P Schrauwen

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Reduced skeletal muscle uncoupling protein-3 content in prediabetic subjects and type 2 diabetic patients: restoration by rosiglitazone treatment
    Patrick Schrauwen
    Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, P O Box 616, NL 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 91:1520-5. 2006
  2. ncbi request reprint The effect of high-fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3-ablated mice
    Joris Hoeks
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    FEBS Lett 580:1371-5. 2006
  3. ncbi request reprint Involvement of UCP3 in mild uncoupling and lipotoxicity
    Joris Hoeks
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, NL 6200 MD, Maastricht, The Netherlands
    Exp Gerontol 41:658-62. 2006
  4. pmc Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle
    Silvie Timmers
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    PLoS ONE 6:e14503. 2011
  5. ncbi request reprint Changes in fat oxidation in response to a high-fat diet
    P Schrauwen
    Department of Human Biology, Maastricht University, Netherlands
    Am J Clin Nutr 66:276-82. 1997
  6. ncbi request reprint UCP2 and UCP3 in muscle controlling body metabolism
    Patrick Schrauwen
    Nutrition and Toxicology Research Institute Maastricht NUTRIM Department of Human Biology, Maastricht University, The Netherlands
    J Exp Biol 205:2275-85. 2002
  7. ncbi request reprint Etomoxir-induced increase in UCP3 supports a role of uncoupling protein 3 as a mitochondrial fatty acid anion exporter
    Patrick Schrauwen
    Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
    FASEB J 16:1688-90. 2002
  8. pmc Reduced tricarboxylic acid cycle flux in type 2 diabetes mellitus?
    P Schrauwen
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Diabetologia 51:1694-7. 2008
  9. ncbi request reprint Physical activity and diabetes: current considerations
    Patrick Schrauwen
    Department of Human Biology, Maastricht University, Nutrition and Toxicology Research Institute, The Netherlands
    Appl Physiol Nutr Metab 32:535-6. 2007
  10. ncbi request reprint High-fat diet, muscular lipotoxicity and insulin resistance
    Patrick Schrauwen
    Department of Human Biology, Maastricht University, Wageningen Center for Food Sciences and Nutrition and Toxicology Research Institute Maastricht, PO Box 616, NL 6200 MD, Maastricht, The Netherlands
    Proc Nutr Soc 66:33-41. 2007

Detail Information

Publications97

  1. ncbi request reprint Reduced skeletal muscle uncoupling protein-3 content in prediabetic subjects and type 2 diabetic patients: restoration by rosiglitazone treatment
    Patrick Schrauwen
    Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, P O Box 616, NL 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 91:1520-5. 2006
    ..Recent evidence points toward mitochondrial aberrations as a major contributor to the development of insulin resistance and diabetes, and UCP3 is reduced in diabetes...
  2. ncbi request reprint The effect of high-fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3-ablated mice
    Joris Hoeks
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    FEBS Lett 580:1371-5. 2006
    ..Succinate dehydrogenase activity, and total protein content of the muscle fatty acid transporter FAT/CD36 were however similar between UCP3-/- and UCP3+/+ mice...
  3. ncbi request reprint Involvement of UCP3 in mild uncoupling and lipotoxicity
    Joris Hoeks
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, NL 6200 MD, Maastricht, The Netherlands
    Exp Gerontol 41:658-62. 2006
    ..Whether UCP3 is causally related to mitochondrial dysfunction and is essential in the prevention and treatment of lipid-induced mitochondrial dysfunction requires further study...
  4. pmc Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle
    Silvie Timmers
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    PLoS ONE 6:e14503. 2011
    ....
  5. ncbi request reprint Changes in fat oxidation in response to a high-fat diet
    P Schrauwen
    Department of Human Biology, Maastricht University, Netherlands
    Am J Clin Nutr 66:276-82. 1997
    ..05), reaching a new balance on day 13, 7 d afterward. In conclusion, when in energy balance, lean subjects are capable of adjusting fat oxidation to fat intake within 7 d of when dietary fat content is increased...
  6. ncbi request reprint UCP2 and UCP3 in muscle controlling body metabolism
    Patrick Schrauwen
    Nutrition and Toxicology Research Institute Maastricht NUTRIM Department of Human Biology, Maastricht University, The Netherlands
    J Exp Biol 205:2275-85. 2002
    ..Therefore, UCP2 and UCP3 remain interesting targets for pharmacological upregulation in the treatment of obesity and diabetes...
