John Dulos

Summary

Affiliation: NV Organon
Country: The Netherlands

Publications

  1. pmc Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor alpha but not estrogen receptor beta
    John Dulos
    Schering Plough Research Institute, PO Box 20, 5340 BH Oss, The Netherlands
    Arthritis Res Ther 12:R101. 2010
  2. ncbi request reprint Severity of murine collagen-induced arthritis correlates with increased CYP7B activity: enhancement of dehydroepiandrosterone metabolism by interleukin-1beta
    John Dulos
    Organon NV, Oss, The Netherlands
    Arthritis Rheum 50:3346-53. 2004
  3. ncbi request reprint CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines
    John Dulos
    University Medical Center Utrecht, The Netherlands
    Arthritis Rheum 52:770-8. 2005
  4. pmc Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b
    John Dulos
    Department of Pharmacology, N V Organon, Oss, The Netherlands
    Arthritis Res Ther 7:R1271-80. 2005
  5. ncbi request reprint DHEA metabolism in arthritis: a role for the p450 enzyme Cyp7b at the immune-endocrine crossroad
    John Dulos
    Department of Pharmacology, Section Autoimmunity, Room RE3211, N V Organon, PO Box 20, 5340 BH Oss, The Netherlands
    Ann N Y Acad Sci 1069:401-13. 2006
  6. doi request reprint PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer
    John Dulos
    Department of Immune Therapeutics, Merck Research Laboratories, MSD, Oss, The Netherlands
    J Immunother 35:169-78. 2012
  7. doi request reprint Therapeutic antibody targeting of CD97 in experimental arthritis: the role of antigen expression, shedding, and internalization on the pharmacokinetics of anti-CD97 monoclonal antibody 1B2
    Dorien M de Groot
    Schering Plough Research Institute, Oss, The Netherlands
    J Immunol 183:4127-34. 2009
  8. doi request reprint Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors
    Allard Kaptein
    Merck Research Laboratories, MSD, Oss, The Netherlands
    Bioorg Med Chem Lett 21:3823-7. 2011

Collaborators

Detail Information

Publications8

  1. pmc Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor alpha but not estrogen receptor beta
    John Dulos
    Schering Plough Research Institute, PO Box 20, 5340 BH Oss, The Netherlands
    Arthritis Res Ther 12:R101. 2010
    ..Estrogens bind both estrogen receptor (ER)alpha and beta. The contribution of ERalpha and ERbeta to ER-mediated immune modulation was studied in delayed type hypersensitivity (DTH) and in experimental arthritis..
  2. ncbi request reprint Severity of murine collagen-induced arthritis correlates with increased CYP7B activity: enhancement of dehydroepiandrosterone metabolism by interleukin-1beta
    John Dulos
    Organon NV, Oss, The Netherlands
    Arthritis Rheum 50:3346-53. 2004
    ..This study was undertaken to investigate the putative role of CYP7B in arthritis using murine collagen-induced arthritis (CIA), an interleukin-1beta (IL-1beta)-dependent model...
  3. ncbi request reprint CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines
    John Dulos
    University Medical Center Utrecht, The Netherlands
    Arthritis Rheum 52:770-8. 2005
    ..The purpose of this study was to investigate the presence of 7alpha-OH-DHEA in synovial samples and the cytokine regulation of CYP7B activity in fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA)...
  4. pmc Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b
    John Dulos
    Department of Pharmacology, N V Organon, Oss, The Netherlands
    Arthritis Res Ther 7:R1271-80. 2005
    ..Our results are in accordance with presence of AP-1 and NF-kappaB binding sites in the Cyp7b promoter...
  5. ncbi request reprint DHEA metabolism in arthritis: a role for the p450 enzyme Cyp7b at the immune-endocrine crossroad
    John Dulos
    Department of Pharmacology, Section Autoimmunity, Room RE3211, N V Organon, PO Box 20, 5340 BH Oss, The Netherlands
    Ann N Y Acad Sci 1069:401-13. 2006
    ..The role of the p450 enzyme Cyp7b in DHEA metabolism and its relevance in the arthritic process will be discussed...
  6. doi request reprint PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer
    John Dulos
    Department of Immune Therapeutics, Merck Research Laboratories, MSD, Oss, The Netherlands
    J Immunother 35:169-78. 2012
    ..How these assays translate to the local antitumor response remains to be established in a clinical setting...
  7. doi request reprint Therapeutic antibody targeting of CD97 in experimental arthritis: the role of antigen expression, shedding, and internalization on the pharmacokinetics of anti-CD97 monoclonal antibody 1B2
    Dorien M de Groot
    Schering Plough Research Institute, Oss, The Netherlands
    J Immunol 183:4127-34. 2009
    ..The pharmacokinetic profile of the 1B2 Ab illustrates the complexity of Ab elimination from an organism and stresses the importance of understanding Ag-Ab interactions when developing therapeutic mAbs...
  8. doi request reprint Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors
    Allard Kaptein
    Merck Research Laboratories, MSD, Oss, The Netherlands
    Bioorg Med Chem Lett 21:3823-7. 2011
    ..This led to the identification of new MK2 inhibitors, such as (S)-23, with low nanomolar biochemical inhibition (EC(50) 7.4 nM) and submicromolar cellular target engagement activity (EC(50) 0.5 μM)...