Jan Willem Voncken

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. pmc Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition
    Jan Willem Voncken
    Division of Molecular Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 100:2468-73. 2003
  2. doi request reprint Genetic modification of the mouse: general technology - pronuclear and blastocyst injection
    Jan Willem Voncken
    Department of Molecular Genetics, Maastricht University Medical Center, Maastricht, The Netherlands
    Methods Mol Biol 693:11-36. 2011
  3. ncbi request reprint MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1
    Jan Willem Voncken
    Research Institute Growth and Development, Molecular Genetics, Maastricht University, Universiteitssingel 50, 6200 MD, Maastricht, The Netherlands
    J Biol Chem 280:5178-87. 2005
  4. pmc Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
    Marianne Koritzinsky
    Department of Radiation Oncology MAASTRO, GROW Research Institute, University of Maastricht, The Netherlands
    EMBO J 25:1114-25. 2006
  5. pmc Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3
    Peggy Prickaerts
    Department of Molecular Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands
    Epigenetics Chromatin 9:46. 2016
  6. ncbi request reprint A novel in vivo model to study endochondral bone formation; HIF-1alpha activation and BMP expression
    Pieter J Emans
    Department of Orthopedic Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Bone 40:409-18. 2007
  7. pmc Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia
    Michiel E Adriaens
    Maastricht Centre for Systems Biology MaCSBio, Maastricht University, Maastricht, The Netherlands Department of Bioinformatics BiGCaT, Maastricht University, Maastricht, The Netherlands
    Epigenetics Chromatin 9:48. 2016
  8. pmc Mapping of protein- and chromatin-interactions at the nuclear lamina
    Nard Kubben
    Center for Heart Failure Research, Maastricht, The Netherlands
    Nucleus 1:460-71. 2010
  9. pmc Talking to chromatin: post-translational modulation of polycomb group function
    Hanneke E C Niessen
    Molecular Genetics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Epigenetics Chromatin 2:10. 2009
  10. pmc MK3 modulation affects BMI1-dependent and independent cell cycle check-points
    Peggy Prickaerts
    Department of Molecular Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 10:e0118840. 2015

Collaborators

Detail Information

Publications10

  1. pmc Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition
    Jan Willem Voncken
    Division of Molecular Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 100:2468-73. 2003
    ..Importantly, this finding implicates Polycomb-mediated repression of the Cdkn2a locus in early murine development...
  2. doi request reprint Genetic modification of the mouse: general technology - pronuclear and blastocyst injection
    Jan Willem Voncken
    Department of Molecular Genetics, Maastricht University Medical Center, Maastricht, The Netherlands
    Methods Mol Biol 693:11-36. 2011
    ..This chapter describes classic biotechnological methods used to generate mice from modified pre-implantation embryos...
  3. ncbi request reprint MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1
    Jan Willem Voncken
    Research Institute Growth and Development, Molecular Genetics, Maastricht University, Universiteitssingel 50, 6200 MD, Maastricht, The Netherlands
    J Biol Chem 280:5178-87. 2005
    ..This suggests a novel mechanism by which a silenced gene status can be modulated and implicates PcG-mediated repression as a dynamically controlled process...
  4. pmc Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
    Marianne Koritzinsky
    Department of Radiation Oncology MAASTRO, GROW Research Institute, University of Maastricht, The Netherlands
    EMBO J 25:1114-25. 2006
    ..Together, our data indicate that acute and prolonged hypoxia regulates mRNA translation through distinct mechanisms, each with important contributions to hypoxic gene expression...
  5. pmc Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3
    Peggy Prickaerts
    Department of Molecular Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands
    Epigenetics Chromatin 9:46. 2016
    ..Using the MCF7 breast epithelial adenocarcinoma cell model, we have determined the relationship between epigenomic and transcriptomic reprogramming as a function of fluctuating oxygen tension...
  6. ncbi request reprint A novel in vivo model to study endochondral bone formation; HIF-1alpha activation and BMP expression
    Pieter J Emans
    Department of Orthopedic Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Bone 40:409-18. 2007
    ..Our model recapitulates essential steps in osteochondrogenesis and provides a new experimental system to study and ultimately control tissue regeneration in the adult organism...
  7. pmc Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia
    Michiel E Adriaens
    Maastricht Centre for Systems Biology MaCSBio, Maastricht University, Maastricht, The Netherlands Department of Bioinformatics BiGCaT, Maastricht University, Maastricht, The Netherlands
    Epigenetics Chromatin 9:48. 2016
    ..Where traditionally ChIP-seq data are often treated as dichotomous data, the model and experiment here necessitate a quantitative, data-driven analysis of both datasets...
  8. pmc Mapping of protein- and chromatin-interactions at the nuclear lamina
    Nard Kubben
    Center for Heart Failure Research, Maastricht, The Netherlands
    Nucleus 1:460-71. 2010
    ..Here we summarize and critically discuss recent technology to analyze lamina-protein and-chromatin interactions...
  9. pmc Talking to chromatin: post-translational modulation of polycomb group function
    Hanneke E C Niessen
    Molecular Genetics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Epigenetics Chromatin 2:10. 2009
    ..Ultimately, increased understanding of signaling to chromatin and the mechanisms involved in epigenetic remodeling will contribute to the development of therapeutic interventions in cell fate decisions in development and disease...
  10. pmc MK3 modulation affects BMI1-dependent and independent cell cycle check-points
    Peggy Prickaerts
    Department of Molecular Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 10:e0118840. 2015
    ....