products
    Laurence L Trannoy
    Research and Development Department, Sanquin Blood Bank Southwest, Leiden, The Netherlands
    Transfusion 48:2629-37. 2008
  10. doi request reprint Intraoperative Anemia and Single Red Blood Cell Transfusion During Cardiac Surgery: An Assessment of Postoperative Outcome Including Patients Refusing Blood Transfusion
    Esther K Hogervorst
    Center for Transfusion Research, Sanquin Research, Leiden, Netherlands Jon J van Rood Center for Clinical Transfusion Research, Leiden University Medical Center, Leiden, Netherlands
    J Cardiothorac Vasc Anesth 30:363-72. 2016

Detail Information

Publications79

  1. doi request reprint Immunological complications of blood transfusions
    Anneke Brand
    Leiden University Medical Centre and Sanquin blood supply, Leiden, Netherlands Electronic address
    Presse Med 45:e313-24. 2016
    ..A (European-wide) registration of clinical and genetic risk factors associated with alloimmunization could support effective use of matched blood products. ..
  2. doi request reprint On the role of HLA antibodies in hematopoietic stem cell transplantation
    A Brand
    Europdonor Foundation, Leiden, The Netherlands
    Tissue Antigens 81:1-11. 2013
    ..Such antibodies, either causally or as confounders, may be associated with negative transplant outcome. We conclude that HLA antibody assessment should be at the forefront in the treatment handbook of HSCT...
  3. pmc Long-term outcome in relationship to neonatal transfusion volume in extremely premature infants: a comparative cohort study
    Jeannette S von Lindern
    Division of Neonatology J6 S, Department of Pediatrics, Leiden University Medical Center, 2300RC Leiden, The Netherlands
    BMC Pediatr 11:48. 2011
    ..The effect of the transfusion volume on long-term outcome is not known...
  4. pmc PATCH: platelet transfusion in cerebral haemorrhage: study protocol for a multicentre, randomised, controlled trial
    Koen de Gans
    Department of Neurology, Academic Medical Centre, H2 222, PO Box 22660 1100 DD Amsterdam, The Netherlands
    BMC Neurol 10:19. 2010
    ..Because intracerebral haemorrhage patients who are on antiplatelet therapy have been shown to be particularly at risk of early haematoma growth, platelet transfusion may have a beneficial effect...
  5. ncbi request reprint Viability does not necessarily reflect the hematopoietic progenitor cell potency of a cord blood unit: results of an interlaboratory exercise
    Anneke Brand
    Leiden Cord Bloodbank, Sanquin, The Netherlands
    Transfusion 48:546-9. 2008
    ..Another reason for a discrepancy between the number of cells in the unit released by the cord blood bank and found in the transplant center may be technical differences in cell counting methods between the two sites...
  6. doi request reprint Patient blood management in elective total hip- and knee-replacement surgery (part 2): a randomized controlled trial on blood salvage as transfusion alternative using a restrictive transfusion policy in patients with a preoperative hemoglobin above 13 g/d
    Cynthia So-Osman
    From the Department Center of Clinical Transfusion Research, Sanquin Blood Supply, Leiden, The Netherlands C S O, J A V H, and A B Department of Orthopedic Surgery, Leiden University Medical Center LUMC, Leiden, The Netherlands R G H H N Department of Anaesthesiology, Albert Schweitzer Hospital, Dordrecht, The Netherlands A W M M K v G Department of Anaesthesiology, Slotervaart Hospital, Amsterdam, The Netherlands E K Department of Orthopedic Surgery, Slotervaart Hospital, and VU University Medical Center, Amsterdam, The Netherlands R G P Department of Orthopedic Surgery, Groene Hart Hospital, Gouda, The Netherlands R O Department of Medical Statistics and BioInformatics, LUMC, Leiden, The Netherlands T M J W and R B Department of Medical Decision Making, LUMC, Leiden, The Netherlands W B v d H and Department of Immunohaematology and Blood Transfusion Service, LUMC, Leiden, The Netherlands A B
    Anesthesiology 120:852-60. 2014
    ..Patients with a preoperative hemoglobin level greater than 13 g/dl were ineligible for erythropoietin and evaluated for the effect of autologous blood reinfusion...
