J W M Lenders

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. doi Pheochromocytoma and pregnancy: a deceptive connection
    Jacques W M Lenders
    Division of General Internal Medicine, Department of Medicine, Radboud Adrenal Centre, St Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB Nijmegen, The Netherlands
    Eur J Endocrinol 166:143-50. 2012
  2. doi Is the excess cardiovascular morbidity in pheochromocytoma related to blood pressure or to catecholamines?
    Roeland F Stolk
    Department of General Internal Medicine, Radboud University Medical Center Nijmegen, Geert Grooteplein Zuid 8, 6525GA, Nijmegen, The Netherlands
    J Clin Endocrinol Metab 98:1100-6. 2013
  3. pmc The first Dutch SDHB founder deletion in paraganglioma-pheochromocytoma patients
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Med Genet 10:34. 2009
  4. pmc Low sensitivity of glucagon provocative testing for diagnosis of pheochromocytoma
    Jacques W M Lenders
    Department of Internal Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525GA Nijmegen, The Netherlands
    J Clin Endocrinol Metab 95:238-45. 2010
  5. ncbi Phaeochromocytoma
    Jacques W M Lenders
    Department of Internal Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen 6525GA, Netherlands
    Lancet 366:665-75. 2005
  6. ncbi Is supine rest necessary before blood sampling for plasma metanephrines?
    Jacques W M Lenders
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Chem 53:352-4. 2007
  7. ncbi Congenital dopamine-beta-hydroxylase deficiency in humans
    H J L M Timmers
    Department of General Internal Medicine, University Medical Center, Nijmegen, Geert Grooteplein Zuid 8, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann N Y Acad Sci 1018:520-3. 2004
  8. ncbi Forearm vasoconstrictor response in uncomplicated type 1 diabetes mellitus
    P J van Gurp
    Division of General Internal Medicine, Department of Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Eur J Clin Invest 36:674-81. 2006
  9. ncbi Comparison of randomization techniques for clinical trials with data from the HOMERUS-trial
    W J Verberk
    University Hospital Maastricht, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, The Netherlands
    Blood Press 14:306-14. 2005
  10. ncbi Baroreflex control of muscle sympathetic nerve activity after carotid body tumor resection
    Henri J L M Timmers
    Department of General Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Hypertension 42:143-9. 2003

Detail Information

Publications72

  1. doi Pheochromocytoma and pregnancy: a deceptive connection
    Jacques W M Lenders
    Division of General Internal Medicine, Department of Medicine, Radboud Adrenal Centre, St Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB Nijmegen, The Netherlands
    Eur J Endocrinol 166:143-50. 2012
    ....
  2. doi Is the excess cardiovascular morbidity in pheochromocytoma related to blood pressure or to catecholamines?
    Roeland F Stolk
    Department of General Internal Medicine, Radboud University Medical Center Nijmegen, Geert Grooteplein Zuid 8, 6525GA, Nijmegen, The Netherlands
    J Clin Endocrinol Metab 98:1100-6. 2013
    ..It is generally accepted that pheochromocytoma is associated with an increased cardiovascular risk. This is however not based on studies with an appropriate control group of patients with essential hypertension...
  3. pmc The first Dutch SDHB founder deletion in paraganglioma-pheochromocytoma patients
    Jean Pierre Bayley
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    BMC Med Genet 10:34. 2009
    ..The majority of variants of the SDH genes are missense and nonsense mutations. To date few large deletions of the SDH genes have been described...
  4. pmc Low sensitivity of glucagon provocative testing for diagnosis of pheochromocytoma
    Jacques W M Lenders
    Department of Internal Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525GA Nijmegen, The Netherlands
    J Clin Endocrinol Metab 95:238-45. 2010
    ..Follow-up tests are, nevertheless, often required to distinguish false-positive from true-positive results. The glucagon stimulation test represents one such test; its diagnostic utility is, however, unclear...
  5. ncbi Phaeochromocytoma
    Jacques W M Lenders
    Department of Internal Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen 6525GA, Netherlands
    Lancet 366:665-75. 2005
    ..If removal of phaeochromocytoma is timely, prognosis is excellent. However, prognosis is poor in patients with metastases, which especially occur in patients with large, extra-adrenal tumours...
