Sanquin Research

Summary

Organization: Sanquin Research
Country: The Netherlands

Top Publications

  1. doi The extent of the anti-citrullinated protein antibody repertoire is associated with arthritis development in patients with seropositive arthralgia
    Lotte A van de Stadt
    Department of Immunopathology, Sanquin Research and Landsteiner Laboratorium, Academic Medical Center, Amsterdam, The Netherlands
    Ann Rheum Dis 70:128-33. 2011
  2. doi Rapid screening by real-time 16S rDNA PCR for bacterial contamination of blood products
    Hendrik W Reesink
    Sanquin Blood Bank North West Region and Sanquin Diagnostic Services, Amsterdam, The Netherlands
    Clin Chem Lab Med 46:954-62. 2008
  3. doi Granulocyte concentrates: prolonged functional capacity during storage in the presence of phenotypic changes
    Agata Drewniak
    Sanquin, Research Institute, Academic Medical Centre, University of Amsterdam, Plesmanlaan, 125, 1066 CX Amsterdam, The Netherlands
    Haematologica 93:1058-67. 2008
  4. doi Preferential decrease in IgG4 anti-citrullinated protein antibodies during treatment with tumour necrosis factor blocking agents in patients with rheumatoid arthritis
    W H Bos
    Sanquin Research, Amsterdam, The Netherlands
    Ann Rheum Dis 68:558-63. 2009
  5. doi Innate immune 'self' recognition: a role for CD47-SIRPalpha interactions in hematopoietic stem cell transplantation
    Timo K van den Berg
    Sanquin Research and Landsteiner Laboratory, Academic Medical Center, 1066 CX Amsterdam, The Netherlands
    Trends Immunol 29:203-6. 2008
  6. doi Prolonged maintenance of 2,3-diphosphoglycerate acid and adenosine triphosphate in red blood cells during storage
    Dirk de Korte
    Sanquin Research, Amsterdam, The Netherlands
    Transfusion 48:1081-9. 2008
  7. ncbi Mannose-binding lectin (MBL) facilitates opsonophagocytosis of yeasts but not of bacteria despite MBL binding
    Nannette Brouwer
    Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands
    J Immunol 180:4124-32. 2008
  8. doi Mechanisms of disease: antiphospholipid antibodies-from clinical association to pathologic mechanism
    Bas de Laat
    Department of Plasma Proteins Blood coagulation at Sanquin Research, Amsterdam, The Netherlands
    Nat Clin Pract Rheumatol 4:192-9. 2008
  9. ncbi Clinica use of platelet additive solutions
    Dick J van Rhenen
    Sanquin Blood Bank South West Region, Department of Haematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Transfus Apher Sci 37:269-72. 2007
  10. ncbi Viability does not necessarily reflect the hematopoietic progenitor cell potency of a cord blood unit: results of an interlaboratory exercise
    Anneke Brand
    Leiden Cord Bloodbank, Sanquin, The Netherlands
    Transfusion 48:546-9. 2008

Scientific Experts

Detail Information

Publications62

  1. doi The extent of the anti-citrullinated protein antibody repertoire is associated with arthritis development in patients with seropositive arthralgia
    Lotte A van de Stadt
    Department of Immunopathology, Sanquin Research and Landsteiner Laboratorium, Academic Medical Center, Amsterdam, The Netherlands
    Ann Rheum Dis 70:128-33. 2011
    ..To determine the fine specificity of anti-citrullinated protein antibodies (ACPA) in the early phase of arthritis development, the ACPA repertoire in arthralgia patients and the association with arthritis development were studied...
  2. doi Rapid screening by real-time 16S rDNA PCR for bacterial contamination of blood products
    Hendrik W Reesink
    Sanquin Blood Bank North West Region and Sanquin Diagnostic Services, Amsterdam, The Netherlands
    Clin Chem Lab Med 46:954-62. 2008
    ..One of these methods, real-time polymerase chain reaction (PCR) with particular focus on real-time 16S rDNA detection, will be discussed in this review...
  3. doi Granulocyte concentrates: prolonged functional capacity during storage in the presence of phenotypic changes
    Agata Drewniak
    Sanquin, Research Institute, Academic Medical Centre, University of Amsterdam, Plesmanlaan, 125, 1066 CX Amsterdam, The Netherlands
    Haematologica 93:1058-67. 2008
    ..The aim of this study was to assess the functional characteristics and efficacy of granulocyte colony-stimulating factor/dexamethasone-mobilized granulocytes used for transfusions...