  7. ncbi request reprint Etomoxir-induced increase in UCP3 supports a role of uncoupling protein 3 as a mitochondrial fatty acid anion exporter
    Patrick Schrauwen
    Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
    FASEB J 16:1688-90. 2002
    ..In addition our data show that up-regulation of uncoupling protein-3 can be beneficial in the treatment of type 2 diabetes...
  8. pmc Reduced tricarboxylic acid cycle flux in type 2 diabetes mellitus?
    P Schrauwen
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Diabetologia 51:1694-7. 2008
    ..Here we re-interpret previously published data on [(13)C]acetate recovery in breath gas obtained during exercise in type 2 diabetic patients and control individuals...
  9. ncbi request reprint Physical activity and diabetes: current considerations
    Patrick Schrauwen
    Department of Human Biology, Maastricht University, Nutrition and Toxicology Research Institute, The Netherlands
    Appl Physiol Nutr Metab 32:535-6. 2007
    ..The reviews in this issue of Applied Physiology, Nutrition, and Metabolism discuss the current knowledge on the role of physical activity in the prevention and treatment of diabetes...
  10. ncbi request reprint High-fat diet, muscular lipotoxicity and insulin resistance
    Patrick Schrauwen
    Department of Human Biology, Maastricht University, Wageningen Center for Food Sciences and Nutrition and Toxicology Research Institute Maastricht, PO Box 616, NL 6200 MD, Maastricht, The Netherlands
    Proc Nutr Soc 66:33-41. 2007
    ..Thus, muscular lipotoxicity may impair mitochondrial function and may be central to insulin resistance and type 2 diabetes mellitus...
  11. ncbi request reprint Putative function and physiological relevance of the mitochondrial uncoupling protein-3: involvement in fatty acid metabolism?
    Patrick Schrauwen
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Prog Lipid Res 45:17-41. 2006
    ..Such function may be clinically relevant in the development of type 2 diabetes mellitus, a condition characterized by muscular fat accumulation, mitochondrial damage and low levels of UCP3...
  12. ncbi request reprint Acylation-stimulating protein: effect of acute exercise and endurance training
    P Schrauwen
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, The Netherlands
    Int J Obes (Lond) 29:632-8. 2005
    ..Acylation-stimulating protein (ASP) is an adipocyte-derived protein that contributes to fatty acid clearance. Regular exercise training improves fatty acid handling...
  13. ncbi request reprint The role of uncoupling protein 3 in fatty acid metabolism: protection against lipotoxicity?
    Patrick Schrauwen
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Departments of Human Biology and Movement Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Proc Nutr Soc 63:287-92. 2004
    ....
  14. ncbi request reprint Uncoupling protein 3 and physical activity: the role of uncoupling protein 3 in energy metabolism revisited
    Patrick Schrauwen
    Nutrition and Toxicology Research Institute Maastricht, Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Proc Nutr Soc 62:635-43. 2003
    ....
  15. ncbi request reprint Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes
    Patrick Schrauwen
    Department of Human Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, Netherlands
    Diabetes 53:1412-7. 2004
    ..Disturbances in this protection mechanism can contribute to the development of type 2 diabetes...
  16. ncbi request reprint The effect of a 3-month low-intensity endurance training program on fat oxidation and acetyl-CoA carboxylase-2 expression
    Patrick Schrauwen
    Department of Human Biology, Nutrition, Toxicology and Environmental Research Institute NUTRIM, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Diabetes 51:2220-6. 2002
    ..07). In conclusion, a minimal amount of physical activity tends to increase fat oxidation and leads to marked changes in the expression of genes encoding for key enzymes in fat metabolism...
  17. doi request reprint Mitochondrial dysfunction and lipotoxicity
    Patrick Schrauwen
    Maastricht University Medical Centre MUMC, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Human Biology, P O Box 616, 6200 MD Maastricht, The Netherlands
    Biochim Biophys Acta 1801:266-71. 2010
    ..These findings support the hypothesis that fat accumulation in skeletal muscle may precede the reduction in mitochondrial function that is observed in type 2 diabetes mellitus...
  18. ncbi request reprint The effect of mild cold exposure on UCP3 mRNA expression and UCP3 protein content in humans
    P Schrauwen
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, The Netherlands
    Int J Obes Relat Metab Disord 26:450-7. 2002
    ..The recently discovered human uncoupling protein 3 is a possible candidate for adaptive thermogenesis in humans. In the present study we examined the effect of mild cold exposure on the mRNA and protein expression of UCP3...
  19. pmc Validation of the [1,2-13C]acetate recovery factor for correction of [U-13C]palmitate oxidation rates in humans
    P Schrauwen
    Department of Human Biology, Maastricht University, The Netherlands
    J Physiol 513:215-23. 1998
    ..The extent of label fixation could largely be explained by accumulation of tracer carbon in glutamine and glutamate, and the accumulation in glucose is negligible...