  6. ncbi Is supine rest necessary before blood sampling for plasma metanephrines?
    Jacques W M Lenders
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Chem 53:352-4. 2007
    ..The impact of blood sampling in sitting vs supine positions on measurements of plasma metanephrines for diagnosis of pheochromocytoma is unknown...
  7. ncbi Congenital dopamine-beta-hydroxylase deficiency in humans
    H J L M Timmers
    Department of General Internal Medicine, University Medical Center, Nijmegen, Geert Grooteplein Zuid 8, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann N Y Acad Sci 1018:520-3. 2004
    ..The only effective treatment of DbetaH deficiency is L-threo-3,4-dihydroxyphenylserine (DOPS). DOPS is converted directly into norepinephrine. Treatment with DOPS results in a sustained relief of orthostatic symptoms...
  8. ncbi Forearm vasoconstrictor response in uncomplicated type 1 diabetes mellitus
    P J van Gurp
    Division of General Internal Medicine, Department of Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Eur J Clin Invest 36:674-81. 2006
    ..In this study we investigated sympathetic activity in patients with uncomplicated type 1 diabetes mellitus (DM)...
  9. ncbi Comparison of randomization techniques for clinical trials with data from the HOMERUS-trial
    W J Verberk
    University Hospital Maastricht, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, The Netherlands
    Blood Press 14:306-14. 2005
    ..A second objective of this article was to describe the baseline characteristics of the HOMERUS-trial...
  10. ncbi Baroreflex control of muscle sympathetic nerve activity after carotid body tumor resection
    Henri J L M Timmers
    Department of General Internal Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Hypertension 42:143-9. 2003
    ..During the Valsalva maneuver, loss of carotid baroreflex control of heart rate is less well compensated for by the extra carotid baroreceptors than the control of muscle sympathetic nerve activity...
  11. ncbi Increased forearm blood flow in longstanding Type 1 diabetic patients without microvascular complications
    P J van Gurp
    Division of General Internal Medicine, Department of Internal Medicine, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Diabet Med 24:208-10. 2007
    ..We hypothesized that patients with longstanding diabetes mellitus (DM), who have not developed microvascular complications, would have normal tissue perfusion...
  12. ncbi Does masked hypertension exist in healthy volunteers and apparently well-controlled hypertensive patients?
    I Aksoy
    Department of Medicine, Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, The Netherlands
    Neth J Med 64:72-77. 2006
    ..Home blood pressure (HB P) measurement is considered to reflect BP during the day better than office BP (OB P). But in some patients HB P is higher than OB P. This is called masked hypertension (MH)...
  13. ncbi Baroreflex and chemoreflex function after bilateral carotid body tumor resection
    Henri J L M Timmers
    Department of General Internal Medicine 541, Department of Otorhinolaryngology, University Medical Center St Radboud, Geert Grooteplein Zuid 8, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Hypertens 21:591-9. 2003
    ..To investigate whether bilateral carotid body tumor resection invariably and chronically affects arterial baroreflex or peripheral chemoreflex function...
  14. doi Overexpression of the natural antisense hypoxia-inducible factor-1alpha transcript is associated with malignant pheochromocytoma/paraganglioma
    P N Span
    Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The
    Endocr Relat Cancer 18:323-31. 2011
    ..Moreover, overexpression of aHIF and VEGF marks a higher metastatic potential in PGL...
  15. ncbi Baroreflex failure: a neglected type of secondary hypertension
    H J L M Timmers
    Department of Internal Medicine, University Medical Centre St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Neth J Med 62:151-5. 2004
    ..Patients with suspected baroreflex failure should be referred to specialised centres for diagnostic testing and treatment...
  16. ncbi [From gene to disease; 'apparent mineralocorticoid excess' syndrome, a syndrome with an apparent excess of mineral corticoids]
    E N Levtchenko
    Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 151:692-4. 2007
    ..Since liquorice can induce the clinical symptoms of AME due to reversible inhibition of the 11beta-HSD2 enzyme by glycyrrhetinic acid, the active ingredient of liquorice, patients suspected of having AME should not consume liquorice...
