Marieke J H Coenen

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint Sequence analysis of the structural nuclear encoded subunits and assembly genes of cytochrome c oxidase in a cohort of 10 isolated complex IV-deficient patients revealed five mutations
    Marieke J H Coenen
    Department of Paediatrics, Nijmegen Centre for Mitochondrial Disorders, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Child Neurol 21:508-11. 2006
  2. pmc Survival dimensionality reduction (SDR): development and clinical application of an innovative approach to detect epistasis in presence of right-censored data
    Lorenzo Beretta
    Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy
    BMC Bioinformatics 11:416. 2010
  3. pmc Dutch myotonic dystrophy type 2 patients and a North-African DM2 family carry the common European founder haplotype
    Marieke J H Coenen
    Department of Human Genetics, Institute for Genetic and Metabolic Diseases, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Hum Genet 19:567-70. 2011
  4. pmc Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome
    Marieke J H Coenen
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Institute for Genetic and Metabolic Disease IGMD, Nijmegen, The Netherlands
    PLoS ONE 5:e14326. 2010
  5. ncbi request reprint Pharmacogenetics of anti-TNF treatment in patients with rheumatoid arthritis
    Marieke J H Coenen
    Radboud University, Nijmegen Medical Centre, Department of Human Genetics, Internal Mail 855, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Pharmacogenomics 8:761-73. 2007
  6. ncbi request reprint The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritis
    Mieke F Roelofs
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Rheumatol 35:558-61. 2008
  7. doi request reprint A First Step toward Personalized Medicine in Osteosarcoma: Pharmacogenetics as Predictive Marker of Outcome after Chemotherapy-Based Treatment
    Melanie M Hagleitner
    Department of Pediatric Hematology and Oncology, Radboud University Medical Center, Nijmegen, The Netherlands
    Clin Cancer Res 21:3436-41. 2015
  8. pmc Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis
    Maša Umićević Mirkov
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 72:1375-81. 2013
  9. doi request reprint HMOX1 promoter polymorphism modulates the relationship between disease activity and joint damage in rheumatoid arthritis
    Frank A D T G Wagener
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3388-93. 2008
  10. pmc Macrophage migration inhibitory factor polymorphisms do not predict therapeutic response to glucocorticoids or to tumour necrosis factor alpha-neutralising treatments in rheumatoid arthritis
    Timothy R D J Radstake
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, PO 6525 GA, Nijmegen, The Netherlands
    Ann Rheum Dis 66:1525-30. 2007

Detail Information

Publications36

  1. ncbi request reprint Sequence analysis of the structural nuclear encoded subunits and assembly genes of cytochrome c oxidase in a cohort of 10 isolated complex IV-deficient patients revealed five mutations
    Marieke J H Coenen
    Department of Paediatrics, Nijmegen Centre for Mitochondrial Disorders, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Child Neurol 21:508-11. 2006
    ..Four patients carried mutations in the complex IV assembly gene SURF1. One patient harbored a mutation in the COX10 gene involved in heme A synthesis. Mutations in the 10 nuclear encoded structural genes were not present...
  2. pmc Survival dimensionality reduction (SDR): development and clinical application of an innovative approach to detect epistasis in presence of right-censored data
    Lorenzo Beretta
    Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy
    BMC Bioinformatics 11:416. 2010
    ..Herein we introduce the Survival Dimensionality Reduction (SDR) algorithm, a non-parametric method specifically designed to detect epistasis in lifetime datasets...
  3. pmc Dutch myotonic dystrophy type 2 patients and a North-African DM2 family carry the common European founder haplotype
    Marieke J H Coenen
    Department of Human Genetics, Institute for Genetic and Metabolic Diseases, Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur J Hum Genet 19:567-70. 2011
    ..This data show that the Dutch patients carry the common founder haplotype and strongly suggest that DM2 mutations in Europe and North Africa originate from a single ancestral founder...
  4. pmc Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome
    Marieke J H Coenen
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Institute for Genetic and Metabolic Disease IGMD, Nijmegen, The Netherlands
    PLoS ONE 5:e14326. 2010
    ..We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication...
  5. ncbi request reprint Pharmacogenetics of anti-TNF treatment in patients with rheumatoid arthritis
    Marieke J H Coenen
    Radboud University, Nijmegen Medical Centre, Department of Human Genetics, Internal Mail 855, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Pharmacogenomics 8:761-73. 2007
    ..Nevertheless, replication and large prospective studies will be needed to demonstrate the validity of the identified genetic markers before implementation into daily clinical practice...
  6. ncbi request reprint The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritis
    Mieke F Roelofs
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Rheumatol 35:558-61. 2008
    ..To investigate functional consequences of the Toll-like receptor 4 (TLR4) variant (Asp299Gly) in rheumatoid arthritis (RA)...
