Paul H A Quax

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Toll-like receptor 4 is involved in human and mouse vein graft remodeling, and local gene silencing reduces vein graft disease in hypercholesterolemic APOE*3Leiden mice
    Jacco C Karper
    Department of Vascular Surgery, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 31:1033-40. 2011
  2. pmc Plaque rupture complications in murine atherosclerotic vein grafts can be prevented by TIMP-1 overexpression
    Margreet R De Vries
    Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e47134. 2012
  3. pmc TLR accessory molecule RP105 (CD180) is involved in post-interventional vascular remodeling and soluble RP105 modulates neointima formation
    Jacco C Karper
    Department of Surgery, LUMC, Leiden, The Netherlands
    PLoS ONE 8:e67923. 2013
  4. doi request reprint A novel urokinase receptor-targeted inhibitor for plasmin and matrix metalloproteinases suppresses vein graft disease
    Daniel Eefting
    Department of Vascular Surgery, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Cardiovasc Res 88:367-75. 2010
  5. doi request reprint MicroRNA-126 modulates endothelial SDF-1 expression and mobilization of Sca-1(+)/Lin(-) progenitor cells in ischaemia
    Coen van Solingen
    Department of Nephrology, LUMC, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Cardiovasc Res 92:449-55. 2011
  6. doi request reprint In vivo suppression of vein graft disease by nonviral, electroporation-mediated, gene transfer of tissue inhibitor of metalloproteinase-1 linked to the amino terminal fragment of urokinase (TIMP-1.ATF), a cell-surface directed matrix metalloproteinase inh
    Daniel Eefting
    Gaubius Laboratory, TNO Quality of Life, Leiden University Medical Center, Leiden, The Netherlands
    J Vasc Surg 51:429-37. 2010
  7. doi request reprint Blocking toll-like receptors 7 and 9 reduces postinterventional remodeling via reduced macrophage activation, foam cell formation, and migration
    Jacco C Karper
    Einthoven Laboratory of Vascular Medicine, Department of Surgery, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 32:e72-80. 2012
  8. doi request reprint Absence of chemokine (C-x-C motif) ligand 10 diminishes perfusion recovery after local arterial occlusion in mice
    Pleunie van den Borne
    From the Laboratory of Experimental Cardiology P v d B, R T H, I E H, G P, D P V d K, Department of Nephrology and Hypertension C C, and Department of Cardiology H J D, University Medical Center Utrecht, Utrecht, The Netherlands Molecular Cardiology Laboratory, Experimental Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands M M B, C C Department of Surgery P H A Q and Einthoven Laboratory of Experimental Vascular Medicine P H A Q, Leiden University Medical Center, Leiden, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands I E H, G P, D P V d K and Cardiovascular Research Institute and Surgery, National University Hospital, Singapore, Singapore D P V d K
    Arterioscler Thromb Vasc Biol 34:594-602. 2014
  9. pmc Sirolimus and paclitaxel provoke different vascular pathological responses after local delivery in a murine model for restenosis on underlying atherosclerotic arteries
    Nuno M M Pires
    TNO Quality of Life, Gaubius Laboratory, Leiden, The Netherlands
    Heart 93:922-7. 2007
  10. ncbi request reprint Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation
    Nuno M M Pires
    Gaubius Laboratory, TNO Quality of Life, Leiden, The Netherlands
    Circulation 115:493-500. 2007

Collaborators

Detail Information

Publications41

  1. doi request reprint Toll-like receptor 4 is involved in human and mouse vein graft remodeling, and local gene silencing reduces vein graft disease in hypercholesterolemic APOE*3Leiden mice
    Jacco C Karper
    Department of Vascular Surgery, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 31:1033-40. 2011
    ..The goal of this study was to explore the role of Toll-like receptor 4 (TLR4) in vein graft remodeling and disease...
  2. pmc Plaque rupture complications in murine atherosclerotic vein grafts can be prevented by TIMP-1 overexpression
    Margreet R De Vries
    Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e47134. 2012
    ..Moreover, inhibition of MMPs by TIMP-1-overexpression resulted in decreased plaque progression, increased stabilization and decreased plaque rupture complications in murine vein grafts...
  3. pmc TLR accessory molecule RP105 (CD180) is involved in post-interventional vascular remodeling and soluble RP105 modulates neointima formation
    Jacco C Karper
    Department of Surgery, LUMC, Leiden, The Netherlands
    PLoS ONE 8:e67923. 2013
    ..The role of RP105 in vascular remodeling, in particular post-interventional remodeling is unknown...
  4. doi request reprint A novel urokinase receptor-targeted inhibitor for plasmin and matrix metalloproteinases suppresses vein graft disease
    Daniel Eefting
    Department of Vascular Surgery, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Cardiovasc Res 88:367-75. 2010
    ..The effect of overexpression of this protein on vein graft disease was studied...