  17. ncbi [From gene to disease; dopamine-beta-hydroxylase deficiency and orthostatic hypotension]
    J Deinum
    Afd Algemeen Inwendige Geneeskunde, Universitair Medisch Centrum St Radboud, Geert Grooteplein 8, 6525 GA Nijmegen
    Ned Tijdschr Geneeskd 148:1771-5. 2004
    ..The orthostatic syndrome of DbetaH deficiency can be treated with the non-natural amino acid L-dihydroxyphenylserine, which is decarboxylated to norepinephrine by the ubiquitous aromatic-L-amino acid decarboxylase...
  18. doi Interaction in COPD experiment (ICE): a hazardous combination of cigarette smoking and bronchodilation in chronic obstructive pulmonary disease
    W D Van Dijk
    Department of Primary Care, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Med Hypotheses 74:277-80. 2010
    ..The implication will be that the urgency to quit smoking is intensified. Besides, chronic bronchodilation - specifically long-acting bronchodilators - needs to be discouraged in smoking COPD patients that refuse to quit...
  19. pmc An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis
    Francien H van Nederveen
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, Netherlands
    Lancet Oncol 10:764-71. 2009
    ..We investigated whether SDHB immunohistochemistry could effectively discriminate between SDH-related and non-SDH-related phaeochromocytomas and paragangliomas in large retrospective and prospective tumour series...
  20. ncbi Long-term effects of carotid sinus denervation on arterial blood pressure in humans
    Arthur A J Smit
    Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 105:1329-35. 2002
    ..We investigated the course of arterial BP level and variability after bilateral denervation of the carotid sinus baroreceptors in humans...
  21. ncbi Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma
    Henri J L M Timmers
    Reproductive Biology and Medicine Branch, National Institutes of Child Health and Human Development, Bethesda MD 20892 1109, USA
    J Clin Oncol 25:2262-9. 2007
    ..Timely and accurate localization of these aggressive tumors is critical for guiding optimal treatment. Our aim is to evaluate the performance of functional imaging modalities in the detection of metastatic lesions of SDHB-associated PGL...
  22. ncbi Mutations associated with succinate dehydrogenase D-related malignant paragangliomas
    Henri J L M Timmers
    Reproductive Biology and Adult Endocrinology Program, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    Clin Endocrinol (Oxf) 68:561-6. 2008
    ..Recently, however, malignant PGLs were also reported among a small minority of Dutch carriers of the SDHD founder mutation D92Y. The aim of the study was to investigate which SDHD mutations are associated with malignant PGL...
  23. ncbi Transport within the interstitial space, rather than membrane permeability, determines norepinephrine recovery in microdialysis
    H Alec Ross
    Department of Chemical Endocrinology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Pharmacol Exp Ther 319:840-6. 2006
    ....
  24. ncbi Biochemical diagnosis of pheochromocytoma: which test is best?
    Jacques W M Lenders
    Department of Internal Medicine, St Radboud University Medical Center, Geert Grooteplein Zuid 8, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    JAMA 287:1427-34. 2002
    ..Diagnosis of pheochromocytoma depends on biochemical evidence of catecholamine production by the tumor. However, the best test to establish the diagnosis has not been determined...
  25. pmc Sympathoinhibitory effect of statins in chronic heart failure
    Marc E Gomes
    Department of Cardiology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Clin Auton Res 20:73-8. 2010
    ..Animal studies suggest that statin therapy can reduce central sympathetic outflow. This study assessed statin effects on (central) sympathetic activity in human chronic heart failure (CHF) patients...
  26. ncbi Pitfall in HPLC assay for urinary metanephrines: an unusual type of interference caused by methenamine intake
    Hanneke W M van Laarhoven
    Department of Medical Oncology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Clin Chem 50:1097-9. 2004
  27. ncbi Long-term effects of unilateral carotid endarterectomy on arterial baroreflex function
    Henri J L M Timmers
    Dept of General Internal Medicine, University Medical Center Nijmegen, Geert Grooteplein Zuid 8, 6500 HB Nijmegen, The Netherlands
    Clin Auton Res 14:72-9. 2004
    ..We investigated the long-term effects of unilateral CE on baroreflex control of function and blood pressure...
