Peter J Sterk

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma
    Annelies M Slats
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 121:1196-202. 2008
  2. pmc Airway inflammation contributes to health status in COPD: a cross-sectional study
    Jiska B Snoeck-Stroband
    General Practice, Leiden University Medical Center, Leiden, The Netherlands
    Respir Res 7:140. 2006
  3. ncbi Airway hyperresponsiveness: using bronchial challenge tests in research and management of asthma
    Peter J Sterk
    Lung Function Laboratory C2 P, Department of Pulmonology, Leiden University Medical Centre, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    J Aerosol Med 15:123-9. 2002
  4. doi CD8(+) T cells characterize early smoking-related airway pathology in patients with asthma
    A Janneke Ravensberg
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Respir Med 107:959-66. 2013
  5. pmc Inhaled steroids modulate extracellular matrix composition in bronchial biopsies of COPD patients: a randomized, controlled trial
    Lisette I Z Kunz
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e63430. 2013
  6. pmc Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD
    Lisette I Z Kunz
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Respir Res 12:34. 2011
  7. ncbi Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:517-27. 2009
  8. ncbi Enhanced airway dilation by positive-pressure inflation of the lungs compared with active deep inspiration in patients with asthma
    Annelies M Slats
    Dept of Pulmonology, Leiden Univ Medical Center, PO Box 9600, NL 2300 RC, Leiden, The Netherlands
    J Appl Physiol (1985) 105:1725-32. 2008
  9. pmc Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD
    Diana C Grootendorst
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Thorax 62:1081-7. 2007
  10. pmc Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients
    Rembert Koczulla
    Department of Pulmonology, Leiden University Medical Center, The Netherlands
    Respir Res 10:78. 2009

Detail Information

Publications43

  1. doi Expression of smooth muscle and extracellular matrix proteins in relation to airway function in asthma
    Annelies M Slats
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 121:1196-202. 2008
    ..However, smooth muscle cells express several contractile and structural proteins, and each of these proteins may influence airway function distinctly...
  2. pmc Airway inflammation contributes to health status in COPD: a cross-sectional study
    Jiska B Snoeck-Stroband
    General Practice, Leiden University Medical Center, Leiden, The Netherlands
    Respir Res 7:140. 2006
    ..It is still unknown which factors are responsible for the impaired health status in COPD. We postulated that airway inflammation negatively contributes to health status in COPD...
  3. ncbi Airway hyperresponsiveness: using bronchial challenge tests in research and management of asthma
    Peter J Sterk
    Lung Function Laboratory C2 P, Department of Pulmonology, Leiden University Medical Centre, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    J Aerosol Med 15:123-9. 2002
    ..The potential benefits of monitoring other phenotypic disease markers is currently under investigation...
  4. doi CD8(+) T cells characterize early smoking-related airway pathology in patients with asthma
    A Janneke Ravensberg
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Respir Med 107:959-66. 2013
    ..Bronchial CD8(+) T cells are implicated in lung function decline in asthma and COPD. We hypothesized that smoking modifies airway inflammation in asthma by increasing the number of CD8(+) T cells at an early stage...
  5. pmc Inhaled steroids modulate extracellular matrix composition in bronchial biopsies of COPD patients: a randomized, controlled trial
    Lisette I Z Kunz
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e63430. 2013
    ..We hypothesized that inhaled corticosteroids and current smoking modulate bronchial extracellular matrix components in COPD...
  6. pmc Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD
    Lisette I Z Kunz
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Respir Res 12:34. 2011
    ..Our aim was to study macrophage heterogeneity using the M2-marker CD163 and selected pro- and anti-inflammatory mediators in bronchoalveolar lavage (BAL) fluid and induced sputum from current smokers and ex-smokers with COPD...
  7. ncbi Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:517-27. 2009
    ..Inhaled corticosteroids (ICSs) and long-acting beta(2)-agonists (LABAs) are used to treat moderate to severe chronic obstructive pulmonary disease (COPD)...