  5. doi request reprint MicroRNA-126 modulates endothelial SDF-1 expression and mobilization of Sca-1(+)/Lin(-) progenitor cells in ischaemia
    Coen van Solingen
    Department of Nephrology, LUMC, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Cardiovasc Res 92:449-55. 2011
    ..Based on the seed sequence, miR-126 can also be predicted to regulate vasculogenesis by modulating the endothelial expression of stromal cell-derived factor-1 (SDF-1)...
  6. doi request reprint In vivo suppression of vein graft disease by nonviral, electroporation-mediated, gene transfer of tissue inhibitor of metalloproteinase-1 linked to the amino terminal fragment of urokinase (TIMP-1.ATF), a cell-surface directed matrix metalloproteinase inh
    Daniel Eefting
    Gaubius Laboratory, TNO Quality of Life, Leiden University Medical Center, Leiden, The Netherlands
    J Vasc Surg 51:429-37. 2010
    ..ATF plasmid to reduce vein graft disease in a murine bypass model. Nonviral gene transfer by electroporation was used to avert major disadvantages of viral gene delivery, such as immune responses and short-term expression...
  7. doi request reprint Blocking toll-like receptors 7 and 9 reduces postinterventional remodeling via reduced macrophage activation, foam cell formation, and migration
    Jacco C Karper
    Einthoven Laboratory of Vascular Medicine, Department of Surgery, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 32:e72-80. 2012
    ..However, the involvement of the endosomal TLRs is unknown. Here, we study the effect of combined blocking of TLR7 and TLR9 on postinterventional remodeling and accelerated atherosclerosis...
  8. doi request reprint Absence of chemokine (C-x-C motif) ligand 10 diminishes perfusion recovery after local arterial occlusion in mice
    Pleunie van den Borne
    From the Laboratory of Experimental Cardiology P v d B, R T H, I E H, G P, D P V d K, Department of Nephrology and Hypertension C C, and Department of Cardiology H J D, University Medical Center Utrecht, Utrecht, The Netherlands Molecular Cardiology Laboratory, Experimental Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands M M B, C C Department of Surgery P H A Q and Einthoven Laboratory of Experimental Vascular Medicine P H A Q, Leiden University Medical Center, Leiden, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands I E H, G P, D P V d K and Cardiovascular Research Institute and Surgery, National University Hospital, Singapore, Singapore D P V d K
    Arterioscler Thromb Vasc Biol 34:594-602. 2014
    ..Toll-like receptors are involved in arteriogenesis; however, the role of CXCL10 is still unclear. In this study, we investigated the role for CXCL10 in a murine hindlimb ischemia model...
  9. pmc Sirolimus and paclitaxel provoke different vascular pathological responses after local delivery in a murine model for restenosis on underlying atherosclerotic arteries
    Nuno M M Pires
    TNO Quality of Life, Gaubius Laboratory, Leiden, The Netherlands
    Heart 93:922-7. 2007
    ..Drug-eluting stents (DES) have been introduced successfully in clinical practice to prevent post-angioplasty restenosis. Nevertheless, concerns about the safety of DES still exist...
  10. ncbi request reprint Activation of nuclear receptor Nur77 by 6-mercaptopurine protects against neointima formation
    Nuno M M Pires
    Gaubius Laboratory, TNO Quality of Life, Leiden, The Netherlands
    Circulation 115:493-500. 2007
    ..We hypothesized that 6-MP inhibits neointima formation through activation of Nur77...
  11. pmc Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene
    Jeffrey J W Verschuren
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e70676. 2013
    ....
  12. pmc Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation
    Martine Bot
    Division of Biopharmaceutics, Leiden Academic Centre for Drug Research, 2333 CC, Leiden University, Leiden, The Netherlands
    J Lipid Res 54:1265-74. 2013
    ..This study points to local LPA availability as an important factor in atherosclerotic plaque stability...
  13. pmc Protease-activated receptor (PAR)2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model
    Lisa G van den Hengel
    Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e61923. 2013
    ..Here, we investigated the physiological role of PAR1 and PAR2 in arteriogenesis in a murine hind limb ischemia model...
  14. ncbi request reprint Short-term dexamethasone treatment inhibits vein graft thickening in hypercholesterolemic ApoE3Leiden transgenic mice
    Abbey Schepers
    Gaubius Laboratory, TNO Quality of Life, Leiden University Medical Center, The Netherlands
    J Vasc Surg 43:809-15. 2006
    ..The aim of this study was to assess whether the anti-inflammatory agent dexamethasone can inhibit vein graft thickening without the occurrence of serious side effects...