  4. doi Preferential decrease in IgG4 anti-citrullinated protein antibodies during treatment with tumour necrosis factor blocking agents in patients with rheumatoid arthritis
    W H Bos
    Sanquin Research, Amsterdam, The Netherlands
    Ann Rheum Dis 68:558-63. 2009
    ..To investigate the dynamics of IgG1 and IgG4 anti-citrullinated protein antibody (ACPA) subclasses during anti-tumour necrosis factor (TNF) treatment in patients with rheumatoid arthritis (RA)...
  5. doi Innate immune 'self' recognition: a role for CD47-SIRPalpha interactions in hematopoietic stem cell transplantation
    Timo K van den Berg
    Sanquin Research and Landsteiner Laboratory, Academic Medical Center, 1066 CX Amsterdam, The Netherlands
    Trends Immunol 29:203-6. 2008
    ....
  6. doi Prolonged maintenance of 2,3-diphosphoglycerate acid and adenosine triphosphate in red blood cells during storage
    Dirk de Korte
    Sanquin Research, Amsterdam, The Netherlands
    Transfusion 48:1081-9. 2008
    ..From the literature it is known that the intracellular pH is an important determinant of RBC metabolism. Therefore, a new, alkaline, AS was developed with the aim to allow cold storage of RBCs with stable product characteristics...
  7. ncbi Mannose-binding lectin (MBL) facilitates opsonophagocytosis of yeasts but not of bacteria despite MBL binding
    Nannette Brouwer
    Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands
    J Immunol 180:4124-32. 2008
    ....
  8. doi Mechanisms of disease: antiphospholipid antibodies-from clinical association to pathologic mechanism
    Bas de Laat
    Department of Plasma Proteins Blood coagulation at Sanquin Research, Amsterdam, The Netherlands
    Nat Clin Pract Rheumatol 4:192-9. 2008
    ..Owing to the diversity of clinical symptoms related to APS, it is likely that other pathologic mechanisms also contribute to the occurrence of APS-related symptoms...
  9. ncbi Clinica use of platelet additive solutions
    Dick J van Rhenen
    Sanquin Blood Bank South West Region, Department of Haematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Transfus Apher Sci 37:269-72. 2007
    ..In this paper a number of recent RCT's is discussed. It can be the start of a development where new transfusion products enter a RCT before the product is applied in clinical practice...
  10. ncbi Viability does not necessarily reflect the hematopoietic progenitor cell potency of a cord blood unit: results of an interlaboratory exercise
    Anneke Brand
    Leiden Cord Bloodbank, Sanquin, The Netherlands
    Transfusion 48:546-9. 2008
    ..Another reason for a discrepancy between the number of cells in the unit released by the cord blood bank and found in the transplant center may be technical differences in cell counting methods between the two sites...
  11. ncbi Overnight storage of whole blood: a comparison of two designs of butane-1,4-diol cooling plates
    Pieter F van der Meer
    Sanquin Blood Bank Northwest Region, Amsterdam, The Netherlands
    Transfusion 47:2038-43. 2007
    ..This study compared cooling efficiency and in vitro quality of plasma and of stored white cell (WBC)-reduced red cells (RBCs) from overnight-stored WB, cooled with either of the systems...
  12. ncbi The presence of the Trim5alpha escape mutation H87Q in the capsid of late stage HIV-1 variants is preceded by a prolonged asymptomatic infection phase
    Neeltje A Kootstra
    Department of Clinical Viro Immunology, Sanquin Research, Landsteiner Laboratory, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    AIDS 21:2015-23. 2007
    ..Human Trim5alpha is also able to inhibit HIV-1 replication in vitro, implying that Trim5alpha may contribute to host control of HIV-1 replication in vivo...
  13. ncbi Detection of bacterial contamination of platelet concentrates
    R N I Pietersz
    Sanquin Blood Bank North West Region, P O Box 9137, NL 1006 AC Amsterdam, The Netherlands
    Vox Sang 93:260-77. 2007
  14. ncbi Altered processing of thawed red cells to improve the in vitro quality during postthaw storage at 4 degrees C
    Johan W M Lagerberg
    Division Research, Sanquin Blood Supply Foundation, Amsterdam, The Netherlands
    Transfusion 47:2242-9. 2007
    ..In this study, the postthaw quality of previously frozen, deglycerolized RBCs resuspended in saline-adenine-glucose-mannitol (SAGM) or additive solution AS-3 was investigated...
