Carl G Figdor

Summary

Affiliation: Radboud University
Country: The Netherlands

Publications

  1. ncbi request reprint Towards efficient cancer immunotherapy: advances in developing artificial antigen-presenting cells
    Loek J Eggermont
    Department of Tumor Immunology, Radboud University Medical Centre and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands
    Trends Biotechnol 32:456-65. 2014
  2. pmc The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity
    Annemiek B van Spriel
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, University Medical Centre, Nijmegen, The Netherlands
    PLoS Pathog 5:e1000338. 2009
  3. pmc Geometry sensing by dendritic cells dictates spatial organization and PGE(2)-induced dissolution of podosomes
    Koen van den Dries
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Cell Mol Life Sci 69:1889-901. 2012
  4. pmc DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells
    Duccio Cavalieri
    Department of Pharmacology, University of Firenze, Firenze, Italy
    Immunome Res 6:10. 2010
  5. pmc Route of administration of the TLR9 agonist CpG critically determines the efficacy of cancer immunotherapy in mice
    Stefan Nierkens
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 4:e8368. 2009
  6. ncbi request reprint No advantage of cell-penetrating peptides over receptor-specific antibodies in targeting antigen to human dendritic cells for cross-presentation
    Paul J Tacken
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Immunol 180:7687-96. 2008
  7. ncbi request reprint Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells
    Gerty Schreibelt
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Blood 116:564-74. 2010
  8. ncbi request reprint Skin-test infiltrating lymphocytes early predict clinical outcome of dendritic cell-based vaccination in metastatic melanoma
    Erik H J G Aarntzen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Res 72:6102-10. 2012
  9. ncbi request reprint Route of administration modulates the induction of dendritic cell vaccine-induced antigen-specific T cells in advanced melanoma patients
    W Joost Lesterhuis
    Department of Medical Oncology, Nijmegen Centre for Molecular Life Sciences, and Laboratory of Medical Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Cancer Res 17:5725-35. 2011
  10. ncbi request reprint Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro
    Luis J Cruz
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands
    J Control Release 144:118-26. 2010

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Towards efficient cancer immunotherapy: advances in developing artificial antigen-presenting cells
    Loek J Eggermont
    Department of Tumor Immunology, Radboud University Medical Centre and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands
    Trends Biotechnol 32:456-65. 2014
    ..Novel optimized aAPCs, combining carefully tuned properties, may lead to efficient immunomodulation and improved clinical responses in cancer immunotherapy. ..
  2. pmc The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity
    Annemiek B van Spriel
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, University Medical Centre, Nijmegen, The Netherlands
    PLoS Pathog 5:e1000338. 2009
    ..Taken together, tetraspanin protein CD37 inhibits IgA responses and regulates the anti-fungal immune response...
  3. pmc Geometry sensing by dendritic cells dictates spatial organization and PGE(2)-induced dissolution of podosomes
    Koen van den Dries
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Cell Mol Life Sci 69:1889-901. 2012
    ....
  4. pmc DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells
    Duccio Cavalieri
    Department of Pharmacology, University of Firenze, Firenze, Italy
    Immunome Res 6:10. 2010
    ..Here, we present DC-ATLAS, a novel and versatile resource for the interpretation of high-throughput data generated perturbing the signaling network of dendritic cells (DCs)...
  5. pmc Route of administration of the TLR9 agonist CpG critically determines the efficacy of cancer immunotherapy in mice
    Stefan Nierkens
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 4:e8368. 2009
    ..We studied whether the efficacy of CpG as an adjuvant in cancer immunotherapy is dependent on the route of CpG administration, in particular when the tumor is destructed in situ...
  6. ncbi request reprint No advantage of cell-penetrating peptides over receptor-specific antibodies in targeting antigen to human dendritic cells for cross-presentation
    Paul J Tacken
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Immunol 180:7687-96. 2008
    ..Given the specificity with which Abs recognize their targets, this favors the use of DC receptor-specific Abs for in vivo vaccination strategies...
