Stephane Heymans

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Inflammation and cardiac remodeling during viral myocarditis
    S Heymans
    Experimental and Molecular Cardiology Laboratory CARIM, Department of Cardiology, University Hospital Maastricht, The Netherlands
    Ernst Schering Res Found Workshop . 2006
  2. ncbi request reprint Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart
    Stephane Heymans
    CARIM, University Hospital Maastricht, Maastricht, The Netherlands
    Circulation 112:1136-44. 2005
  3. ncbi request reprint Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis
    Stephane Heymans
    Molecular and Experimental Cardiology, CARIM, Department of Cardiology, P Debyelaan 25, PO Box 5800, 6202AZ Maastricht, The Netherlands
    Circulation 114:565-73. 2006
  4. pmc Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology
    Stephane Heymans
    Experimental and Molecular Cardiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Eur J Heart Fail 11:119-29. 2009
  5. pmc MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure
    Geert C Van Almen
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Aging Cell 10:769-79. 2011
  6. doi request reprint Absence of thrombospondin-2 causes age-related dilated cardiomyopathy
    Melissa Swinnen
    Center for Heart Failure Research, CARIM, Maastricht University, Maastricht, The Netherlands
    Circulation 120:1585-97. 2009
  7. pmc Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction
    Mark W M Schellings
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, University Hospital Maastricht, 6229 HX Maastricht, The Netherlands
    J Exp Med 206:113-23. 2009
  8. pmc Differences in virus prevalence and load in the hearts of patients with idiopathic dilated cardiomyopathy with and without immune-mediated inflammatory diseases
    Robert Dennert
    Heart Failure Research Center, Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    Clin Vaccine Immunol 19:1182-7. 2012
  9. doi request reprint Syndecan-1 amplifies angiotensin II-induced cardiac fibrosis
    Mark W M Schellings
    Department of Cardiology, Cardiovascular Research Institute Maastricht, University Hospital Maastricht, Maastricht, The Netherlands
    Hypertension 55:249-56. 2010
  10. doi request reprint Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy
    Geert C Van Almen
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    J Mol Cell Cardiol 51:318-28. 2011

Detail Information

Publications51

  1. ncbi request reprint Inflammation and cardiac remodeling during viral myocarditis
    S Heymans
    Experimental and Molecular Cardiology Laboratory CARIM, Department of Cardiology, University Hospital Maastricht, The Netherlands
    Ernst Schering Res Found Workshop . 2006
    ....
  2. ncbi request reprint Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart
    Stephane Heymans
    CARIM, University Hospital Maastricht, Maastricht, The Netherlands
    Circulation 112:1136-44. 2005
    ..Whether their expression is related to interstitial fibrosis or LV dysfunction in patients with chronic pressure overload-induced LV hypertrophy, however, is unknown...
  3. ncbi request reprint Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis
    Stephane Heymans
    Molecular and Experimental Cardiology, CARIM, Department of Cardiology, P Debyelaan 25, PO Box 5800, 6202AZ Maastricht, The Netherlands
    Circulation 114:565-73. 2006
    ....
  4. pmc Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology
    Stephane Heymans
    Experimental and Molecular Cardiology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Eur J Heart Fail 11:119-29. 2009
    ..This consensus document represents the outcome of the workshop and defines key research questions that still need to be addressed as well as considering the requirements for future clinical trials in this area...
  5. pmc MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure
    Geert C Van Almen
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Aging Cell 10:769-79. 2011
    ..During aging, decreased miR-18/19 and increased CTGF and TSP-1 levels identify the failure-prone heart...
  6. doi request reprint Absence of thrombospondin-2 causes age-related dilated cardiomyopathy
    Melissa Swinnen
    Center for Heart Failure Research, CARIM, Maastricht University, Maastricht, The Netherlands
    Circulation 120:1585-97. 2009
    ..The present study investigated whether the matricellular protein thrombospondin-2 (TSP-2) may affect cardiac dimensions and function with physiological aging of the heart...
  7. pmc Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction
    Mark W M Schellings
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, University Hospital Maastricht, 6229 HX Maastricht, The Netherlands
    J Exp Med 206:113-23. 2009
    ..The protective effects of SPARC emphasize the potential therapeutic applications of this protein to prevent cardiac dilatation and dysfunction after MI...
