Cees A Swenne

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi Galen Wagner, M.D., Ph.D. (1939-2016) as international mentor of young investigators in electrocardiology
    Cees A Swenne
    Cardiology Department, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    J Electrocardiol 50:21-46. 2017
  2. doi Mechanisms of exercise-recovery hysteresis in the ECG: ISCE 2015 paper
    Cees A Swenne
    Cardiology Department, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    J Electrocardiol 48:1006-9. 2015
  3. pmc Baroreflex sensitivity: mechanisms and measurement
    C A Swenne
    Cardiology Department, Leiden University Medical Center, PO Box 9600, 2300, RC Leiden, The Netherlands
    Neth Heart J 21:58-60. 2013
  4. pmc Cardiovascular disease, risk factors and heart rate variability in the elderly general population: design and objectives of the CARdiovascular disease, Living and Ageing in Halle (CARLA) Study
    Karin H Greiser
    Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle Wittenberg, Magdeburger Str 27, 06097 Halle Saale, Germany
    BMC Cardiovasc Disord 5:33. 2005
  5. pmc Association of health behaviour with heart rate variability: a population-based study
    Alexander Kluttig
    Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle Wittenberg, Halle, Saale, Germany
    BMC Cardiovasc Disord 10:58. 2010
  6. ncbi Neurocardiological basis for intraindividual ECG variability
    Cees A Swenne
    Cardiology Department, Leiden University Medical Center, The Neitherlands
    J Electrocardiol 35:239-42. 2002
  7. doi Influence of the vectorcardiogram synthesis matrix on the power of the electrocardiogram-derived spatial QRS-T angle to predict arrhythmias in patients with ischemic heart disease and systolic left ventricular dysfunction
    Sumche Man
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    J Electrocardiol 44:410-5. 2011
  8. doi Biventricular pacing-induced acute response in baroreflex sensitivity has predictive value for midterm response to cardiac resynchronization therapy
    Maaike G J Gademan
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Physiol Heart Circ Physiol 297:H233-7. 2009
  9. doi Biventricular pacing in chronic heart failure acutely facilitates the arterial baroreflex
    Maaike G J Gademan
    Dept of Cardiology, Leiden Univ Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Am J Physiol Heart Circ Physiol 295:H755-60. 2008
  10. ncbi Pulmonary valve replacement in tetralogy of Fallot improves the repolarization
    Bart Hooft van Huysduynen
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
    Int J Cardiol 124:301-6. 2008

Collaborators

Detail Information

Publications54

  1. doi Galen Wagner, M.D., Ph.D. (1939-2016) as international mentor of young investigators in electrocardiology
    Cees A Swenne
    Cardiology Department, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    J Electrocardiol 50:21-46. 2017
    ....
  2. doi Mechanisms of exercise-recovery hysteresis in the ECG: ISCE 2015 paper
    Cees A Swenne
    Cardiology Department, Leiden University Medical Center, Leiden, The Netherlands Electronic address
    J Electrocardiol 48:1006-9. 2015
    ..It also discusses the possible association between exercise-recovery ECG hysteresis and arrhythmogeneity...
  3. pmc Baroreflex sensitivity: mechanisms and measurement
    C A Swenne
    Cardiology Department, Leiden University Medical Center, PO Box 9600, 2300, RC Leiden, The Netherlands
    Neth Heart J 21:58-60. 2013
    ..Development of new baroreflex assessing procedures is still ongoing, with a focus on increased reliability in difficult measuring circumstances, e.g., in patients with a weak baroreflex and in patients with frequent arrhythmias...
  4. pmc Cardiovascular disease, risk factors and heart rate variability in the elderly general population: design and objectives of the CARdiovascular disease, Living and Ageing in Halle (CARLA) Study
    Karin H Greiser
    Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle Wittenberg, Magdeburger Str 27, 06097 Halle Saale, Germany
    BMC Cardiovasc Disord 5:33. 2005
    ..This paper describes the design and objectives of the CARLA Study...
  5. pmc Association of health behaviour with heart rate variability: a population-based study
    Alexander Kluttig
    Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle Wittenberg, Halle, Saale, Germany
    BMC Cardiovasc Disord 10:58. 2010
    ..The autonomic dysfunction is a potential mediator of the association of behavioural risk factors with adverse health outcomes. We studied the association of HRV with behavioural risk factors in an elderly population...