  15. ncbi Transendothelial migration drives dissociation of plateletmonocyte complexes
    Janine M van Gils
    Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academical Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thromb Haemost 100:271-9. 2008
    ..PMC-mediated deposition of activated platelets at sites of vascular inflammation is likely relevant for cardiovascular disease progression or vascular regeneration...
  16. doi Blood outgrowth endothelial cells from cord blood and peripheral blood: angiogenesis-related characteristics in vitro
    R T van Beem
    Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Thromb Haemost 7:217-26. 2009
    ..Although cord blood (CB) BOEC have been reported as more proliferative than peripheral blood (PB) BOEC, not much is known about their functional properties...
  17. doi High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's
    Diana Wouters
    Department of Immunopathology, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands
    Mol Immunol 46:592-600. 2009
    ..In conclusion, the combination of MLPA and ELISA is very suitable to study the geno- and phenotype of complement C4 in large patient groups...
  18. doi Hematologically important mutations: X-linked chronic granulomatous disease (third update)
    Dirk Roos
    Sanquin Research, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands
    Blood Cells Mol Dis 45:246-65. 2010
    ..This article lists all mutations identified in CYBB in the X-linked form of CGD. Moreover, apparently benign polymorphisms in CYBB are also given, which should facilitate the recognition of future disease-causing mutations...
  19. pmc Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium
    Jaap D van Buul
    Sanquin Research and Landsteiner Laboratory, Department of Molecular Cell Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 5:e11336. 2010
    ..Therefore, we studied the dynamics of endothelial ICAM-1 under non-clustered and clustered conditions...
  20. doi Toll-like receptor-induced reactivity and strongly potentiated IL-8 production in granulocytes mobilized for transfusion purposes
    Agata Drewniak
    Department of Blood Cell Research, Phagocyte Laboratory, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands
    Blood 115:4588-96. 2010
    ..In summary, granulocytes mobilized for transfusion purposes show enhanced TLR responsiveness in cytokine production, which is anticipated to be beneficial for the function of these cells on transfusion into patients...
  21. doi Monophosphoryl lipid A plus IFNgamma maturation of dendritic cells induces antigen-specific CD8+ cytotoxic T cells with high cytolytic potential
    Anja ten Brinke
    Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, P O Box 9190, 1006 AD, Amsterdam, The Netherlands
    Cancer Immunol Immunother 59:1185-95. 2010
    ..Furthermore, the CTLs proved to kill tumour cells expressing endogenous tumour antigen in vitro. Therefore, MPLA/IFNgamma DCs are very promising for the use in future cancer immunotherapy...
  22. doi Hybrid IgG4/IgG4 Fc antibodies form upon 'Fab-arm' exchange as demonstrated by SDS-PAGE or size-exclusion chromatography
    Theo Rispens
    Sanquin Research, Amsterdam, The Netherlands
    Mol Immunol 47:1592-4. 2010
    ....
  23. doi Traces of pFc' in IVIG interact with human IgG Fc domains and counteract aggregation
    Theo Rispens
    Sanquin Research, Amsterdam, The Netherlands
    Eur J Pharm Sci 40:62-8. 2010
    ..Thus, pFc' can modulate Fc interactions and may therefore reduce adverse effects of IVIG, in particular by preventing oligomerization...
  24. doi Reliability of fetal sex determination using maternal plasma
    Peter G Scheffer
    Division of Perinatology and Gynaecology, University Medical Center Utrecht, The Netherlands
    Obstet Gynecol 115:117-26. 2010
    ..To determine the diagnostic accuracy of noninvasive fetal sex determination in maternal plasma...
  25. pmc The presence of alpha-catenin in the VE-cadherin complex is required for efficient transendothelial migration of leukocytes
    Jaap D van Buul
    Dept Molecular Cell Biology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands
    Int J Biol Sci 5:695-705. 2009
    ..In conclusion, our results show for the first time that the association of alpha-catenin with the cadherin-catenin complex is required for efficient leukocyte TEM...
