Sarah Rowland-Jones

Summary

Affiliation: Medical Research Council Laboratories
Country: The Gambia

Publications

  1. ncbi Out of Africa: what can we learn from HIV-2 about protective immunity to HIV-1?
    Sarah L Rowland-Jones
    Medical Research Council Laboratories, Fajara, The Gambia, West Africa
    Nat Immunol 8:329-31. 2007
  2. ncbi Tenets of protection from progression to AIDS: lessons from the immune responses to HIV-2 infection
    Aleksandra Leligdowicz
    Medical Research Council Laboratories, Fajara, Atlantic Road, PO Box 273, The Gambia, West Africa
    Expert Rev Vaccines 7:319-31. 2008
  3. ncbi Protective immunity against HIV infection: lessons from HIV-2 infection
    Sarah Rowland-Jones
    MRC Laboratories, Fajara, The Gambia
    Future Microbiol 1:427-33. 2006
  4. ncbi Two distinct epidemics: the rise of HIV-1 and decline of HIV-2 infection between 1990 and 2007 in rural Guinea-Bissau
    Carla van Tienen
    Medical Research Council Laboratories, Fajara, The Gambia
    J Acquir Immune Defic Syndr 53:640-7. 2010
  5. pmc HTLV-1 in rural Guinea-Bissau: prevalence, incidence and a continued association with HIV between 1990 and 2007
    Carla van Tienen
    Medical Research Council, Fajara, The Gambia
    Retrovirology 7:50. 2010
  6. ncbi Presence of a multidrug-resistance mutation in an HIV-2 variant infecting a treatment-naive individual in Caio, Guinea Bissau
    Sabelle Jallow
    Medical Research Council Laboratories, Fajara, PO Box 273, Banjul, The Gambia
    Clin Infect Dis 48:1790-3. 2009
  7. pmc Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection
    Aleksandra Leligdowicz
    Medical Research Council Laboratories, Fajara, Republic of The Gambia
    J Clin Invest 117:3067-74. 2007
  8. pmc HTLV-1 and HIV-2 infection are associated with increased mortality in a rural West African community
    Carla van Tienen
    Medical Research Council, Fajara, The Gambia
    PLoS ONE 6:e29026. 2011
  9. ncbi Mycobacterial T cell responses in HIV-infected patients with advanced immunosuppression
    Abdulrahman S Hammond
    Bacterial and Viral Diseases Programme, Medical Research Council Laboratories, Fajara, Banjul, The Gambia, West Africa
    J Infect Dis 197:295-9. 2008
  10. ncbi Population dynamics of HIV-2 in rural West Africa: comparison with HIV-1 and ongoing transmission at the heart of the epidemic
    Thushan I de Silva
    Medical Research Council UK Laboratories, Fajara, The Gambia
    AIDS 27:125-34. 2013

Detail Information

Publications59

  1. ncbi Out of Africa: what can we learn from HIV-2 about protective immunity to HIV-1?
    Sarah L Rowland-Jones
    Medical Research Council Laboratories, Fajara, The Gambia, West Africa
    Nat Immunol 8:329-31. 2007
    ..Here we review what is known about the basis of viral control in HIV-2 infection...
  2. ncbi Tenets of protection from progression to AIDS: lessons from the immune responses to HIV-2 infection
    Aleksandra Leligdowicz
    Medical Research Council Laboratories, Fajara, Atlantic Road, PO Box 273, The Gambia, West Africa
    Expert Rev Vaccines 7:319-31. 2008
    ....
  3. ncbi Protective immunity against HIV infection: lessons from HIV-2 infection
    Sarah Rowland-Jones
    MRC Laboratories, Fajara, The Gambia
    Future Microbiol 1:427-33. 2006
    ..What can be learned from HIV-2 infection about how the human host can peacefully coexist with a pathogenic retrovirus?..
