Theo S Plantinga

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. pmc The impact of caspase-12 on susceptibility to candidemia
    D C Rosentul
    Department of Medicine, Radboud University Nijmegen Medical Centre, internal postal code 463, P O Box 9101, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 31:277-80. 2012
  2. pmc Functional consequences of DECTIN-1 early stop codon polymorphism Y238X in rheumatoid arthritis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 12:R26. 2010
  3. doi request reprint Modulation of Toll-like receptor ligands and Candida albicans-induced cytokine responses by specific probiotics
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cytokine 59:159-65. 2012
  4. doi request reprint Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2
    Theo S Plantinga
    Department of Medicine, Radboud University, Nijmegen Medical Centre, internal postal code 463, P O Box 9101, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Gut 60:1229-35. 2011
  5. pmc Role of autophagy genetic variants for the risk of Candida infections
    Diana C Rosentul
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Med Mycol 52:333-41. 2014
  6. doi request reprint Variation in genes of β-glucan recognition pathway and susceptibility to opportunistic infections in HIV-positive patients
    Diana C Rosentul
    Department of Internal Medicine, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Geert Grooteplein 8, Nijmegen, The Netherlands
    Immunol Invest 40:735-50. 2011
  7. doi request reprint Human genetic susceptibility to Candida infections
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Med Mycol 50:785-94. 2012
  8. pmc Low prevalence of lactase persistence in Neolithic South-West Europe
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Hum Genet 20:778-82. 2012
  9. pmc Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia
    Diana C Rosentul
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 204:1138-45. 2011
  10. pmc The Y238X stop codon polymorphism in the human β-glucan receptor dectin-1 and susceptibility to invasive aspergillosis
    Louis Y A Chai
    Department of Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    J Infect Dis 203:736-43. 2011

Detail Information

Publications35

  1. pmc The impact of caspase-12 on susceptibility to candidemia
    D C Rosentul
    Department of Medicine, Radboud University Nijmegen Medical Centre, internal postal code 463, P O Box 9101, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Eur J Clin Microbiol Infect Dis 31:277-80. 2012
    ..Although the functional CASPASE-12 allele has been suggested to increase susceptibility to bacterial sepsis, this could not be confirmed in our larger cohort of fungal sepsis patients...
  2. pmc Functional consequences of DECTIN-1 early stop codon polymorphism Y238X in rheumatoid arthritis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 12:R26. 2010
    ..In this study, dectin-1 mRNA and protein expression, as well as the recently characterized DECTIN-1 Y238X early stop codon polymorphism, were studied in relation to rheumatoid arthritis (RA) susceptibility and severity...
  3. doi request reprint Modulation of Toll-like receptor ligands and Candida albicans-induced cytokine responses by specific probiotics
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cytokine 59:159-65. 2012
    ..In conclusion, specific probiotic strains exhibit cross-tolerance effects towards other inflammatory stimuli, especially C. albicans, which might have beneficial effects on gut inflammation...
  4. doi request reprint Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2
    Theo S Plantinga
    Department of Medicine, Radboud University, Nijmegen Medical Centre, internal postal code 463, P O Box 9101, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    Gut 60:1229-35. 2011
    ..Here, the effect of ATG16L1 genetic variation on cytokine responses has been assessed in humans...
  5. pmc Role of autophagy genetic variants for the risk of Candida infections
    Diana C Rosentul
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Med Mycol 52:333-41. 2014
    ..Despite moderate effects on the modulation of proinflammatory cytokine production, genetic variation in the autophagy genes ATG16L1 and IRGM has a minor impact on the susceptibility to both mucosal and systemic Candida infections. ..
  6. doi request reprint Variation in genes of β-glucan recognition pathway and susceptibility to opportunistic infections in HIV-positive patients
    Diana C Rosentul
    Department of Internal Medicine, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Geert Grooteplein 8, Nijmegen, The Netherlands
    Immunol Invest 40:735-50. 2011
    ..These results suggest a role of dectin-1 in the host defense against respiratory bacterial infections, and future studies are warranted to confirm this association...
