P W Wirtz

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint [Proximal muscle weakness, depressed tendon reflexes and autonomic dysfunction: the Lambert-Eaton myasthenic syndrome]
    P W Wirtz
    Leids Universitair Medisch Centrum, afd Neurologie, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 145:57-61. 2001
  2. ncbi request reprint P/Q-type calcium channel antibodies, Lambert-Eaton myasthenic syndrome and survival in small cell lung cancer
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Neuroimmunol 164:161-5. 2005
  3. ncbi request reprint Lambert-Eaton myasthenic syndrome has a more progressive course in patients with lung cancer
    Paul W Wirtz
    Department of Neurology, J3R 166, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Muscle Nerve 32:226-9. 2005
  4. ncbi request reprint Associated autoimmune diseases in patients with the Lambert-Eaton myasthenic syndrome and their families
    Paul W Wirtz
    Department of Neurology, J3R 166 Leiden University Medical Centre, P O Box 9600, 2300, RC Leiden, The Netherlands
    J Neurol 251:1255-9. 2004
  5. ncbi request reprint The epidemiology of the Lambert-Eaton myasthenic syndrome in the Netherlands
    P W Wirtz
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Neurology 63:397-8. 2004
  6. ncbi request reprint HLA-B8 in patients with the Lambert-Eaton myasthenic syndrome reduces likelihood of associated small cell lung carcinoma
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Ann N Y Acad Sci 998:200-1. 2003
  7. ncbi request reprint High innate production of interleukin-10 and tumor necrosis factor-alpha contributes to susceptibility for non-paraneoplastic Lambert-Eaton myasthenic syndrome
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    J Neuroimmunol 140:194-7. 2003
  8. ncbi request reprint The epidemiology of myasthenia gravis, Lambert-Eaton myasthenic syndrome and their associated tumours in the northern part of the province of South Holland
    Paul W Wirtz
    Department of Neurology, J3R 166, Leiden University Medical Centre, P O Box 9600, The Netherlands
    J Neurol 250:698-701. 2003
  9. ncbi request reprint Anti-Ri antibody positive opsoclonus-myoclonus in a male patient with breast carcinoma
    Paul W Wirtz
    Department of Neurology, J3R 166, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Neurol 249:1710-2. 2002
  10. pmc Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome
    P W Wirtz
    Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands
    J Neurol Neurosurg Psychiatry 73:766-8. 2002