  4. ncbi Two distinct epidemics: the rise of HIV-1 and decline of HIV-2 infection between 1990 and 2007 in rural Guinea-Bissau
    Carla van Tienen
    Medical Research Council Laboratories, Fajara, The Gambia
    J Acquir Immune Defic Syndr 53:640-7. 2010
    ..To assess changes in HIV incidence and prevalence in Caió, a rural area of Guinea-Bissau, between 1990 and 2007...
  5. pmc HTLV-1 in rural Guinea-Bissau: prevalence, incidence and a continued association with HIV between 1990 and 2007
    Carla van Tienen
    Medical Research Council, Fajara, The Gambia
    Retrovirology 7:50. 2010
    ..In the current study, data from three cross-sectional community surveys performed in 1990, 1997 and 2007, were used to assess changes in HTLV-1 prevalence, incidence and its associations with HIV-1 and HIV-2 and potential risk factors...
  6. ncbi Presence of a multidrug-resistance mutation in an HIV-2 variant infecting a treatment-naive individual in Caio, Guinea Bissau
    Sabelle Jallow
    Medical Research Council Laboratories, Fajara, PO Box 273, Banjul, The Gambia
    Clin Infect Dis 48:1790-3. 2009
    ..Finding this mutation among a drug-naive population presents an important public health issue that needs to be addressed for treatment to be effective...
  7. pmc Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection
    Aleksandra Leligdowicz
    Medical Research Council Laboratories, Fajara, Republic of The Gambia
    J Clin Invest 117:3067-74. 2007
    ..A better understanding of how HIV-2 infection is controlled may identify correlates of effective protective immunity essential for the design of HIV vaccines...
  8. pmc HTLV-1 and HIV-2 infection are associated with increased mortality in a rural West African community
    Carla van Tienen
    Medical Research Council, Fajara, The Gambia
    PLoS ONE 6:e29026. 2011
    ..We compared mortality rates of HIV-1, HIV-2, and HTLV-1 infected subjects with those of retrovirus-uninfected people in a rural community in Guinea-Bissau...
  9. ncbi Mycobacterial T cell responses in HIV-infected patients with advanced immunosuppression
    Abdulrahman S Hammond
    Bacterial and Viral Diseases Programme, Medical Research Council Laboratories, Fajara, Banjul, The Gambia, West Africa
    J Infect Dis 197:295-9. 2008
    ..This may reflect early signs of reactivation, reinfection, or a restricted, inefficient immune response to Mycobacterium tuberculosis...
  10. ncbi Population dynamics of HIV-2 in rural West Africa: comparison with HIV-1 and ongoing transmission at the heart of the epidemic
    Thushan I de Silva
    Medical Research Council UK Laboratories, Fajara, The Gambia
    AIDS 27:125-34. 2013
    ..To compare the population dynamics of HIV-2 and HIV-1, and to characterize ongoing HIV-2 transmission in rural Guinea-Bissau...
  11. pmc Are plasma biomarkers of immune activation predictive of HIV progression: a longitudinal comparison and analyses in HIV-1 and HIV-2 infections?
    Samuel Nyamweya
    Medical Research Council UK, Banjul, The Gambia, West Africa
    PLoS ONE 7:e44411. 2012
    ..Their evaluation in cohort resources is therefore needed to further their development and use in HIV research...
  12. pmc Placental malaria is associated with reduced early life weight development of affected children independent of low birth weight
    Brigitte Walther
    MRC Laboratories, Atlantic Boulevard, Fajara, PO Box 273 Banjul, The Gambia
    Malar J 9:16. 2010
    ..However, little is known about the possible direct impact of the specific disease processes occurring in PM on longer term outcomes such as subsequent retarded growth development independent of LBW...
  13. ncbi HIV-2 capsids distinguish high and low virus load patients in a West African community cohort
    Clayton O Onyango
    Medical Research Council Laboratories, Fajara, Atlantic Road, PO Box 273, The Gambia
    Vaccine 28:B60-7. 2010
    ..These results provide new insights into HIV-2 pathogenesis...