  20. ncbi request reprint Skeletal muscle UCP2 and UCP3 expression in trained and untrained male subjects
    P Schrauwen
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 23:966-72. 1999
    ..Endurance training has been suggested to have effects on resting metabolic rate and energy efficiency. We therefore determined UCP2 and UCP3 mRNA levels in skeletal muscle of trained and untrained male subjects...
  21. ncbi request reprint Determinants of the acetate recovery factor: implications for estimation of [13C]substrate oxidation
    P Schrauwen
    Department of Human Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Clin Sci (Lond) 98:587-92. 2000
    ..Failure to do this might result in large under- or over-estimation of plasma substrate oxidation, and hence to artificial differences between groups...
  22. ncbi request reprint Increase in fat oxidation on a high-fat diet is accompanied by an increase in triglyceride-derived fatty acid oxidation
    P Schrauwen
    Department of Human Biology, Maastricht University, The Netherlands
    Diabetes 49:640-6. 2000
    ....
  23. ncbi request reprint The role of high-fat diets and physical activity in the regulation of body weight
    P Schrauwen
    Department of Human Biology, Maastricht University, The Netherlands
    Br J Nutr 84:417-27. 2000
    ..In conclusion, the increased intake of dietary fat and a decreasing physical activity level are the most important environmental factors explaining the increased prevalence of obesity in westernized societies...
  24. ncbi request reprint Fiber type dependent upregulation of human skeletal muscle UCP2 and UCP3 mRNA expression by high-fat diet
    P Schrauwen
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 25:449-56. 2001
    ....
  25. ncbi request reprint Improved glucose homeostasis in mice overexpressing human UCP3: a role for AMP-kinase?
    P Schrauwen
    Department of Human Biology, Maastricht University, The Netherlands
    Int J Obes Relat Metab Disord 28:824-8. 2004
    ..Since overexpression of UCP3 might affect the energy charge of the cell, we investigated whether these mice have an increased AMP-activated protein kinase (AMPK) activity...
  26. ncbi request reprint An alternative function for human uncoupling protein 3: protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix
    P Schrauwen
    Department of Human Biology, Maastricht University, The Netherlands
    FASEB J 15:2497-502. 2001
    ..In this way, UCP3 is involved in the protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix...
  27. ncbi request reprint Uncoupling protein 3 content is decreased in skeletal muscle of patients with type 2 diabetes
    P Schrauwen
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Diabetes 50:2870-3. 2001
    ..In conclusion, UCP3 content is lower in type 2 diabetic patients compared with healthy control subjects. These results are consistent with a role for UCP3 in glucose homeostasis and suggest a role for UCP3 in type 2 diabetes...
  28. ncbi request reprint Effect of acute exercise on uncoupling protein 3 is a fat metabolism-mediated effect
    Patrick Schrauwen
    Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 282:E11-7. 2002
    ..Therefore, the previously observed increase in UCP3 expression appears to be an effect of prolonged elevation of plasma FFA levels and/or increased fatty acid oxidation...
  29. ncbi request reprint Skeletal muscle uncoupling protein 3 (UCP3): mitochondrial uncoupling protein in search of a function
    Patrick Schrauwen
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, The Netherlands
    Curr Opin Clin Nutr Metab Care 5:265-70. 2002
    ..Therefore, uncoupling protein 3 remains an interesting target for pharmacological upregulation in the treatment of obesity and diabetes...
  30. ncbi request reprint Uncoupling protein 3 as a mitochondrial fatty acid anion exporter
    Patrick Schrauwen
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, The Netherlands
    FASEB J 17:2272-4. 2003
    ..These data are compatible with a physiological function of UCP3 in facilitating outward transport of long-chain fatty acid anions, which cannot be oxidized, from the mitochondrial matrix...
  31. ncbi request reprint Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Int J Obes (Lond) 31:1302-10. 2007
    ....
  32. ncbi request reprint Skeletal muscle uncoupling protein-3 restores upon intervention in the prediabetic and diabetic state: implications for diabetes pathogenesis?
    M Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetes Obes Metab 9:594-6. 2007
    ..Here we examined whether intervention programs known to improve insulin sensitivity are paralleled by an increase in skeletal muscle UCP3 protein levels...
