Robert P Takes

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint Staging of the neck in patients with head and neck squamous cell cancer: imaging techniques and biomarkers
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, University Medical Center Nijmegen, P O Box 9101, 6500 HB, The Netherlands
    Oral Oncol 40:656-67. 2004
  2. doi request reprint The controversy in the management of the N0 neck for squamous cell carcinoma of the maxillary sinus
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur Arch Otorhinolaryngol 271:899-904. 2014
  3. ncbi request reprint Endoscopic myotomy of the cricopharyngeal muscle with CO2 laser surgery
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Head Neck 27:703-9. 2005
  4. doi request reprint Can biomarkers play a role in the decision about treatment of the clinically negative neck in patients with head and neck cancer?
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Head Neck 30:525-38. 2008
  5. doi request reprint Future of the TNM classification and staging system in head and neck cancer
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Head Neck 32:1693-711. 2010
  6. doi request reprint Distant metastases from head and neck squamous cell carcinoma. Part I. Basic aspects
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Oral Oncol 48:775-9. 2012
  7. doi request reprint Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis
    Remco de Bree
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Oral Oncol 48:780-6. 2012
  8. doi request reprint Paratracheal lymph node dissection in cancer of the larynx, hypopharynx, and cervical esophagus: the need for guidelines
    Remco de Bree
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Head Neck 33:912-6. 2011
  9. doi request reprint Sinonasal tumors: a clinicopathologic update of selected tumors
    Pieter J Slootweg
    Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur Arch Otorhinolaryngol 270:5-20. 2013
  10. doi request reprint Questionable necessity to remove the submandibular gland in neck dissection
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Head Neck 33:743-5. 2011

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Staging of the neck in patients with head and neck squamous cell cancer: imaging techniques and biomarkers
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, University Medical Center Nijmegen, P O Box 9101, 6500 HB, The Netherlands
    Oral Oncol 40:656-67. 2004
    ..Moreover, the additional use of biomarkers studied on a protein, RNA or DNA level may provide even better information about the chance of occult nodal metastasis in head and neck cancer patients...
  2. doi request reprint The controversy in the management of the N0 neck for squamous cell carcinoma of the maxillary sinus
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur Arch Otorhinolaryngol 271:899-904. 2014
    ....
  3. ncbi request reprint Endoscopic myotomy of the cricopharyngeal muscle with CO2 laser surgery
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Head Neck 27:703-9. 2005
    ..Several treatment modalities are available, such as external myotomy of the muscle, dilatation, and local infiltration with botulinum toxin. Recently, endoscopic transmucosal myotomies using a CO2 laser have been described...
  4. doi request reprint Can biomarkers play a role in the decision about treatment of the clinically negative neck in patients with head and neck cancer?
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Head Neck 30:525-38. 2008
    ..If these results can be confirmed in larger studies, they may play a role in future clinical decision making on treatment of the clinically N0 neck...
  5. doi request reprint Future of the TNM classification and staging system in head and neck cancer
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Head Neck 32:1693-711. 2010
    ..Further improvement of the TNM classification is expected to result in better treatment choices, outcome and prognostication of patients with head and neck cancer...
  6. doi request reprint Distant metastases from head and neck squamous cell carcinoma. Part I. Basic aspects
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Oral Oncol 48:775-9. 2012
    ..Increasing knowledge of the biology of distant metastasis may result in the development of diagnostic and therapeutic strategies targeted to this usually terminal stage for patients with HNSCC...
  7. doi request reprint Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis
    Remco de Bree
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Oral Oncol 48:780-6. 2012
    ..Eventually, whole-body-MRI (WB-MRI) may possibly replace PET-CT for screening patients for distant metastases...
  8. doi request reprint Paratracheal lymph node dissection in cancer of the larynx, hypopharynx, and cervical esophagus: the need for guidelines
    Remco de Bree
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Head Neck 33:912-6. 2011
    ..Moreover, improved diagnostic imaging is needed to detect (occult) PTLN metastases more reliably. Based on future studies, clinical guidelines have to be developed to avoid undertreatment and overtreatment...
  9. doi request reprint Sinonasal tumors: a clinicopathologic update of selected tumors
    Pieter J Slootweg
    Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur Arch Otorhinolaryngol 270:5-20. 2013
    ..Also new entities that have the sinonasal tract as a site of predilection, such as sinonasal renal cell-like adenocarcinoma and NUT midline carcinoma are highlighted...
  10. doi request reprint Questionable necessity to remove the submandibular gland in neck dissection
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Head Neck 33:743-5. 2011
    ..Clinical studies to validate this concept are needed...
  11. doi request reprint Current trends in initial management of hypopharyngeal cancer: the declining use of open surgery
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Head Neck 34:270-81. 2012
    ..In this respect, technical improvements in radiotherapy such as intensity-modulated radiotherapy, advances in supportive care, and incorporation of newer systemic agents such as targeted therapy, are relevant developments...