  28. ncbi Plasma metanephrine levels are decreased in type 1 diabetic patients with a severely impaired epinephrine response to hypoglycemia, indicating reduced adrenomedullary stores of epinephrine
    Bastiaan E De Galan
    Department of Medicine, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    J Clin Endocrinol Metab 89:2057-61. 2004
    ....
  29. ncbi The role of carotid chemoreceptors in the sympathetic activation by adenosine in humans
    Henri J L M Timmers
    Department of General Internal Medicine, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Sci (Lond) 106:75-82. 2004
    ..In addition, blunting of the baroreflex sympathetic response to adenosine-induced hypotension may indicate a direct sympatho-inhibitory effect of adenosine...
  30. pmc Denervation of carotid baro- and chemoreceptors in humans
    Henri J L M Timmers
    Department of Internal Medicine, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Physiol 553:3-11. 2003
    ..Conversely, carotid chemoreceptor denervation leads to permanent abolition of normocapnic ventilatory responses to hypoxia and reduced ventilatory responses to hypercapnia...
  31. ncbi Cardiovascular responses to stress after carotid baroreceptor denervation in humans
    Henri J L M Timmers
    Department of General Internal Medicine, University Medical Center Nijmegen, Geert Grooteplein Zuid 8, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann N Y Acad Sci 1018:515-9. 2004
    ..However, unopposed sympathetic activation in response to physical and emotional stress appears to be limited to the acute phase of baroreflex failure...
  32. doi Metastases but not cardiovascular mortality reduces life expectancy following surgical resection of apparently benign pheochromocytoma
    H J L M Timmers
    Department of Endocrinology 741, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Endocr Relat Cancer 15:1127-33. 2008
    ..Only one-third becomes normotensive without antihypertensive medication. Therefore, lifelong follow-up is warranted...
  33. ncbi Both body and arm position significantly influence blood pressure measurement
    R T Netea
    Division of General Internal Medicine, Department of Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands
    J Hum Hypertens 17:459-62. 2003
    ..In every study reporting BP values, the position of both the body and especially the arm should be precisely mentioned...
  34. doi Increased sympathetic activity in chronic pancreatitis patients is associated with hyperalgesia
    H C J L Buscher
    Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Pain Palliat Care Pharmacother 24:362-6. 2010
    ..042). In severe chronic pancreatitis patients, increased sympathetic activity and hyperalgesia appear associated, suggesting that sympathetic activity may also play a role in these patients' pain...
  35. ncbi Hemodynamic and neurohumoral responses to head-up tilt in patients with chronic fatigue syndrome
    H J L M Timmers
    Department of General Internal Medicine, University Medical Center St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Auton Res 12:273-80. 2002
    ..Data on the prevalence of orthostatic intolerance (OI) in patients with chronic fatigue syndrome (CFS) are limited and controversial. We tested the hypothesis that a majority of CFS patients exhibit OI during head-up tilt...
  36. ncbi Aldosterone-to-renin ratio as a screening test for primary aldosteronism--the Dutch ARRAT Study
    P M Jansen
    Department of Internal Medicine, Division of Vascular Pharmacology and Metabolism, Erasmus Medical Centre, Rotterdam, The Netherlands
    Neth J Med 66:220-8. 2008
    ..The Dutch ARR AT Study will run until the end of 2009 and will contribute to the formulation of uniform guidelines for the screening for PA in the Netherlands...
  37. ncbi Home versus Office blood pressure MEasurements: Reduction of Unnecessary treatment Study: rationale and study design of the HOMERUS trial
    W J Verberk
    Cardiovascular Research Institute Maastricht, Maastricht University, Department of Internal Medicine, University Hospital Maastricht, The Netherlands
    Blood Press 12:326-33. 2003
    ..In addition, medication compliance is recorded within random subgroups of the SP and OP groups by means of Medication Event Monitoring System (MEMS) V TrackCaps...