  7. doi request reprint High anti-HLA response in women exposed to intrauterine transfusions for severe alloimmune hemolytic disease is associated with mother-child HLA triplet mismatches, high anti-D titer, and new red blood cell antibody formation
    Esther P Verduin
    Sanquin LUMC Jon J van Rood Center for Clinical Transfusion Research and the Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 53:939-47. 2013
    ..Women whose fetuses were treated with intrauterine transfusions (IUTs) for alloimmune hemolytic disease are high responders to red blood cell (RBC) antigens. We investigated the risk for HLA alloimmunization...
  8. ncbi request reprint Differential effect of pretransplant blood transfusions on immune effector and regulatory compartments in HLA-sensitized and nonsensitized recipients
    Michael Eikmans
    Department of Immunohematology and Blood Transfusion, Leiden UniversityMedical Center, Leiden, The Netherlands
    Transplantation 90:1192-9. 2010
    ....
  9. doi request reprint Photodynamic treatment with mono-phenyl-tri-(N-methyl-4-pyridyl)-porphyrin for pathogen inactivation in cord blood stem cell products
    Laurence L Trannoy
    Research and Development Department, Sanquin Blood Bank Southwest, Leiden, The Netherlands
    Transfusion 48:2629-37. 2008
    ..The application of a method of pathogen inactivation in red blood cells using photodynamic treatment (PDT) was investigated for the decontamination of cord blood stem cell (CBSC) products...
  10. doi request reprint Intraoperative Anemia and Single Red Blood Cell Transfusion During Cardiac Surgery: An Assessment of Postoperative Outcome Including Patients Refusing Blood Transfusion
    Esther K Hogervorst
    Center for Transfusion Research, Sanquin Research, Leiden, Netherlands Jon J van Rood Center for Clinical Transfusion Research, Leiden University Medical Center, Leiden, Netherlands
    J Cardiothorac Vasc Anesth 30:363-72. 2016
    ..The authors examined the association between uncorrected hemoglobin (Hb) levels and selected postoperative outcomes as well as the effects of RBCs...
  11. doi request reprint Exploring the use of expanded erythroid cells for autologous transfusion for anemia of prematurity
    Chantal M Khodabux
    Department of Research, Sanquin Blood Bank, Leiden Department of Immuno Hematology and Blood Transfusion, Leiden University Medical Center, Leiden, The, Netherlands Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The, Netherlands
    Transfusion 53:3230-9. 2013
    ..To explore whether expanded CB cells could provide additional autologous cells suitable for transfusion, we set up a simple one-step protocol to expand premature CB cells...
  12. pmc The impact of a restrictive transfusion trigger on post-operative complication rate and well-being following elective orthopaedic surgery: a post-hoc analysis of a randomised study
    Cynthia So-Osman
    Department of Research and Development, Sanquin Blood Bank South West Region, Leiden, The Netherlands
    Blood Transfus 11:289-95. 2013
    ..Peri-operative red blood cell transfusions have been associated with post-operative complications in patients undergoing elective orthopaedic hip or knee replacement surgery...
  13. doi request reprint Does an alloimmune response to strong immunogenic red blood cell antigens enhance a response to weaker antigens?
    Henk Schonewille
    Department Research and Development, Sanquin Blood Bank South West Region, Leiden, The Netherlands
    Transfusion 48:958-63. 2008
    ..This question is in particular relevant for patients who are currently transfused with RH- and/or K-matched RBCs...
  14. doi request reprint Functional characterization of TPO-expanded CD34+ cord blood cells identifies CD34- CD61- cells as platelet-producing cells early after transplantation in NOD/SCID mice and rCD34+ cells as CAFC colony-forming cells
    Laurus F Schipper
    Sanquin Blood Supply Foundation, Division of Research, Department of Transfusion Medicine, Leiden, The Netherlands
    Stem Cells 30:988-96. 2012
    ..These data support that functional characterization of the expanded cell populations is warranted to make future expansion protocols suitable for clinical application...
  15. doi request reprint Factors associated with persistence of red blood cell antibodies in woman after pregnancies complicated by fetal alloimmune haemolytic disease treated with intrauterine transfusions
    Esther P Verduin
    Centre for Clinical Transfusion Research, Sanquin Research, Leiden, the Netherlands Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, the Netherlands Jon J van Rood Centre for Clinical Transfusion Research, Sanquin Leiden University Medical Centre, Leiden, The Netherlands
    Br J Haematol 168:443-51. 2015
    ..In conclusion, persistence of antibodies mainly depends on antibody strength and specificity. Difference between fetal or non-fetal immunogens suggests maintenance of antigenic stimulation possibly by long-term fetomaternal chimerism. ..