  7. ncbi request reprint Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells
    Gerty Schreibelt
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Blood 116:564-74. 2010
    ..These data thus identify a new clinical application for a mixture of commonly used preventive vaccines in the generation of Th1-inducing clinical-grade mature DCs...
  8. ncbi request reprint Skin-test infiltrating lymphocytes early predict clinical outcome of dendritic cell-based vaccination in metastatic melanoma
    Erik H J G Aarntzen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Res 72:6102-10. 2012
    ....
  9. ncbi request reprint Route of administration modulates the induction of dendritic cell vaccine-induced antigen-specific T cells in advanced melanoma patients
    W Joost Lesterhuis
    Department of Medical Oncology, Nijmegen Centre for Molecular Life Sciences, and Laboratory of Medical Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Cancer Res 17:5725-35. 2011
    ....
  10. ncbi request reprint Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro
    Luis J Cruz
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands
    J Control Release 144:118-26. 2010
    ..Consequently, targeted delivery only improved antigen presentation of NPs and induced antigen-dependent T cell responses at 10-100 fold lower concentrations than nontargeted NPs...
  11. ncbi request reprint The C-type lectin DC-SIGN internalizes soluble antigens and HIV-1 virions via a clathrin-dependent mechanism
    Alessandra Cambi
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, The Netherlands
    Eur J Immunol 39:1923-8. 2009
    ..Detailed information about how different Ag are internalized via these receptors will facilitate the rational design of targeted therapeutic strategies...
  12. ncbi request reprint In situ expression of tumor antigens by messenger RNA-electroporated dendritic cells in lymph nodes of melanoma patients
    Danita H Schuurhuis
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Res 69:2927-34. 2009
    ..Together these data show that mature DC electroporated with mRNA encoding TAA migrate and express antigens in the lymph nodes and induce specific immune responses...
  13. ncbi request reprint Polyinosinic polycytidylic acid prevents efficient antigen expression after mRNA electroporation of clinical grade dendritic cells
    Danita H Schuurhuis
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Immunol Immunother 58:1109-15. 2009
    ..Together these data show that electroporation of mature DC with TAA-encoding mRNA is attractive for use in DC vaccination protocols in cancer patients, but protein expression should be tested for each maturation cocktail...
  14. ncbi request reprint Maximizing dendritic cell migration in cancer immunotherapy
    Pauline Verdijk
    Radboud University Nijmegen Medical Centre, Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein 28, Nijmegen, The Netherlands
    Expert Opin Biol Ther 8:865-74. 2008
    ..The success of dendritic cell (DC)-based immunotherapy in inducing cellular immunity against tumors is highly dependent on accurate delivery and trafficking of the DC to T-cell-rich areas of secondary lymphoid tissues...
  15. ncbi request reprint DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production
    Friederike Meyer-Wentrup
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    J Leukoc Biol 85:518-25. 2009
    ..These data provide further support to the concept of CLR/TLR cross-talk in modulating immune responses...
  16. ncbi request reprint Relevance of DC-SIGN in DC-induced T cell proliferation
    Karlijn Gijzen
    Department of Tumor Immunology, NCMLS 278, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26 28, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 81:729-40. 2007
    ..This study indicates an initial and transient role for DC-SIGN in T cell proliferation, which becomes apparent when T cell proliferation is low and when the percentage of DC-SIGN binding PBL is high...
  17. ncbi request reprint Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody
    Paul J Tacken
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 106:1278-85. 2005
    ..This identifies DC-SIGN as a promising target molecule for DC-based vaccination strategies...
  18. ncbi request reprint Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination
    Erik H J G Aarntzen
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre RUNMC, Nijmegen, The Netherlands
    Cancer Res 73:19-29. 2013
    ..0089). In conclusion, coactivating TAA-specific CD4(+) T-helper cells with DCs pulsed with both MHC class I and II-restricted epitopes augments TAA-specific CD8(+) T-cell responses, contributing to improved clinical responses...