  33. ncbi request reprint Short-term training is accompanied by a down regulation of ACC2 mRNA in skeletal muscle
    V B Schrauwen-Hinderling
    Department of Radiology, University Hospital Maastricht, Maastricht, The Netherlands
    Int J Sports Med 27:786-91. 2006
    ..The present data are in line with the hypothesis that the fat oxidative capacity might be more important than the IMCL content in determining insulin sensitivity...
  34. ncbi request reprint Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects
    V B Schrauwen-Hinderling
    Department of Radiology, University Hospital Maastricht, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Diabetologia 50:113-20. 2007
    ..As obesity is an independent determinant of IMCL content, we examined mitochondrial function and IMCL content in overweight type 2 diabetes patients and BMI-matched normoglycaemic controls...
  35. pmc Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals
    E Phielix
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Human Biology, Maastricht University Medical Centre, P O Box 616, NL6200 MD Maastricht, The Netherlands
    Diabetologia 53:1714-21. 2010
    ..Here, we examined if exercise training could increase intrinsic mitochondrial function in diabetic patients compared with control individuals...
  36. ncbi request reprint Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids
    J Hoeks
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Diabetologia 49:2419-26. 2006
    ..We examined whether lipid-induced insulin resistance was associated with downregulation of expression of skeletal muscle genes involved in oxidative metabolism and mitochondrial biogenesis in humans...
  37. ncbi request reprint Uncoupling protein-3 content is decreased in peripheral skeletal muscle of patients with COPD
    H R Gosker
    Dept of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Eur Respir J 22:88-93. 2003
    ..The low uncoupling protein-3 content is independent of the loss of oxidative capacity observed in these patients...
  38. doi request reprint PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle
    A H V Remels
    Department of Respiratory Medicine, Maastricht University, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 297:E174-83. 2009
    ..These findings demonstrate that muscle-specific inhibition of NF-kappaB activation may be an interesting therapeutic avenue for treatment of several inflammation-associated skeletal muscle abnormalities...
  39. ncbi request reprint PPARgamma activity in subcutaneous abdominal fat tissue and fat mass gain during short-term overfeeding
    A M C P Joosen
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Int J Obes (Lond) 30:302-7. 2006
    ..As the peroxisome proliferator-activated receptor gamma (PPARgamma) plays a central role in fat mass regulation, we investigated whether initial subcutaneous PPARgamma activity is related to fat mass generation during overfeeding...
  40. pmc Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity
    Ruth C R Meex
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes 59:572-9. 2010
    ..We examined whether exercise training could restore mitochondrial function and insulin sensitivity in patients with type 2 diabetes...
  41. ncbi request reprint Effect of 2 weeks of endurance training on uncoupling protein 3 content in untrained human subjects
    P Schrauwen
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, PO Box 616, NL 6200 MD Maastricht, The Netherlands
    Acta Physiol Scand 183:273-80. 2005
    ..Here, we examined the effect of a 2-week training programme on skeletal muscle UCP3 protein content in untrained human subjects, and hypothesized that UCP3 will be reduced after the training programme...
  42. doi request reprint Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity
    M Bosma
    Department of Human Biology, NUTRIM, Maastricht University Medical Centre, The Netherlands
    Biochim Biophys Acta 1831:844-52. 2013
    ..Here we investigated the effects of PLIN5 overexpression - in comparison with the effects of PLIN2 - on skeletal muscle lipid levels, gene expression profiles and insulin sensitivity...
  43. doi request reprint TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia?
    A H V Remels
    Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    FASEB J 24:5052-62. 2010
    ..In conclusion, these results demonstrate that TNF-α impairs muscle oxphen in a NF-κB-dependent manner...
  44. ncbi request reprint UCP3 in muscle wasting, a role in modulating lipotoxicity?
    Ronnie Minnaard
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    FEBS Lett 580:5172-6. 2006
    ..Muscular levels of the lipid peroxidation byproduct 4-hydroxy-2-nonenal (4-HNE) were increased at days 6 and 11 in zymosan-treated rats, supporting a role for UCP3 in modulating lipotoxicity during cachexia...
  45. doi request reprint The use of statins potentiates the insulin-sensitizing effect of exercise training in obese males with and without Type 2 diabetes
    Ruth C R Meex
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Clin Sci (Lond) 119:293-301. 2010
    ..The combined prescription of statins along with exercise training is safe and should be considered for subjects prone to develop insulin resistance...
  46. ncbi request reprint Muscular mitochondrial dysfunction and type 2 diabetes mellitus
    Vera B Schrauwen-Hinderling
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 10:698-703. 2007
    ..Here, we review human studies that investigated various aspects of mitochondrial function in relation to muscular insulin sensitivity and/or diabetes...
