- Multicentre, parallel-group, comparative trial evaluating the efficacy and safety of sugammadex in patients with end-stage renal failure or normal renal functionL M Staals
Department of Anaesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Br J Anaesth 101:492-7. 2008..As sugammadex is primarily cleared renally, this phase III trial investigated the efficacy and safety of sugammadex for reversal of rocuronium-induced neuromuscular block (NMB) in patients with end-stage renal failure...
- Reduced clearance of rocuronium and sugammadex in patients with severe to end-stage renal failure: a pharmacokinetic studyL M Staals
Department of Anaesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Br J Anaesth 104:31-9. 2010..The sugammadex-rocuronium complex is eliminated by the kidneys. This trial investigated the pharmacokinetics (PKs) of sugammadex and rocuronium in patients with renal failure and healthy controls...
- Train-of-four ratio recovery often precedes twitch recovery when neuromuscular block is reversed by sugammadexL M Staals
Department of Anaesthesiology, Erasmus University Medical Centre, Sophia Children s Hospital, Rotterdam, The Netherlands
Acta Anaesthesiol Scand 55:700-7. 2011..9. The recovery time of T1 was not described. This retrospective investigation describes the recovery of T1 vs. TOF ratio after the reversal of NMB with sugammadex...