  14. pmc Development and evaluation of an oligonucleotide ligation assay for detection of drug resistance-associated mutations in the human immunodeficiency virus type 2 pol gene
    Sabelle Jallow
    Medical Research Council Laboratories, Banjul, The Gambia
    J Clin Microbiol 45:1565-71. 2007
    ..In conclusion, we have developed a simple, easy-to-use, and economical assay for genotyping of drug resistance in HIV-2 that is more sustainable for use in resource-poor settings than is consensus sequencing...
  15. pmc Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians
    Modou Jobarteh
    Medical Research Council, Fajara, P O Box 273, Banjul, The Gambia
    Virol J 7:230. 2010
    ..The prevalence of HIV/hepatitis co-infection in sub-Saharan Africa is not well documented, while both HIV and HBV are endemic in this area...
  16. pmc Emergence of HBV resistance to lamivudine (3TC) in HIV/HBV co-infected patients in The Gambia, West Africa
    Balint Stewart
    Medical Research Council, Fajara, P O Box 273, Banjul, The Gambia, West Africa
    BMC Res Notes 4:561. 2011
    ..abstract:..
  17. pmc Immune reconstitution inflammatory syndrome and the influence of T regulatory cells: a cohort study in The Gambia
    Irfan Zaidi
    Medical Research Council UK Unit, Fajara, The Gambia
    PLoS ONE 7:e39213. 2012
    ..The levels of T regulatory cells were measured using flow cytometry at baseline and all follow-up visits. Baseline cytokine levels of IL-2, IL-6, IFN-γ, TNF-α, MIP-1β, IL-1, IL-12, IL-13, and IL-10 were measured in all patients...
  18. pmc Potent autologous and heterologous neutralizing antibody responses occur in HIV-2 infection across a broad range of infection outcomes
    Thushan I de Silva
    Medical Research Council United Kingdom Laboratories, Fajara, The Gambia
    J Virol 86:930-46. 2012
    ....
  19. ncbi The effect of placental malaria infection on cord blood and maternal immunoregulatory responses at birth
    Katie L Flanagan
    MRC Laboratories, Fajara, The Gambia
    Eur J Immunol 40:1062-72. 2010
    ..The findings might explain some of the adverse effects on the health of babies born to women with PM...
  20. pmc Risk factors for and clinical outcome of congenital cytomegalovirus infection in a peri-urban West-African birth cohort
    Marianne A B van der Sande
    Medical Research Council Laboratories, Fajara, Gambia
    PLoS ONE 2:e492. 2007
    ..Epidemiology and clinical outcomes are known to vary with socio-economic background, but few data are available from developing countries, where the overall burden of infectious diseases is frequently high...
  21. ncbi Virological and immunological correlates of mother-to-child transmission of cytomegalovirus in The Gambia
    Steve Kaye
    MRC Laboratories, Fajara, The Gambia
    J Infect Dis 197:1307-14. 2008
    ..We studied correlates of vertical transmission of CMV in The Gambia, where most children acquire CMV during the first year of life...
  22. ncbi Comparing HIV-1 and HIV-2 infection: Lessons for viral immunopathogenesis
    Samuel Nyamweya
    Medical Research Council Laboratories, Fajara, The Gambia
    Rev Med Virol 23:221-40. 2013
    ..If such immune responses could be replicated or induced in HIV-1 infected patients, they might extend survival and reduce requirements for antiretroviral therapy...
  23. pmc Resisting immune exhaustion in HIV-1 infection
    Sarah Rowland-Jones
    Medical Research Council Laboratories, Banjul, The Gambia
    PLoS Med 5:e103. 2008
  24. ncbi Virological and immunological response to Combivir and emergence of drug resistance mutations in a cohort of HIV-2 patients in The Gambia
    Sabelle Jallow
    Medical Research Council Laboratories, Banjul, The Gambia
    AIDS 20:1455-8. 2006
  25. pmc Revisiting the effect of acute P. falciparum malaria on Epstein-Barr virus: host balance in the setting of reduced malaria endemicity
    Shamanthi Jayasooriya
    Medical Research Council Laboratories, Fajara, The Gambia
    PLoS ONE 7:e31142. 2012
    ....