  8. pmc Differences in virus prevalence and load in the hearts of patients with idiopathic dilated cardiomyopathy with and without immune-mediated inflammatory diseases
    Robert Dennert
    Heart Failure Research Center, Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
    Clin Vaccine Immunol 19:1182-7. 2012
    ..These findings may suggest that DCM patients with an IMID have a different pathophysiologic mechanism from that which is present in the virus-induced form of DCM...
  9. doi request reprint Syndecan-1 amplifies angiotensin II-induced cardiac fibrosis
    Mark W M Schellings
    Department of Cardiology, Cardiovascular Research Institute Maastricht, University Hospital Maastricht, Maastricht, The Netherlands
    Hypertension 55:249-56. 2010
    ..In conclusion, loss of Synd1 reduces cardiac fibrosis and dysfunction during angiotensin II-induced hypertension...
  10. doi request reprint Absence of thrombospondin-2 increases cardiomyocyte damage and matrix disruption in doxorubicin-induced cardiomyopathy
    Geert C Van Almen
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    J Mol Cell Cardiol 51:318-28. 2011
    ..Taken together, this study is the first to provide evidence for the implication of the matrix element TSP-2 in protecting against DOX-induced cardiac injury and dysfunction...
  11. doi request reprint Thrombospondin-2 prevents cardiac injury and dysfunction in viral myocarditis through the activation of regulatory T-cells
    Anna Pia Papageorgiou
    Department of Cardiology, Center for Heart Failure Research, CARIM, Maastricht University, The Netherlands
    Cardiovasc Res 94:115-24. 2012
    ..Thrombospondin-2 (TSP-2) modulates matrix integrity and myocyte survival in the hypertensive or ageing heart. Whether TSP-2 may affect cardiac inflammation and injury, in particular during acute viral myocarditis, is completely unknown...
  12. doi request reprint miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling
    Rudy F Duisters
    Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
    Circ Res 104:170-8, 6p following 178. 2009
    ....
  13. doi request reprint Macrophage microRNA-155 promotes cardiac hypertrophy and failure
    Stephane Heymans
    Center for Heart Failure Research, Department of Cardiology S H, M F C, W V, P C, R E W v L, K C, T P, M H, M v B, A P P, B S, Department of Molecular Genetics L S, M P J d W, Department of Pathology E W, E L, Department of Pharmacology B J J, Department of Cardiology L J d W, and Department of Internal Medicine K W, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands S H Center for Molecular and Cardiovascular Biology, Department of Cardiovascular Sciences, Leuven, Belgium S H, P C, A P P Department of Medical Biochemistry L S, E L, M P J d W and Heart Failure Research Center E E C, Y M P, Academic Medical Center, Amsterdam
    Circulation 128:1420-32. 2013
    ..We recently reported that microRNA-155 is a key mediator of cardiac inflammation and injury in infectious myocarditis. Here, we investigated the impact of microRNA-155 manipulation in hypertensive heart disease...
  14. ncbi request reprint Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction
    Davy Vanhoutte
    Experimental and Molecular Cardiology CARIM, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Circulation 115:475-82. 2007
    ..The present study investigated whether Synd1 may also regulate cardiac inflammation, matrix remodeling, and function after myocardial infarction (MI)...
  15. ncbi request reprint Imatinib attenuates end-organ damage in hypertensive homozygous TGR(mRen2)27 rats
    Mark W M Schellings
    Experimental and Molecular Cardiology, Cardiovascular Research Institute Maastricht, University Hospital Maastricht, The Netherlands
    Hypertension 47:467-74. 2006
    ..The simultaneous improvement in both heart and kidneys suggests that inhibition of the PDGFRbeta has broad protective effects that may provide novel avenues for a blood pressure-independent protection against end-organ damage...
  16. doi request reprint Intravenous immunoglobulin therapy for patients with idiopathic cardiomyopathy and endomyocardial biopsy-proven high PVB19 viral load
    Robert Dennert
    Department of Cardiology, CARIM, University Hospital Maastricht, Maastricht, The Netherlands
    Antivir Ther 15:193-201. 2010
    ..Such therapy might improve cardiac function in patients with chronic dilated cardiomyopathy (DCM) and a significant PVB19 viral load in the heart...
  17. doi request reprint MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis
    Maarten F Corsten
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, The Netherlands
    Circ Res 111:415-25. 2012
    ..The involvement of microRNAs and their usefulness as therapeutic targets in this process are unknown...