  8. ncbi Enhanced airway dilation by positive-pressure inflation of the lungs compared with active deep inspiration in patients with asthma
    Annelies M Slats
    Dept of Pulmonology, Leiden Univ Medical Center, PO Box 9600, NL 2300 RC, Leiden, The Netherlands
    J Appl Physiol (1985) 105:1725-32. 2008
    ..6 +/- 0.2 vs. -1.0 +/- 0.3 cmH(2)O.l(-1).s, P = 0.18). Positive-pressure inflation of the lungs can significantly enhance deep inspiration-induced bronchodilation in patients with asthma...
  9. pmc Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD
    Diana C Grootendorst
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Thorax 62:1081-7. 2007
    ..Results from in vitro studies with roflumilast indicate that it has anti-inflammatory properties that may be applicable for the treatment of COPD...
  10. pmc Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients
    Rembert Koczulla
    Department of Pulmonology, Leiden University Medical Center, The Netherlands
    Respir Res 10:78. 2009
    ..Analysis of exhaled breath condensate (EBC) is a non-invasive method for studying the acidity (pH) of airway secretions in patients with inflammatory lung diseases...
  11. doi An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD
    Silvano Dragonieri
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Lung Cancer 64:166-70. 2009
    ..We hypothesized that an electronic nose can discriminate patients with lung cancer from COPD patients and healthy controls by analyzing the VOC-profile in exhaled breath...
  12. ncbi Small airways dysfunction and neutrophilic inflammation in bronchial biopsies and BAL in COPD
    Thérèse S Lapperre
    Department of Pulmonology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    Chest 131:53-9. 2007
    ..We investigated whether uneven ventilation and airway closure are associated with specific markers of airway inflammation as obtained by bronchial biopsies, BAL, and induced sputum in patients with manifest COPD...
  13. pmc Differential distribution of inflammatory cells in large and small airways in smokers
    Salvatore Battaglia
    Department of Pulmonology, Leiden University Medical Centre LUMC, Leiden, The Netherlands
    J Clin Pathol 60:907-11. 2007
    ..Hypothesis: The content of cells infiltrating the airway wall differs between LA and SA...
  14. ncbi Improvement in bronchodilation following deep inspiration after a course of high-dose oral prednisone in asthma
    Annelies M Slats
    Department of Pulmonology C2 P 62, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Chest 130:58-65. 2006
    ..We hypothesized that oral steroid treatment further optimizes deep inspiration-induced bronchodilation in clinically stable asthmatic patients who are receiving therapy with inhaled corticosteroids...
  15. ncbi An electronic nose in the discrimination of patients with asthma and controls
    Silvano Dragonieri
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 120:856-62. 2007
    ..Exhaled breath contains thousands of volatile organic compounds (VOCs) that could serve as biomarkers of lung disease. Electronic noses can distinguish VOC mixtures by pattern recognition...
  16. ncbi Expression of the anaphylatoxin receptors C3aR and C5aR is increased in fatal asthma
    Laura Fregonese
    Department of Pulmonology, Leiden University Medical Centre, Albinusdreef 2, 2233 ZA Leiden, The Netherlands
    J Allergy Clin Immunol 115:1148-54. 2005
    ..Recent studies suggest the involvement of the anaphylatoxins C3a and C5a, generated during complement activation, and their receptors C3aR and C5aR in the pathogenesis of asthma...
  17. ncbi Bronchial CD8 cell infiltrate and lung function decline in asthma
    Elizabeth L J Van Rensen
    Department of Pulmonology, C3 P, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Am J Respir Crit Care Med 172:837-41. 2005
    ..Patients with asthma have an accelerated decline in lung function, which can lead to irreversible airway obstruction. It is generally assumed that this is related to specific aspects of airway inflammation and/or remodeling...
  18. ncbi Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease
    Annelies M Slats
    Leiden University Medical Center, Department of Pulmonology C2 P 62, P O Box 9600, 2300 RC Leiden, and Department of Pediatrics, Erasmus University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Am J Respir Crit Care Med 176:121-8. 2007
    ..Airway inflammation has been suggested to alter airway mechanics during deep inspiration...
  19. ncbi Internet-based self-management plus education compared with usual care in asthma: a randomized trial
    Victor van der Meer
    Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 151:110-20. 2009
    ..The Internet may support patient self-management of chronic conditions, such as asthma...