  6. ncbi Neurocardiological basis for intraindividual ECG variability
    Cees A Swenne
    Cardiology Department, Leiden University Medical Center, The Neitherlands
    J Electrocardiol 35:239-42. 2002
    ..More extreme experimental conditions and/or more sensitive substrates than healthy young men are likely to entail larger ECG differences. It may be clinically relevant to further explore this source of intra-individual ECG variability...
  7. doi Influence of the vectorcardiogram synthesis matrix on the power of the electrocardiogram-derived spatial QRS-T angle to predict arrhythmias in patients with ischemic heart disease and systolic left ventricular dysfunction
    Sumche Man
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    J Electrocardiol 44:410-5. 2011
    ..Our current study aims to compare the predictive power of these SA variants for the occurrence of potentially lethal arrhythmias...
  8. doi Biventricular pacing-induced acute response in baroreflex sensitivity has predictive value for midterm response to cardiac resynchronization therapy
    Maaike G J Gademan
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Physiol Heart Circ Physiol 297:H233-7. 2009
    ..Our study demonstrates that a CRT-induced acute BRS increase has predictive value for the echocardiographic response to CRT. This finding suggests that the autonomic nervous system is actively involved in CRT-related reverse remodeling...
  9. doi Biventricular pacing in chronic heart failure acutely facilitates the arterial baroreflex
    Maaike G J Gademan
    Dept of Cardiology, Leiden Univ Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Am J Physiol Heart Circ Physiol 295:H755-60. 2008
    ..Follow-up studies should verify the mechanism of the acute response and the possible predictive value of an acute positive BRS response...
  10. ncbi Pulmonary valve replacement in tetralogy of Fallot improves the repolarization
    Bart Hooft van Huysduynen
    Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
    Int J Cardiol 124:301-6. 2008
    ..To assess the effect of pulmonary valve replacement (PVR) on the repolarization of patients with tetralogy of Fallot...
  11. doi Improved ECG detection of presence and severity of right ventricular pressure load validated with cardiac magnetic resonance imaging
    Ivo R Henkens
    Cardiology Department, Leiden University Medical Center, Leiden, The Netherlands
    Am J Physiol Heart Circ Physiol 294:H2150-7. 2008
    ..The use of the ventricular gradient allows ECG detection of even mildly increased RV pressure load...
  12. doi Exercise-resembling effects of periodic somatosensory stimulation in heart failure
    Maaike G J Gademan
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands Department of Public Health, Academic Medical Centre, Amsterdam, The Netherlands
    Int J Cardiol 168:3327-33. 2013
    ..To demonstrate this, we compared the effects of periodic electrical somatosensory stimulation in patients with CHF with the effects of exercise training and with usual care...
  13. doi Relation of resting heart rate to prognosis in patients with idiopathic pulmonary arterial hypertension
    Ivo R Henkens
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 103:1451-6. 2009
    ..ECG-derived HR at rest is an important marker of prognosis and should be assessed before and at frequent intervals after initiation of treatment for PAH...
  14. doi Exercise training increases oxygen uptake efficiency slope in chronic heart failure
    Maaike G J Gademan
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Cardiovasc Prev Rehabil 15:140-4. 2008
    ..slope. Exercise training improves(Equation is included in full-text article.)and(Equation is included in full-text article.)in CHF patients. We hypothesized that exercise training also improves OUES...
  15. doi Normal limits of the spatial QRS-T angle and ventricular gradient in 12-lead electrocardiograms of young adults: dependence on sex and heart rate
    Roderick W C Scherptong
    Department of Cardiology, C5 P, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 41:648-55. 2008
    ..We determined normal limits for these variables derived from standard 12-lead electrocardiograms (ECGs) of 660 male and female students aged 18 to 29 years...
  16. doi Predictive power of T-wave alternans and of ventricular gradient hysteresis for the occurrence of ventricular arrhythmias in primary prevention cardioverter-defibrillator patients
    Sumche Man
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 44:453-9. 2011
    ....