  18. doi request reprint Parvovirus-B19-associated fulminant myocarditis successfully treated with immunosuppressive and antiviral therapy
    Robert Dennert
    Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands
    Antivir Ther 15:681-5. 2010
    ..This case demonstrates the importance of a detailed diagnosis, allowing better classification of the underlying pathology and subsequent targeted treatment...
  19. pmc Acute viral myocarditis
    Robert Dennert
    Department of Cardiology, CARIM, University Hospital Maastricht, The Netherlands
    Eur Heart J 29:2073-82. 2008
    ..The present review proposes a general diagnostic approach, focuses on the viral aetiology and associated autoimmune processes, and reviews treatment options for patients with acute viral myocarditis...
  20. pmc A novel 72-kDa leukocyte-derived osteoglycin enhances the activation of toll-like receptor 4 and exacerbates cardiac inflammation during viral myocarditis
    Marieke Rienks
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands
    Cell Mol Life Sci . 2016
    ..SLRP's may affect inflammatory and fibrotic processes, but the implication of OGN in cardiac inflammation and the resulting injury upon viral myocarditis is unknown...
  21. doi request reprint The microRNA-221/-222 cluster balances the antiviral and inflammatory response in viral myocarditis
    Maarten Corsten
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, Maastricht University, P Debyelaan 25, Maastricht AZ 6202, The Netherlands
    Eur Heart J 36:2909-19. 2015
    ..We explored the role of the miR-221/-222 family that is up-regulated in VM...
  22. doi request reprint Virus infection of the heart--unmet therapeutic needs
    Mark Hazebroek
    Department of Cardiology, CARIM, University Hospital Maastricht, Maastricht, The Netherlands
    Antivir Chem Chemother 22:249-53. 2012
    ..This article will focus on the pathogenesis of viral myocarditis, especially parvovirus B19-induced, its progression to inflammatory DCM and future treatment strategies...
  23. doi request reprint Small but smart--microRNAs in the centre of inflammatory processes during cardiovascular diseases, the metabolic syndrome, and ageing
    Blanche Schroen
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, Maastricht University, Universiteitssingel 50, Maastricht 6229 ER, The Netherlands
    Cardiovasc Res 93:605-13. 2012
    ....
  24. doi request reprint Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease
    Maarten F Corsten
    Center for Heart Failure Research, Cardiovascular Research Institute, Universiteitssingel 50, Maastricht, The Netherlands
    Circ Cardiovasc Genet 3:499-506. 2010
    ..Small RNA molecules, called microRNAs, freely circulate in human plasma and correlate with varying pathologies. In this study, we explored their diagnostic potential in a selection of prevalent cardiovascular disorders...
  25. doi request reprint Osteoglycin prevents cardiac dilatation and dysfunction after myocardial infarction through infarct collagen strengthening
    Lucas N L Van Aelst
    From the Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Catholic University of Leuven, Leuven, Belgium L N L V A, P C, A P P, S H Department of Cardiology L N L V A, M S and Department of Pathology E V, University Hospitals Leuven, Leuven, Belgium Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany S V, H N, C T, H M Department of Cardiology, Cardiovascular Research Institute Maastricht CARIM, University Hospital Maastricht, Maastricht, The Netherlands P C, R V L, S S v W, L E, H P B L R, A P P, S H Department of Pediatrics, Molecular Cardiovascular Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, OH D V Department of Molecular Cell Biology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands F K V National Heart and Lung Institute, TNO
    Circ Res 116:425-36. 2015
    ..Osteoglycin is a small leucine-rich proteoglycan previously described as a marker of cardiac hypertrophy...
  26. ncbi request reprint Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy
    Blanche Schroen
    Experimental and Molecular Cardiology CARIM, University of Maastricht, Maastricht, The Netherlands
    Circ Res 95:515-22. 2004
    ..This suggests that expression of TSP2 marks an early-stage molecular program that is activated uniquely in hypertrophied hearts that are prone to fail...
  27. doi request reprint Inflammation in viral myocarditis: friend or foe?
    Maarten F Corsten
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands
    Trends Mol Med 18:426-37. 2012
    ..This review aims to provide an overview of the sometimes contrasting observations from experimental viral myocarditis models and to translate the lessons learned into opportunities for future investigations and therapies...