  47. ncbi request reprint Substrate oxidation differences between high- and low-intensity exercise are compensated over 24 hours in obese men
    W H M Saris
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Int J Obes Relat Metab Disord 28:759-65. 2004
    ..It is however unclear what is the most beneficial exercise regime for obese people. We therefore studied the effect of either high-intensity (HI) or LI exercise on 24 h energy expenditure (24 h EE) and substrate metabolism...
  48. ncbi request reprint Towards comprehension of the physiological role of UCP3
    M K Hesselink
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, The Netherlands
    Horm Metab Res 37:550-4. 2005
    ..The present review aims to provide an overview of studies testing the feasibility of this unconventional function of UCP3...
  49. pmc Exercise-induced modulation of cardiac lipid content in healthy lean young men
    L Bilet
    NUTRIM, School of Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    Basic Res Cardiol 106:307-15. 2011
    ..Although the lower cardiac energy status is in line with a lipotoxic action of cardiac lipid content, a causal relationship cannot be proven...
  50. doi request reprint Adaptations in mitochondrial function parallel, but fail to rescue, the transition to severe hyperglycemia and hyperinsulinemia: a study in Zucker diabetic fatty rats
    Ellen Lenaers
    NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Obesity (Silver Spring) 18:1100-7. 2010
    ..In fact, improved mitochondrial capacity in hyperinsulinemic hyperglycemic rats does not rescue the progression toward advanced stages of insulin resistance...
  51. doi request reprint The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice
    Miranda Nabben
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
    FEBS Lett 582:4147-52. 2008
    ..State 4o respiration was higher in UCP3Tg animals. To conclude, UCP3 overexpression leads to increased state 4o respiration and, in presence of 4-HNE, blunts the age-induced increase in ROS production...
  52. doi request reprint Regulation of mitochondrial biogenesis during myogenesis
    A H V Remels
    Department of Respiratory Medicine, Maastricht University Medical Centre, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Mol Cell Endocrinol 315:113-20. 2010
    ..In particular, PGC-1alpha and PPAR-alpha may be involved in the regulation of mitochondrial biogenesis during myogenesis...
  53. ncbi request reprint Energy metabolism in humans at a lowered ambient temperature
    M S Westerterp-Plantenga
    Department of Human Biology, University of Maastricht, Maastricht, The Netherlands
    Eur J Clin Nutr 56:288-96. 2002
    ..Assessment of the effect of a lowered ambient temperature, ie 16 degrees C (61 degrees F), compared to 22 degrees C (72 degrees F), on energy intake (EI), energy expenditure (EE) and respiratory quotient (RQ) in men...
  54. ncbi request reprint DGAT1 overexpression in muscle by in vivo DNA electroporation increases intramyocellular lipid content
    Berber D Roorda
    Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Lipid Res 46:230-6. 2005
    ..14%; P <0.05). Our findings indicate that DGAT1 contributes to the storage of IMCL and that in vivo DNA electroporation is a promising tool to examine the functional consequences of altered gene expression in mature skeletal muscle...
  55. doi request reprint Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice
    S Paglialunga
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, The Netherlands
    Diabetologia 55:2759-68. 2012
    ..Here we investigated whether mitochondrial ROS sequestering can circumvent HF-induced oxidative stress; we also determined the impact of any reduced oxidative stress on muscle insulin sensitivity and mitochondrial function...
  56. pmc Acute exercise does not decrease liver fat in men with overweight or NAFLD
    L Bilet
    1 NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands 2 Department of Human Biology, Maastricht University Medical Center, Maastricht, The Netherlands
    Sci Rep 5:9709. 2015
    ..Moreover, IHL increased 4 h post-exercise in the fasted condition, an increase that was absent in the glucose-supplemented condition. These data suggest that a single bout of exercise may not be able to lower IHL. ..
  57. ncbi request reprint Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD
    A H Remels
    Department of Respiratory Medicine, University of Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 30:245-52. 2007
    ..Therefore, a disturbed expression of these regulatory factors may well underlie the disturbed skeletal muscle functioning in chronic obstructive pulmonary disease...
  58. doi request reprint Peroxisome proliferator-activated receptors: a therapeutic target in COPD?
    A H Remels
    Dept of Respiratory Medicine, University of Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 31:502-8. 2008
    ..Proposed mechanisms will be outlined in the present article, as well as the therapeutic potential of peroxisome proliferator-activated receptor modulation in the treatment of skeletal muscle dysfunction...