  26. ncbi CD4(+) T cell responses to cytomegalovirus in early life: a prospective birth cohort study
    David J C Miles
    Medical Research Council Laboratories, Gambia, Banjul, The Gambia
    J Infect Dis 197:658-62. 2008
    ..By 12 months after diagnosis, viremia was rarely detectable, indicating that CMV was controlled despite the slow development of CMV-specific CD4(+) T cell responses...
  27. pmc Natural killer cell function is well preserved in asymptomatic human immunodeficiency virus type 2 (HIV-2) infection but similar to that of HIV-1 infection when CD4 T-cell counts fall
    Samuel Victor Nuvor
    MRC Laboratories, Banjul, The Gambia
    J Virol 80:2529-38. 2006
    ..Enhancement of these functions may be important in immune-based therapy to control HIV disease...
  28. pmc HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children
    Michael Walther
    Medical Research Council Laboratories, Fajara, Banjul, Gambia
    PLoS Pathog 8:e1002579. 2012
    ..These add important information to the discussion about possible therapeutic manipulation of HO-1 in critically ill patients...
  29. ncbi Cross-reactive cytotoxic T lymphocytes against a HIV-1 p24 epitope in slow progressors with B*57
    Geraldine M A Gillespie
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    AIDS 16:961-72. 2002
    ....
  30. ncbi Dynamics of T cell responses in HIV infection
    Victor Appay
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 168:3660-6. 2002
    ..These observations have significant implications for our understanding of T cell responses in human viral infections in general and indicate that the definition of effector and memory subsets in humans may need revision...
  31. pmc Polyfunctional T cell responses are a hallmark of HIV-2 infection
    Melody G Duvall
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    Eur J Immunol 38:350-63. 2008
    ..Polyfunctional HIV-specific T cell responses are a hallmark of non-progressive HIV-2 infection and may be related to good clinical outcome in this setting...
  32. ncbi Correlates of delayed disease progression in HIV-1-infected Kenyan children
    Rana Chakraborty
    Pediatric Infectious Diseases Unit, St George s Hospital, London, United Kingdom
    J Immunol 174:8191-9. 2005
    ..As HIV-1-specific helper cells support anti-HIV-1 effector responses in active disease, their presence may be important in delaying disease progression...
  33. ncbi Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection
    Melody G Duvall
    Medical Research Council MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 176:6973-81. 2006
    ..This study demonstrates that HIV-2-infected donors have a well-preserved and functionally heterogeneous HIV-specific memory CD4+ T cell response that is associated with delayed disease progression in the majority of infected people...
  34. ncbi Identification of a novel HLA B*57 restricted cytotoxic T-lymphocyte epitope within HIV-1 rev
    Azure T Makadzange
    Medical Research Council, Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    AIDS 20:462-4. 2006
    ..Here we describe the identification of a novel HLA-B5701, B5703 restricted epitope within HIV-1 rev, which accounted for up to 25 and 40% of the total cytotoxic T-lymphocyte responses in two patients...
  35. ncbi Immunisation with recombinant modified vaccinia virus Ankara expressing HIV-1 gag in HIV-1-infected subjects stimulates broad functional CD4+ T cell responses
    Beatrice O Ondondo
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Eur J Immunol 36:2585-94. 2006
    ..These findings indicate that functional virus-specific T helper cells can be boosted by vaccination in chronic HIV-1 infection. Further evaluation of their role in viraemia control is warranted...