  12. doi request reprint Management of the N0 neck in early stage oral squamous cell cancer: a modeling study of the cost-effectiveness
    Tim M Govers
    Department of Operating Rooms, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Oral Oncol 49:771-7. 2013
    ..To assess the cost-effectiveness of five strategies for diagnosing and treating cT1-2N0 oral squamous cell cancer...
  13. doi request reprint Normalcy of food intake in patients with head and neck cancer supported by combined dietary counseling and swallowing therapy: A randomized clinical trial
    Manon G A van den Berg
    Department of Gastroenterology and Hepatology Dietetics and Intestinal Failure, Radboud University Medical Centre, Nijmegen, The Netherlands
    Head Neck 38:E198-206. 2016
    ..This randomized trial investigated the effect of combined individual dietary counseling with individualized swallowing therapy (intervention) compared to individual dietary counseling (control) on normalcy of food intake (NFI)...
  14. doi request reprint Advances in diagnostic modalities to detect occult lymph node metastases in head and neck squamous cell carcinoma
    Remco de Bree
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Head Neck 37:1829-39. 2015
    ..Therefore, complementary to improvements in imaging techniques, developments in more invasive diagnostic procedures, such as sentinel node biopsy (SNB) will add to the accuracy of diagnostic algorithms for the staging of the neck...
  15. doi request reprint Nutritional status, food intake, and dysphagia in long-term survivors with head and neck cancer treated with chemoradiotherapy: a cross-sectional study
    Manon G A van den Berg
    Department of Gastroenterology and Hepatology Dietetics and Intestinal Failure, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Head Neck 36:60-5. 2014
    ..The aim of this study was to evaluate nutritional status, food intake, and dysphagia in long-term head and neck cancer survivors...
  16. doi request reprint Long-term outcome and morbidity after treatment with accelerated radiotherapy and weekly cisplatin for locally advanced head-and-neck cancer: results of a multidisciplinary late morbidity clinic
    Heidi Rütten
    Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Radiat Oncol Biol Phys 81:923-9. 2011
    ..To evaluate the long-term outcome and morbidity after intensified treatment for locally advanced head-and-neck cancer...
  17. doi request reprint Outcomes of endoscopic cricopharyngeal myotomy with CO2 laser surgery: A retrospective study of 47 patients
    Arta Hoesseini
    Department of Otolaryngology Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands
    Head Neck 38:1022-7. 2016
    ..Endoscopic cricopharyngeal myotomy (ECPM) using CO2 laser surgery presents a less invasive treatment technique when compared to transcervical cricopharyngeal myotomy...
  18. doi request reprint Human papillomavirus detection in fine needle aspiration cytology of lymph node metastasis of head and neck squamous cell cancer
    Robert P Takes
    Department of Otolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands
    J Clin Virol 85:22-26. 2016
    ..However, in a certain percentage of the cases who present with lymph node metastases no primary tumor can be identified and only fine needle aspiration cytology (FNAC) is available for analysis...
  19. doi request reprint Simultaneous assessment of DNA ploidy and biomarker expression in paraffin-embedded tissue sections
    Stijn J H M Fleskens
    Department of Otolaryngology Head and Neck Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Histopathology 57:14-26. 2010
    ..Existing ploidy analysis methods in sections suffer from limited sensitivity. The aim was to reliably assess ploidy in sections, combined with simultaneous assessment of other markers at the individual cell level...
  20. doi request reprint Management of laryngeal premalignant lesions in the Netherlands
    Stijn A J H M Fleskens
    Department of Otorhinolaryngology Head and Neck Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Laryngoscope 120:1326-35. 2010
    ..Then to compare the investigated practice with the results published in the literature...
  21. doi request reprint Toxicity and efficacy of accelerated radiotherapy with concurrent weekly cisplatin for locally advanced head and neck carcinoma
    Chantal M L Driessen
    Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands
    Head Neck 38:E559-65. 2016
    ..The purpose of this report was to present the results of accelerated radiotherapy (RT) with concomitant weekly cisplatin in head and neck cancer...
  22. doi request reprint HPV vaccination to prevent oropharyngeal carcinoma: What can be learned from anogenital vaccination programs?
    Robert P Takes
    Department of Otolaryngology Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands Electronic address
    Oral Oncol 51:1057-60. 2015
    ....
  23. doi request reprint Hypoxia in larynx carcinomas assessed by pimonidazole binding and the value of CA-IX and vascularity as surrogate markers of hypoxia
    Ilse J Hoogsteen
    Department of Radiation Oncology, 341, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Cancer 45:2906-14. 2009
    ..A combination of staining patterns of exogenous and endogenous markers might give important additive information about tumour biology and behaviour...
  24. doi request reprint Effectiveness and toxicity of hypofractionated high-dose intensity-modulated radiotherapy versus 2- and 3-dimensional radiotherapy in incurable head and neck cancer
    Kirsty M van Beek
    Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands
    Head Neck 38:E1264-70. 2016
    ..This retrospective study evaluates efficacy and tolerability of high-dose hypofractionated radiotherapy (RT) in patients with head and neck cancer...