  17. doi Follow-up after pulmonary valve replacement in adults with tetralogy of Fallot: association between QRS duration and outcome
    Roderick W C Scherptong
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Am Coll Cardiol 56:1486-92. 2010
    ..The aim of this study was to analyze whether QRS duration, before and after pulmonary valve replacement (PVR), is related to long-term outcome in patients with tetralogy of Fallot (TOF)...
  18. doi Predicting ventricular arrhythmias in patients with ischemic heart disease: clinical application of the ECG-derived QRS-T angle
    C Jan Willem Borleffs
    Department of Cardiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    Circ Arrhythm Electrophysiol 2:548-54. 2009
    ..The aim of this study was to assess the value of the QRS-T angle for prediction of ICD therapy and mortality in primary prevention patients with ischemic heart disease...
  19. doi Reconstruction of standard 12-lead electrocardiograms from 12-lead electrocardiograms recorded with the Mason-Likar electrode configuration
    Sum Che Man
    Cardiology Department, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 41:211-9. 2008
    ..Both types of matrices were able to reverse the underdiagnosis of inferior myocardial infarctions and the erroneous statements about the QRS frontal axis that arose in the ECGs that were made by using the Mason-Likar electrode positions...
  20. doi Rehabilitation: Periodic somatosensory stimulation increases arterial baroreflex sensitivity in chronic heart failure patients
    Maaike G J Gademan
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Int J Cardiol 152:237-41. 2011
    ..In our hypothesis-generating study we propose that at least part of this effect is mediated by neural afferent information, and more specifically, by exercise-induced somatosensory nerve traffic...
  21. doi Role of the vectorcardiogram-derived spatial QRS-T angle in diagnosing left ventricular hypertrophy
    Sumche Man
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 45:154-60. 2012
    ..In this study, we attempted to improve the diagnostic accuracy for LVH by using a combination of demographic, anthropomorphic, ECG, and vectorcardiographic variables...
  22. doi Diagnosis and mortality prediction in pulmonary hypertension: the value of the electrocardiogram-derived ventricular gradient
    Roderick W C Scherptong
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 45:312-8. 2012
    ..The aim of this study was to investigate the use of the electrocardiogram-derived ventricular gradient, projected on the x-axis (VGx), for detection of pulmonary hypertension (PH) and for prediction of all-cause mortality in PH patients...
  23. ncbi Early changes in rat hearts with developing pulmonary arterial hypertension can be detected with three-dimensional electrocardiography
    Ivo R Henkens
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Physiol Heart Circ Physiol 293:H1300-7. 2007
    ..Three-dimensional ECG analysis appears to be very sensitive to early changes in RV afterload...
  24. doi The spatial QRS-T angle in the Frank vectorcardiogram: accuracy of estimates derived from the 12-lead electrocardiogram
    Charlotte A Schreurs
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    J Electrocardiol 43:294-301. 2010
    ..Our present study aimed to perform this essential validation...
  25. ncbi Baroreflex sensitivity, blood pressure buffering, and resonance: what are the links? Computer simulation of healthy subjects and heart failure patients
    Hedde Van De Vooren
    Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Appl Physiol 102:1348-56. 2007
    ..Hence, the clinical benefit of a high BRS is most likely to be attributed to vagal effects on the heart instead of to effective BP buffering...
  26. ncbi Dispersion of repolarization in cardiac resynchronization therapy
    Bart Hooft Van Huysduynen
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Heart Rhythm 2:1286-93. 2005
    ..The possibility of identifying these patients by ECG repolarization indices has been suggested...
  27. ncbi Elucidation of the spatial ventricular gradient and its link with dispersion of repolarization
    Harmen H M Draisma
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Heart Rhythm 3:1092-9. 2006
    ..The main focus is the role of the spatial ventricular gradient in ECG assessment of dispersion of repolarization, a key factor in arrhythmogeneity...
  28. doi Detection of elevated pulmonary pressures by the ECG-derived ventricular gradient: A comparison of conversion matrices in patients with suspected pulmonary hypertension
    Marlieke L A Haeck
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 50:115-122. 2017
    ..The aim was to assess the diagnostic value of the Inverse Dower (INVD)-derived vectorcardiogram (VCG) and the Kors-derived VCG to detect elevated systolic pulmonary artery pressure (SPAP) in suspected pulmonary hypertension (PH)...