  19. ncbi request reprint Wild-type and modified gp100 peptide-pulsed dendritic cell vaccination of advanced melanoma patients can lead to long-term clinical responses independent of the peptide used
    W Joost Lesterhuis
    Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Immunol Immunother 60:249-60. 2011
    ....
  20. ncbi request reprint Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity
    Paul J Tacken
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    Blood 118:6836-44. 2011
    ..We conclude that the targeted delivery of adjuvants may improve the efficacy and safety of DC-based vaccines...
  21. ncbi request reprint Limited amounts of dendritic cells migrate into the T-cell area of lymph nodes but have high immune activating potential in melanoma patients
    Pauline Verdijk
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Science, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Cancer Res 15:2531-40. 2009
    ..In this study, we investigated the fate of DC after intradermal (i.d.) or intranodal (i.n.) administration and the consequences for the immune activating potential of DC vaccines in melanoma patients...
  22. ncbi request reprint Distinct kinetic and mechanical properties govern ALCAM-mediated interactions as shown by single-molecule force spectroscopy
    Joost Te Riet
    Department of Tumour Immunology 278, Nijmegen Centre for Molecular Life Sciences NCMLS, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB Nijmegen, The Netherlands
    J Cell Sci 120:3965-76. 2007
    ....
  23. pmc Cord blood mesenchymal stem cells propel human dendritic cells to an intermediate maturation state and boost interleukin-12 production by mature dendritic cells
    Lieke C J van den Berk
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Immunology 128:564-72. 2009
    ..DCs are able to discriminate the different MSC subtypes, resulting in diverse differentiation programmes...
  24. ncbi request reprint Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation
    Paul J Tacken
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Blood 118:4111-9. 2011
    ..Our studies demonstrate that anti-neck antibodies trigger a distinct mode of DC-SIGN internalization that shows potential for targeted vaccination strategies...
  25. pmc The tetraspanin CD37 protects against glomerular IgA deposition and renal pathology
    Angelique L Rops
    Nephrology Research Laboratory and Department of Nephrology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Pathol 176:2188-97. 2010
    ..Therefore, CD37 may protect against the development of IgA nephropathy...
  26. ncbi request reprint Synergy between in situ cryoablation and TLR9 stimulation results in a highly effective in vivo dendritic cell vaccine
    Martijn H M G M den Brok
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Cancer Res 66:7285-92. 2006
    ..Therefore, in situ tumor destruction in combination with CpG-oligodeoxynucleotide administration creates a unique "in situ DC vaccine" that is readily applicable in the clinic...
  27. ncbi request reprint Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy
    I Jolanda M de Vries
    Department of Tumor Immunology, Radboud University Nijmegen Medical Center and Nijmegen Center for Molecular Life Sciences, Geert Grooteplein 28, 6500 HB Nijmegen, The Netherlands
    Nat Biotechnol 23:1407-13. 2005
    ..MRI cell tracking using iron oxides appears clinically safe and well suited to monitor cellular therapy in humans...
  28. ncbi request reprint Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: a phase I/II study in metastatic melanoma patients
    Joannes F M Jacobs
    Department of Medical Oncology, Laboratory of Medical Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Cancer Res 16:5067-78. 2010
    ..In this study we investigated whether transient monoclonal antibody-mediated depletion of CD25(high) regulatory T cells (Treg) is capable of enhancing the immunostimulatory efficacy of dendritic cell vaccines...
  29. ncbi request reprint Phenotypic and functional characterization of mature dendritic cells from pediatric cancer patients
    Joannes F M Jacobs
    Department of Pediatric Hemato Oncology, Nijmegen Centre of Molecular Life Sciences, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Pediatr Blood Cancer 49:924-7. 2007
    ..We studied whether sufficient amounts of mature monocyte-derived DCs can be cultured from peripheral blood of pediatric cancer patients...
