Sanne A B Hermsen

Summary

Affiliation: National Institute for Public Health and the Environment
Country: The Netherlands

Publications

  1. doi Transcriptomic analysis in the developing zebrafish embryo after compound exposure: individual gene expression and pathway regulation
    Sanne A B Hermsen
    Centre for Health Protection, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands Department of Toxicogenomics, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands Institute for Risk Assessment Sciences IRAS, Utrecht University, P O Box 80 178, 3508 TD, Utrecht, The Netherlands Electronic address
    Toxicol Appl Pharmacol 272:161-71. 2013
  2. doi Triazole-induced gene expression changes in the zebrafish embryo
    Sanne A B Hermsen
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Reprod Toxicol 34:216-24. 2012
  3. doi Concentration-response analysis of differential gene expression in the zebrafish embryotoxicity test following flusilazole exposure
    Sanne A B Hermsen
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    Toxicol Sci 127:303-12. 2012
  4. doi Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies
    Sanne A B Hermsen
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Toxicol In Vitro 25:745-53. 2011
  5. doi Chemical class-specific gene expression changes in the zebrafish embryo after exposure to glycol ether alkoxy acids and 1,2,4-triazole antifungals
    Sanne A B Hermsen
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Reprod Toxicol 32:245-52. 2011
  6. doi Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles
    Esther De Jong
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Toxicol Appl Pharmacol 253:103-11. 2011

Detail Information

Publications6

  1. doi Transcriptomic analysis in the developing zebrafish embryo after compound exposure: individual gene expression and pathway regulation
    Sanne A B Hermsen
    Centre for Health Protection, National Institute for Public Health and the Environment RIVM, P O Box 1, 3720 BA Bilthoven, The Netherlands Department of Toxicogenomics, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands Institute for Risk Assessment Sciences IRAS, Utrecht University, P O Box 80 178, 3508 TD, Utrecht, The Netherlands Electronic address
    Toxicol Appl Pharmacol 272:161-71. 2013
    ..Overall, the present study suggests that the use of individual gene expression signatures as well as pathway regulation may be useful starting points for defining gene biomarkers for predicting embryotoxicity. ..
  2. doi Triazole-induced gene expression changes in the zebrafish embryo
    Sanne A B Hermsen
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Reprod Toxicol 34:216-24. 2012
    ..The zebrafish embryo model can therefore be considered a useful vertebrate model providing information of relevant pathways related to anti-fungal mechanism of action and toxicological activity...
  3. doi Concentration-response analysis of differential gene expression in the zebrafish embryotoxicity test following flusilazole exposure
    Sanne A B Hermsen
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    Toxicol Sci 127:303-12. 2012
    ..However, the interpretation of differential gene expression in terms of predicting morphological effects is not straightforward and requires further study...
  4. doi Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies
    Sanne A B Hermsen
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Toxicol In Vitro 25:745-53. 2011
    ..This alternative test method may also be useful for the detection of embryotoxic properties of other classes of chemicals...
  5. doi Chemical class-specific gene expression changes in the zebrafish embryo after exposure to glycol ether alkoxy acids and 1,2,4-triazole antifungals
    Sanne A B Hermsen
    Laboratory for Health Protection Research, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Reprod Toxicol 32:245-52. 2011
    ..In addition, information about mechanisms of action of substances may become available, thereby facilitating the extrapolation of findings to mammalian species including man...
  6. doi Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles
    Esther De Jong
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Toxicol Appl Pharmacol 253:103-11. 2011
    ..These differences in the efficacy between the test systems might be due to differences in compound kinetics, in developmental stages represented and in the relative complexity of the alternative assays...