  16. doi request reprint Double umbilical cord blood transplantation: a study of early engraftment kinetics in leukocyte subsets using HLA-specific monoclonal antibodies
    Judith A E Somers
    JJ van Rood Center for Clinical Transfusion Research Sanquin Blood Supply, Leiden, The Netherlands
    Biol Blood Marrow Transplant 19:266-73. 2013
    ..These findings show that engraftment kinetics of the various leukocyte subsets vary considerably after double UCBT and may suggest an important role for CD4+ T cells in a presumed alloreactive graft-versus-graft rejection...
  17. doi request reprint Neonatal morbidity after exchange transfusion for red cell alloimmune hemolytic disease
    Vivianne E H J Smits-Wintjens
    Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
    Neonatology 103:141-7. 2013
    ..Exchange transfusion (ET) is a high-risk procedure. The type and rate of complications in neonatal red cell alloimmune hemolytic disease exclusively are not clear...
  18. doi request reprint A clinical study on the feasibility of autologous cord blood transfusion for anemia of prematurity
    Chantal M Khodabux
    Department of Research and Development, Sanquin Blood Bank, Southwest Division, Leiden, The Netherlands
    Transfusion 48:1634-43. 2008
    ..The objective was to investigate the use of autologous red blood cells (RBCs) derived from umbilical cord blood (UCB), as an alternative for allogeneic transfusions in premature infants admitted to a tertiary neonatal center...
  19. doi request reprint Is female sex a risk factor for red blood cell alloimmunization after transfusion? A systematic review
    Esther P Verduin
    Sanquin LUMC, Jon J van Rood Center for Clinical Transfusion Research, Leiden, The Netherlands
    Transfus Med Rev 26:342-53, 353.e1-5. 2012
    ....
  20. pmc A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial
    Paula F Ypma
    Department of Hematology, HAGA Teaching Hospital Den Haag, The Netherlands Center for Clinical Transfusion Research, Sanquin Research, Leiden, The Netherlands
    BMJ Open 6:e010156. 2016
    ....
  21. ncbi request reprint Additional red blood cell alloantibodies after blood transfusions in a nonhematologic alloimmunized patient cohort: is it time to take precautionary measures?
    Henk Schonewille
    Sanquin Blood Bank, Southwest Region, Leiden, The Netherlands
    Transfusion 46:630-5. 2006
    ....
  22. doi request reprint Severe fetal thrombocytopenia in Rhesus D alloimmunized pregnancies
    Eline S A van den Akker
    Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands
    Am J Obstet Gynecol 199:387.e1-4. 2008
    ..The objective of the study was to evaluate the incidence of fetal thrombocytopenia and association with hydrops in Rhesus D alloimmunization...
  23. doi request reprint Thrombocytopaenia and intraventricular haemorrhage in very premature infants: a tale of two cities
    Jeannette S von Lindern
    Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, J 6S, PO Box 9800, Leiden, 2300RC, The Netherlands
    Arch Dis Child Fetal Neonatal Ed 97:F348-52. 2012
    ....
  24. ncbi request reprint High additional maternal red cell alloimmunization after Rhesus- and K-matched intrauterine intravascular transfusions for hemolytic disease of the fetus
    Henk Schonewille
    Sanquin Blood Bank, South West Region, Leiden, The Netherlands
    Am J Obstet Gynecol 196:143.e1-6. 2007
    ..However, maternal additional antibody formation is a complication of the procedure. In this study, we determined antibody formation after introduction of preventive Rh-D, -C, -c, -E, and -e and K matching of IUT donors...
  25. pmc No Synergistic Effect of Cotransplantation of MSC and Ex Vivo TPO-Expanded CD34(+) Cord Blood Cells on Platelet Recovery and Bone Marrow Engraftment in NOD SCID Mice
    Mark van der Garde
    1Jon J van Rood Center for Clinical Transfusion Research, Sanquin Blood Supply Foundation, Leiden, The Netherlands
    Stem Cells Dev 24:1448-56. 2015
    ..A combination of both strategies even adds a risk of non engraftment. ..
  26. doi request reprint Cryopreservation of cord blood CD34+ cells before or after thrombopoietin expansion differentially affects early platelet recovery in NOD SCID mice
    Yvette van Hensbergen
    Jon J van Rood Center for Clinical Transfusion Research, Sanquin Blood Supply Foundation, Leiden, The Netherlands
    Transfusion 55:1772-81. 2015
    ..Clinical implementation, however, will depend on practical and effective protocols. The best timing of TPO expansion in relation to cryopreservation in this respect is unknown...