  38. ncbi Sympathetic nervous system function in HIV-associated adipose redistribution syndrome
    Petra J van Gurp
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    AIDS 20:773-5. 2006
    ..This could promote localized lipolysis in subcutaneous adipose tissue and contribute to the development of HARS...
  39. pmc Bilateral thoracoscopic splanchnicectomy for pain in patients with chronic pancreatitis impairs adrenomedullary but not noradrenergic sympathetic function
    H C J L Buscher
    Department of Surgery, Radboud University Nijmegen Medical Centre, P O Box 9100, 6500 HB Nijmegen, The Netherlands
    Surg Endosc 26:2183-8. 2012
    ..The purpose of this study was to assess whether and how BTS affects sympathetic noradrenergic and adrenomedullary function in patients with chronic pancreatitis...
  40. ncbi Measurement of leg blood pressure: the most straightforward way to the diagnosis
    R Gilles
    Department of Medicine, Division of General Internal Medicine, Nijmegen, The Netherlands
    Neth J Med 66:81-4. 2008
    ....
  41. ncbi Sustained hyperglycaemia increases muscle blood flow but does not affect sympathetic activity in resting humans
    P J van Gurp
    Division of General Internal Medicine, Department of Internal Medicine, University Medical Center St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Appl Physiol 93:648-54. 2005
    ..In conclusion, sustained hyperglycaemia in normal subjects induces moderate vasodilation in skeletal muscle, but this increased blood flow can not be attributed to a decreased sympathetic tone...
  42. ncbi New advances in the biochemical diagnosis of pheochromocytoma: moving beyond catecholamines
    Jacques W M Lenders
    Department of Internal Medicine, St Radboud University Medical Center, Nijmegen, The Netherlands
    Ann N Y Acad Sci 970:29-40. 2002
    ....
  43. doi Steroid Hormone Production in Patients with Aldosterone Producing Adenomas
    M Moors
    Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
    Horm Metab Res 47:967-72. 2015
    ....
  44. doi Should every patient diagnosed with a phaeochromocytoma have a ¹²³ I-MIBG scintigraphy?
    A van Berkel
    Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
    Clin Endocrinol (Oxf) 81:329-33. 2014
    ....
  45. doi High dose ascorbic acid does not reverse central sympathetic overactivity in chronic heart failure
    M E Gomes
    Department of Internal Medicine Department of Cardiology Department of Pharmacology Toxicology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Clin Pharm Ther 36:546-52. 2011
    ..Our objective was to undertake a trial to test our hypothesis that administration of the well-known antioxidant and ROS scavenger ascorbic acid, would reverse or reduce the sympathetic overactivity in CHF patients...
  46. ncbi Short-term cortisol infusion in the brachial artery, with and without inhibiting 11 beta-hydroxysteroid dehydrogenase, does not alter forearm vascular resistance in normotensive and hypertensive subjects
    S H M van Uum
    Department of Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Eur J Clin Invest 32:874-81. 2002
    ..We studied the acute effect of cortisol on forearm vascular resistance (FVR) by infusing cortisol directly into the brachial artery, both with and without inhibition of 11 beta-HSD, in normotensive and hypertensive subjects...
  47. pmc A method to study the effect of bronchodilators on smoke retention in COPD patients: study protocol for a randomized controlled trial
    W D Van Dijk
    Department of Primary and Community Care, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Trials 12:37. 2011
    ..In this paper, we report our study protocol that explores the fundamental interaction, i.e. smoke retention...
  48. ncbi Stability of urinary fractionated metanephrines and catecholamines during collection, shipment, and storage of samples
    Jacques J Willemsen
    Department of Chemical Endocrinology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Chem 53:268-72. 2007
    ..Measurements of 24-h fractionated urinary metanephrines and catecholamines are used for the diagnosis of pheochromocytoma, but adequate information is needed regarding collection, storage, and shipment conditions...