  28. pmc MicroRNA involvement in immune activation during heart failure
    Mathijs van de Vrie
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, PO Box 5800, 6202, AZ Maastricht, The Netherlands
    Cardiovasc Drugs Ther 25:161-70. 2011
    ..Future research will have to point out if dampening the immune response, and the miRNAs associated with it, during the development of heart failure is a therapeutically plausible route to follow...
  29. doi request reprint Liver X receptor activation enhances CVB3 viral replication during myocarditis by stimulating lipogenesis
    Anna Pia Papageorgiou
    Centre for Molecular and Vascular Biology CMVB, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium CArdiovascular Research Institute Maastricht CARIM, Universiteitssingel 50, 6229 ER Maastricht, The Netherlands
    Cardiovasc Res 107:78-88. 2015
    ..Liver X receptor (LXR) agonists have both anti-inflammatory and lipid-lowering properties. This study investigates whether LXR agonist T0901317 may modulate viral replication and cardiac inflammation during VM...
  30. doi request reprint Myocardial extracellular matrix: an ever-changing and diverse entity
    Marieke Rienks
    From Maastricht University Medical Centre, Maastricht, The Netherlands
    Circ Res 114:872-88. 2014
    ....
  31. pmc A deep sequencing approach to uncover the miRNOME in the human heart
    Stefanos Leptidis
    Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 8:e57800. 2013
    ..The current study provides a starting point for a more comprehensive understanding of the role of miRNAs in regulating human heart disease...
  32. doi request reprint MicroRNAs are involved in end-organ damage during hypertension
    Ward A Heggermont
    Center for Molecular and Vascular Research, University of Leuven, Leuven, Belgium
    Hypertension 60:1088-93. 2012
    ..Some future perspectives in miR research are highlighted with respect to novel therapeutic strategies in the cardiovascular field...
  33. doi request reprint Relevance of cardiac parvovirus B19 in myocarditis and dilated cardiomyopathy: review of the literature
    Job Verdonschot
    Department of Cardiology, CARIM, Maastricht University Medical Centre, The Netherlands
    Eur J Heart Fail 18:1430-1441. 2016
    ..In addition, the immunogenetic background of MC/DCM patients that makes them susceptible to develop heart failure upon presence of B19V should be more thoroughly investigated...
  34. doi request reprint The Network Library: a framework to rapidly integrate network biology resources
    Georg Summer
    CARIM, Maastricht University, Maastricht, The Netherlands TNO, Zeist, The Netherlands
    Bioinformatics 32:i473-i478. 2016
    ..Integrating and connecting these vast knowledge repositories is an extremely useful method to support life sciences research and help formulate novel hypotheses...
  35. doi request reprint Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure
    Ellen Dirkx
    1 Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, 6229 ER Maastricht, The Netherlands 2
    Nat Cell Biol 15:1282-93. 2013
    ..Our results reveal that signalling cascades integrate with microRNAs to induce the expression of the bHLH transcription factor Hand2 in the postnatal mammalian myocardium with impact on embryonic gene programs in heart failure. ..
  36. ncbi request reprint Matricellular proteins in the heart: possible role during stress and remodeling
    Mark W M Schellings
    Experimental and Molecular Cardiology CARIM, Department of Cardiology, University of Maastricht, P Debyelaan 25 PO box 5800, 6202 AZ Maastricht, Maastricht, The Netherlands
    Cardiovasc Res 64:24-31. 2004
    ..This review will focus on the expression, regulation and function of these matricellular proteins, and will discuss the crucial functions that these proteins might exert during remodeling of the stressed heart...
  37. doi request reprint The diverse functions of osteoglycin: a deceitful dwarf, or a master regulator of disease?
    Sophie Deckx
    Department of Cardiology, Maastricht University, Maastricht, The Netherlands and Center for Molecular and Vascular Biology, Katholieke Universiteit KU Leuven, Leuven, Belgium
    FASEB J 30:2651-61. 2016
    ..Deckx, S., Heymans, S., Papageorgiou, A.-P. The diverse functions of osteoglycin: a deceitful dwarf, or a master regulator of disease? ..
  38. pmc Breeding Strategy Determines Rupture Incidence in Post-Infarct Healing WARPing Cardiovascular Research
    Sophie Deckx
    Department of Cardiology, Maastricht University, Maastricht, The Netherlands Centre for Molecular and Vascular Biology, KULeuven, Leuven, Belgium
    PLoS ONE 10:e0139199. 2015
    ..Based upon its involvement in matrix biology and its expression in the heart, we hypothesized that WARP regulates cardiac remodeling processes in the post-infarct healing process...