  59. pmc Human skeletal muscle mitochondrial uncoupling is associated with cold induced adaptive thermogenesis
    Sander L J Wijers
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, The Netherlands
    PLoS ONE 3:e1777. 2008
    ..Therefore we hypothesized that cold-induced adaptive thermogenesis in humans is accompanied by an increase in mitochondrial uncoupling in skeletal muscle...
  60. doi request reprint Improved ejection fraction after exercise training in obesity is accompanied by reduced cardiac lipid content
    Vera B Schrauwen-Hinderling
    Department of Radiology, Maastricht University Medical Center, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Clin Endocrinol Metab 95:1932-8. 2010
    ..In skeletal muscle, physical activity paradoxically increases fat accumulation, despite improvement in insulin sensitivity. Whether cardiac muscle responds similarly remains unknown...
  61. doi request reprint The insulin-sensitizing effect of rosiglitazone in type 2 diabetes mellitus patients does not require improved in vivo muscle mitochondrial function
    Vera B Schrauwen-Hinderling
    Department of Radiology, Maastricht University Hospital, Maastricht, The Netherlands
    J Clin Endocrinol Metab 93:2917-21. 2008
    ..Our objective was to investigate whether improved in vivo mitochondrial function in skeletal muscle and intramyocellular lipids (IMCLs) contribute to the insulin-sensitizing effect of rosiglitazone...
  62. doi request reprint Cold-activated brown adipose tissue in healthy men
    Wouter D van Marken Lichtenbelt
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, The Netherlands
    N Engl J Med 360:1500-8. 2009
    ..Brown-adipose-tissue activity was studied in relation to body composition and energy metabolism...
  63. pmc Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance
    Joris Hoeks
    Department of Human Biology, School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes 59:2117-25. 2010
    ..It is therefore anticipated that skeletal muscle mitochondrial function is maintained to accommodate increased fat oxidation unless factors secondary to insulin resistance exert negative effects on mitochondrial function...
  64. pmc Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients
    Esther Phielix
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Diabetes 57:2943-9. 2008
    ..The nature of this reduction is unknown. Here, we tested the hypothesis that a lower intrinsic mitochondrial respiratory capacity may underlie lower in vivo mitochondrial function observed in diabetic patients...
  65. doi request reprint Adipocyte differentiation-related protein and OXPAT in rat and human skeletal muscle: involvement in lipid accumulation and type 2 diabetes mellitus
    Ronnie Minnaard
    NUTRIM School for Nutrition, Toxicology, and Metabolism, Department of Human Movement Sciences, Maastricht University Medical Center, NL 6200 MD Maastricht, The Netherlands
    J Clin Endocrinol Metab 94:4077-85. 2009
    ..Lipid droplet proteins of the PAT [perilipin, adipocyte differentiation-related protein (ADRP), and TIP47] family have been shown to regulate lipid accumulation and intracellular metabolism in other tissues...
  66. doi request reprint Mitochondrial function, content and ROS production in rat skeletal muscle: effect of high-fat feeding
    Joris Hoeks
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    FEBS Lett 582:510-6. 2008
    ..Intramyocellular lipid levels increased significantly illustrating that a reduced innate mitochondrial function is not a prerequisite for intra-muscular fat accumulation...
  67. ncbi request reprint Exercise training restores uncoupling protein-3 content in limb muscles of patients with chronic obstructive pulmonary disease
    Harry R Gosker
    Dept of Respiratory Medicine, Maastricht Univ, Nutrition and Toxicology Research Institute Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 290:E976-81. 2006
    ..We conclude that exercise-training can restore muscle UCP3 protein level in COPD, and the nature of this response complies with the hypothesis that UCP3 may protect against lipotoxicity...
  68. ncbi request reprint Effect of beta1- and beta2-adrenergic stimulation on energy expenditure, substrate oxidation, and UCP3 expression in humans
    Joris Hoeks
    NUTRIM, Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 285:E775-82. 2003
    ....
  69. ncbi request reprint Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation
    Joris Hoeks
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    FEBS Lett 555:631-7. 2003
    ..This study supports a role of UCP3 in export of non-metabolizable fatty acids...
  70. ncbi request reprint Eat the meat or feed the meat: protein turnover in remodeling muscle
    Matthijs K C Hesselink
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Movement Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
    Curr Opin Clin Nutr Metab Care 9:672-6. 2006
    ..The present review outlines the role of muscle protein turnover in muscle remodeling, with emphasis on the effects of nutrition and exercise...
  71. doi request reprint Diet and nonalcoholic fatty liver disease
    Ronald P Mensink
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Curr Opin Lipidol 19:25-9. 2008
    ..The purpose of this review is to summarize recent findings from human studies on dietary effects on hepatic lipid accumulation...