  49. ncbi Stability of plasma free metanephrines during collection and storage as assessed by an optimized HPLC method with electrochemical detection
    Jacques J Willemsen
    Department of Chemical Endocrinology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    Clin Chem 49:1951-3. 2003
  50. ncbi Pheochromocytoma as an endocrine emergency
    Frederieke M Brouwers
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, University Medical Center, St Radboud Nijmegen, Nijmegen, The Netherlands
    Rev Endocr Metab Disord 4:121-8. 2003
  51. ncbi Occam's razor; anaemia and orthostatic hypotension
    Marc E R Gomes
    Department of Internal Medicine, St Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands
    Lancet 362:1282. 2003
  52. ncbi Arterial baroreflex and peripheral chemoreflex function after radiotherapy for laryngeal or pharyngeal cancer
    Henri J L M Timmers
    Department of Internal Medicine, University Medical Center, Nijmegen, The Netherlands
    Int J Radiat Oncol Biol Phys 53:1203-10. 2002
    ..We investigated whether radiation therapy for laryngeal or pharyngeal cancer affects baroreflex and chemoreflex function...
  53. pmc Central and cerebrovascular effects of leg crossing in humans with sympathetic failure
    Mark P M Harms
    Department of Internal Medicine, AMC Center for Heart Failure Research, Academic Medical Center, Amsterdam, The Netherlands
    Clin Sci (Lond) 118:573-81. 2010
    ....
  54. ncbi Systematic review: diagnostic procedures to differentiate unilateral from bilateral adrenal abnormality in primary aldosteronism
    Marlies J E Kempers
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Intern Med 151:329-37. 2009
    ..This distinction is crucial because unilateral primary aldosteronism can be treated surgically, whereas bilateral primary aldosteronism should be treated medically...
  55. ncbi Effect of glycyrrhetinic acid on 11 beta-hydroxysteroid dehydrogenase activity in normotensive and hypertensive subjects
    Stan H M van Uum
    Department of Medicine, Geert Grooteplein 8, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Sci (Lond) 102:203-11. 2002
    ....
  56. doi Which physiological mechanism is responsible for the increase in blood pressure during leg crossing?
    Lenneke Fj van Groningen
    Department of Medicine, Division of General Internal Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands
    J Hypertens 26:433-7. 2008
    ..To determine which physiological mechanism is responsible for the blood pressure increase during leg crossing at knee-level in the sitting position...
  57. ncbi Prevalence of the white-coat effect at multiple visits before and during treatment
    Willem J Verberk
    Cardiovascular Research Institute Maastricht CARIM, Maastricht University and Department of Internal Medicine, University Hospital Maastricht, Nijmegen, The Netherlands
    J Hypertens 24:2357-63. 2006
    ..To investigate the prevalence and persistence of the white-coat effect (WCE) and white-coat hypertension (WCH) on multiple blood pressure measurement occasions in hypertensive patients with and without treatment...
  58. pmc Bromide as marker for drug adherence in hypertensive patients
    Richard L Braam
    Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Clin Pharmacol 65:733-6. 2008
    ..Currently, methods that measure drug adherence objectively are lacking. Objective methods are needed to help improve blood pressure control and outcome in hypertensive patients...
  59. ncbi The position of the arm during blood pressure measurement in sitting position
    Ahmet Adiyaman
    Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Blood Press Monit 11:309-13. 2006
    ..Determining the influence of the position of the arm on blood pressure measurement in the sitting position...
  60. ncbi The effect of crossing legs on blood pressure
    Ahmet Adiyaman
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Blood Press Monit 12:189-93. 2007
    ..To determine whether crossing of the legs at the knee or at the ankles during blood pressure measurement in sitting position has an effect on blood pressure...
  61. ncbi Choice of biochemical test for diagnosis of pheochromocytoma: validation of plasma metanephrines
    Graeme Eisenhofer
    Building 10, Room 6N252, 10 Center Drive, MSC 1620, National Institutes of Health, Bethesda, MD 20892 1620, USA
    Curr Hypertens Rep 4:250-5. 2002
    ..Measurements of plasma concentrations of free metanephrines thereby promise more reliable and efficient diagnosis of pheochromocytoma than offered by conventional biochemical tests...