  29. doi Body fat, especially visceral fat, is associated with electrocardiographic measures of sympathetic activation
    Stefanie Hillebrand
    Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Obesity (Silver Spring) 22:1553-9. 2014
    ..The association between body fat, specifically visceral fat, and electrocardiographic measures of sympathetic activation in a population with structurally normal hearts was investigated...
  30. doi Intra-individual ECG changes over 25 years: How long can elective ECGs be used as reference for acute ischemia detection?
    Marjolein C De Jongh
    Cardiology Department, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 48:490-7. 2015
    ..In the current study, we investigate if reference ECGs remain valid in time...
  31. ncbi Validation of ECG indices of ventricular repolarization heterogeneity: a computer simulation study
    Bart Hooft Van Huysduynen
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    J Cardiovasc Electrophysiol 16:1097-103. 2005
    ....
  32. ncbi Reduction of QRS duration after pulmonary valve replacement in adult Fallot patients is related to reduction of right ventricular volume
    Bart Hooft Van Huysduynen
    Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur Heart J 26:928-32. 2005
    ..Pulmonary regurgitation is a common cause of right ventricular (RV) failure and QRS lengthening. We studied the effects of pulmonary valve replacement (PVR) on QRS duration and RV volume...
  33. ncbi Effect of exercise training on autonomic derangement and neurohumoral activation in chronic heart failure
    Maaike G J Gademan
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Card Fail 13:294-303. 2007
    ..However, pharmacologic treatment can not yet reduce autonomic derangement and neurohumoral activation in CHF to a minimum. Various studies suggest that exercise training is effective in this respect...
  34. doi Position of ST-deviation measurements relative to the J-point: Impact for ischemia detection
    Sumche Man
    Cardiology Department, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 50:82-89. 2017
    ..There is no consensus about the time instant relative to the J point where ST deviation has to be measured for detection of acute ischemia in the ECG...
  35. doi Comparison of model-based and expert-rule based electrocardiographic identification of the culprit artery in patients with acute coronary syndrome
    Vivian P Kamphuis
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 48:483-9. 2015
    ..We compared a model-based automated method (Olson method) with an expert-rule based method for the culprit artery assessment...
  36. doi Performance of ST and ventricular gradient difference vectors in electrocardiographic detection of acute myocardial ischemia
    Roderick W Treskes
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 48:498-504. 2015
    ..Serial analysis could improve ECG diagnosis of myocardial ischemia caused by acute coronary occlusion...
  37. doi Difference vectors to describe dynamics of the ST segment and the ventricular gradient in acute ischemia
    C Cato Ter Haar
    Cardiology Department, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 46:302-11. 2013
    ..However, preexisting non-zero ST amplitudes (diagnostic, but also non-diagnostic) can obscure or even preclude this diagnosis...
  38. doi Acute coronary syndrome with a totally occluded culprit artery: relation of the ST injury vector with ST-elevation and non-ST elevation ECGs
    Sumche Man
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 47:183-90. 2014
    ..In order to elucidate reasons for this discrepancy we examined ST injury vector orientation and magnitude in ACS patients with and without STE, all admitted for primary PCI and having a completely occluded culprit artery...
  39. doi Subtraction electrocardiography: Detection of ischemia-induced ST displacement without the need to identify the J point
    C Cato Ter Haar
    Cardiology Department, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 49:316-22. 2016
    ..No concrete recommendations for this comparison exist, neither is known how to handle J-point identification difficulties. Here we present a J-point independent method for such a comparison...
  40. doi Incremental prognostic value of an abnormal baseline spatial QRS-T angle in chronic dialysis patients
    Mihaly K de Bie
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    Europace 15:290-6. 2013
    ..The objective of this study was to establish the prognostic value of the spatial QRS-T angle...
  41. doi Heart rate variability and first cardiovascular event in populations without known cardiovascular disease: meta-analysis and dose-response meta-regression
    Stefanie Hillebrand
    Department of Clinical Epidemiology, Leiden University Medical Centre, Albinusdreef 2, Leiden, The Netherlands
    Europace 15:742-9. 2013
    ..It is less clear whether HRV is associated with a first cardiovascular event. Therefore, we performed a meta-analysis to study the association between HRV and incident cardiovascular events in populations without known CVD...