  20. pmc Weekly self-monitoring and treatment adjustment benefit patients with partly controlled and uncontrolled asthma: an analysis of the SMASHING study
    Victor van der Meer
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Respir Res 11:74. 2010
    ..We hypothesized that self-management guided by weekly monitoring of asthma control tailors pharmacological therapy to individual needs and improves asthma control for patients with partly controlled or uncontrolled asthma...
  21. ncbi Dissociation of lung function and airway inflammation in chronic obstructive pulmonary disease
    Thérèse S Lapperre
    Lung Function Lab, C2 P, Department of Pulmonology, Leiden University Medical Center, Albinusdreef 2, P O Box 9600 2300 RC Leiden, The Netherlands
    Am J Respir Crit Care Med 170:499-504. 2004
    ..We conclude that airflow limitation, airway inflammation, and features commonly associated with asthma are separate and largely independent factors in the pathophysiology of COPD...
  22. ncbi Are rhinovirus-induced airway responses in asthma aggravated by chronic allergen exposure?
    Josephine de Kluijver
    Lung Function Laboratory, Department of Pulmonology, Leiden University Medical Center, P O Box 9600, NL 2300 RC Leiden, The Netherlands
    Am J Respir Crit Care Med 168:1174-80. 2003
    ..This suggests that preceding allergen exposure, at the used dose and duration, is not a determinant of the severity of RV-induced exacerbations in patients with mild to moderate asthma...
  23. ncbi Fully automated assessment of inflammatory cell counts and cytokine expression in bronchial tissue
    Jacob K Sont
    Department of Medical Decision Making, J10 S Leiden University Medical Center, P O Box 9600, NL 2300 RC Leiden, The Netherlands
    Am J Respir Crit Care Med 167:1496-503. 2003
    ..40-0.84). We conclude that fully automated cell counts and automated densitometric analyses in bronchial tissue of patients with asthma are unbiased and help to reduce variability in inflammatory outcomes...
  24. ncbi Asymptomatic worsening of airway inflammation during low-dose allergen exposure in asthma: protection by inhaled steroids
    Josephine de Kluijver
    Department of Pulmonology, Lung Function Laboratory, C2 P 62 Leiden University Medical Center, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    Am J Respir Crit Care Med 166:294-300. 2002
    ..This suggests that antiinflammatory therapy is beneficial during allergen exposure, even during asymptomatic episodes...
  25. pmc Asthma control cost-utility randomized trial evaluation (ACCURATE): the goals of asthma treatment
    Persijn J Honkoop
    Dept of Medical Decision Making Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    BMC Pulm Med 11:53. 2011
    ..sufficiently controlled asthma2. strictly controlled asthma3. strictly controlled asthma based on exhaled nitric oxide as an additional disease marker..
  26. ncbi Assessment of microvascular leakage via sputum induction: the role of substance P and neurokinin A in patients with asthma
    Elizabeth L J Van Rensen
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Respir Crit Care Med 165:1275-9. 2002
    ..This investigational model of "dual induction" (first leakage, then sputum) may therefore be useful to test the antiexudative effect of newly develop drugs, such as NK1 antagonists...
  27. ncbi Internet-based self-management offers an opportunity to achieve better asthma control in adolescents
    Victor van der Meer
    Department of Medical Decision Making, J10 87, Leiden University Medical Center, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    Chest 132:112-9. 2007
    ..Our objective was to reveal the barriers and benefits perceived by adolescents with well-controlled and poorly controlled asthma to current and internet-based asthma management...
  28. ncbi Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge
    A Janneke Ravensberg
    Department of Pulmonology, Lung Function Laboratory C2 P 62, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Allergy Clin Immunol 115:779-85. 2005
    ..Eotaxin-2 and eotaxin-3 might play a role in the subsequent persistence of allergen-induced bronchial eosinophilia...
  29. ncbi Enhanced expression of fibroblast growth factors and receptor FGFR-1 during vascular remodeling in chronic obstructive pulmonary disease
    Andor R Kranenburg
    Department of Pharmacology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Am J Respir Cell Mol Biol 27:517-25. 2002
    ..007) and was inversely correlated with FEV(1) values (P < 0.007). Our results suggest an autocrine role of the FGF-FGFR-1 system in the pathogenesis of COPD-associated vascular remodeling...
  30. ncbi Eosinophil progenitors in sputum: throwing out the baby with the bath water?