  72. ncbi request reprint The use of the [1,2-13C]acetate recovery factor in metabolic research
    Luc J C van Loon
    Nutrition Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Appl Physiol 89:377-83. 2003
    ..Therefore, theoretical acetate recovery factors taken from previous literature are not generally applicable...
  73. ncbi request reprint Individual variation in body temperature and energy expenditure in response to mild cold
    Wouter D van Marken Lichtenbelt
    Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 282:E1077-83. 2002
    ..This shows that interindividual differences exist with respect to the relative contribution of metabolic and insulative adaptations to cold...
  74. ncbi request reprint Human uncoupling protein-3 and obesity: an update
    Matthijs K C Hesselink
    Department of Movement Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands
    Obes Res 11:1429-43. 2003
    ..Regardless of the origin of the fatty acid anions, this putative function of UCP3 might be of great importance in protecting mitochondria against fatty acid accumulation and may help to maintain muscular fat oxidative capacity...
  75. pmc Increased uncoupling protein 3 content does not affect mitochondrial function in human skeletal muscle in vivo
    Matthijs K C Hesselink
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Clin Invest 111:479-86. 2003
    ..Taken together, our findings demonstrate that increasing muscle UCP3 expression does not diminish the rate of PCr resynthesis, allowing us to conclude that the primary role of UCP3 in humans is not uncoupling...
  76. doi request reprint Low brown adipose tissue activity in endurance-trained compared with lean sedentary men
    M J Vosselman
    Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    Int J Obes (Lond) 39:1696-702. 2015
    ..Our objective was to test whether endurance-trained athletes had increased cold-stimulated BAT activity and browning of subcutaneous WAT compared with lean sedentary males...
  77. doi request reprint Increase in brown adipose tissue activity after weight loss in morbidly obese subjects
    G H E J Vijgen
    Department of Human Biology, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    J Clin Endocrinol Metab 97:E1229-33. 2012
    ..Stimulation of thermogenesis in brown adipose tissue (BAT) is a potential target to treat obesity. We earlier demonstrated that BAT activity is relatively low in obese subjects. It is unknown whether BAT can be recruited in adult humans...
  78. doi request reprint Modulation of myocellular fat stores: lipid droplet dynamics in health and disease
    Ruth C R Meex
    Departments of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 297:R913-24. 2009
    ....
  79. ncbi request reprint Intramyocellular lipids and insulin sensitivity: does size really matter?
    Matthijs K C Hesselink
    Departments of Movement Sciences, Maastricht University, Nutrition and Toxiology Research Institute Maastricht, The Netherlands
    Obes Res 12:741-2. 2004
  80. doi request reprint Prolonged fasting and the effects on biomarkers of inflammation and on adipokines in healthy lean men
    N A van Herpen
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    Horm Metab Res 45:378-82. 2013
    ..In healthy young lean men, fasting-induced increases in FFAs leading to insulin resistance do not cause changes in concentrations of the inflammatory cytokines. VEGF concentrations increased and those of chemerin decreased...
  81. doi request reprint The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men
    E Konings
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    Int J Obes (Lond) 38:470-3. 2014
    ..Further research is necessary to investigate whether resveratrol improves adipose tissue function. ..
  82. pmc Differential effects of saturated versus unsaturated dietary fatty acids on weight gain and myocellular lipid profiles in mice
    S Timmers
    1 Top Institute Food and Nutrition TIFN, Wageningen, The Netherlands 2 Department of Human Biology, School for Nutrition, Toxicology and Metabolism NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    Nutr Diabetes 1:e11. 2011
    ..Conclusion:Already after a relatively short period, the dietary FA intake relates to the FA composition of the lipid metabolites in the muscle. A diet rich in polyunsaturated FAs seems to prevent myocellular lipid accumulation...
  83. doi request reprint Muscular diacylglycerol metabolism and insulin resistance
    Silvie Timmers
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, The Netherlands
    Physiol Behav 94:242-51. 2008
    ..Furthermore, we will discuss if and how modulation of skeletal muscle DAG levels could function as a possible therapeutic target for the treatment of type 2 diabetes mellitus...
  84. ncbi request reprint Intramyocellular lipid content and molecular adaptations in response to a 1-week high-fat diet
    Vera B Schrauwen-Hinderling
    Department of Radiology, University Hospital Maastricht, The Netherlands
    Obes Res 13:2088-94. 2005
    ..To investigate molecular adaptations that accompany the elevation of intramyocellular lipid (IMCL) content on a high-fat (HF) diet for 1 week...