  39. pmc Long Non-Coding RNA Malat-1 Is Dispensable during Pressure Overload-Induced Cardiac Remodeling and Failure in Mice
    Tim Peters
    Center for Heart Failure Research, Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 11:e0150236. 2016
    ..We therefore hypothesized that Malat-1 may act as regulator of cardiac hypertrophy and failure during cardiac pressure overload induced by thoracic aortic constriction (TAC) in mice...
  40. pmc Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice
    Marjo M P C Donners
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 7:e35877. 2012
    ..Additionally, besides a known role in lymphoid cell development, we show a crucial role of miR155 in myeloid lineage differentiation...
  41. doi request reprint Myocardial scar predicts monomorphic ventricular tachycardia but not polymorphic ventricular tachycardia or ventricular fibrillation in nonischemic dilated cardiomyopathy
    Sebastiaan R D Piers
    Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands
    Heart Rhythm 12:2106-14. 2015
    ..The relation between myocardial scar and different types of ventricular arrhythmias in patients with nonischemic dilated cardiomyopathy (NIDCM) is unknown...
  42. pmc cyNeo4j: connecting Neo4j and Cytoscape
    Georg Summer
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht CARIM, University Hospital Maastricht, Maastricht, The Netherlands, TNO, Zeist, The Netherlands
    Bioinformatics 31:3868-9. 2015
    ..We implemented a Neo4j NetworkAnalyzer, ForceAtlas2 layout and Cypher component to demonstrate the possibilities a distributed setup of Cytoscape and Neo4j have...
  43. doi request reprint Prognostic Relevance of Gene-Environment Interactions in Patients With Dilated Cardiomyopathy: Applying the MOGE(S) Classification
    Mark R Hazebroek
    Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands Electronic address
    J Am Coll Cardiol 66:1313-23. 2015
    ..The multifactorial pathogenesis leading to dilated cardiomyopathy (DCM) makes stratification difficult. The recent MOGE(S) (morphofunctional, organ involvement, genetic or familial, etiology, stage) classification addresses this issue...
  44. doi request reprint Cardiac involvement in Churg-Strauss syndrome
    Robert M Dennert
    Maastricht University, Maastricht, The Netherlands
    Arthritis Rheum 62:627-34. 2010
    ..The aim of the present study was to determine in detail the incidence of cardiac involvement in a large population of ambulatory CSS patients...
  45. pmc Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy
    Blanche Schroen
    Department of Experimental and Molecular Cardiology, University of Maastricht, Maastricht, Netherlands
    J Exp Med 204:1227-35. 2007
    ..Collectively, our data show that LIMP-2 is crucial to mount the adaptive hypertrophic response to cardiac loading. We demonstrate a novel role for LIMP-2 as an important mediator of the ID...
  46. pmc Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice
    Stephane Heymans
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute, Herestraat 49, B 3000 Leuven, Belgium
    Am J Pathol 166:15-25. 2005
    ..Deficiency of MMP-9 had an intermediate effect. These findings suggest that the use of u-PA- or MMP-inhibitors might preserve cardiac pump function in LV pressure overloading...
  47. pmc Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy
    Sudeshna Fisch
    Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, 2103 Cornell Road, Room 4 503, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 104:7074-9. 2007
    ..These studies identify KLF15 as part of a heretofore unrecognized pathway regulating the cardiac response to hemodynamic stress...
  48. ncbi request reprint Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: a temporal and spatial window
    Davy Vanhoutte
    Molecular and Vascular Biology and Center for Transgene Technology and Gene Therapy, University of Leuven, Belgium
    Cardiovasc Res 69:604-13. 2006
    ..It summarizes (1) the MMP/TIMP levels at different time points post-MI, (2) the alterations seen in post-MI healing in genetically modified mice, and (3) the effects and limitations of therapeutic MMP-inhibition post-MI...
  49. ncbi request reprint Myocarditis and heart failure: need for better diagnostic, predictive, and therapeutic tools
    Stephane Heymans
    Eur Heart J 28:1279-80. 2007
  50. ncbi request reprint Annexin A5 and the failing heart; lost or found in translation?
    Leonard Hofstra
    Eur Heart J 28:2695-6. 2007