  26. doi The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study
    B de Laat
    Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands
    J Thromb Haemost 7:1767-73. 2009
    ..Anti-beta2-glycoprotein I (beta 2GPI) antibodies play a central role in the disease process of APS...
  27. doi The use of cord blood for transfusion purposes: current status
    C M Khodabux
    Sanquin Blood Bank, Department of Research and Development, Leiden, The Netherlands
    Vox Sang 97:281-93. 2009
    ..Altogether, we could find no disencouraging evidence to collect UCB, which could be processed into an easily available RBC product for paediatric transfusion in resource-restricted countries...
  28. doi Changes in gene expression of granulocytes during in vivo granulocyte colony-stimulating factor/dexamethasone mobilization for transfusion purposes
    Agata Drewniak
    Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam
    Blood 113:5979-98. 2009
    ..These studies provide new insight in the genotypic changes as well as in the regulation of the immunologic functions and viability of mobilized granulocytes used for clinical transfusion purposes...
  29. doi Human IgG4 binds to IgG4 and conformationally altered IgG1 via Fc-Fc interactions
    Theo Rispens
    Sanquin Research, Amsterdam, The Netherlands
    J Immunol 182:4275-81. 2009
    ..By contrast, IgG4 Fc recognizes IgG1 only after a conformational change that renders CH3(IgG1) accessible to an interaction with the CH3(IgG4). Such Fc interactions may enhance Ag binding of IgG4 in vivo...
  30. doi Acquired Glanzmann's thrombasthenia caused by glycoprotein IIb/IIIa autoantibodies of the immunoglobulin G1 (IgG1), IgG2 or IgG4 subclass: a study in six cases
    L Porcelijn
    Immunohematology Diagnostic Services Department, Sanquin Diagnostic Services, Amsterdam, The Netherlands
    Vox Sang 95:324-30. 2008
    ..Acquired Glanzmann's thrombasthenia (GT) is an uncommon bleeding disorder caused by glycoprotein (GP) IIb/IIIa-specific autoantibodies. Covering of the fibrinogen binding site of GPIIb/IIIa results in a moderate-to-severe bleeding tendency...
  31. ncbi Is haemovigilance improving transfusion practice?--The european experience
    P F W Strengers
    Sanquin at CLB, Amsterdam, The Netherlands
    Dev Biol (Basel) 127:215-24. 2007
    ..In Europe, experience has shown that haemovigilance offers an effective tool in improving transfusion practice...
  32. ncbi Flow cytometric CD34+ stem cell enumeration: lessons from nine years' external quality assessment within the Benelux countries
    Wilfried H B M Levering
    Laboratory for Histocompatibility and Immunogenetics, Sanquin Blood Bank South West Region, Rotterdam, The Netherlands
    Cytometry B Clin Cytom 72:178-88. 2007
    ..In an evaluation of the results of 16 send-outs, we studied the effects of the methods used on assay outcome and whether or not this exercise was effective in reducing between-laboratory variation...
  33. ncbi Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro
    S B Geutskens
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    J Leukoc Biol 78:845-52. 2005
    ..It is important that this increase of F4/80-positive cells was paralleled by an increase in the number of insulin-producing cells, suggesting that macrophages support the growth of these endocrine cells...
  34. ncbi Closed system generation of dendritic cells from a single blood volume for clinical application in immunotherapy
    M Elias
    Sanquin Division North East, GG Groningen, The Netherlands
    J Clin Apher 20:197-207. 2005
    ....
  35. ncbi Correlation between the extent of platelet activation in platelet concentrates and in vitro and in vivo parameters
    M J Dijkstra-Tiekstra
    Sanquin Blood Bank North West Region, Amsterdam, The Netherlands
    Vox Sang 87:257-63. 2004
    ....
  36. ncbi Storage of platelets in additive solution for up to 12 days with maintenance of good in-vitro quality
    Pieter F van der Meer
    Sanquin Blood Bank North West Region, Amsterdam, The Netherlands
    Transfusion 44:1204-11. 2004
    ..The aim of this study was to examine in-vitro storage characteristics of PCs in various storage solutions: plasma only, or mixtures of plasma with PAS-II, PAS-III, PAS-IIIM, and Composol...