  7. doi request reprint Human genetic susceptibility to Candida infections
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Med Mycol 50:785-94. 2012
    ..This review provides an overview of the current insights in genetic susceptibility to Candida infections and their consequences for the immune response against Candida...
  8. pmc Low prevalence of lactase persistence in Neolithic South-West Europe
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Hum Genet 20:778-82. 2012
    ....
  9. pmc Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia
    Diana C Rosentul
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 204:1138-45. 2011
    ..The role of genetic variation of DECTIN-1 and CARD9 genes on the susceptibility to candidemia is unknown...
  10. pmc The Y238X stop codon polymorphism in the human β-glucan receptor dectin-1 and susceptibility to invasive aspergillosis
    Louis Y A Chai
    Department of Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    J Infect Dis 203:736-43. 2011
    ..We investigated whether defective Dectin-1 receptor function, because of the early stop codon polymorphism Y238X, enhances susceptibility to invasive aspergillosis (IA) in at-risk patients...
  11. pmc Toll-like receptor 1 polymorphisms increase susceptibility to candidemia
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    J Infect Dis 205:934-43. 2012
    ..Recognition of Candida species is mediated through pattern recognition receptors such as Toll-like receptors (TLRs). This study assessed whether genetic variation in TLR signaling influences susceptibility to candidemia...
  12. pmc Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1β (IL-1β)
    Kathrin Buffen
    Department of Medicine, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
    J Biol Chem 288:8658-66. 2013
    ..Our results thus demonstrate the induction of autophagy, which, in turn, modulates cytokine production by B. burgdorferi for the first time...
  13. doi request reprint Role of NOD1 polymorphism in susceptibility and clinical progression of rheumatoid arthritis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, internal postal code 463, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Rheumatology (Oxford) 52:806-14. 2013
    ..In this study, the effect of the insertion/deletion polymorphism in NOD1 on RA susceptibility and severity was assessed...
  14. pmc Polymorphisms in autophagy genes and susceptibility to tuberculosis
    Mário Songane
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 7:e41618. 2012
    ..This first examination of a broad set of polymorphisms in autophagy genes fails to show a clear association with TB, with M. tuberculosis Beijing genotype infection or with ex-vivo pro-inflammatory cytokine production...
  15. pmc STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis
    Sanne P Smeekens
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 6:e29248. 2011
    ..The challenge for the future is to translate this knowledge into novel strategies for the treatment of this severe immunodeficiency...
  16. pmc Human dectin-1 deficiency and mucocutaneous fungal infections
    Bart Ferwerda
    Department of Internal Medicine and the Nijmegen Institute for Infection, Inflammation, and Immunity, Radboud University Nijmegen, Nijmegen, The Netherlands
    N Engl J Med 361:1760-7. 2009
    ....
  17. doi request reprint The evolutionary history of TLR4 polymorphisms in Europe
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Innate Immun 4:168-75. 2012
    ..In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis...
  18. pmc Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response
    Johanneke Kleinnijenhuis
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Immunology 134:341-8. 2011
    ....
  19. pmc Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease
    Hilbert S de Vries
    Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 4:e7818. 2009
    ..714T>G (p.Y238X) polymorphism is associated with lower disease susceptibility or severity in IBD and to investigate the level of dectin-1 expression in inflamed and non-inflamed colon tissue of IBD patients...
  20. pmc Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans
    Sanne P Smeekens
    Department of Medicine 463, Radboud University Nijmegen Medical Centre, Geert Grooteplein Zuid 8, 6525GA Nijmegen, The Netherlands
    Nat Commun 4:1342. 2013
    ..These findings indicate that the type I interferon pathway is a main signature of Candida-induced inflammation and has a crucial role in anti-Candida host defence in humans...
  21. doi request reprint A role for TLR1, TLR2 and NOD2 in cytokine induction by Bacteroides fragilis
    Mark H T Stappers
    Department of Medicine, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cytokine 60:861-9. 2012
    ..This study identifies the receptor pathways of the innate immune response to B. fragilis, and thus provides new insights in the host defense against B. fragilis...
  22. doi request reprint Modulation of inflammation by autophagy: consequences for Crohn's disease
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Opin Pharmacol 12:497-502. 2012
    ..This review summarizes the recent advances in understanding the complex interaction between innate immunity pathways and autophagy, with a focus on the modulatory effects of autophagy on inflammation...