  27. doi request reprint Posttransfusion platelet increments after different platelet products in neonates: a retrospective cohort study
    Aine Honohan
    Sanquin LUMC Jon J van Rood Center for Clinical Transfusion Research, Leiden, The Netherlands Sanquin Blood Supply Foundation, Amsterdam, The Netherlands Department of Pediatrics, Division of Neonatology, Beatrix Children s Hospital, University Medical Center, Groningen, The Netherlands Department of Pediatrics, Division of Neonatology, Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands Department of Pediatrics, Division of Neonatology, Sophia Children s Hospital, Erasmus Medical Center, Rotterdam, The Netherlands
    Transfusion 53:3100-9. 2013
    ..These are standard products at three different neonatal intensive care units where local transfusion guidelines apply. Here we assess the posttransfusion count increments with these products...
  28. doi request reprint Antifibrinolytics attenuate inflammatory gene expression after cardiac surgery
    Alexander F L Later
    Department of Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands
    J Thorac Cardiovasc Surg 145:1611-6, 1616.e1-4. 2013
    ..The study of messenger ribonucleic acid synthesis provides a valuable asset in evaluating the inflammatory pathways involved...
  29. doi request reprint Long-term neurodevelopmental outcome after intrauterine transfusion for hemolytic disease of the fetus/newborn: the LOTUS study
    Irene T Lindenburg
    Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands
    Am J Obstet Gynecol 206:141.e1-8. 2012
    ..To determine the incidence and risk factors for neurodevelopmental impairment (NDI) in children with hemolytic disease of the fetus/newborn treated with intrauterine transfusion (IUT)...
  30. doi request reprint HLA-DRB1 associations in individuals with single and multiple clinically relevant red blood cell antibodies
    Henk Schonewille
    Center for Clinical Transfusion research, Sanquin Research, Leiden, the Netherlands Jon J van Rood Center for Clinical Transfusion Research, Sanquin Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 54:1971-80. 2014
    ....
  31. doi request reprint Patient blood management in elective total hip- and knee-replacement surgery (Part 1): a randomized controlled trial on erythropoietin and blood salvage as transfusion alternatives using a restrictive transfusion policy in erythropoietin-eligible patients
    Cynthia So-Osman
    From the Department Center of Clinical Transfusion Research, Sanquin Blood Supply, Leiden, The Netherlands C S O, J A V H, and A B Department of Orthopedic Surgery, Leiden University Medical Center, RC Leiden, The Netherlands R G H H N Department of Anaesthesiology, Albert Schweitzer Hospital, Dordrecht, The Netherlands A W M M K v G Department of Anaesthesiology, Slotervaart Hospital, Amsterdam, The Netherlands E K Department of Orthopedic Surgery, Slotervaart Hospital, Amsterdam, The Netherlands, and VU University Medical Center, Amsterdam, The Netherlands R G P Department of Orthopedic Surgery, Groene Hart Hospital, Gouda, The Netherlands R O Department of Medical Statistics and BioInformatics, Leiden University Medical Center, Leiden, The Netherlands T M J W and R B Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands W B v d H and Department of Immunohaematology and Blood Transfusion Service, Leiden University Medical Center, Leiden, The Netherlands A B
    Anesthesiology 120:839-51. 2014
    ..Integrated use of erythropoietin, cell saver, and/or postoperative drain reinfusion devices on allogeneic erythrocyte use was evaluated using a restrictive transfusion threshold...
  32. pmc Comparison of different blood sample processing methods for sensitive detection of low level chimerism by RHD real-time PCR assay
    Ahmad Javadi
    Sanquin LUMC J J van Rood Center for Transfusion Medicine, Division Research, Leiden, The Netherlands
    Chimerism 4:9-14. 2013
    ..We conclude that RHD chimerism using singleplex exon 5 and 7 qPCR is linearly detectable down to 1.0 GE, without an advantage of fraction enrichment. ..
  33. doi request reprint Validation of human monoclonal HLA Class I antibodies to evaluate the kinetics of donor chimerism in different cell subsets after double-cord-blood transplantation in the NOD/SCID model
    Yvette van Hensbergen
    Department of Research, Division of Transfusion Medicine, Sanquin Blood Supply Foundation, and the Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 53:104-14. 2013
    ..We conducted studies in a mouse model to develop a new analytic method using anti-human HLA Class I allele-specific monoclonal antibodies (HLA-MoAbs) in flow cytometry...