  37. ncbi Van Creveld, pioneer of hemophilia care and coagulation research in the Netherlands: a personal account
    J A Van Mourik
    Sanquin Blood Supply Foundation, Department of Blood Coagulation and Department of Plasma Proteins, Amsterdam, The Netherlands
    J Thromb Haemost 2:1029-33. 2004
  38. ncbi IgE testing in capillary blood
    Steven O Stapel
    Sanquin CLB, Department of Allergy, Amsterdam, The Netherlands
    Pediatr Allergy Immunol 15:230-3. 2004
    ....
  39. ncbi Molecular diagnostics in immunohaematology
    C E van der Schoot
    Sanquin Research at CLB, Amsterdam, Netherlands
    Vox Sang 87:189-92. 2004
  40. ncbi Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor
    Nikolai A Maianski
    Emma Childrens Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 172:7024-30. 2004
    ..Together our results support an integrative role of the mitochondria in induction and/or amplification of caspase activity and show that G-CSF may act by blocking Bid/Bax redistribution and inhibiting caspase activation...
  41. ncbi Quantitative real-time detection of parvovirus B19 DNA in plasma
    Marco H G M Koppelman
    Viral Diagnostic Services Department, Sanquin Diagnostic Services, Amsterdam, The Netherlands
    Transfusion 44:97-103. 2004
    ....
  42. ncbi Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers
    Merel C M Strik
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Blood 103:2710-7. 2004
    ..In conclusion, SERPINB6 is abundantly expressed by normal mast cells and by mast cells in mastocytoma lesions. We suggest that in mast cells, SERPINB6 serves to regulate the activity of endogenous beta-tryptase in the cytoplasm...
  43. ncbi Detection of bacterial contamination of platelet concentrates
    R N I Pietersz
    Sanquin Blood Bank North West Region, Amsterdam, The Netherlands
    Vox Sang 85:224-39. 2003
  44. ncbi Future counselling of donors and recipients of blood products concerning prion-related diseases
    H W Reesink
    Sanquin Blood Bank region North West, Amsterdam, The Netherlands
    Vox Sang 85:126-48. 2003
  45. ncbi Endothelial signaling in leukocyte transmigration
    Peter Hordijk
    Department of Experimental Immunohematology, Sanquin Research at CLB, Amsterdam, The Netherlands
    Cell Biochem Biophys 38:305-22. 2003
    ..This review discusses what is currently known about control of VE-cadherin function via intracellular signaling, and its induction by endothelial adhesion molecules of the immunoglobulin superfamily...
  46. ncbi Assessment of sequence homology and cross-reactivity
    Rob C Aalberse
    Department of Immunopathology, Sanquin Research at CLB, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Toxicol Appl Pharmacol 207:149-51. 2005
    ..Yet, pre-existing cross-reactive T cell activity is likely to influence the outcome not only of the immune response, but also of the effector phase of the allergic reaction...
  47. ncbi Evaluation of COBAS AmpliPrep nucleic acid extraction in conjunction with COBAS AmpliScreen HBV DNA, HCV RNA and HIV-1 RNA amplification and detection
    M H G M Koppelman
    Sanquin Diagnostic Services, Viral Diagnostic Services Department, Amsterdam, Netherlands
    Vox Sang 89:193-200. 2005
    ....
  48. ncbi Production, purification and characterisation of recombinant Fahsin, a novel antistasin-type proteinase inhibitor
    Eric C de Bruin
    Department of Immunopathology, Sanquin Research at CLB, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    FEMS Yeast Res 5:1069-77. 2005
    ..Thus, Fahsin constitutes a novel member of a still expanding family of naturally occurring inhibitors of serine proteinases with potential therapeutic use for treatment of human diseases...
  49. ncbi Structure and function of C1-inhibitor
    Ineke G A Wagenaar-Bos
    Department of Immunopathology, Sanquin Research at CLB and Landsteiner Laboratory, Academical Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Immunol Allergy Clin North Am 26:615-32. 2006
    ..Recent studies suggest some anti-inflammatory functions for this N-terminal part, possibly explaining the effects of C1-INH in diseases other than HAE...
  50. ncbi Chronic granulomatous disease caused by mutations other than the common GT deletion in NCF1, the gene encoding the p47phox component of the phagocyte NADPH oxidase
    Dirk Roos
    Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Hum Mutat 27:1218-29. 2006
    ..Family members with either the GT deletion or one of these other mutations were identified as carriers. This knowledge was used in one of the families for prenatal diagnosis...