    Peter J Sterk
    Am J Respir Crit Care Med 169:549-50. 2004
  31. ncbi Chronic sinusitis in severe asthma is related to sputum eosinophilia
    Anneke ten Brinke
    Department of Pulmonary Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 109:621-6. 2002
    ..We hypothesized that the extent of inflammation in the nasal mucosa is related to lung function and inflammation in the bronchial mucosa in patients with severe asthma...
  32. ncbi Asthma therapy and airway remodeling
    Thais Mauad
    Department of Pathology, Sao Paulo University Medical School, Sao Paulo, Brazil
    J Allergy Clin Immunol 120:997-1009; quiz 1010-1. 2007
    ..Progress in this area requires the explicit linking of modern structure-function analysis with innovative biopharmaceutical approaches...
  33. ncbi "Refractory" eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroids
    Anneke ten Brinke
    Department of Pulmonary Diseases, Leeuwarden Medical Center, The Netherlands
    Am J Respir Crit Care Med 170:601-5. 2004
    ..This implies that these patients with severe asthma need additional or alternative antiinflammatory treatment to combat the eosinophilia and associated poor prognosis...
  34. ncbi Chronic obstructive pulmonary disease is associated with enhanced bronchial expression of FGF-1, FGF-2, and FGFR-1
    Andor R Kranenburg
    Department of Pharmacology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Pathol 206:28-38. 2005
    ....
  35. ncbi Nitric oxide in health and disease of the respiratory system
    Fabio L M Ricciardolo
    Dept of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Physiol Rev 84:731-65. 2004
    ....
  36. ncbi Effect of an NK1/NK2 receptor antagonist on airway responses and inflammation to allergen in asthma
    Johan D Boot
    Centre for Human Drug Research, Zernikedreef 10 2333 CL, Leiden, The Netherlands
    Am J Respir Crit Care Med 175:450-7. 2007
    ..Objective: We tested the safety, tolerability, and pharmacologic and biological efficacy of a tachykinin NK(1)/NK(2) receptor antagonist, AVE5883, in patients with asthma in two double-blind, placebo-controlled crossover studies...
  37. ncbi Enhanced bronchial expression of extracellular matrix proteins in chronic obstructive pulmonary disease
    Andor R Kranenburg
    Department of Pharmacology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Am J Clin Pathol 126:725-35. 2006
    ..Our data suggest that COPD exhibits increased bronchial deposition of ECM proteins that contribute to deteriorated lung function and airway remodeling...
  38. ncbi Relationship between airway responsiveness to neurokinin A and methacholine in asthma
    Judith Cohen
    Centre for Human Drug Research, Zernikedreef 10, 2333 CL Leiden, The Netherlands
    Pulm Pharmacol Ther 18:171-6. 2005
    ..Based on our data and previous studies in asthma, it can be hypothesized that this direct NKA-induced bronchoconstrictor response may be mediated by predominant stimulation of the tachykinin NK-2 receptors on airway smooth muscle cells...
  39. ncbi Heterogeneity of airway hyperresponsiveness: time for unconventional, but traditional, studies
    Peter J Sterk
    J Appl Physiol 96:2017-8. 2004
  40. ncbi Transcriptional machinery in asthma: closing the gap with clinical phenotypes
    Peter J Sterk
    Am J Respir Crit Care Med 166:260-1. 2002
  41. ncbi The trials and tribulations of anti-IL-5 em leader
    Trevor T Hansel
    J Allergy Clin Immunol 109:575-6. 2002
  42. ncbi Severe asthma in adults: what are the important questions?
    Pascal Chanez
    INSERM U454 and Clinique des Maladies Respiratoires, Montpellier, France
    J Allergy Clin Immunol 119:1337-48. 2007
    ..Inhaled corticosteroids and bronchodilators are the mainstay of treatment, but patients with SRA remain uncontrolled, indicating a need for new therapies...
  43. ncbi Automatic negative evaluation of suffocation sensations in individuals with suffocation fear
    Sabine Kroeze
    Department of Psychology, Leiden University, Leiden, The Netherlands
    J Abnorm Psychol 114:466-70. 2005
    ..The findings are relevant to the cognitive model of panic disorder because automatic negative appraisal of sensations may play a role in initiating a panic attack...