  85. ncbi request reprint Reduced adipose tissue triglyceride synthesis and increased muscle fatty acid oxidation in C5L2 knockout mice
    Sabina Paglialunga
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Endocrinol 194:293-304. 2007
    ..05) were significantly increased in C5L2KO mice versus WT (100%). The study shows that in response to reduced TG storage in white adipose tissue, C5L2KO mice have developed a compensatory mechanism of increased muscle fat oxidation...
  86. doi request reprint Shift in metabolic fuel in acylation-stimulating protein-deficient mice following a high-fat diet
    Christian Roy
    Centre de recherche Hopital Laval, Y 2186, Chemin Ste Foy, QC, Canada
    Am J Physiol Endocrinol Metab 294:E1051-9. 2008
    ..However, these in vivo data suggest that ASP inhibition could be a potentially viable approach in correcting muscle metabolic dysfunction in obesity...
  87. ncbi request reprint Divergent effects of acute exercise and endurance training on UCP3 expression
    Matthijs K C Hesselink
    Am J Physiol Endocrinol Metab 284:E449-50; author reply 450-1. 2003
  88. doi request reprint Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes
    Henk M De Feyter
    Yale University, MRRC, TAC N 136, 300 Cedar St, PO Box 208043, New Haven, CT 06520 8043, USA
    FASEB J 22:3947-55. 2008
    ..Accordingly, we can conclude that in the ZDF rat model, type 2 diabetes develops in the absence of skeletal muscle mitochondrial dysfunction...
  89. ncbi request reprint Of the fit and the fat: mitochondrial abnormalities and type 2 diabetes mellitus
    Patrick Schrauwen
    J Clin Endocrinol Metab 92:1229-31. 2007
  90. ncbi request reprint The effect of etomoxir on 24-h substrate oxidation and satiety in humans
    Vera B Hinderling
    Institute of Animal Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Clin Nutr 76:141-7. 2002
    ..The carnitine O-palmitoyltransferase I (EC 2.3.1.21) inhibitor etomoxir inhibits fatty acid oxidation, and hepatic fatty acid oxidation has been suggested to be a metabolic satiety signal in subjects who consume high-fat diets...
  91. ncbi request reprint Decreased uncoupling protein expression and intramyocytic triglyceride depletion in formerly obese subjects
    Geltrude Mingrone
    Istituto di Clinica Medica and Clinica Chirurgica and Centro CNR Fisiopatologia Shock, Universita Cattolica S Cuore, Rome, Italy
    Obes Res 11:632-40. 2003
    ..To examine the muscular uncoupling protein expression 2 (UCP2) and UCP3 gene expression in morbid obese subjects before and after bariatric surgery [bilio-pancreatic diversion (BPD)]...
  92. ncbi request reprint Decreased fatty acid beta-oxidation in riboflavin-responsive, multiple acylcoenzyme A dehydrogenase-deficient patients is associated with an increase in uncoupling protein-3
    Aaron P Russell
    Department of Medical Biochemistry, University of Geneva Medical Center, 1206 Geneva, Switzerland
    J Clin Endocrinol Metab 88:5921-6. 2003
    ....
  93. ncbi request reprint Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise
    Aaron P Russell
    Clinique Romande de réadaptation SUVA Care, Sion, Switzerland
    FASEB J 19:986-8. 2005
    ....
  94. ncbi request reprint Intramyocellular lipid content in human skeletal muscle
    Vera B Schrauwen-Hinderling
    Department of Radiology, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Obesity (Silver Spring) 14:357-67. 2006
    ....
  95. ncbi request reprint Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes
    Anthony E Civitarese
    Dept of Human Physiology, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 289:E1023-9. 2005
    ..05). In conclusion, glucose ingestion during exercise decreases the expression of genes involved in lipid metabolism rather than increasing genes involved in carbohydrate metabolism...
  96. ncbi request reprint Systemic inflammation correlates with increased expression of skeletal muscle ubiquitin but not uncoupling proteins in cancer cachexia
    Cornelis H C Dejong
    Department of Surgery, University Hospital Maastricht, PO Box 5800, Maastricht NL 6202 AZ, The Netherlands
    Oncol Rep 14:257-63. 2005
    ..The pro-inflammatory network and ubiquitin proteasome pathway may be targets for intervention in pancreatic cancer cachexia...
  97. ncbi request reprint Regional variations in intramyocellular lipid concentration correlate with muscle fiber type distribution in rat tibialis anterior muscle
    Henk M M L De Feyter
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Magn Reson Med 56:19-25. 2006
    ..These results stress the importance of voxel positioning when single-voxel 1H MRS is used to study IMCL in rodent muscle...