  51. ncbi An evaluation of automated blood collection mixers
    P F van der Meer
    Sanquin Blood Bank North West Region, Amsterdam, The Netherlands
    Vox Sang 91:275-7. 2006
    ..We investigated the mixing capacity of two whole blood (WB) collection mixers...
  52. ncbi Endothelial signalling events during leukocyte transmigration
    Peter L Hordijk
    Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands
    FEBS J 273:4408-15. 2006
    ..This minireview discusses our current knowledge on the regulation of leukocyte transmigration through endothelial signalling...
  53. ncbi In silico predictability of allergenicity: from amino acid sequence via 3-D structure to allergenicity
    Rob C Aalberse
    Sanquin Research at CLB, Landsteiner Laboratory, Academic Medical Centre, Department of Immunopathology, Amsterdam, The Netherlands
    Mol Nutr Food Res 50:625-7. 2006
    ..The question of whether any antigen can be allergenic is still a matter of debate...
  54. ncbi The effect of whole-blood storage time on the number of white cells and platelets in whole blood and in white cell-reduced red cells
    Pieter F van der Meer
    Sanquin Blood Bank Northwest Region, Amsterdam
    Transfusion 46:589-94. 2006
    ..The effect of storage time on the composition of WB and subsequently prepared WBC-reduced RBCs was studied...
  55. ncbi Factor XIII in severe sepsis and septic shock
    Sacha Zeerleder
    Sanquin Research at CLB, Amsterdam, The Netherlands
    Thromb Res 119:311-8. 2007
    ..Activated FXIII (FXIIIa) forms stable fibrin clots by covalently cross-linking fibrin monomers. Therefore, we investigated the impact of FXIII antigen and activity levels on disease severity and fatality in sepsis patients...
  56. ncbi Evaluation of classical complement pathway activation in rheumatoid arthritis: measurement of C1q-C4 complexes as novel activation products
    Diana Wouters
    Department of Immunopathology, Sanquin Research at CLB and Academic Medical Centre, Amsterdam, The Netherlands
    Arthritis Rheum 54:1143-50. 2006
    ....
  57. ncbi Neutrophil responsiveness to IgG, as determined by fixed ratios of mRNA levels for activating and inhibitory FcgammaRII (CD32), is stable over time and unaffected by cytokines
    Edwin van Mirre
    Department of Blood Cell Research, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, The Netherlands
    Blood 108:584-90. 2006
    ..4 haplotype of the FCGR2B promoter with increased transcriptional activity in individuals with 1:1 ratios and the more common low-expression 2B.1 haplotype in individuals with FcgammaRIIa/FcgammaRIIb2 mRNA ratios of 2:1, 3:1, or 4:1...
  58. ncbi Regulation of NADPH oxidases: the role of Rac proteins
    Peter L Hordijk
    Department Molecular Cell Biology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 98:453-62. 2006
    ..This review focuses on the role of the Rac1 and Rac2 GTPases in the activation of the various NOX family members...
  59. ncbi Mannan-binding lectin (MBL)-mediated opsonization is enhanced by the alternative pathway amplification loop
    Nannette Brouwer
    Sanquin Research Academic Medical Centre Landsteiner Laboratory, Amsterdam, The Netherlands
    Mol Immunol 43:2051-60. 2006
    ..In conclusion, our data demonstrate that the MBL-mediated route of complement activation depends on the alternative pathway amplification loop for optimal opsonization of zymosan...
  60. ncbi Proteolytic cleavage of protein S during the hemostatic response
    H J M Brinkman
    Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands
    J Thromb Haemost 3:2712-20. 2005
    ..It contains a so-called thrombin-sensitive region (TSR), which is susceptible to cleavage by coagulation factor Xa (FXa) and thrombin. Upon cleavage, the anticoagulant activity of protein S is abolished...
  61. ncbi Structural features of allergenic molecules
    Rob C Aalberse
    Sanquin Research at CLB and Karl Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Chem Immunol Allergy 91:134-46. 2006
    ..According to this working hypothesis, the choice between these two routes is determined at the level of the germinal center activity...
  62. ncbi The functional integrity of the serpin domain of C1-inhibitor depends on the unique N-terminal domain, as revealed by a pathological mutant
    Ineke G A Bos
    Department of Immunopathology, Sanquin Research at CLB, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 278:29463-70. 2003
    ....