  62. ncbi Clinical presentations, biochemical phenotypes, and genotype-phenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas
    Henri J L M Timmers
    Section on Medical Neuroendocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, 10 Center Drive, Building 10, CRC, Room 1 E 3140, MSC 1109, Bethesda, Maryland 20892 1109, USA
    J Clin Endocrinol Metab 92:779-86. 2007
    ..Mutations of the gene encoding succinate dehydrogenase subunit B (SDHB) predispose to malignant paraganglioma (PGL). Recognition of the SDHB phenotype in apparently sporadic PGL directs appropriate treatment and family screening...
  63. ncbi Plasma metanephrines in renal failure
    Graeme Eisenhofer
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892 1620, USA
    Kidney Int 67:668-77. 2005
    ..The metanephrines may be measured as free metabolites or after a deconjugation step where measurements reflect mainly sulfate-conjugated metabolites. The influence of renal insufficiency states on these various measurements is unclear...
  64. ncbi Biochemical diagnosis of pheochromocytoma: how to distinguish true- from false-positive test results
    Graeme Eisenhofer
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 88:2656-66. 2003
    ..Patterns of biochemical test results and responses of plasma normetanephrine to clonidine can then help distinguish true- from false-positive results...
  65. ncbi Pheochromocytoma catecholamine phenotypes and prediction of tumor size and location by use of plasma free metanephrines
    Graeme Eisenhofer
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
    Clin Chem 51:735-44. 2005
    ..Measurements of plasma free metanephrines (normetanephrine and metanephrine) provide a useful test for diagnosis of pheochromocytoma and may provide other information about the nature of these tumors...
  66. ncbi Somatic SDHB mutation in an extraadrenal pheochromocytoma
    Francien H van Nederveen
    N Engl J Med 357:306-8. 2007
  67. ncbi Biochemical diagnosis and localization of pheochromocytoma: can we reach a consensus?
    Ashley Grossman
    Department of Endocrinology, St Bartholomew s Hospital, West Smithfield, London, EC1A 7BE, UK, and Department of Medicine, University of Toronto, Ontario, Canada
    Ann N Y Acad Sci 1073:332-47. 2006
    ..This article summarizes the discussion and recommendations derived from that session...
  68. ncbi Antecedent adrenaline attenuates the responsiveness to but not the release of counterregulatory hormones during subsequent hypoglycemia
    Bastiaan E De Galan
    Department of Medicine, University Medical Center Nijmegen, Nijmegen 6500HB, The Netherlands
    J Clin Endocrinol Metab 88:5462-7. 2003
    ..As such, adrenaline's role in the development of hypoglycemia unawareness is limited...
  69. ncbi The optimal scheme of self blood pressure measurement as determined from ambulatory blood pressure recordings
    Willem J Verberk
    Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    J Hypertens 24:1541-8. 2006
    ..To determine how many self-measurements of blood pressure (BP) should be taken at home in order to obtain a reliable estimate of a patient's BP...
  70. ncbi Cortisol, 11beta-hydroxysteroid dehydrogenases, and hypertension
    Stan H M van Uum
    Division of Endocrinology and Metabolism, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Semin Vasc Med 4:121-8. 2004
    ..More studies are needed to clarify the role of 11beta-HSDs in the pathogenesis of hypertension...
  71. ncbi Emergencies caused by pheochromocytoma, neuroblastoma, or ganglioneuroma
    Frederieke M Brouwers
    Section on Medical Neuroendocrinology, Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892 1109, USA
    Endocrinol Metab Clin North Am 35:699-724, viii. 2006
    ..If they occur, they are often linked to catecholamine excess, paraneoplastic phenomena, or local tumor mass effect...
  72. ncbi Gene expression profiling of benign and malignant pheochromocytoma
    Frederieke M Brouwers
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, CRC, Room 1E 1 3140, 10 Center Drive, MSC 1109, Bethesda, MD 20892 1109, USA
    Ann N Y Acad Sci 1073:541-56. 2006
    ....