Anne S Kienhuis

Summary

Affiliation: National Institute for Public Health and the Environment
Country: The Netherlands

Publications

  1. doi A test strategy for the assessment of additive attributed toxicity of tobacco products
    Anne S Kienhuis
    Centre for Health Protection, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands Electronic address
    Food Chem Toxicol 94:93-102. 2016
  2. doi Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans
    Anne S Kienhuis
    Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands
    Toxicol Sci 107:544-52. 2009
  3. doi A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo
    Anne S Kienhuis
    Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands
    Toxicol In Vitro 23:1163-9. 2009
  4. doi Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study
    Anne S Kienhuis
    Laboratory for Health Protection Research, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Appl Pharmacol 250:96-107. 2011
  5. doi Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis
    Anne S Kienhuis
    Center for Health Protection, National Institute for Public Health and the Environment RIVM, 3720 BA, Bilthoven, The Netherlands
    Toxicol Lett 221:225-36. 2013
  6. doi Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans
    Marja Driessen
    Centre for Health Protection, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands Division of Toxicology, Leiden Amsterdam Centre for Drug Research, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands
    Toxicol Lett 230:48-56. 2014
  7. doi Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling
    Marja Driessen
    Centre for Health Protection, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA, Bilthoven, The Netherlands
    Arch Toxicol 87:807-23. 2013
  8. doi Mechanisms of amiodarone and valproic acid induced liver steatosis in mouse in vivo act as a template for other hepatotoxicity models
    Alexa P Vitins
    Center for Health Protection, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Arch Toxicol 88:1573-88. 2014
  9. doi Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes
    Karen Mathijs
    Department of Health Risk Analyses and Toxicology, Maastricht University, Maastricht, The Netherlands
    Drug Metab Dispos 37:1305-11. 2009
  10. doi A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen
    Marja Driessen
    Centre for Health Protection, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands Division of Toxicology, Leiden Amsterdam Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands Electronic address
    Toxicol Lett 232:403-12. 2015

Collaborators

Detail Information

Publications12

  1. doi A test strategy for the assessment of additive attributed toxicity of tobacco products
    Anne S Kienhuis
    Centre for Health Protection, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands Electronic address
    Food Chem Toxicol 94:93-102. 2016
    ..Combined with risk assessment, this approach allows assessment of effectiveness of harm reduction strategies, including banning or reducing of additives. ..
  2. doi Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans
    Anne S Kienhuis
    Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands
    Toxicol Sci 107:544-52. 2009
    ..The present study is the first that used a toxicogenomics-based parallelogram approach, extrapolating in vitro to in vivo and interspecies, to reveal relevant mechanisms indicative of APAP-induced liver toxicity in humans in vivo...
  3. doi A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo
    Anne S Kienhuis
    Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands
    Toxicol In Vitro 23:1163-9. 2009
    ....
  4. doi Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study
    Anne S Kienhuis
    Laboratory for Health Protection Research, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicol Appl Pharmacol 250:96-107. 2011
    ..The challenge herein is to assess which toxicogenomic responses are relevant for induction of the apical effect and whether perturbations are sufficient for the induction of downstream events, eventually causing toxicity...
  5. doi Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis
    Anne S Kienhuis
    Center for Health Protection, National Institute for Public Health and the Environment RIVM, 3720 BA, Bilthoven, The Netherlands
    Toxicol Lett 221:225-36. 2013
    ..We conclude that the applicability of in vitro models for hepatotoxicity testing fully depends on a solid in vivo phenotype anchored analysis. ..
  6. doi Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans
    Marja Driessen
    Centre for Health Protection, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands Division of Toxicology, Leiden Amsterdam Centre for Drug Research, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands
    Toxicol Lett 230:48-56. 2014
    ..In conclusion, the ZFE model allows for identification of hepatotoxicants, without discrimination into specific phenotypes. ..
  7. doi Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling
    Marja Driessen
    Centre for Health Protection, National Institute for Public Health and the Environment RIVM, PO Box 1, 3720 BA, Bilthoven, The Netherlands
    Arch Toxicol 87:807-23. 2013
    ..This supports the applicability of the whole ZFE model for compound-induced hepatotoxicity screening...
  8. doi Mechanisms of amiodarone and valproic acid induced liver steatosis in mouse in vivo act as a template for other hepatotoxicity models
    Alexa P Vitins
    Center for Health Protection, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA, Bilthoven, The Netherlands
    Arch Toxicol 88:1573-88. 2014
    ..We conclude that concordance is found on the process level independent of species, model or dose*time point...
  9. doi Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes
    Karen Mathijs
    Department of Health Risk Analyses and Toxicology, Maastricht University, Maastricht, The Netherlands
    Drug Metab Dispos 37:1305-11. 2009
    ..These results indicate that the sandwich-cultured primary mouse hepatocyte system is robust and seems to maintain its metabolic competence better than that of the rat hepatocyte system...
  10. doi A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen
    Marja Driessen
    Centre for Health Protection, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands Division of Toxicology, Leiden Amsterdam Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands Electronic address
    Toxicol Lett 232:403-12. 2015
    ....
  11. doi An inventory of methods suitable to assess additive-induced characterising flavours of tobacco products
    Reinskje Talhout
    Centre for Health Protection, National Institute for Public Health and the Environment RIVM, Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands Electronic address
    Drug Alcohol Depend 161:9-14. 2016
    ..This is the first study to identify, review and synthesize the existing peer-reviewed and tobacco industry literature in order to provide an inventory of methods suitable to assess characterising flavours...
  12. ncbi Vegetables affect the expression of genes involved in anticarcinogenic processes in the colonic mucosa of C57BL/6 female mice
    Simone G J van Breda
    Department of Health Risk Analysis and Toxicology, Maastricht University, The Netherlands
    J Nutr 135:1879-88. 2005
    ..These genes are of particular interest because they were consistently affected and could be involved in the prevention of CRC by vegetable consumption...