  23. doi request reprint MEFV mutations affecting pyrin amino acid 577 cause autosomal dominant autoinflammatory disease
    Monique Stoffels
    Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 73:455-61. 2014
    ..We aimed to unravel the genetic cause of the symptoms...
  24. pmc Role of genetic variants of autophagy genes in susceptibility for non-medullary thyroid cancer and patients outcome
    Theo S Plantinga
    Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands Division of Endocrinology, Radboud University Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 9:e94086. 2014
    ..In conclusion, genetic variation in ATG5, a central player in the autophagy process, is found to be associated with increased susceptibility for thyroid carcinoma, indicating a role for autophagy in thyroid carcinogenesis. ..
  25. doi request reprint A promoter polymorphism in human interleukin-32 modulates its expression and influences the risk and the outcome of epithelial cell-derived thyroid carcinoma
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen, 6525 GA, The Netherlands
    Carcinogenesis 34:1529-35. 2013
    ..Subsequently, they require higher dosages of RAI to achieve successful tumor remission. These data suggest an important role of IL-32 in the pathogenesis of TC. ..
  26. ncbi request reprint ATG16L1 polymorphisms are associated with NOD2-induced hyperinflammation
    Theo S Plantinga
    Department of Medicine, and Nijmegen Institute for Infection, Inflammation and Immunity N4i, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Autophagy 7:1074-5. 2011
    ....
  27. pmc Inflammasome-independent modulation of cytokine response by autophagy in human cells
    Tania O Crişan
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 6:e18666. 2011
    ..In conclusion, autophagy modulates the secretion of proinflammatory cytokines in human cells through an inflammasome-independent pathway, and this is a novel mechanism that may be targeted in inflammatory diseases...
  28. doi request reprint Genetic basis for recurrent vulvo-vaginal candidiasis
    Martin Jaeger
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Curr Infect Dis Rep 15:136-42. 2013
    ..A better understanding of the genetic and immunological mechanisms leading to RVVC is important for both the understanding of the pathophysiology of the disease and the design of novel therapeutic strategies...
  29. pmc Genetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Acquir Immune Defic Syndr 55:87-94. 2010
    ..We investigated whether genetic variations in the innate immune genes DECTIN-1, TLR2, TLR4, TIRAP, and CASPASE-12 are associated with the presence of OPC in HIV-infected subjects from East Africa...
  30. doi request reprint Assessment of inflammasome activation in primary human immune cells
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Methods Mol Biol 1040:29-39. 2013
    ..In this chapter, methods are described for assessing the degree of activity of these regulatory stages, which include mRNA transcription, caspase-1 activation, and secretion of the bioactive proteins...
  31. doi request reprint Chocolate consumption modulates cytokine production in healthy individuals
    Stejara A Netea
    Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Cytokine 62:40-3. 2013
    ..In contrast, production of the Th17-derived cytokine IL-22 was inhibited by chocolate. Modulation of inflammation could represent an important mechanism through which chocolate consumption influences acne...
  32. pmc Blueprints of signaling interactions between pattern recognition receptors: implications for the design of vaccine adjuvants
    Kim Timmermans
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Vaccine Immunol 20:427-32. 2013
    ..These consistent signaling interactions between PRR combinations may represent promising targets for immunomodulation and vaccine adjuvant development...
  33. pmc Differential Toll-like receptor recognition and induction of cytokine profile by Bifidobacterium breve and Lactobacillus strains of probiotics
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Clin Vaccine Immunol 18:621-8. 2011
    ..No role for TLR4, NOD2, and C-type lectin receptors was apparent. In conclusion, TLR signaling is involved in the differentiation of inflammatory responses between probiotic strains used as food supplements...
  34. doi request reprint Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients
    Theo S Plantinga
    Departments of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Infect Dis 49:724-32. 2009
    ....
  35. doi request reprint STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 365:54-61. 2011
    ..Patients with recessive CMC and autoimmunity have mutations in the autoimmune regulator AIRE. The cause of autosomal dominant CMC is unknown...