  30. ncbi request reprint Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells
    Erik H J G Aarntzen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre RUNMC, Nijmegen, The Netherlands
    Clin Cancer Res 19:1525-33. 2013
    ..However, these migration rates are typically very poor. Improving the targeting of ex vivo generated DCs to LNs might increase vaccine efficacy and reduce costs. We investigated DC migration in vivo in humans under different conditions...
  31. ncbi request reprint Human plasmacytoid dendritic cells efficiently cross-present exogenous Ags to CD8+ T cells despite lower Ag uptake than myeloid dendritic cell subsets
    Jurjen Tel
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Blood 121:459-67. 2013
    ..Our findings may therefore have important consequences for the development of antitumor immunotherapy...
  32. ncbi request reprint Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production
    Friederike Meyer-Wentrup
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Blood 111:4245-53. 2008
    ..Collectively, the data show that targeting of DCIR can modulate human pDC function and may be applied in disease prevention and treatment...
  33. ncbi request reprint Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells
    Aukje W Zimmerman
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, The Netherlands
    Blood 107:3212-20. 2006
    ....
  34. ncbi request reprint Vaccination with mRNA-electroporated dendritic cells induces robust tumor antigen-specific CD4+ and CD8+ T cells responses in stage III and IV melanoma patients
    Erik H J G Aarntzen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Clin Cancer Res 18:5460-70. 2012
    ..We investigated the immunologic and clinical responses to vaccination with mRNA-electroporated DC in stage III and IV melanoma patients...
  35. ncbi request reprint Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting
    Paul J Tacken
    Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Tumour Immunology, Postbox 9101, Nijmegen, 6500HB, Netherlands
    Nat Rev Immunol 7:790-802. 2007
    ..Here, we discuss how direct targeting of antigens to DC surface receptors in vivo might replace laborious and expensive ex vivo culturing, and facilitate large-scale application of DC-based vaccination therapies...
  36. ncbi request reprint Comparison of antibodies and carbohydrates to target vaccines to human dendritic cells via DC-SIGN
    Luis J Cruz
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525 GA, Nijmegen, The Netherlands
    Biomaterials 33:4229-39. 2012
    ..From these findings we conclude that receptor-specific Abs are more effective than carbohydrates for DC-targeted vaccination strategies...
  37. pmc Organization of the integrin LFA-1 in nanoclusters regulates its activity
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Mol Biol Cell 17:4270-81. 2006
    ....
  38. ncbi request reprint Maturation of dendritic cells is a prerequisite for inducing immune responses in advanced melanoma patients
    I Jolanda M de Vries
    Department of Tumor Immunology, University Medical Center St Radboud Nijmegen and Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Clin Cancer Res 9:5091-100. 2003
    ..We have investigated the capacity of immature and mature monocyte-derived DCs pulsed with melanoma-associated peptides (gp100 and tyrosinase) to induce a primary cytotoxic T-lymphocyte response in vivo...
  39. ncbi request reprint TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation
    Kristopher Clark
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Mol Biol 378:790-803. 2008
    ..In conclusion, our data demonstrate that TRPM7 regulates myosin IIA filament stability and localization by phosphorylating a short stretch of amino acids within the alpha-helical tail of the myosin IIA heavy chain...
  40. ncbi request reprint The alpha-kinases TRPM6 and TRPM7, but not eEF-2 kinase, phosphorylate the assembly domain of myosin IIA, IIB and IIC
    Kristopher Clark
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    FEBS Lett 582:2993-7. 2008
    ..In conclusion, TRPM6 and TRPM7 share exogenous substrates among themselves but not with functionally distant alpha-kinases...
  41. pmc In vivo imaging of therapy-induced anti-cancer immune responses in humans
    Erik H J G Aarntzen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Cell Mol Life Sci 70:2237-57. 2013
    ..The last section provides future directions that we envision to be crucial for further development...