  34. doi request reprint Postoperative complications associated with transfusion of platelets and plasma in cardiac surgery
    Yavuz M Bilgin
    Department of Immunohematology and Blood Transfusion and Cardiothoracic Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 51:2603-10. 2011
    ..Whether platelet (PLT) and/or plasma transfusions are a marker for more concomitant RBC transfusions or are independently associated with complications after cardiac surgery is unknown...
  35. doi request reprint A comparison of volume-reduced versus standard HLA/HPA-matched apheresis platelets in alloimmunized adult patients
    Aine Honohan
    Department of Transfusion Medicine, Sanquin Blood Services, Plesmanlaan 1a, 2333 BZ, Leiden, The Netherlands
    Transfusion 52:742-51. 2012
    ..Here we compared the clinical effectiveness of VR apheresis PLTs (APs) with standard APs...
  36. ncbi request reprint Red blood cell alloantibodies after transfusion: factors influencing incidence and specificity
    Henk Schonewille
    Sanquin Blood Bank South West Region, Leiden, The Netherlands
    Transfusion 46:250-6. 2006
    ..Alloimmunization after exposure to red cell (RBC) alloantigens depends on genetic and acquired patient-related factors, dose and route of administration, and the immunogenicity of the antigen, but exact kinetics are still unknown...
  37. doi request reprint Impact of photodynamic treatment with meso-substituted porphyrin on the immunomodulatory capacity of white blood cell-containing red blood cell products
    Laurence Trannoy
    Department of Research and Education, Sanquin Blood Bank South west, Leiden, The Netherlands
    Photochem Photobiol 86:223-30. 2010
    ..It seems worthwhile to further explore PDT-induced immunomodulation to optimize conditions which may result in allo-tolerance by AAM phi...
  38. pmc Naturally acquired tolerance and sensitization to minor histocompatibility antigens in healthy family members
    Astrid G S van Halteren
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Blood 114:2263-72. 2009
    ....
  39. ncbi request reprint The immunologic profile of infants born after maternal immunoglobulin treatment and intrauterine platelet transfusions for fetal/neonatal alloimmune thrombocytopenia
    Celine M Radder
    Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands
    Am J Obstet Gynecol 191:815-20. 2004
    ....
  40. ncbi request reprint Ex vivo culture of human CD34+ cord blood cells with thrombopoietin (TPO) accelerates platelet engraftment in a NOD/SCID mouse model
    Yvette van Hensbergen
    Sanquin Blood Bank, Department of Research and Education, Leiden, The Netherlands
    Exp Hematol 34:943-50. 2006
    ..Expansion of CB SC may be one way to improve the recovery, but there is concern that ex vivo expansion compromises the repopulating ability of SC...
  41. doi request reprint In vivo tracking of transfused platelets for recovery and survival studies: an appraisal of labeling methods
    Pieter F van der Meer
    Sanquin Blood Bank South West Region, Plesmanlaan 1a, 2333 BZ Leiden, P O Box 2184, 2301 CD Leiden, The Netherlands
    Transfus Apher Sci 42:53-61. 2010
    ..This paper reviews alternative, non-radioactive methods, which includes biotinylation of platelets, and discrimination of transfused platelets based on HLA discrepancy. The benefits and disadvantages of these methods will be discussed...
  42. doi request reprint Clinical effectiveness of leucoreduced, pooled donor platelet concentrates, stored in plasma or additive solution with and without pathogen reduction
    Jean Louis H Kerkhoffs
    Sanquin Blood Bank, Southwest Region, Rotterdam, The Netherlands
    Br J Haematol 150:209-17. 2010
    ....
  43. ncbi request reprint A multicenter randomized study of the efficacy of transfusions with platelets stored in platelet additive solution II versus plasma
    Jean Louis H Kerkhoffs
    Sanquin Blood Bank South West Region, Plesmanlaan 1a, 2333 BZ Leiden, The Netherlands
    Blood 108:3210-5. 2006
    ..We showed safety and efficacy of PAS II PCs in intensively treated patients; however, plasma PCs show superior increments...
