Ingrid Dijkgraaf

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. pmc PET imaging of αvβ₃ integrin expression in tumours with ⁶⁸Ga-labelled mono-, di- and tetrameric RGD peptides
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Nucl Med Mol Imaging 38:128-37. 2011
  2. ncbi Improved targeting of the alpha(v)beta (3) integrin by multimerisation of RGD peptides
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Nucl Med Mol Imaging 34:267-73. 2007
  3. ncbi Alpha v beta 3 integrin-targeting of intraperitoneally growing tumors with a radiolabeled RGD peptide
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Cancer 120:605-10. 2007
  4. ncbi Effects of linker variation on the in vitro and in vivo characteristics of an 111In-labeled RGD peptide
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, PO Box 9101, HB Nijmegen 6500, The Netherlands
    Nucl Med Biol 34:29-35. 2007
  5. doi Radionuclide imaging of tumor angiogenesis
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Cancer Biother Radiopharm 24:637-47. 2009
  6. pmc Molecular imaging of angiogenesis with SPECT
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    Eur J Nucl Med Mol Imaging 37:S104-13. 2010
  7. ncbi Improved tumor targeting of radiolabeled RGD peptides using rapid dose fractionation
    Marcel Janssen
    Department of Nuclear Medicine, University Medical Center Nijmegen, The Netherlands
    Cancer Biother Radiopharm 19:399-404. 2004
  8. ncbi Synthesis and biological evaluation of potent alphavbeta3-integrin receptor antagonists
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nucl Med Biol 33:953-61. 2006
  9. ncbi Comparison of a monomeric and dimeric radiolabeled RGD-peptide for tumor targeting
    Marcel Janssen
    Department of Nuclear Medicine and Obstetrics and Gynecology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Biother Radiopharm 17:641-6. 2002
  10. ncbi Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model
    Marcel L Janssen
    Department of Nuclear Medicine, University Medical Center Nijmegen, The Netherlands
    Cancer Res 62:6146-51. 2002

Collaborators

Detail Information

Publications14

  1. pmc PET imaging of αvβ₃ integrin expression in tumours with ⁶⁸Ga-labelled mono-, di- and tetrameric RGD peptides
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Nucl Med Mol Imaging 38:128-37. 2011
    ..In this study the α(v)β(3)-binding characteristics of (68)Ga-labelled monomeric, dimeric and tetrameric RGD peptides were determined and compared with their (111)In-labelled counterparts...
  2. ncbi Improved targeting of the alpha(v)beta (3) integrin by multimerisation of RGD peptides
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur J Nucl Med Mol Imaging 34:267-73. 2007
    ..In this study the alpha(v)beta(3) binding characteristics of an (111)In-labelled monomeric, dimeric and tetrameric RGD analogue were compared...
  3. ncbi Alpha v beta 3 integrin-targeting of intraperitoneally growing tumors with a radiolabeled RGD peptide
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Cancer 120:605-10. 2007
    ..p. Radiolabeled DOTA-E-c(RGDfK) is suitable for targeting of i.p. growing tumors and potentially can be used for peptide receptor radionuclide therapy of these tumors...
  4. ncbi Effects of linker variation on the in vitro and in vivo characteristics of an 111In-labeled RGD peptide
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, PO Box 9101, HB Nijmegen 6500, The Netherlands
    Nucl Med Biol 34:29-35. 2007
    ....
  5. doi Radionuclide imaging of tumor angiogenesis
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Cancer Biother Radiopharm 24:637-47. 2009
    ..In this review, an overview on the currently used nuclear imaging probes for noninvasive visualization of tumor angiogenesis is given...
  6. pmc Molecular imaging of angiogenesis with SPECT
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    Eur J Nucl Med Mol Imaging 37:S104-13. 2010
    ..The resolution of microSPECT cameras (<0.5 mm) is higher than that of microPET cameras (>1.5 mm). In this report, studies on new radiolabelled tracers for SPECT imaging of angiogenesis in tumours are reviewed...
  7. ncbi Improved tumor targeting of radiolabeled RGD peptides using rapid dose fractionation
    Marcel Janssen
    Department of Nuclear Medicine, University Medical Center Nijmegen, The Netherlands
    Cancer Biother Radiopharm 19:399-404. 2004
    ..In conclusion, dose fractionation resulted in higher radiation doses. However, therapeutic efficacy of the radiolabeled peptide was not significantly improved by dose fractionation...
  8. ncbi Synthesis and biological evaluation of potent alphavbeta3-integrin receptor antagonists
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nucl Med Biol 33:953-61. 2006
    ..Due to the selective expression of alpha(v)beta(3) integrin in tumors, radiolabeled RGD peptides and peptidomimetics are attractive candidates for tumor targeting...
  9. ncbi Comparison of a monomeric and dimeric radiolabeled RGD-peptide for tumor targeting
    Marcel Janssen
    Department of Nuclear Medicine and Obstetrics and Gynecology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Cancer Biother Radiopharm 17:641-6. 2002
    ..Furthermore, kidney retention of the dimeric peptide was higher than that of the monomeric peptide...
  10. ncbi Tumor targeting with radiolabeled alpha(v)beta(3) integrin binding peptides in a nude mouse model
    Marcel L Janssen
    Department of Nuclear Medicine, University Medical Center Nijmegen, The Netherlands
    Cancer Res 62:6146-51. 2002
    ..Injection of (90)Y-DOTA-E-[c(RGDfK)](2) induced a significant delay in tumor growth. Potentially, these peptides can be used for peptide receptor radionuclide imaging as well as therapy...
  11. doi PET of tumors expressing gastrin-releasing peptide receptor with an 18F-labeled bombesin analog
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 53:947-52. 2012
    ..In this study, the GRPR-targeting potential of (18)F-labeled NOTA-8-Aoc-BBN(7-14)NH(2) was studied using (68)Ga-NOTA-8-Aoc-BBN(7-14)NH(2) as a reference...
  12. ncbi Development and application of peptide-based radiopharmaceuticals
    Ingrid Dijkgraaf
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Anticancer Agents Med Chem 7:543-51. 2007
    ..In addition, the current state of clinical use of radiopeptides for diagnosis and therapy of tumors is discussed...
  13. pmc Nuclear medicine imaging and therapy of neuroendocrine tumours
    Martin Gotthardt
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cancer Imaging 6:S178-84. 2006
    ..Advantages of the method compared to other techniques (such as the use of radiolabelled antibodies or antibody fragments) are discussed as well as pitfalls and limitations...
  14. ncbi Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes
    Ingrid Dijkgraaf
    Department of Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P O BOX 80082, 3508 TB Utrecht, The Netherlands
    Org Biomol Chem 5:935-44. 2007
    ..These studies showed that the tetrameric RGD-dendrimer had better tumor targeting properties than its dimeric and monomeric congeners...