Detail Information

Publications19

  1. ncbi request reprint [Proximal muscle weakness, depressed tendon reflexes and autonomic dysfunction: the Lambert-Eaton myasthenic syndrome]
    P W Wirtz
    Leids Universitair Medisch Centrum, afd Neurologie, Postbus 9600, 2300 RC Leiden
    Ned Tijdschr Geneeskd 145:57-61. 2001
    ..In conclusion, in every patient presenting with unexplained proximal weakness, LEMS should be considered, especially if depressed tendon reflexes and autonomic dysfunction are found as well...
  2. ncbi request reprint P/Q-type calcium channel antibodies, Lambert-Eaton myasthenic syndrome and survival in small cell lung cancer
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Neuroimmunol 164:161-5. 2005
    ..In both series, only patients with LEMS had a remarkably long survival, whereas presence of the antibodies without LEMS did not result in a better prognosis...
  3. ncbi request reprint Lambert-Eaton myasthenic syndrome has a more progressive course in patients with lung cancer
    Paul W Wirtz
    Department of Neurology, J3R 166, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Muscle Nerve 32:226-9. 2005
    ..The presence of a particular symptom associated with LEMS did not predict the presence of SCLC, but in patients with rapidly progressive LEMS the possibility of underlying lung cancer should be of particular concern...
  4. ncbi request reprint Associated autoimmune diseases in patients with the Lambert-Eaton myasthenic syndrome and their families
    Paul W Wirtz
    Department of Neurology, J3R 166 Leiden University Medical Centre, P O Box 9600, 2300, RC Leiden, The Netherlands
    J Neurol 251:1255-9. 2004
    ..This suggests that NT-LEMS shares immunogenetic factors with other AIDs. In families of NT-LEMS, a remarkable preponderance of maternal inheritance was seen, as has been reported previously in myasthenia gravis...
  5. ncbi request reprint The epidemiology of the Lambert-Eaton myasthenic syndrome in the Netherlands
    P W Wirtz
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Neurology 63:397-8. 2004
  6. ncbi request reprint HLA-B8 in patients with the Lambert-Eaton myasthenic syndrome reduces likelihood of associated small cell lung carcinoma
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Ann N Y Acad Sci 998:200-1. 2003
  7. ncbi request reprint High innate production of interleukin-10 and tumor necrosis factor-alpha contributes to susceptibility for non-paraneoplastic Lambert-Eaton myasthenic syndrome
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    J Neuroimmunol 140:194-7. 2003
    ..Our findings suggest that high innate production of Il-10 and TNF-alpha is a susceptibility factor for non-paraneoplastic LEMS...
  8. ncbi request reprint The epidemiology of myasthenia gravis, Lambert-Eaton myasthenic syndrome and their associated tumours in the northern part of the province of South Holland
    Paul W Wirtz
    Department of Neurology, J3R 166, Leiden University Medical Centre, P O Box 9600, The Netherlands
    J Neurol 250:698-701. 2003
    ..The frequency of LEMS in our patients with SCLC was lower than reported in previous studies. In patients with a SCLC or thymoma, the tumour was diagnosed at younger age in those who had the associated myasthenic syndrome...
  9. ncbi request reprint Anti-Ri antibody positive opsoclonus-myoclonus in a male patient with breast carcinoma
    Paul W Wirtz
    Department of Neurology, J3R 166, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Neurol 249:1710-2. 2002
    ..These features suggest an immune response against both Nova-1 and Nova-2 antigens throughout the central nervous system...
  10. pmc Difference in distribution of muscle weakness between myasthenia gravis and the Lambert-Eaton myasthenic syndrome
    P W Wirtz
    Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands
    J Neurol Neurosurg Psychiatry 73:766-8. 2002
    ..Myasthenia gravis and the Lambert-Eaton myasthenic syndrome (LEMS) may have a similar distribution of muscle weakness. Deciding on a diagnosis of myasthenia gravis or LEMS on clinical grounds may therefore be difficult...
  11. ncbi request reprint Differences in clinical features between the Lambert-Eaton myasthenic syndrome with and without cancer: an analysis of 227 published cases
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Clin Neurol Neurosurg 104:359-63. 2002
    ..The high frequency of additional immunological disorders in patients without malignancy, together with the younger age at onset suggests a similar etiology as other non-paraneoplastic autoimmune diseases...
  12. ncbi request reprint HLA class I and II in Lambert-Eaton myasthenic syndrome without associated tumor
    P W Wirtz
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Hum Immunol 62:809-13. 2001
    ..e. HLA-DR3 and -DQ2). HLA-B8+ patients had significantly younger age at onset of LEMS and tended to be female. This study shows that HLA-class I haplotype is associated with a distinct phenotype in NT-LEMS...
  13. doi request reprint The Lambert-Eaton myasthenic syndrome 1988-2008: a clinical picture in 97 patients
    M J Titulaer
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    J Neuroimmunol 201:153-8. 2008
    ..We studied how this clinical information, which is readily available at the first consultation, can be used to predict the presence of SCLC...
  14. doi request reprint Clinical fluctuations in MuSK myasthenia gravis are related to antigen-specific IgG4 instead of IgG1
    E H Niks
    Department of Neurology, J3 R 166, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Neuroimmunol 195:151-6. 2008
    ..The results support an important role for IgG4 in the pathogenesis of MuSK MG, in contrast to MG with anti-acetylcholine receptor antibodies...
  15. doi request reprint Efficacy of 3,4-diaminopyridine and pyridostigmine in the treatment of Lambert-Eaton myasthenic syndrome: a randomized, double-blind, placebo-controlled, crossover study
    P W Wirtz
    Department of Neurology, Haga Hospital, The Hague, The Netherlands
    Clin Pharmacol Ther 86:44-8. 2009
    ..Therefore, we performed a placebo-controlled, double-dummy, double-blind, randomized, crossover study in nine patients with LEMS...
  16. ncbi request reprint HLA and smoking in prediction and prognosis of small cell lung cancer in autoimmune Lambert-Eaton myasthenic syndrome
    Paul W Wirtz
    Department of Neurology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Neuroimmunol 159:230-7. 2005
    ..Moreover, negativity for HLA-B8 combined with smoking behavior points more strongly to an underlying SCLC and predicts a worse prognosis in SCLC-LEMS patients...
  17. doi request reprint Screening for small-cell lung cancer: a follow-up study of patients with Lambert-Eaton myasthenic syndrome
    Maarten J Titulaer
    Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Clin Oncol 26:4276-81. 2008
    ..We evaluated screening to optimize screening strategy for SCLC. It is important to detect these tumors early in newly diagnosed patients with LEMS to offer optimal patient treatment...
  18. ncbi request reprint Available treatment options for the management of Lambert-Eaton myasthenic syndrome
    Jan J G M Verschuuren
    Leiden University Medical Centre, Department of Neurology, PO Box 9600, 2300 RC Leiden, Leiden, The Netherlands
    Expert Opin Pharmacother 7:1323-36. 2006
    ..Chemotherapy has successfully ameliorated the course of disease in Lambert-Eaton myasthenic syndrome patients with an underlying tumour...
  19. doi request reprint Re: Lambert-Eaton myasthenic syndrome with pure ocular weakness
    Maarten J Titulaer
    Neurology 70:86; author reply 86-7. 2008