  44. doi request reprint Anti-K formation is not associated with the storage time of transfused red blood cells
    Esther Hogervorst
    Center for Clinical Transfusion research, Sanquin Research, Leiden, The Netherlands
    Transfusion 55:1472-7. 2015
    ..This study aims to quantify the association of anti-K formation with RBC storage time...
  45. pmc Thrombopoietin treatment of one graft in a double cord blood transplant provides early platelet recovery while contributing to long-term engraftment in NSG mice
    Mark van der Garde
    1 Jon J van Rood Center for Clinical Transfusion Research, Sanquin Blood Supply Foundation, Leiden, The Netherlands
    Stem Cells Dev 24:67-76. 2015
    ..Furthermore, although the contribution of the TPO treated graft to long-term hematological engraftment was reduced, the TPO treated and untreated grafts both contributed significantly to long-term chimerism in vivo. ..
  46. ncbi request reprint HLA and RBC immunization after filtered and buffy coat-depleted blood transfusion in cardiac surgery: a randomized controlled trial
    Leo van de Watering
    Sanquin, Blood Bank Southwest, Leiden, The Netherlands
    Transfusion 43:765-71. 2003
    ..Prevention of immunologic side effects of transfusions is part of the motivation. To compare the immunogenicity of before- or after-storage WBC-reduced RBCs with RBCs without buffy coat, a randomized clinical trial was performed...
  47. ncbi request reprint Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients
    Leo van de Watering
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 46:1712-8. 2006
    ..The aim in this study was to investigate the possible role of the storage time of RBC transfusions on the outcome of coronary artery bypass graft (CABG) surgery patients...
  48. ncbi request reprint Intravenous immunoglobulins without initial and follow-up cordocentesis in alloimmune fetal and neonatal thrombocytopenia at high risk for intracranial hemorrhage
    Humphrey H H Kanhai
    Department of Obstetrics, Leiden University Medical Center, Leiden, The Netherlands
    Fetal Diagn Ther 21:55-60. 2006
    ..To report on a less invasive treatment strategy in alloimmune fetal and neonatal thrombocytopenia (FNAIT) at high risk for either in utero or neonatal intracranial hemorrhage (ICH)...
  49. pmc Long-Term follow up after intra-Uterine transfusionS; the LOTUS study
    Esther P Verduin
    Division Research, Department of Transfusion Medicine, Sanquin Blood Supply Foundation, Leiden, The Netherlands
    BMC Pregnancy Childbirth 10:77. 2010
    ..Most study groups report high perinatal survival, resulting in a shift in attention towards short- and long-term outcome in surviving children...
  50. doi request reprint Alloimmune response after additional red blood cell antigen challenge in immunized hematooncology patients
    Henk Schonewille
    Sanquin Blood Bank, South West Region, Leiden, The Netherlands
    Transfusion 49:453-7. 2009
    ..After initial alloimmunization, 20 to 25 percent of immunized nonhematooncology patients develop additional red blood cell (RBC) antibodies after subsequent transfusions. This figure is unknown for hematooncology patients...
  51. ncbi request reprint Potential use of autologous umbilical cord blood red blood cells for early transfusion needs of premature infants
    Marijke Jansen
    Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, and the Sanquin Blood Bank, Leiden, The Netherlands
    Transfusion 46:1049-56. 2006
    ....
  52. doi request reprint The use of blood products in perinatal medicine
    Jeannette S von Lindern
    Department of Neonatology, Leiden University Medical Centre, Leiden, The Netherlands
    Semin Fetal Neonatal Med 13:272-81. 2008
    ..Most of the protocols used are expert based...
  53. doi request reprint Half a century of Dutch transplant immunology
    Jon J van Rood
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Immunol Lett 162:145-9. 2014
    ..In this review we will look back at some early highlights of Dutch transplant immunology and put them in the perspective of some recent developments. ..
  54. doi request reprint Tolerance of intraoperative hemoglobin decrease during cardiac surgery
    Esther Hogervorst
    Center for Clinical Transfusion Reseach, Sanquin LUMC, Leiden, The Netherlands
    Transfusion 54:2696-704. 2014
    ..0 g/dL. In this study the relation between intraoperative Hb decline of at least 50% and a composite endpoint was analyzed...
  55. ncbi request reprint Alloimmunization to red blood cell antigens after universal leucodepletion. A regional multicentre retrospective study
    Henk Schonewille
    Sanquin Bloodbank, Southwest Region, Leiden, The Netherlands
    Br J Haematol 129:151-6. 2005
    ..In conclusion, compared with buffy-coat leucoreduction, universal prestorage filter leucodepletion did not alter the development of clinically significant red blood cell alloimmunization...