  42. ncbi request reprint Antibodies and carbohydrate ligands binding to DC-SIGN differentially modulate receptor trafficking
    Paul J Tacken
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Immunol 42:1989-98. 2012
    ..Vaccine efficacy may therefore be enhanced by strategies increasing the amount of Ag entering via a single receptor molecule, such as the use of targeting moieties allowing DC-SIGN recycling or Ab-coated vaccine carriers...
  43. ncbi request reprint Interaction of acute lymphopblastic leukemia cells with C-type lectins DC-SIGN and L-SIGN
    Karlijn Gijzen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Exp Hematol 36:860-70. 2008
    ..Additional studies are necessary to ascertain the possible role of these results in terms of disease pathogenesis and their potential as target to eradicate leukemic cells...
  44. ncbi request reprint Activation of human plasmacytoid dendritic cells by TLR9 impairs Fc gammaRII-mediated uptake of immune complexes and presentation by MHC class II
    Daniel Benitez-Ribas
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Immunol 181:5219-24. 2008
    ..We hypothesize that pDC, once activated via TLR9-ligands reaching the late endosomes, can only present initially sampled Ags and thus are protected from uptake and processing of additional potential self-Ags...
  45. ncbi request reprint Functional differences between mesenchymal stem cell populations are reflected by their transcriptome
    Bastiaan J H Jansen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Stem Cells Dev 19:481-90. 2010
    ..Furthermore, these differences indicate a demand for effective differentiation protocols tailored to each stem cell type...
  46. ncbi request reprint TLR4-mediated podosome loss discriminates gram-negative from gram-positive bacteria in their capacity to induce dendritic cell migration and maturation
    Suzanne F G van Helden
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Immunol 184:1280-91. 2010
    ....
  47. pmc Dendritic cell interaction with Candida albicans critically depends on N-linked mannan
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Biol Chem 283:20590-9. 2008
    ..Better insight in the carbohydrate recognition profile of C-type lectins will ultimately provide relevant information for the development of new drugs targeting specific fungal cell wall antigens...
  48. pmc Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice
    W Joost Lesterhuis
    Department of Medical Oncology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    J Clin Invest 121:3100-8. 2011
    ..This dual action of platinum compounds may extend their therapeutic application in cancer patients and provides a rationale for their use in combination with immunostimulatory compounds...
  49. ncbi request reprint Multimodal imaging of nanovaccine carriers targeted to human dendritic cells
    Luis J Cruz
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, University Medical Centre, Nijmegen, The Netherlands
    Mol Pharm 8:520-31. 2011
    ....
  50. ncbi request reprint The influence of PEG chain length and targeting moiety on antibody-mediated delivery of nanoparticle vaccines to human dendritic cells
    Luis J Cruz
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, 6500 HB Nijmegen, Nijmegen, The Netherlands
    Biomaterials 32:6791-803. 2011
    ..Thereby, the implications of our findings are not limited to the future design of nanovaccines specifically targeted to DC-SIGN, but apply to the general design of targeted nanocarriers...
  51. ncbi request reprint Dominant processes during human dendritic cell maturation revealed by integration of proteome and transcriptome at the pathway level
    Sonja I Buschow
    Department of Tumor Immunology and CMBI at the Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Proteome Res 9:1727-37. 2010
    ..We conclude that integration of different but related data sets at the pathway level can significantly increase the predictive power of multi "omics" analyses...
  52. ncbi request reprint Targeting uptake receptors on human plasmacytoid dendritic cells triggers antigen cross-presentation and robust type I IFN secretion
    Jurjen Tel
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen 6500 HB, The Netherlands
    J Immunol 191:5005-12. 2013
    ..These findings pave the way to actively recruit human pDCs for cellular cancer immunotherapy. ..
  53. ncbi request reprint The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells
    Gerty Schreibelt
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    Blood 119:2284-92. 2012
    ..We conclude that CLEC9A is a promising target for in vivo antigen delivery in humans to increase the efficiency of vaccines against infectious or malignant diseases...