  36. ncbi A human immunodeficiency virus 1 (HIV-1) clade A vaccine in clinical trials: stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara (MVA) vaccines in humans
    Matilu Mwau
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, The John Radcliffe, Oxford OX3 9DS, UK
    J Gen Virol 85:911-9. 2004
    ..These results are very encouraging and justify further vaccine development...
  37. ncbi HLA typing in a Kenyan cohort identifies novel class I alleles that restrict cytotoxic T-cell responses to local HIV-1 clades
    Thomas G Bird
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK
    AIDS 16:1899-904. 2002
    ..To investigate HLA class I allele frequencies in a Kenyan commercial sex worker (CSW) cohort, and to examine HIV-1 specific cytotoxic T lymphocyte (CTL) responses directed against epitopes derived from locally prevalent clade A virus...
  38. pmc Dendritic cells are less susceptible to human immunodeficiency virus type 2 (HIV-2) infection than to HIV-1 infection
    Melody G Duvall
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom
    J Virol 81:13486-98. 2007
    ....
  39. ncbi Interactions between malaria and HIV infection-an emerging public health problem?
    Sarah L Rowland-Jones
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, OX3 0DW, Oxford, UK
    Microbes Infect 4:1265-70. 2002
    ..This is most serious in pregnant women, where HIV infection increases the risk of placental malaria, leading to increased infant morbidity and mortality...
  40. ncbi Premature ageing of the immune system: the cause of AIDS?
    Victor Appay
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK OX3 9DS
    Trends Immunol 23:580-5. 2002
    ..This hypothesis might shed new light on HIV-1 pathogenesis and could suggest the need to reconsider current immunotherapeutic strategies to fight the virus...
  41. ncbi Functional discrepancies in HIV-specific CD8+ T-lymphocyte populations are related to plasma virus load
    Annetie Oxenius
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, England
    J Clin Immunol 22:363-74. 2002
    ....
  42. ncbi HIV: Bad news for stop--start therapy?
    Andrew J McMichael
    Nature 420:371, 373. 2002
  43. ncbi HIV-1-specific CD8 T cell responses in a pediatric slow progressor infected as a premature neonate
    Rana Chakraborty
    University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, UK
    AIDS 16:2085-7. 2002
    ..HIV-1 infection as early as 25 weeks' gestation may thus results in the development of immune responses that control viral replication and lead to prolonged survival...
  44. ncbi Association between maternal and infant class I and II HLA alleles and of their concordance with the risk of perinatal HIV type 1 transmission
    Anastasia Polycarpou
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    AIDS Res Hum Retroviruses 18:741-6. 2002
    ..79; p = 0.030) were retained as independent predictors of transmission. HLA alleles, and in particular the class I concordance between maternal and neonatal HLA, may regulate the risk of perinatal HIV-1 transmission...
  45. ncbi Characterization of CD4(+) CTLs ex vivo
    Victor Appay
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 168:5954-8. 2002
    ..The existence of CD4(+) cytotoxic T cells in vivo at relatively high levels in chronic viral infection suggests a role in the immune response...
  46. ncbi Gonococcal cervicitis is associated with reduced systemic CD8+ T cell responses in human immunodeficiency virus type 1-infected and exposed, uninfected sex workers
    Rupert Kaul
    Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
    J Infect Dis 185:1525-9. 2002
    ..Impaired function of virus-specific CD8(+) lymphocytes may partly explain the deleterious effects of gonococcal cervicitis on HIV-1 immune control and susceptibility...
  47. ncbi Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
    Victor Appay
    MRC Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nat Med 8:379-85. 2002
    ..These findings challenge the current definitions of memory and effector subsets in humans, and suggest that ascribing effector and memory functions to subsets with different differentiation phenotypes is no longer appropriate...
  48. ncbi Viral coinfections among African children infected with human immunodeficiency virus type 1
    Rana Chakraborty
    Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
    Clin Infect Dis 36:922-4. 2003
    ..A protective role for hepatitis G virus cannot be excluded but likely affects only a minority of HIV-1-infected African children...
