Bart P van de Warrenburg

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint [A swollen, painless calf caused by neurogenic muscle (pseudo)-hypertrophy]
    B P van de Warrenburg
    Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen, afd Neurologie
    Ned Tijdschr Geneeskd 147:2183-6. 2003
  2. doi request reprint Antineuronal antibodies in Parkinson's disease
    Bart P C van de Warrenburg
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 23:958-63. 2008
  3. ncbi request reprint The phenomenon of disproportionate antecollis in Parkinson's disease and multiple system atrophy
    Bart P C van de Warrenburg
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 22:2325-31. 2007
  4. ncbi request reprint [Parkinson's disease(s): recent insight into genetic factors]
    B P C van de Warrenburg
    Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 151:1665-8. 2007
  5. ncbi request reprint Recent advances in hereditary spinocerebellar ataxias
    Bart P C van de Warrenburg
    Department of Neurology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Neuropathol Exp Neurol 64:171-80. 2005
  6. ncbi request reprint Age at onset variance analysis in spinocerebellar ataxias: a study in a Dutch-French cohort
    Bart P C van de Warrenburg
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    Ann Neurol 57:505-12. 2005
  7. doi request reprint Republished: A practical approach to late-onset cerebellar ataxia: putting the disorder with lack of order into order
    Judith van Gaalen
    Department of Neurology, Radboud University Nijmegen Medical Centre, Reinier Postlaan 4, Nijmegen, The Netherlands
    Postgrad Med J 88:407-17. 2012
  8. ncbi request reprint Peripheral nerve involvement in spinocerebellar ataxias
    Bart P C van de Warrenburg
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    Arch Neurol 61:257-61. 2004
  9. ncbi request reprint Myelopathy due to spinal epidural abscess without cord compression: a diagnostic pitfall
    B P C van de Warrenburg
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    Clin Neuropathol 23:102-6. 2004
  10. pmc Effects of acetyl-DL-leucine in patients with cerebellar ataxia: a case series
    Michael Strupp
    Department of Neurology, University Hospital Munich and German Center for Vertigo and Balance Disorders, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany
    J Neurol 260:2556-61. 2013