  56. doi request reprint The clinical impact of platelet refractoriness: correlation with bleeding and survival
    Jean Louis H Kerkhoffs
    Sanquin Blood Bank, South West Region, Leiden, The Netherlands
    Transfusion 48:1959-65. 2008
    ..The clinical impact of PLT transfusion failure was investigated in 117 patients, part of a randomized PLT transfusion trial, which excluded patients with HLA and/or HPA alloantibodies...
  57. ncbi request reprint Positively charged porphyrins: a new series of photosensitizers for sterilization of RBCs
    Laurence L Trannoy
    Department of Research and Development, Sanquin Blood Supply Foundation, Blood bank South west, Leiden, The Netherlands
    Transfusion 44:1186-96. 2004
    ..Using the most efficacious photosensitizer, various in-vitro human RBC quality variables and in-vivo RBC survival in Rhesus monkeys were evaluated...
  58. ncbi request reprint Pretransplant blood transfusions revisited: a role for CD(4+) regulatory T cells?
    Dave Roelen
    Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 77:S26-8. 2004
    ....
  59. ncbi request reprint Pregnancy induces minor histocompatibility antigen-specific cytotoxic T cells: implications for stem cell transplantation and immunotherapy
    Rob M Verdijk
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Blood 103:1961-4. 2004
    ..Thus, pregnancy can lead to alloimmune responses against the infant's paternal minor H antigens. The minor H antigen immunization status of female donors raises important questions for the clinical practice of stem cell transplantation...
  60. ncbi request reprint Differential maturation of megakaryocyte progenitor cells from cord blood and mobilized peripheral blood
    Laurus F Schipper
    Blood Bank Leiden Haaglanden, Leiden, The Netherlands
    Exp Hematol 31:324-30. 2003
    ..We compared the hematopoietic composition of these grafts and determined the distribution of mature and immature megakaryocyte progenitor cells in cord blood and mobilized peripheral blood and their in vitro kinetic behavior...
  61. doi request reprint Predictors for successful PBSC collection on the fourth day of G-CSF-induced mobilization in allogeneic stem cell donors
    Anja van Oostrum
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    J Clin Apher . 2017
    ..In conclusion, PBSC collection on day 4 will not result in a successful harvest in most stem cell donors, however using a twice daily G-CSF scheme increases the yield...
  62. pmc The increase of the global donor inventory is of limited benefit to patients of non-Northwestern European descent
    Suzanna M van Walraven
    Europdonor Foundation, Leiden, The Netherlands
    Haematologica 102:176-183. 2017
    ....
  63. doi request reprint Noninherited maternal antigens identify acceptable HLA mismatches: benefit to patients and cost-effectiveness for cord blood banks
    Henk G M van der Zanden
    Europdonor Foundation, Leiden, Netherlands Electronic address
    Biol Blood Marrow Transplant 20:1791-5. 2014
    ..The elucidation of donors' maternal HLA phenotypes can provide significant numbers of 6/6 and 5/6 virtually matched CBUs to patients and is potentially cost effective...
  64. doi request reprint Mannose-binding lectin is involved in multiple organ dysfunction syndrome after cardiac surgery: effects of blood transfusions
    Yavuz M Bilgin
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Transfusion 48:601-8. 2008
    ..Preoperative transfusions of allogeneic white blood cells (WBCs) contribute to infectious and inflammatory complications. This study investigates the role of MBL in relation to blood transfusions and complications after cardiac surgery...
  65. doi request reprint Postoperative anemia after joint replacement surgery is not related to quality of life during the first two weeks postoperatively
    Cynthia So-Osman
    Department of Research and Development, Sanquin Blood Bank South West Region, Leiden, The Netherlands
    Transfusion 51:71-81. 2011
    ....
  66. ncbi request reprint A sensitive quantitative single-platform flow cytometry protocol to measure human platelets in mouse peripheral blood
    Laurus F Schipper
    Sanquin Blood Bank, Southwest Region, Leidenm, The Netherlands
    Transfusion 47:2305-14. 2007
    ..This study describes a single-platform protocol to count human platelets (hPLTs) after transfusion and CB transplantation in the peripheral blood (PB) of the mouse...