  49. ncbi Timeline: AIDS pathogenesis: what have two decades of HIV research taught us?
    Sarah L Rowland-Jones
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 0DW, UK
    Nat Rev Immunol 3:343-8. 2003
    ..are the landmarks in HIV research over the past two decades, and what questions still remain to be answered? What has the intense study of HIV infection taught us about other virus infections and how our immune system responds to them?..
  50. ncbi Lack of KIR3DS1 binding to MHC class I Bw4 tetramers in complex with CD8+ T cell epitopes
    Geraldine M A Gillespie
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    AIDS Res Hum Retroviruses 23:451-5. 2007
    ..We speculate that our negative finding may be a consequence of the MHC class I molecules and peptide epitopes chosen, but could also relate to key amino acid differences that distinguish KIR3DS1 from KIR3DL1...
  51. pmc Modified vaccinia Ankara expressing HIVA antigen stimulates HIV-1-specific CD8 T cells in ELISpot assays of HIV-1 exposed infants
    Jennifer A Slyker
    Department of Medical Microbiology, University of Nairobi, Kenya
    Vaccine 23:4711-9. 2005
    ..These results demonstrate the relevance of HIV-1 clade A consensus-derived immunogen HIVA for the viruses currently circulating in Nairobi...
  52. ncbi Strong TCR conservation and altered T cell cross-reactivity characterize a B*57-restricted immune response in HIV-1 infection
    Geraldine M A Gillespie
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    J Immunol 177:3893-902. 2006
    ..Collectively, our findings highlight unusual features of the B*5701/B*5703-KF11-specific immune responses which could influence disease progression and that might be important to consider when designing future vaccine regimens...
  53. ncbi Modulation of interleukin-7 receptor expression characterizes differentiation of CD8 T cells specific for HIV, EBV and CMV
    François Boutboul
    Laboratoire d Immunologie Cellulaire, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    AIDS 19:1981-6. 2005
    ....
  54. pmc HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor
    Tao Dong
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS UK
    J Exp Med 200:1547-57. 2004
    ..Selection of Vbeta13.2 TCRs by some patients early in the FL8-specific CTL response may be linked with better clinical outcome...
  55. ncbi HIV-1 Env-specific cytotoxic T-lymphocyte responses in exposed, uninfected Kenyan sex workers: a prospective analysis
    Rupert Kaul
    Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
    AIDS 18:2087-9. 2004
    ..Annual HIV incidence was 5.8%. CTL were independently associated with age and recent HIV-1 exposure,but were not prospectively associated with protection in a multivariable model that included HIV-1 exposure and duration of sex work...
  56. pmc Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection
    Laura Papagno
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Biol 2:E20. 2004
    ..It can be driven by excessive levels of immune stimulation. This may be part of the mechanism through which HIV-1-mediated immune activation exhausts the capacity of the immune system...
  57. ncbi The HIV protease inhibitor indinavir reduces immature dendritic cell transendothelial migration
    Kathryn T Whelan
    Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, GB
    Eur J Immunol 33:2520-30. 2003
    ..Our results strongly suggest that IDV inhibits host proteases necessary for DC migration and may, therefore, affect DC immunoregulation in HIV-1-infected patients...
  58. ncbi Quantitative ex vivo analysis of functional virus-specific CD8 T lymphocytes in the blood and genital tract of HIV-infected women
    Rupert Kaul
    Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
    AIDS 17:1139-44. 2003
    ..The induction and monitoring of mucosal CD8 cell responses will be an important component of HIV-1 vaccine trials, but information regarding the frequency, phenotype and function of genital tract CD8 cell responses is lacking...
  59. ncbi Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression
    Victor Appay
    Medical Research Council Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    AIDS 16:161-70. 2002
    ..It leads to significant reductions of plasma viremia, often to undetectable levels, but it can also be linked with the reduction and disappearance of detectable HIV-specific CD8 T-cell responses...