  7. doi request reprint A First Step toward Personalized Medicine in Osteosarcoma: Pharmacogenetics as Predictive Marker of Outcome after Chemotherapy-Based Treatment
    Melanie M Hagleitner
    Department of Pediatric Hematology and Oncology, Radboud University Medical Center, Nijmegen, The Netherlands
    Clin Cancer Res 21:3436-41. 2015
    ..We applied a pathway-based approach to evaluate the cumulative effect of genes involved in the metabolism of cisplatin and doxorubicin in relationship to clinical outcome...
  8. pmc Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis
    Maša Umićević Mirkov
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 72:1375-81. 2013
    ..Currently, there are no means of identifying these patients before treatment. This study was aimed at identifying genetic factors predicting anti-TNF treatment outcome in patients with RA using a genome-wide association approach...
  9. doi request reprint HMOX1 promoter polymorphism modulates the relationship between disease activity and joint damage in rheumatoid arthritis
    Frank A D T G Wagener
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3388-93. 2008
    ..The aim of this study was to determine whether the (GT)n-repeat length within the HMOX1 promoter region is associated with RA disease severity and radiographic joint damage...
  10. pmc Macrophage migration inhibitory factor polymorphisms do not predict therapeutic response to glucocorticoids or to tumour necrosis factor alpha-neutralising treatments in rheumatoid arthritis
    Timothy R D J Radstake
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, PO 6525 GA, Nijmegen, The Netherlands
    Ann Rheum Dis 66:1525-30. 2007
    ..Therefore, the question of whether two functional variants in MIF are associated with the response to tumour necrosis factor (TNF)alpha-neutralising and GC treatments in RA was investigated...
  11. doi request reprint Common and different genetic background for rheumatoid arthritis and coeliac disease
    Marieke J H Coenen
    Department of Human Genetics, Institute for Genetic and Metabolic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Mol Genet 18:4195-203. 2009
    ..We confirmed two known loci and identified four novel ones for shared CD-RA genetic risk. Most of the shared loci further emphasize a role for adaptive and innate immunity in these diseases...
  12. doi request reprint The -2518A>G promoter polymorphism in the CCL2 gene is not associated with systemic sclerosis susceptibility or phenotype: results from a multicenter study of European Caucasian patients
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University, Nijmegen Medical Centre, The Netherlands
    Hum Immunol 70:130-3. 2009
    ..Our results demonstrate that the functional variant -2518A>G of CCL2 is not implicated in the susceptibility or phenotype of SSc...
  13. doi request reprint The functional polymorphism 844 A>G in FcαRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility
    Jasper C A Broen
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Rheumatol 38:446-9. 2011
    ..To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility...
  14. pmc A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C
    Judith G M Bergboer
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    PLoS ONE 7:e32045. 2012
    ..We aimed to replicate these studies in a large Dutch cohort...
  15. ncbi request reprint Heme oxygenase-1 promoter polymorphisms do not influence susceptibility to systemic sclerosis and its clinical phenotypes
    Lenny van Bon
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Exp Rheumatol 31:186. 2013
    ....
  16. ncbi request reprint The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 54:3828-37. 2006
    ..The purpose of this study was to unravel the role of the inhibitory FcgammaRIIb in rheumatoid arthritis (RA) by studying the effect of the FCGR2B 695T>C polymorphism on susceptibility to RA, severity of the disease, and DC function...
  17. doi request reprint Estimation of heritability of different outcomes for genetic studies of TNFi response in patients with rheumatoid arthritis
    Maša Umićević Mirkov
    Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands
    Ann Rheum Dis 74:2183-7. 2015
    ..It is expected that genetic architecture of such complex score is heterogeneous and not very suitable for pharmacogenetic studies. We aimed to select the most optimal phenotype for TNFi response using heritability estimates...
  18. pmc Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts
    Melanie M Hagleitner
    Department of Pediatric Hematology and Oncology, Radboud University Medical Center, Nijmegen, The Netherlands
    PLoS ONE 9:e115869. 2014
    ..With this largest meta-analysis performed to date, we show that the influence of TPMT and COMT on the development of cisplatin-induced hearing loss may be less important than previously suggested. ..
  19. pmc Validation study of existing gene expression signatures for anti-TNF treatment in patients with rheumatoid arthritis
    Erik J M Toonen
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 7:e33199. 2012
    ..Our results confirm that gene expression profiling prior to treatment is a useful tool to predict anti-TNF (non) response...
  20. doi request reprint Skewed X chromosomal inactivation impacts T regulatory cell function in systemic sclerosis
    Jasper C A Broen
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 69:2213-6. 2010
    ..gt; To investigate the role of X chromosomal inactivation (XCI) in systemic sclerosis (SSc) and its effects on forkhead box P3 (Foxp3) expression in T regulatory cells (Tregs)...
  21. ncbi request reprint Impaired complex I assembly in a Leigh syndrome patient with a novel missense mutation in the ND6 gene
    Cristina Ugalde
    Nijmegen Center for Mitochondrial Disorders, Department of Pediatrics, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann Neurol 54:665-9. 2003
    ....