Collaborators

Detail Information

Publications34

  1. ncbi request reprint [A swollen, painless calf caused by neurogenic muscle (pseudo)-hypertrophy]
    B P van de Warrenburg
    Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen, afd Neurologie
    Ned Tijdschr Geneeskd 147:2183-6. 2003
    ..The underlying pathophysiological mechanism is unclear, but probably includes compensatory hypertrophy, abnormal stretching, and spontaneous electrical activity of denervated muscle fibres...
  2. doi request reprint Antineuronal antibodies in Parkinson's disease
    Bart P C van de Warrenburg
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 23:958-63. 2008
    ..We conclude that ANAs do not play a role in the majority of patients with IPD, but might be relevant in the pathogenesis of IPD with atypical features...
  3. ncbi request reprint The phenomenon of disproportionate antecollis in Parkinson's disease and multiple system atrophy
    Bart P C van de Warrenburg
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 22:2325-31. 2007
    ..However, a primary but yet unexplained neck extensor myopathy still remains the alternative possibility and longitudinal studies are necessary to settle this issue...
  4. ncbi request reprint [Parkinson's disease(s): recent insight into genetic factors]
    B P C van de Warrenburg
    Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 151:1665-8. 2007
    ..Further research is likely to contribute to the understanding and future treatment of idiopathic Parkinson's disease...
  5. ncbi request reprint Recent advances in hereditary spinocerebellar ataxias
    Bart P C van de Warrenburg
    Department of Neurology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Neuropathol Exp Neurol 64:171-80. 2005
    ..In this review, the clinical and neuropathologic features of the recently identified spinocerebellar ataxias are described, and the various molecular mechanisms that have been demonstrated to be involved in these disorders are discussed...
  6. ncbi request reprint Age at onset variance analysis in spinocerebellar ataxias: a study in a Dutch-French cohort
    Bart P C van de Warrenburg
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    Ann Neurol 57:505-12. 2005
    ..Besides polyglutamine motif (determined by the expanded CAG repeat length), we identified the following age at onset modifiers: protein context in SCA2; familial factors in SCA2 and SCA3; and the nonexpanded CAG repeat in SCA1 and SCA6...
  7. doi request reprint Republished: A practical approach to late-onset cerebellar ataxia: putting the disorder with lack of order into order
    Judith van Gaalen
    Department of Neurology, Radboud University Nijmegen Medical Centre, Reinier Postlaan 4, Nijmegen, The Netherlands
    Postgrad Med J 88:407-17. 2012
    ..Although only a minority of underlying diseases are treatable, there are still many options for supportive care...
  8. ncbi request reprint Peripheral nerve involvement in spinocerebellar ataxias
    Bart P C van de Warrenburg
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    Arch Neurol 61:257-61. 2004
    ....
  9. ncbi request reprint Myelopathy due to spinal epidural abscess without cord compression: a diagnostic pitfall
    B P C van de Warrenburg
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    Clin Neuropathol 23:102-6. 2004
    ..Clinicians and neuropathologists should be aware of the variable mechanisms underlying the neurological involvement in SEA. Absence of spinal cord compression by the abscess may hamper early diagnosis and treatment...
  10. pmc Effects of acetyl-DL-leucine in patients with cerebellar ataxia: a case series
    Michael Strupp
    Department of Neurology, University Hospital Munich and German Center for Vertigo and Balance Disorders, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany
    J Neurol 260:2556-61. 2013
    ..In conclusion, acetyl-DL-leucine significantly improved ataxic symptoms without side effects and therefore showed a good risk-benefit profile. These findings need to be confirmed in placebo-controlled trials...
  11. pmc Task-free functional MRI in cervical dystonia reveals multi-network changes that partially normalize with botulinum toxin
    Cathérine C S Delnooz
    Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Nijmegen, The Netherlands
    PLoS ONE 8:e62877. 2013
    ....
  12. doi request reprint Is TOR1A a risk factor in adult-onset primary torsion dystonia?
    Justus L Groen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mov Disord 28:827-31. 2013
    ..Studies of genetic association between TOR1A and adult-onset primary torsion dystonia have contradictory results...
  13. doi request reprint Mutational analysis of TARDBP in Parkinson's disease
    Marka van Blitterswijk
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurobiol Aging 34:1517.e1-3. 2013
    ..S332S, no missense mutations were present in our cohort. Our findings, therefore, demonstrate that TARDBP mutations do not appear to contribute to the pathogenesis of Parkinson's disease in The Netherlands...
  14. doi request reprint Cervical dystonia and genetic common variation in the dopamine pathway
    Justus L Groen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Parkinsonism Relat Disord 19:346-9. 2013
    ..Possibly, risk alleles in this pathway may be rarer than detectable in this study, or might be located in downstream dopamine signaling pathway. Alternatively, found dopamine level changes are secondary to the dystonia disease processes...
  15. doi request reprint Normal eyeblink classical conditioning in patients with fixed dystonia
    Sabine Janssen
    Department of Neurology 935, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Exp Brain Res 232:1805-9. 2014
    ..Our study argues against abnormal cerebellar function in non-medicated, fixed dystonia patients without CRPS or spread of symptoms...
  16. pmc Promotion of physical activity and fitness in sedentary patients with Parkinson's disease: randomised controlled trial
    Marlies van Nimwegen
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Evidence Based Practice, Nijmegen, Netherlands
    BMJ 346:f576. 2013
    ..To evaluate whether a multifaceted behavioural change programme increases physical activities in patients with Parkinson's disease...
  17. doi request reprint BDNF polymorphism associates with decline in set shifting in Parkinson's disease
    Nicolien M Van der Kolk
    Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands
    Neurobiol Aging 36:1605.e1-6. 2015
    ..Contrary to previous assumptions, these results indicate that mental flexibility is one of the cognitive processes that may benefit from the BDNF Met allele in PD patients...
  18. doi request reprint Genetic variation in ataxia gene ATXN7 influences cerebellar grey matter volume in healthy adults
    Charlotte D C C van der Heijden
    Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cerebellum 12:390-5. 2013
    ..This finding may also imply that genes associated with cerebellar volume in healthy subjects are valid candidates for causing or modifying ataxia...
  19. doi request reprint Cerebellar brain inhibition is decreased in active and surround muscles at the onset of voluntary movement
    Panagiotis Kassavetis
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK
    Exp Brain Res 209:437-42. 2011
    ..Our findings fail to functionally link SI with CBI, but they do indicate a non-topographically specific modulation of CBI in association with initiation of voluntary movement...
  20. doi request reprint How might physical activity benefit patients with Parkinson disease?
    Arlène D Speelman
    Department of Neurology, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Nat Rev Neurol 7:528-34. 2011
    ....
  21. pmc Rapidly deteriorating course in Dutch hereditary spastic paraplegia type 11 patients
    Susanne T de Bot
    Department of Neurology, Radboud University, Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    Eur J Hum Genet 21:1312-5. 2013
    ..Our study of 18 Dutch SPG11-patients shows the potential serious long-term consequences of SPG11 including a possibly restricted life span. ..
  22. pmc Clinical exome sequencing for cerebellar ataxia and spastic paraplegia uncovers novel gene-disease associations and unanticipated rare disorders
    Bart P van de Warrenburg
    Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands
    Eur J Hum Genet 24:1460-6. 2016
    ..In addition, clinical exome sequencing results have shown their value in guiding practical patient management. ..
  23. doi request reprint Inhibition of the dorsal premotor cortex does not repair surround inhibition in writer's cramp patients
    Lidwien C Veugen
    Department of Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    Exp Brain Res 225:85-92. 2013
    ..This questions the involvement of the PMd in the loss of surround inhibition, and perhaps also the direct link between surround inhibition and dystonia...
  24. pmc Mutations in DDHD2, encoding an intracellular phospholipase A(1), cause a recessive form of complex hereditary spastic paraplegia
    Janneke H M Schuurs-Hoeijmakers
    Department of Human Genetics 855, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Hum Genet 91:1073-81. 2012
    ..We show that mutations in DDHD2 cause a specific complex HSP subtype (SPG54), thereby linking a member of the PLA(1) family to human neurologic disease...
  25. doi request reprint Patients with primary cervical dystonia have evidence of discrete deficits in praxis
    Britt Sofie Hoffland
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, London, UK
    J Neurol Neurosurg Psychiatry 82:615-9. 2011
    ..The aim of this study was to use a battery of tests of praxis, based on those tests used in routine clinical examination, to uncover evidence of higher motor dysfunction in patients with primary cervical dystonia...
  26. ncbi request reprint The clinical heterogeneity of drug-induced myoclonus: an illustrated review
    Sabine Janssen
    Department of Neurology 935, Radboud University Medical Center, Donders Institute of Brain, Cognition and Behaviour, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    J Neurol . 2016
    ....
  27. doi request reprint Pallidopyramidal disease: a misnomer?
    Martin W I M Horstink
    Department of Neurology, Donders Centre for Brain, Cognition, and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mov Disord 25:1109-15. 2010
    ..We conclude that the existence of PPD/S as a distinct clinico-pathological nosological entity, as proposed by Davison, is doubtful. In cases reported as Davison's PPD/S, the description "pallidopyramidal" seems to be a misnomer...
  28. doi request reprint Reliability and validity of the range of motion scale (ROMS) in patients with abnormal postures
    Diana E van Rooijen
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Pain Med 16:488-93. 2015
    ..The range of motion scale (ROMS) was therefore developed to assess the severity based on the possible active range of motion of all joints (arms, legs, trunk, and neck), and the present study evaluates its reliability and validity...
  29. doi request reprint Movement disorders in spinocerebellar ataxias
    Judith van Gaalen
    Department of Neurology, Donders Institute of Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mov Disord 26:792-800. 2011
    ....
  30. doi request reprint Movement disorders in GLUT1 deficiency syndrome respond to the modified Atkins diet
    Wilhelmina G Leen
    Department of Neurology, Radboud University Medical Centre, Donders Institute for Brain, Cognition, and Behaviour, Nijmegen, The Netherlands
    Mov Disord 28:1439-42. 2013
    ..First-choice treatment is a ketogenic diet, but compliance is poor. We have investigated the effect of the modified Atkins diet as an alternative treatment for movement disorders in GLUT1DS...
  31. doi request reprint Genotype-phenotype correlations in spastic paraplegia type 7: a study in a large Dutch cohort
    Koen L I van Gassen
    Department of Human Genetics, Institute for Genetic and Metabolic Disease, Radboud University Nijmegen Medical Centre, Nijmegen, 6500 HB, The Netherlands
    Brain 135:2994-3004. 2012
    ..Functional studies are required to further investigate these interactions...
  32. doi request reprint DYT6 dystonia: mutation screening, phenotype, and response to deep brain stimulation
    Justus L Groen
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mov Disord 25:2420-7. 2010
    ..Four DYT6 dystonia patients were treated with GPi DBS with moderate to good response on motor function but marginal benefit on speech...
  33. doi request reprint Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis
    Michael A van Es
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Ann Neurol 70:964-73. 2011
    ..We therefore investigated whether ANG variants could predispose to both ALS and PD...