  15. doi request reprint Shear induced collateral artery growth modulated by endoglin but not by ALK1
    Leonard Seghers
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Mol Med 16:2440-50. 2012
    ..Importantly, endoglin contributes to both shear induced collateral artery growth and to ischaemia induced angiogenesis, whereas ALK1 is only involved in ischaemia induced angiogenesis...
  16. doi request reprint Annexin A5 therapy attenuates vascular inflammation and remodeling and improves endothelial function in mice
    Mark M Ewing
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 31:95-101. 2011
    ..Annexin A5 (AnxA5) has antithrombotic, antiapoptotic, and antiinflammatory properties; we investigated its effectiveness against vascular inflammation, remodeling, and dysfunction in accelerated atherosclerosis...
  17. ncbi request reprint The effect of interleukin-10 knock-out and overexpression on neointima formation in hypercholesterolemic APOE*3-Leiden mice
    Daniel Eefting
    Gaubius Laboratory, TNO Quality of Life, Leiden, The Netherlands
    Atherosclerosis 193:335-42. 2007
    ..The aim of this study was to assess the effects of IL10 modulation on cuff-induced neointima formation in hypercholesterolemic APOE*3-Leiden mice...
  18. pmc Lysine acetyltransferase PCAF is a key regulator of arteriogenesis
    Antonius J N M Bastiaansen
    Department of Surgery, Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 33:1902-10. 2013
    ..Because arteriogenesis is an inflammation-driven process, we hypothesized that PCAF acts as multifactorial regulator of arteriogenesis...
  19. ncbi request reprint The influence of established genetic variation in the haemostatic system on clinical restenosis after percutaneous coronary interventions
    Douwe Pons
    Leiden University Medical Center, Department of Cardiology, C5 P, Albinusdreef 2, P O Box 9600, 2300 RC Leiden, The Netherlands
    Thromb Haemost 98:1323-8. 2007
    ..41, 95% CI: 0.19-0.86). Our findings indicate that polymorphisms in the factorV and PAI-1 genes may play a role in the process of restenosis...
  20. ncbi request reprint Vascular remodeling and intimal hyperplasia in a novel murine model of arteriovenous fistula failure
    Chun Yu Wong
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    J Vasc Surg 59:192-201.e1. 2014
    ..Here we describe a novel murine model of AVF failure in which the configuration (end-to-side) is similar to what is most frequently performed in humans...
  21. ncbi request reprint Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice
    Daniel Eefting
    Gaubius Laboratory, TNO Quality of Life, Leiden, The Netherlands
    J Vasc Surg 50:152-60. 2009
    ..A murine model for vein graft disease was used to study the effect of local application of lentiviral short hairpin RNA (shRNA) targeted against CCR2...
  22. doi request reprint Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease
    Margreet R De Vries
    Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands
    Cardiovasc Res 97:311-20. 2013
    ..We hypothesize that C5a-mediated mast cell activation is involved in the development and destabilization of vein graft lesions...
  23. pmc TLR4 Accessory Molecule RP105 (CD180) Regulates Monocyte-Driven Arteriogenesis in a Murine Hind Limb Ischemia Model
    Antonius J N M Bastiaansen
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 9:e99882. 2014
    ..As RP105 inhibits TLR4 signaling, we hypothesized that RP105 deficiency would lead to an unrestrained TLR4-mediated inflammatory response and hence to enhanced blood flow recovery after ischemia...
  24. ncbi request reprint Inhibition of neointima formation by local delivery of estrogen receptor alpha and beta specific agonists
    Yvonne D Krom
    Department of Human Genetics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Cardiovasc Res 73:217-26. 2007
    ..However, the role of estrogen receptor beta (ERbeta) is not fully elucidated. In the present study, the specific role of vascular ERalpha and ERbeta in neointima formation is assessed...
  25. doi request reprint Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies
    Douwe Pons
    Department of Cardiology, Leiden University Medical Center, RC Leiden, The Netherlands
    Heart 97:143-50. 2011
    ....
  26. doi request reprint Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention
    Pascalle S Monraats
    Leiden University Medical Center, Department of Cardiology, C5 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    Expert Opin Ther Targets 14:243-51. 2010
    ..Since the inflammatory response is implicated in restenosis, VDR-gene variants could therefore contribute to the risk of restenosis...
  27. ncbi request reprint Epigenetics in atherosclerosis and inflammation
    Rutger J Wierda
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Mol Med 14:1225-40. 2010
    ..Moreover we highlight potential therapeutic interventions based on epigenetic mechanisms...
  28. doi request reprint Arteriovenous access failure: more than just intimal hyperplasia?
    Tonia C Rothuizen
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Nephrol Dial Transplant 28:1085-92. 2013
    ..Further unravelling the (patho)physiology of outward remodelling and IH could contribute to novel therapies and enhance fistula patency...