  22. doi request reprint Allelic imbalance analysis using a single-nucleotide polymorphism microarray for the detection of bladder cancer recurrence
    Marieke J H Coenen
    Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Cancer Res 14:8198-204. 2008
    ..We investigated whether this method is suitable to detect allelic imbalance as an indicator of recurrences in non-muscle-invasive bladder cancer follow-up...
  23. doi request reprint Deciphering the genetic background of systemic sclerosis
    Jasper C A Broen
    Department of Rheumatology, Radboud University Medical Centre, Nijmegen, The Netherlands
    Expert Rev Clin Immunol 7:449-62. 2011
    ..We discuss indicators for a genetic component present in SSc, family studies, chromosomal aberrances, the involvement of the HLA region and multiple candidate genes and, finally, genome-wide association studies...
  24. doi request reprint Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease
    Marieke J H Coenen
    Department of Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands Electronic address
    Gastroenterology 149:907-17.e7. 2015
    ..We performed a prospective study to determine whether genotype analysis of TPMT before thiopurine treatment, and dose selection based on the results, affects the outcomes of patients with IBD...
  25. doi request reprint High-quality genotyping data from formalin-fixed, paraffin-embedded tissue on the drug metabolizing enzymes and transporters plus array
    Hanneke I Vos
    Department of Pediatric Hematology and Oncology, Radboud University Medical Center, Nijmegen, The Netherlands
    J Mol Diagn 17:4-9. 2015
    ..This finding provides an opportunity for pharmacogenetic studies in diseases with high mortality rates and prevents a bias in studies where otherwise only alive patients can be included. ..
  26. pmc TRPC6 single nucleotide polymorphisms and progression of idiopathic membranous nephropathy
    Julia M Hofstra
    Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands
    PLoS ONE 9:e102065. 2014
    ..g. iMN. Hence, we hypothesized that genetic variants in TRPC6 might affect susceptibility to development or progression of iMN...
  27. doi request reprint Pharmacogenetics of disease-modifying antirheumatic drugs in rheumatoid arthritis: towards personalized medicine
    Maša Umićević Mirkov
    Department of Human Genetics, Radboud University Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Pharmacogenomics 14:425-44. 2013
    ..This review will summarize the pharmacogenetics of commonly used synthetic and biological DMARDs...
  28. doi request reprint Taqman genotyping assays can be used on decalcified and paraffin-embedded tissue from patients with osteosarcoma
    Melanie M Hagleitner
    Department of Pediatric Hematology and Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
    Pediatr Blood Cancer 56:35-8. 2011
    ..However, this material generally has been decalcified and formalin-fixed for many years. In our study, we investigated whether DNA obtained from these tissues can be used for reliable single nucleotide polymorphism (SNP) genotyping...
  29. pmc Genetics of systemic sclerosis: an update
    Jasper C A Broen
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Rheumatol Rep 14:11-21. 2012
    ..This year has been of particular interest due to the publication of a large genome-wide association study, further investigations into gene-gene interactions, and the tendency to validate genetic results in functional models...
  30. ncbi request reprint Cytochrome c oxidase biogenesis in a patient with a mutation in COX10 gene
    Marieke J H Coenen
    Department of Paediatrics, Nijmegen Centre for Mitochondrial Disorders, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Ann Neurol 56:560-4. 2004
    ..Overexpression of the COX10 protein in the patient's fibroblasts proved that the detected mutation was indeed the disease cause...
  31. pmc Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy
    Marieke J H Coenen
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Am Soc Nephrol 24:677-83. 2013
    ..In conclusion, rare variants in the coding sequence of PLA2R1, including splice sites, are unlikely to explain the pathogenesis of iMN...
  32. ncbi request reprint Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency
    Marieke J H Coenen
    Nijmegen Center for Mitochondrial Disorders, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    N Engl J Med 351:2080-6. 2004
    ..Sequencing of EFG1 revealed a mutation affecting a conserved residue of the guanosine triphosphate (GTP)-binding domain. These results define a new class of gene defects underlying disorders of oxidative phosphorylation...
  33. pmc Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis
    Chunyu Liu
    Biogen Idec Inc, Cambridge, Massachusetts, USA
    Mol Med 14:575-81. 2008
    ..Replications of these results in independent and larger data sets clearly are required. We provide a reference list of candidate SNPs (P < 0.01) that can be investigated in future pharmacogenomic studies...
  34. pmc Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases
    Alexandra Zhernakova
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hum Genet 81:1284-8. 2007
    ..72 [95% CI 0.61-0.86]). Our results replicate and extend the association found in the KIAA1109/Tenr/IL2/IL21 gene region with autoimmune diseases, implying that this locus is a general risk factor for multiple autoimmune diseases...
  35. ncbi request reprint Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis
    Behrooz Z Alizadeh
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Mol Genet 16:2552-9. 2007
    ..If replicated, our findings would suggest FcgRIIa*519G as a common risk factor for auto-immune diseases. This may have clinical implications with regard to efficacy or safety of antibody-based immuno-modulator therapies...
  36. doi request reprint Association of STAT4 with rheumatoid arthritis: a replication study in three European populations
    Gisela Orozco
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Arthritis Rheum 58:1974-80. 2008
    ....