  25. doi request reprint Recurrences after thyroglossal duct cyst surgery: Results in 207 consecutive cases and review of the literature
    Daan Rohof
    Department of Oto Rhino Laryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands
    Head Neck 37:1699-704. 2015
    ..Surgical removal is very effective. However, in some cases, a cyst recurs. The purpose of this study was to identify factors that predispose to recurrence of a thyroglossal duct cyst...
  26. doi request reprint Hypoxia, metabolism, and growth factor signaling in head and neck squamous cell carcinoma: correlation between primary and xenograft tumors
    Hanneke Stegeman
    Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Head Neck 36:1288-95. 2014
    ..The purpose of this study was to determine whether head and neck squamous cell carcinoma (HNSCC) xenografts show similar biological and molecular characteristics as the primary tumor they originate from...
  27. doi request reprint Sentinel node biopsy for squamous cell carcinoma of the oral cavity and oropharynx: a diagnostic meta-analysis
    Tim M Govers
    Department of Operating Rooms, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Oral Oncol 49:726-32. 2013
    ..The aim of the study was to systematically assess the accuracy of a sentinel lymph node biopsy (SLNB) in cT1/T2N0 oral cavity and oropharyngeal squamous cell carcinoma patients...
  28. doi request reprint Endoscopic carbon dioxide laser diverticulostomy versus endoscopic staple-assisted diverticulostomy to treat Zenker's diverticulum
    Veronique J O Verhaegen
    Department of Otolaryngology Head and Neck Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Head Neck 33:154-9. 2011
    ..The 2 most frequently used endoscopic methods to treat Zenker's diverticulum are staple-assisted and CO(2) laser esophagodiverticulostomy...
  29. doi request reprint Cost-effectiveness of selective neck dissection versus modified radical neck dissection for treating metastases in patients with oral cavity cancer: A modelling study
    Tim M Govers
    Department of Operating Rooms, Radboud University Medical Center, Nijmegen, The Netherlands
    Head Neck 37:1762-8. 2015
    ....
  30. doi request reprint Malignant tumors of the nasal cavity and paranasal sinuses: long-term outcome and morbidity with emphasis on hypothalamic-pituitary deficiency
    An Snyers
    Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Radiat Oncol Biol Phys 73:1343-51. 2009
    ..To evaluate the long-term outcome after surgery and radiotherapy for patients with sinonasal cancer and assess late toxicity, with special emphasis on hypothalamic-pituitary dysfunction...
  31. doi request reprint Activated leukocyte cell adhesion molecule expression predicts lymph node metastasis in oral squamous cell carcinoma
    Michiel van den Brand
    Department of Pathology, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Oral Oncol 46:393-8. 2010
    ..Membranous ALCAM expression at the invasive front serves as a molecular marker for lymphatic metastasis and may facilitate better treatment choices concerning the neck in patients with oral SCC...
  32. ncbi request reprint Neck dissection: then and now
    Alfio Ferlito
    Department of Surgical Sciences, ENT Clinic, University of Udine, Udine, Italy
    Auris Nasus Larynx 33:365-74. 2006
    ..The authors conclude that neck dissection, as evolved over the past century, is a fundamental tool in management of patients with head and neck cancer, but is still a work in progress...
  33. doi request reprint Neck dissection for laryngeal cancer
    Alfio Ferlito
    Department of Surgical Sciences, ENT Clinic, University of Udine, Udine, Italy
    J Am Coll Surg 207:587-93. 2008
  34. ncbi request reprint DNA ploidy status as a prognostic marker and predictor of lymph node metastasis in laryngeal carcinoma
    Robert P Takes
    Department of Otorhinolaryngology Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Otol Rhinol Laryngol 111:1015-20. 2002
    ..The DNA ploidy status may be a useful marker for metastatic behavior in head and neck squamous cell carcinoma and may therefore be helpful in decision-making concerning elective treatment of the neck...
  35. ncbi request reprint Markers for nodal metastasis in head and neck squamous cell cancer
    Robert P Takes
    Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital, Leiden, The Netherlands
    Arch Otolaryngol Head Neck Surg 128:512-8. 2002
    ..To identify markers that are relevant as predictors of lymph node metastasis in head and neck squamous cell cancer...
  36. doi request reprint Emerging perspectives in epidermal growth factor receptor targeting in head and neck cancer
    Seungwon Kim
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Head Neck 30:667-74. 2008
    ..In the case of cetuximab, these correlative biomarkers may include elements of the immune system in addition to the signal transduction proteins involved in EGFR pathway...
  37. doi request reprint Basic evidence of molecular targeted therapy for oral cancer and salivary gland cancer
    Hiroyuki Hamakawa
    Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime, Japan
    Head Neck 30:800-9. 2008
    ..The aim of this review is to introduce the basic evidences to support the molecular targeting for OSCC and SGC...