  29. doi request reprint Restenosis after PCI. Part 1: pathophysiology and risk factors
    J Wouter Jukema
    Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Nat Rev Cardiol 9:53-62. 2012
    ..In this Review, we will evaluate the available evidence on the pathophysiological mechanisms of restenosis and provide an overview of the various risk factors, together with the possible clinical application of this knowledge...
  30. doi request reprint Future potential biomarkers for postinterventional restenosis and accelerated atherosclerosis
    Jacco C Karper
    Department of Surgery, Leiden University Medical Center, The Netherlands
    Biomark Med 6:53-66. 2012
    ..This review provides an overview of a number of potential biomarkers selected on the basis of their role in the remodeling process...
  31. doi request reprint Restenosis after PCI. Part 2: prevention and therapy
    J Wouter Jukema
    Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Nat Rev Cardiol 9:79-90. 2012
    ..In this Review we provide an overview of the latest innovations for optimizing outcomes of coronary stenting, and up-to-date information about prevention and treatment of in-stent restenosis...
  32. pmc Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors
    Rutger J Wierda
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Mol Med 16:1866-77. 2012
    ..Together, these data indicate that epigenetic modifications of DNA, and of histones, contribute to the control of CCR5 transcription in immune effector cells...
  33. doi request reprint Cardiovascular metabolic syndrome: mediators involved in the pathophysiology from obesity to coronary heart disease
    Cornelis J Roos
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Biomark Med 6:35-52. 2012
    ..The second part evaluates several mediators from this pathophysiologic pathway for their applicability as biomarkers for the identification of coronary heart disease...
  34. ncbi request reprint Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation
    Rutger L van Bezooijen
    Department of Endocrinology and Metabolic Diseases, Leiden Univerity Medical Center, Ther Netherlands
    J Bone Miner Res 22:19-28. 2007
    ..It inhibits BMP-stimulated bone formation both in vitro and in vivo but has no direct effect on BMP signaling. Instead, sclerostin inhibits Wnt signaling that is required for BMP-stimulated osteoblastic differentiation...
  35. doi request reprint Clinical performance of drug-eluting stents with biodegradable polymeric coating: a meta-analysis and systematic review
    Tarek A N Ahmed
    Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
    EuroIntervention 7:505-16. 2011
    ..We sought to; 1) evaluate the risk of target lesion revascularisation (TLR) and definite stent thrombosis (DST) among different groups of biodegradable-polymer (BioPol) DES, and 2) to compare them with permanent polymer (PermPol) DES...
  36. doi request reprint Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease
    Douwe Pons
    Department of Cardiology, Leiden University Medical Center, C5 P, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur Heart J 30:266-77. 2009
    ....
  37. doi request reprint Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis
    Coen van Solingen
    Department of Nephrology and the Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, The Netherlands
    J Cell Mol Med 13:1577-85. 2009
    ..Our data demonstrate a facilitary function for miR-126 in ischemia-induced angiogenesis and show the efficacy and specificity of antagomir-induced silencing of EC-specific microRNAs in vivo...
  38. doi request reprint Toll-like receptor 4 inhibitor TAK-242 treatment does not influence perfusion recovery in tissue ischemia
    Pleunie van den Borne
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands Department of Surgery and Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands and Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands
    J Cardiovasc Pharmacol 63:16-22. 2014
    ..TAK-242 attenuated TLR4 responses in vivo but did not inhibit perfusion recovery in mice. In conclusion, TAK-242 does not negatively influence perfusion recovery following hind limb ischemia despite its TLR4 inhibiting properties...
  39. ncbi request reprint Tumor necrosis factor-alpha plays an important role in restenosis development
    Pascalle S Monraats
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    FASEB J 19:1998-2004. 2005
    ..Therefore, TNFalpha genotype may be used as a risk marker for restenosis and may contribute to individual patient screening prior to PCI in clinical practice. Inhibition of TNFalpha may be an anti-restenotic target strategy...
  40. ncbi request reprint Hypercholesterolemia reduces collateral artery growth more dominantly than hyperglycemia or insulin resistance in mice
    Vincent van Weel
    Gaubius Laboratory TNO Biomedical Research, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 26:1383-90. 2006
    ..Here, we compared the effects of either disturbed glucose metabolism or disturbed lipid metabolism on arteriogenesis...
  41. ncbi request reprint Vascular endothelial growth factor overexpression in ischemic skeletal muscle enhances myoglobin expression in vivo
    Vincent van Weel
    Gaubius Laboratory TNO PG, PO Box 2215 2301CE, Leiden, The Netherlands
    Circ Res 95:58-66. 2004
    ..Increased myoglobin expression in VEGF-treated muscle implies an improved muscle oxygenation, which may, at least partly, explain observed clinical improvements in VEGF-treated patients, in the absence of improved vascularization...