  54. ncbi request reprint The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells
    Alessandra Cambi
    Department of Tumor Immunology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Eur J Immunol 33:532-8. 2003
    ..albicans receptor expressed by DC. Together, these results demonstrate that DC-SIGN is an exquisite pathogen-uptake receptor that captures not only viruses but also fungi...
  55. ncbi request reprint The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival
    Annemiek B van Spriel
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen 6525 GA, The Netherlands
    Sci Signal 5:ra82. 2012
    ..CD37 was required for the mobility and clustering of α(4)β(1) integrins in the plasma membrane, thus regulating the membrane distribution of α(4)β(1) integrin necessary for activation of the Akt survival pathway in the immune system...
  56. ncbi request reprint Vaccine-specific local T cell reactivity in immunotherapy-associated vitiligo in melanoma patients
    Joannes F M Jacobs
    Department of Pediatric Hemato Oncology, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Cancer Immunol Immunother 58:145-51. 2009
    ..This directly links vitiligo to the immuno-therapeutic intervention and supports the hypothesis that vitiligo is a marker of immunity against melanoma cells...
  57. pmc The chemotherapeutic drug oxaliplatin differentially affects blood DC function dependent on environmental cues
    Jurjen Tel
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    Cancer Immunol Immunother 61:1101-11. 2012
    ..Our results demonstrate that platinum-based anticancer drugs adapt TLR-induced signaling in human pDCs and myeloid DCs (mDCs), thereby downgrading their immunostimulatory potential...
  58. ncbi request reprint Dendritic cells: tools and targets for antitumor vaccination
    Martijn H M G M den Brok
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands
    Expert Rev Vaccines 4:699-710. 2005
    ....
  59. ncbi request reprint DEC-205 mediates antigen uptake and presentation by both resting and activated human plasmacytoid dendritic cells
    Jurjen Tel
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Immunol 41:1014-23. 2011
    ..We observed that TLR-mediated signaling increases DEC-205 expression levels without affecting receptor internalization. Moreover, human pDCs retained the capacity to present antigens via DEC-205 following TLR activation...
  60. ncbi request reprint In vivo colocalization of antigen and CpG [corrected] within dendritic cells is associated with the efficacy of cancer immunotherapy
    Stefan Nierkens
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands
    Cancer Res 68:5390-6. 2008
    ..These data might aid in the design of future immunotherapeutic strategies for cancer patients...
  61. ncbi request reprint Natural human plasmacytoid dendritic cells induce antigen-specific T-cell responses in melanoma patients
    Jurjen Tel
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Res 73:1063-75. 2013
    ..These results indicate that vaccination with naturally occurring pDC is feasible with minimal toxicity and that in patients with metastatic melanoma, it induces favorable immune responses...
  62. pmc Maturation of monocyte-derived dendritic cells with Toll-like receptor 3 and 7/8 ligands combined with prostaglandin E2 results in high interleukin-12 production and cell migration
    A C Inge Boullart
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Science, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Immunol Immunother 57:1589-97. 2008
    ..We propose a novel clinical grade maturation protocol in which TLR ligands poly(I:C) and R848 are combined with PGE2 to generate DC with both high migratory capacity and IL-12p70 production upon T cell encounter...
  63. ncbi request reprint Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production
    Friederike Meyer-Wentrup
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, University Medical Centre, Nijmegen, The Netherlands
    J Immunol 178:154-62. 2007
    ..Taken together, these findings show that tetraspanin CD37 is important for dectin-1 stabilization in APC membranes and controls dectin-1-mediated IL-6 production...
  64. pmc A novel (19)F agent for detection and quantification of human dendritic cells using magnetic resonance imaging
    Fernando Bonetto
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Int J Cancer 129:365-73. 2011
    ..This is well within acceptable limits for clinical studies, and thus, we conclude that (19)F MRI for quantitative cell tracking in a clinical setting has great potential...