  42. doi Vectorcardiographic diagnostic & prognostic information derived from the 12-lead electrocardiogram: Historical review and clinical perspective
    Sumche Man
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 48:463-75. 2015
    ..This paper gives an overview of these historical developments, elaborates on the vector concept and seeks to define where VCG analysis/interpretation can add diagnostic/prognostic value to conventional 12-lead ECG analysis. ..
  43. doi Directionality and proportionality of the ST and ventricular gradient difference vectors during acute ischemia
    C Cato Ter Haar
    Cardiology Department, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 47:500-4. 2014
    ..The ventricular gradient (VG) is independent of conduction and might be an alternative ECG-based variable for ischemia detection...
  44. doi Will future troponin measurement overrule the ECG as the primary diagnostic tool in patients with acute coronary syndrome?
    Arnoud van der Laarse
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    J Electrocardiol 46:312-7. 2013
    ..More evidence and future trials are needed to find out whether in patients with NSTE ACS hs cTn I/T tests should be combined with other tests, such as a test of B-type natriuretic peptide or NT-proBNP. ..
  45. doi Electrocardiographic detection of right ventricular pressure overload in patients with suspected pulmonary hypertension
    Vivian P Kamphuis
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    J Electrocardiol 47:175-82. 2014
    ..Our study evaluated the diagnostic accuracy of the electrocardiographically derived Butler-Leggett (BL) score and ventricular gradient (VG) to estimate mean pulmonary artery pressure (PAP)...
  46. ncbi Viscerosensory-cardiovascular reflexes: altered baroreflex sensitivity in irritable bowel syndrome
    Patrick P J van der Veek
    Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 289:R970-6. 2005
    ..The increased BRS in IBS patients at baseline may either be a training-effect (frequent challenging of the reflex) or reflects altered viscerosensory processing at the nucleus tractus solitarii...
  47. ncbi Tryptophan depletion affects heart rate variability and impulsivity in remitted depressed patients with a history of suicidal ideation
    Linda Booij
    Department of Psychology, Leiden University, Wassenaarseweg, Leiden, The Netherlands
    Biol Psychiatry 60:507-14. 2006
    ..The present study investigated whether experimental lowering of serotonin would decrease heart rate variability and increase impulsivity in remitted depressed patients, in particular in those patients with disturbed impulse control...
  48. ncbi Hypertensive stress increases dispersion of repolarization
    Bart Hooft Van Huysduynen
    Cardiology Department, Leiden University Medical Center, Leiden, The Netherlands
    Pacing Clin Electrophysiol 27:1603-9. 2004
    ..Hypertensive stressors are associated with arrhythmogeneity in vulnerable hearts. This may in part be explained by the induction of repolarization heterogeneity by hypertensive stress...
  49. ncbi Pacemaking in the AV node
    Cees A Swenne
    Heart Rhythm 4:1336-7. 2007
  50. ncbi Effect of n-3 fatty acids on heart rate variability and baroreflex sensitivity in middle-aged subjects
    Anouk Geelen
    Wageningen Centre for Food Sciences, Wageningen, The Netherlands
    Am Heart J 146:E4. 2003
    ..Effects of n-3 fatty acids on these risk indicators of arrhythmia have not been widely studied. We investigated the effect of supplemental intake of n-3 fatty acids on HRV and BRS in apparently healthy subjects aged 50 to 70 years...
  51. ncbi Biventricular pacing and transmural dispersion of the repolarization
    Cees A Swenne
    Europace 9:48-9; author reply 61. 2007
  52. ncbi (N-3) fatty acids do not affect electrocardiographic characteristics of healthy men and women
    Anouk Geelen
    Wageningen Centre for Food Sciences WCFS, The Netherlands
    J Nutr 132:3051-4. 2002
    ..These results do not support the hypothesis that (n-3) fatty acids prevent arrhythmia through electrophysiologic effects on heart cell membranes. However, an effect on the ECG in more susceptible populations can not be excluded...