  67. ncbi request reprint Platelet transfusion therapy: from 1973 to 2005
    Anneke Brand
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    Hum Immunol 67:413-8. 2006
    ..For efficient use of health care resources, blood banks and stem cell donor banks could share their typed donor files...
  68. ncbi request reprint Multiple-laboratory comparison of in vitro assays utilized to characterize hematopoietic cells in cord blood
    Gary Moroff
    American Red Cross, Jerome H Holland Laboratory for the Biomedical Sciences, Rockville, MD 20855, USA
    Transfusion 46:507-15. 2006
    ..Understanding the variability in results obtained by multiple laboratories is important because cord blood units are distributed worldwide for transplantation...
  69. ncbi request reprint The putative mechanism of the immunomodulating effect of HLA-DR shared allogeneic blood transfusions on the alloimmune response
    Marloes M Waanders
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, RC Leiden, The Netherlands
    Transfus Med Rev 19:281-7. 2005
    ....
  70. ncbi request reprint Immunological aspects of blood transfusions
    Anneke Brand
    Leiden University Medical Center, Department of Immunohaematology and Blood Transfusion, Sanquin Foundation, The Netherlands
    Transpl Immunol 10:183-90. 2002
    ..However, every blood transfusion interferes with the immune system of the recipient. The available evidence of harm from immune responses not leading to severe transfusion reactions will be discussed...
  71. ncbi request reprint Stability after thawing of RBCs frozen with the high- and low-glycerol method
    Charles C M Lelkens
    Military Blood Bank, Leiden, The Netherlands
    Transfusion 43:157-64. 2003
    ..To date, the use of frozen RBCs is hampered by a 24-hour outdating period after thawing. A closed washing system (ACP 215) may solve this problem...
  72. ncbi request reprint Independent association of massive blood loss with mortality in cardiac surgery
    Leo van de Watering
    Transfusion 45:1235; author reply 1235-6. 2005
  73. ncbi request reprint Relation between K+ leakage and damage to band 3 in photodynamically treated red cells
    Laurence L Trannoy
    Blood Bank Leiden Haaglanden, Leiden, The Netherlands
    Photochem Photobiol 75:167-71. 2002
    ..Glucose transport was not affected by DMMB-mediated PDT. The present results are the first to show a causal relationship between DMMB-mediated photodamage to band 3 and increased cation permeability of red blood cells...
  74. ncbi request reprint Autoimmunoreactivity to Schwann cells in patients with inflammatory neuropathies
    Marcel S G Kwa
    Department of Neurology, Academic Medical Centre, University of Amsterdam, The Netherlands
    Brain 126:361-75. 2003
    ..These data suggest that, at least part of the immunoreactivity is not directed against myelin, but towards non-myelin proteins and epitopes possibly involved in Schwann cell-axon interaction...
  75. pmc Effects of transfusion with red cells filtered to remove leucocytes: randomised controlled trial in patients undergoing major surgery
    Joost A van Hilten
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center and Sanquin Blood Supply, PO Box 9600, 2300 RC Leiden, Netherlands
    BMJ 328:1281. 2004
    ..To compare postoperative complications in patients undergoing major surgery who received non-filtered or filtered red blood cell transfusions...
  76. ncbi request reprint Follow up of children after antenatal treatment for alloimmune thrombocytopenia
    Celine M Radder
    Department of Obstetrics, Leiden University Medical Center, H4 P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Early Hum Dev 80:65-76. 2004
    ..To evaluate the long-term follow-up of surviving offspring after antenatal treatment for fetal or neonatal alloimmune thrombocytopenia (FNAIT)...
  77. ncbi request reprint Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1
    Bregje Mommaas
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Blood 105:1823-7. 2005
    ..Moreover, since the fetus cannot be primed against Y chromosome-encoded minor H antigens, cord blood is an attractive stem cell source for male patients...
  78. ncbi request reprint Postnatal management of fetal and neonatal alloimmune thrombocytopenia: the role of matched platelet transfusion and IVIG
    Arjan B Te Pas
    Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, RC Leiden, The Netherlands
    Eur J Pediatr 166:1057-63. 2007
    ..In neonatally diagnosed cases not treated before birth, multiple matched platelet transfusions may be required. We found no evidence to support the use of IVIG in neonates with FNAIT...
  79. doi request reprint Protocolled blood transfusions in recipients of a simultaneous pancreas-kidney transplant reduce severe acute graft rejection
    Marloes M Waanders
    Transplantation 85:1668-70. 2008